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All Journal journal of internal medicine WMJ (Warmadewa Medical Journal) Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal EduHealth Aesculapius Medical Journal Warmadewa Minesterium Medical Journal
Luh Gede Sri Yenny
Universitas Warmadewa
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health Social Sciences Veterinary

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Effect of Candesartan on Creatinine and Albuminuria in Geriatric Patients with Diabetic Nephropathy Sri Yenny, Luh Gede; Ni Wayan Rusni
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Diabetes can cause various chronic complications, one of the most feared being diabetic nephropathy. Diabetic nephropathy is characterized by proteinuria and/or decreased glomerular filtration rate. Diabetic nephropathy is a major cause of chronic kidney disease, which can lead to end-stage renal disease requiring hemodialysis. Candesartan is an angiotensin receptor blocker antihypertensive drug. In addition to lowering blood pressure, candesartan is also thought to decrease renal vascular resistance, resulting in a decrease in microalbuminuria or proteinuria in patients with diabetes mellitus. Diabetic nephropathy increases with age, and geriatric patients have a lower response to therapy than adults. To determine the effect of candesartan on creatinine and albuminuria in geriatric patients with diabetic nephropathy. This was a cross-sectional study of 25 geriatric patients diagnosed with diabetic nephropathy who had been given 16 mg of candesartan as an antihypertensive at the Puri Raharja Hospital Denpasar outpatient clinic. Subjects who met the inclusion and exclusion criteria were recruited using consecutive sampling. The diabetic nephropathy subjects were evaluated for creatinine and proteinuria levels at the time of diagnosis and 3 months after receiving 16 mg of candesartan. All data were obtained from medical records. The study involved 25 patients consisting of 13 men (52%) and 12 women (485%). Subjects aged between 60-82 years with initial creatinine levels of 0.80-2.60 mg/dL, final creatinine levels of 1.395 ± 0.50 SD, initial positive proteinuria levels of 0-2, and final positive creatinine levels of 0-1. Based on the T-test, there was no significant difference between initial and final creatinine levels with a p value = 0.892 (95% CI -0.045-0.051). Based on the Wilcoxon test, there was a significant difference between proteinuria levels before and after candesartan administration with a p value p <0.05. This study did not find a significant decrease in creatinine after candesartan administration. However, candesartan significantly reduced proteinuria in geriatric patients with diabetic nephropathy.
Effect of Candesartan on Creatinine and Albuminuria in Geriatric Patients with Diabetic Nephropathy Luh Gede Sri Yenny; Ni Wayan Rusni
Jurnal EduHealth Vol. 17 No. 01 (2026): Jurnal EduHealt, January-March 2026
Publisher : Sean Institute

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Diabetic nephropathy (DN) is a major complication of diabetes, leading to proteinuria and declining kidney function. Candesartan, an angiotensin receptor blocker, may offer renal benefits beyond blood pressure control. Its specific effects on creatinine and proteinuria in geriatric DN patients remain underexplored. A cross-sectional study was conducted with 25 geriatric DN outpatients at Puri Raharja Hospital. Using consecutive sampling, subjects receiving 16 mg candesartan daily had their serum creatinine and proteinuria levels evaluated from medical records at baseline and after three months. The cohort (60-82 years) comprised 13 men and 12 women. Initial creatinine ranged from 0.80-2.60 mg/dL, with a final mean of 1.395 ± 0.50 mg/dL. Statistical analysis (paired T-test) showed no significant change in creatinine levels (p=0.892). However, proteinuria significantly decreased post-treatment (Wilcoxon test, p=0.005). Candesartan administration did not significantly reduce serum creatinine in geriatric DN patients over three months. However, the significant reduction in proteinuria indicates a beneficial effect on renal pathology, potentially slowing DN progression in this population.
Co-Authors Anak Agung Sri Agung Aryastuti Cahyawati, Putu Nita Hegard Sukmawati, Ni Made I Ketut Suastika I Made Wandia I Made Wandia, I Made K Tangking Widarsa Kadek Dean Ariska Aryawangsa Komang Rossa Triana Kusumadewi Komang Trisna Sumadewi Ni Putu Ayu Indah Eliani Ni Wayan Ayu Maha Dewi Ni Wayan Rusni Ni Wayan Rusni Nita Cahyawati, Putu Pande Ayu Naya Kasih Permatananda Ratna Juwita, Dewa Ayu Putu Sri Agung Aryastuti, Anak Agung Tanjung Subrata Wira Gotera