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POTENTIAL ACCELERATING EFFECT OF Ageratum conyzoides L. LEAVES EXTRACT ON FIBROBLASTS DENSITY OF INCISION WOUND OF MALE WHITE MICE (Mus musculus) Lestari, Mega Ayu; Sari, Ariestya Indah Permata; Amanah, Amanah
Proceedings of the International Conference on Applied Science and Health No 3 (2018)
Publisher : Proceedings of the International Conference on Applied Science and Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (845.459 KB)

Background: Wound treatment using traditional medicine has been known widely in various countries in the world. Ageratum conyzoidesL. is commonly known by the ancient people to treat wound due to its potential anti-inflammatory effect. This study aims determine the effect of Ageratum conyzoidesL. leaves extract on fibroblast density of incision wound of male white mice (Mus musculus). Methods: This post-test only control group design experimental study used 35 male white mice which were randomly divided into five groups, i.e. negative control group K(-), positive control group K(+) (10% povidone iodine), and treatment group P1, P2, and P3 that were each given billy-goat weed leaf with increasing dose (15%, 30%, and 45% respectively). On each day, the length of the incision was measured by a ruler. After 7 days, the mice were terminated to obtain wound tissue which were used to prepare H&E stained histopathological sections to observe fibroblast density. Non-parametric analyses using Kruskall-Wallis and Mann Whitney test were used to compare the wound length and fibroblasts density. Results: Lengths of incision wound between all pairs of groups at the 7th day are significantly different (p< 0.05) with group P3 showed the shortest one. Significant differences were also observed in fibroblasts density between group K(-) and K(+), K(-) and P1, K(-) and P2, K(-) and P3, K(+) and P3, P1 and P3, P2 and P3 (p< 0.05) with group P3 showed the highest density among all groups. Conclusions: Ageratum conyzoidesL. leaves extract 45% has more potential effect than povidone iodine 10% in accelerating healing process by enhancing fibroblasts density.Â

EFFECT OF TREE MARIGOLD (Tithonia diversifolia (HEMSL.) A. GRAY) LEAVES INFUSION AND ETHANOL EXTRACT ON BLOOD GLUCOSE LEVEL AND LIVER HISTOPATHOLOGY OF STREPTOZOTOCIN-INDUCED MALE WISTAR RATS Maulidiany, Rachma Ayu; Suhaeni, Eni; Sulistiyana, Catur Setiya; Sari, Ariestya Indah Permata
Proceedings of the International Conference on Applied Science and Health No 3 (2018)
Publisher : Proceedings of the International Conference on Applied Science and Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (563.222 KB)

Background: Common Indonesians often use alternative therapy for Diabetes Mellitus (DM) due to its high prevalence. Tree marigold (Tithonia difersivolia (Hemsl.) A. Gray) leaves show its positive effect in decreasing blood glucose level. Thus, it is important to analyze the negative effect of consuming the proposing alternative including its toxicity level to vital organs. This study aims to observe the blood glucose level and liver histopathology in streptozotocin-induced diabetic male rats treated by infusion and ethanol extract of the tree marigold leaves. Methods: Pretest and posttest with control group design experiment was conducted to analyze effect on blood glucose level and posttest only with control group design was for determining liver histopathology. Twenty-four male white rats (Wistar strain) were randomly divided into 4 groups: normal control group (KN), positive control group (K+) treated with 0.45mg/kg of glibenclamid, treatment group 1 (P1) treated by 100 mg/kg of tree marigold leaves ethanol extract, and treatment group 2 (P2) treated by 1373 mg/kg of tree marigold leaves infusion. The rats at the groups of K+, P1, and P2 were induced by streptozotocin to reach hyperglycemic state. Comparison of blood glucose level effect between infusion and ethanol extract was analyzed by One-Way ANOVA continued by post-hoc test, while comparison of liver histopathology effect was determined by Kruskal-Wallis continued by Mann-Whitney test. Results: Significant differences of blood glucose level decrease were found in all groups. Group P2 significantly decreased blood glucose level more than P1 (p=0.000) as much as 124.97 mg/dl and 101.46 mg/dl respectively. Significant differences of liver histopathology were obtained between KN vs K(+), KN vs P2, K(+) vs P2, and P1 vs P2. Group P2 showed more severe of liver histopathology changes than P1 (p=0.025). Conclusion: Tree marigold leaves extract is more effective in lowering blood glucose level and has less toxic effect to liver histopathology than its infusion.Â

