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Novita Carolia
Universitas Lampung
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The Use of Vitamin D in Heart Failure Management: A Literature Review Ratu Bertha Sofiani; Novita Carolia; Wiwi Febriani; Juspeni Kartika
International Journal Of Health Science Vol. 5 No. 3 (2025): November : International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i3.6152

Abstract

Heart failure is a clinical syndrome characterized by structural or functional cardiac dysfunction that leads to hemodynamic disturbances and increased morbidity and mortality. Vitamin D, a prohormone with a vital role in metabolism, is known to exert cardioprotective effects through anti-inflammatory and anti-fibrotic mechanisms, modulation of calcium homeostasis, and inhibition of the renin–angiotensin–aldosterone system. Vitamin D deficiency has been shown to be highly prevalent among patients with heart failure and is correlated with poorer clinical outcomes. Numerous preclinical studies support the protective role of vitamin D against ventricular remodeling and myocardial hypertrophy; however, clinical trials in humans have yielded inconsistent and often contradictory findings regarding its effects on systolic function, surrogate parameters, and primary outcomes such as mortality and hospitalization. Consequently, vitamin D supplementation cannot yet be recommended as a standard therapy for heart failure, except in patients with confirmed deficiency. Further research with robust methodologies and stratified populations remains essential to elucidate its potential clinical benefits.
Co-Authors agustyas tjiptaningrum Akhmad Rizki Farhan Ari Wahyuni Arif Yudho Prabowo Dheti Efrilia - Dian Isti Angraini Efriyan Imantika Evy Kurniawaty Fitria Saftarina Intanri Kurniati Jaya Firmansyah Juspeni Kartika Letifa Rahmadani Maya Ganda Ratna Merry Indah Sari Mustofa Mustofa Ramadhana Komala Rasmi Zakiah Oktarlina Ratu Bertha Sofiani Salsabila Dzakiyyah Zahra Sri Hasnawati Syazili Mustofa Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani Zenith Puspitawati