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Novita Carolia
Universitas Lampung
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The Use of Vitamin D in Heart Failure Management: A Literature Review Ratu Bertha Sofiani; Novita Carolia; Wiwi Febriani; Juspeni Kartika
International Journal Of Health Science Vol. 5 No. 3 (2025): November : International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i3.6152

Abstract

Heart failure is a clinical syndrome characterized by structural or functional cardiac dysfunction that leads to hemodynamic disturbances and increased morbidity and mortality. Vitamin D, a prohormone with a vital role in metabolism, is known to exert cardioprotective effects through anti-inflammatory and anti-fibrotic mechanisms, modulation of calcium homeostasis, and inhibition of the renin–angiotensin–aldosterone system. Vitamin D deficiency has been shown to be highly prevalent among patients with heart failure and is correlated with poorer clinical outcomes. Numerous preclinical studies support the protective role of vitamin D against ventricular remodeling and myocardial hypertrophy; however, clinical trials in humans have yielded inconsistent and often contradictory findings regarding its effects on systolic function, surrogate parameters, and primary outcomes such as mortality and hospitalization. Consequently, vitamin D supplementation cannot yet be recommended as a standard therapy for heart failure, except in patients with confirmed deficiency. Further research with robust methodologies and stratified populations remains essential to elucidate its potential clinical benefits.
Uji Aktivitas Antibakteri Ekstrak Daun Jambu Air (Syzygium aqueum) : Sebuah Tinjauan Sistematis Muhammad Ariq Naufal; Susianti Susianti; Suryani Agustina Daulay; Novita Carolia
Jurnal Kesehatan Amanah Vol. 8 No. 2 (2024): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v8i2.693

Abstract

Indonesia is a country that dominated by tropical rainforests with adequate rainfall. These conditions allow various plant species to thrive. One such plant is water apple (Syzygium aqueum). The use of water apple leaf extract as an antibacterial agent has garnered attention due to the increasing trend of bacterial resistance againts antibiotics. The aim of this study is to describe the antibacterial effects of water apple (Syzygium aqueum) leaf extract on several bacterial species by observing the diameter of the inhibition zone. The method employed is a systematic review. Article searches were conducted through databases such as PubMed Central, ScienceDirect, Google Scholar, and Garuda. The journal selection and formulation of research questions were guided by the PICO method. Article searches followed the 2020 PRISMA methodology. The article search yielded six articles reviewed from a total of 9,911 articles identified. The findings from the reviewed articles indicate that water apple leaf extract (Syzygium aqueum) exhibits antibacterial effects on both gram-positive and gram-negative bacteria. The active compounds in water apple leaf extract that exhibit antibacterial properties are flavonoids, terpenoids, saponins, tannins, and alkaloids.
Co-Authors agustyas tjiptaningrum Akhmad Rizki Farhan Ari Wahyuni Arif Yudho Prabowo Dheti Efrilia - Dian Isti Angraini Efriyan Imantika Evy Kurniawaty Fitria Saftarina Intanri Kurniati Jaya Firmansyah Juspeni Kartika Letifa Rahmadani Maya Ganda Ratna Merry Indah Sari Muhammad Ariq Naufal Mustofa Mustofa Ramadhana Komala Rasmi Zakiah Oktarlina Ratu Bertha Sofiani Salsabila Dzakiyyah Zahra Sri Hasnawati Suryani Agustina Daulay Susianti Susianti Syazili Mustofa Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani Zenith Puspitawati