The International Conferences on Applied Science and Health (ICASH): Efforts and Commitments in Translating Research Results into Policy and Practices, for a Better Society Widyastari, Dyah Anantalia; Sinaga, Doni Marisi; Wibowo, Canggih Puspo; Rahman, Pamuko Aditya; Noor, Hafizh Muhammad; Irawan, Dimas Sondang; Fatmarizka, Tiara; Diary, Dwina Gustia; Putra, I Gusti Ngurah Edi; Maretalinia, Maretalinia; Viniriani, Marina Ayu; Destiwi, Monita; Shidiq, Galih Albarra; Pratiwi, Ivana Aprilia; Kusuma, Made Dian Shanti; Dharmapatni, Ni Wayan Kesari; Pratama, Mahendrawan Nugraha Aji; Norsaputra, Ary; Pancanugraha, Andi; Kurniawan, Febrian Hendra; Putra, Wahyu Manggala; Fattah, Rifqi Abdul; Moehas, Puput Kusumawardani; Samosir, Ricky Alexander; Hananto, Andang Adi Fitria; Agastya, I Gusti Ngurah; Susilo, Taufik Eko; Vejvisithsakul, Pichpisith Pierre; Nauphar, Donny; Sari, Ariestya Indah Permata; Macnab, Andrew John
GHMJ (Global Health Management Journal) Vol 3, No 3 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Hubungan Status Gizi dengan Risiko Jatuh pada Lansia di Wilayah Kerja Puskesmas Jagasatru Kota Cirebon Ariestya Indah Permata Sari; Gunawan Gunawan
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 1, No 4 (2014): Tunas Medika Jurnal Kedokteran & Kesehatan
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Jatuh merupakan kegagalan manusia untuk mempertahankan keseimbangan badan untuk berdiri. Jatuh memiliki faktor risiko intrinsik dan ekstrinsik, status gizi dapat menjadi suatu faktor risiko jatuh pada lansia. Apabila malnutrisi pada lansia terjadi dalam kondisi lama maka akan berdampak pada kelemahan otot dan kelelahan karena energi yang menurun. Penelitian ini bertujuan untuk menganalisis hubungan antara status gizi dengan risiko jatuh pada lansia di wilayah kerja Puskesmas Jagasatru, Kejaksan. Penelitian ini merupakan penelitian deskriptif analitik dengan studi cross sectional dengan sampel yang terdiri dari lansia yang berada di Wilayah kerja Puskesmas Jagasatru Kota Cirebon dengan usia 60-70 tahun. Hubungan antara kedua variabel dianalisis dengan uji cross tabs dan uji korelasi Rank spearman. Dari analisis korelasi didapatkan p value = 0,037 (p < 0,05) dan besar korelasi r = - 0,234. Penelitian ini menunjukkan bahwa terdapat hubungan yang signifikan antara status gizi dengan risiko jatuh pada lansia dengan korelasi negatif yang lemah.Kata Kunci: lansia, status gizi, risiko jatuh Fall is the human failure to stay balanced to standing. There are risk factors contribute to fall accident, one of them is nutritional status in aged people. If malnutrition occurs in a very long time in aged people, this would cause weakness of muscles and fatigue due to deterioration of energy. The aim of this study is to analyze correlation between nutritional status with fall accident in aged people in the working area of public health center Jagasatru, Kejaksan. This was an analytic descriptive study with cross sectional approach. Samples were aged people between 60-70 years old. Correlation between the two variables was analyzed by cross tab and Rank spearman test with p value 0.037 (p<0.05) and r correlation = - 0.234. This conclude that there is significant correlation between nutritional status with fall risk in aged people with weak negative correlation.Keywords: aged people, nutritional status, fall risk

POTENTIAL ACCELERATING EFFECT OF Ageratum conyzoides L. LEAVES EXTRACT ON FIBROBLASTS DENSITY OF INCISION WOUND OF MALE WHITE MICE (Mus musculus) Mega Ayu Lestari; Ariestya Indah Permata Sari; Amanah Amanah
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Wound treatment using traditional medicine has been known widely in various countries in the world. Ageratum conyzoidesL. is commonly known by the ancient people to treat wound due to its potential anti-inflammatory effect. This study aims determine the effect of Ageratum conyzoidesL. leaves extract on fibroblast density of incision wound of male white mice (Mus musculus). Methods: This post-test only control group design experimental study used 35 male white mice which were randomly divided into five groups, i.e. negative control group K(-), positive control group K(+) (10% povidone iodine), and treatment group P1, P2, and P3 that were each given billy-goat weed leaf with increasing dose (15%, 30%, and 45% respectively). On each day, the length of the incision was measured by a ruler. After 7 days, the mice were terminated to obtain wound tissue which were used to prepare H&E stained histopathological sections to observe fibroblast density. Non-parametric analyses using Kruskall-Wallis and Mann Whitney test were used to compare the wound length and fibroblasts density. Results: Lengths of incision wound between all pairs of groups at the 7th day are significantly different (p< 0.05) with group P3 showed the shortest one. Significant differences were also observed in fibroblasts density between group K(-) and K(+), K(-) and P1, K(-) and P2, K(-) and P3, K(+) and P3, P1 and P3, P2 and P3 (p< 0.05) with group P3 showed the highest density among all groups. Conclusions: Ageratum conyzoidesL. leaves extract 45% has more potential effect than povidone iodine 10% in accelerating healing process by enhancing fibroblasts density.

EFFECT OF TREE MARIGOLD (Tithonia diversifolia (HEMSL.) A. GRAY) LEAVES INFUSION AND ETHANOL EXTRACT ON BLOOD GLUCOSE LEVEL AND LIVER HISTOPATHOLOGY OF STREPTOZOTOCIN-INDUCED MALE WISTAR RATS Rachma Ayu Maulidiany; Eni Suhaeni; Catur Setiya Sulistiyana; Ariestya Indah Permata Sari
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Common Indonesians often use alternative therapy for Diabetes Mellitus (DM) due to its high prevalence. Tree marigold (Tithonia difersivolia (Hemsl.) A. Gray) leaves show its positive effect in decreasing blood glucose level. Thus, it is important to analyze the negative effect of consuming the proposing alternative including its toxicity level to vital organs. This study aims to observe the blood glucose level and liver histopathology in streptozotocin-induced diabetic male rats treated by infusion and ethanol extract of the tree marigold leaves. Methods: Pretest and posttest with control group design experiment was conducted to analyze effect on blood glucose level and posttest only with control group design was for determining liver histopathology. Twenty-four male white rats (Wistar strain) were randomly divided into 4 groups: normal control group (KN), positive control group (K+) treated with 0.45mg/kg of glibenclamid, treatment group 1 (P1) treated by 100 mg/kg of tree marigold leaves ethanol extract, and treatment group 2 (P2) treated by 1373 mg/kg of tree marigold leaves infusion. The rats at the groups of K+, P1, and P2 were induced by streptozotocin to reach hyperglycemic state. Comparison of blood glucose level effect between infusion and ethanol extract was analyzed by One-Way ANOVA continued by post-hoc test, while comparison of liver histopathology effect was determined by Kruskal-Wallis continued by Mann-Whitney test. Results: Significant differences of blood glucose level decrease were found in all groups. Group P2 significantly decreased blood glucose level more than P1 (p=0.000) as much as 124.97 mg/dl and 101.46 mg/dl respectively. Significant differences of liver histopathology were obtained between KN vs K(+), KN vs P2, K(+) vs P2, and P1 vs P2. Group P2 showed more severe of liver histopathology changes than P1 (p=0.025). Conclusion: Tree marigold leaves extract is more effective in lowering blood glucose level and has less toxic effect to liver histopathology than its infusion.

The International Conferences on Applied Science and Health (ICASH): Efforts and Commitments in Translating Research Results into Policy and Practices, for a Better Society Dyah Anantalia Widyastari; Doni Marisi Sinaga; Canggih Puspo Wibowo; Pamuko Aditya Rahman; Hafizh Muhammad Noor; Dimas Sondang Irawan; Tiara Fatmarizka; Dwina Gustia Diary; I Gusti Ngurah Edi Putra; Maretalinia Maretalinia; Marina Ayu Viniriani; Monita Destiwi; Galih Albarra Shidiq; Ivana Aprilia Pratiwi; Made Dian Shanti Kusuma; Ni Wayan Kesari Dharmapatni; Mahendrawan Nugraha Aji Pratama; Ary Norsaputra; Andi Pancanugraha; Febrian Hendra Kurniawan; Wahyu Manggala Putra; Rifqi Abdul Fattah; Puput Kusumawardani Moehas; Ricky Alexander Samosir; Andang Adi Fitria Hananto; I Gusti Ngurah Agastya; Taufik Eko Susilo; Pichpisith Pierre Vejvisithsakul; Donny Nauphar; Ariestya Indah Permata Sari; Andrew John Macnab
GHMJ (Global Health Management Journal) Vol. 3 No. 3 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-33451

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The International Conferences on Applied Science and Health (ICASH): Efforts and Commitments in Translating Research Results into Policy and Practices, for a Better Society Dyah Anantalia Widyastari; Doni Marisi Sinaga; Canggih Puspo Wibowo; Pamuko Aditya Rahman; Hafizh Muhammad Noor; Dimas Sondang; Tiara Fatmarizka; Dwina Gustia Diary; I Gusti Ngurah Edi Putra; Maretalinia; Marina Ayu Viniriani; Monita Destiwi; Galih Albarra Shidiq; Ivana Aprilia Pratiwi; Made Dian Shanti Kusuma; Ni Wayan Kesari Dharmapatni; Mahendrawan Nugraha Aji Pratama; Ary Norsaputra; Andi Pancanugraha; Febrian Hendra Kurniawan; Wahyu Manggala Putra; Rifqi Abdul Fattah; Puput Kusumawardani Moehas; Ricky Alexander Samosir; Andang Adi Fitria Hananto; I Gusti Ngurah Agastya; Taufik Eko Susilo; Pichpisith Pierre Vejvisithsakul; Donny Nauphar; Ariestya Indah Permata Sari; Andrew John Macnab
GHMJ (Global Health Management Journal) Vol. 3 No. 3 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-33580

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POTENTIAL ACCELERATING EFFECT OF Ageratum conyzoides L. LEAVES EXTRACT ON FIBROBLASTS DENSITY OF INCISION WOUND OF MALE WHITE MICE (Mus musculus) Mega Ayu Lestari; Ariestya Indah Permata Sari; Amanah Amanah
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Wound treatment using traditional medicine has been known widely in various countries in the world. Ageratum conyzoidesL. is commonly known by the ancient people to treat wound due to its potential anti-inflammatory effect. This study aims determine the effect of Ageratum conyzoidesL. leaves extract on fibroblast density of incision wound of male white mice (Mus musculus). Methods: This post-test only control group design experimental study used 35 male white mice which were randomly divided into five groups, i.e. negative control group K(-), positive control group K(+) (10% povidone iodine), and treatment group P1, P2, and P3 that were each given billy-goat weed leaf with increasing dose (15%, 30%, and 45% respectively). On each day, the length of the incision was measured by a ruler. After 7 days, the mice were terminated to obtain wound tissue which were used to prepare H&E stained histopathological sections to observe fibroblast density. Non-parametric analyses using Kruskall-Wallis and Mann Whitney test were used to compare the wound length and fibroblasts density. Results: Lengths of incision wound between all pairs of groups at the 7th day are significantly different (p< 0.05) with group P3 showed the shortest one. Significant differences were also observed in fibroblasts density between group K(-) and K(+), K(-) and P1, K(-) and P2, K(-) and P3, K(+) and P3, P1 and P3, P2 and P3 (p< 0.05) with group P3 showed the highest density among all groups. Conclusions: Ageratum conyzoidesL. leaves extract 45% has more potential effect than povidone iodine 10% in accelerating healing process by enhancing fibroblasts density.

EFFECT OF TREE MARIGOLD (Tithonia diversifolia (HEMSL.) A. GRAY) LEAVES INFUSION AND ETHANOL EXTRACT ON BLOOD GLUCOSE LEVEL AND LIVER HISTOPATHOLOGY OF STREPTOZOTOCIN-INDUCED MALE WISTAR RATS Rachma Ayu Maulidiany; Eni Suhaeni; Catur Setiya Sulistiyana; Ariestya Indah Permata Sari
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Common Indonesians often use alternative therapy for Diabetes Mellitus (DM) due to its high prevalence. Tree marigold (Tithonia difersivolia (Hemsl.) A. Gray) leaves show its positive effect in decreasing blood glucose level. Thus, it is important to analyze the negative effect of consuming the proposing alternative including its toxicity level to vital organs. This study aims to observe the blood glucose level and liver histopathology in streptozotocin-induced diabetic male rats treated by infusion and ethanol extract of the tree marigold leaves. Methods: Pretest and posttest with control group design experiment was conducted to analyze effect on blood glucose level and posttest only with control group design was for determining liver histopathology. Twenty-four male white rats (Wistar strain) were randomly divided into 4 groups: normal control group (KN), positive control group (K+) treated with 0.45mg/kg of glibenclamid,treatment group 1 (P1) treated by 100 mg/kg of tree marigold leaves ethanol extract, and treatment group 2 (P2) treated by 1373 mg/kg of tree marigold leaves infusion. The rats at the groups of K+, P1, and P2 were induced by streptozotocin to reach hyperglycemic state. Comparison of blood glucose level effect between infusion and ethanol extract was analyzed by One-Way ANOVA continued by post-hoc test, while comparison of liver histopathology effect was determined by Kruskal-Wallis continued byMann-Whitney test. Results: Significant differences of blood glucose level decrease were found in all groups. Group P2 significantly decreased blood glucose level more than P1 (p=0.000) as much as 124.97 mg/dl and 101.46 mg/dl respectively. Significant differences of liver histopathology were obtained between KN vs K(+), KN vs P2, K(+) vs P2, and P1 vs P2. Group P2 showed more severe of liver histopathology changes than P1 (p=0.025). Conclusion: Tree marigold leaves extract is more effective in lowering blood glucose level and has less toxic effect to liver histopathology than its infusion.

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