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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Proceedings of the International Conference on Applied Science and Health Global Health Management Journal Tunas Medika Jurnal Kedokteran & Kesehatan
Ariestya Indah Permata Sari
Fakultas Kedokteran Unswagati
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Karakteristik Pasien Atresia Duodenum Di RSD Gunung Jati Cirebon Periode 2019 – 2023 Tilova, Izaura Navra; Hermawan, Iwan; Permata Sari, Ariestya Indah
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.61678

Abstract

Latar Belakang : Atresia duodenum adalah kelainan kongenital berupa penutupan total lumen duodenum sehingga menyebabkan terhalangnya absorbsi makanan. Atresia duodenum menyumbang 50% dari kelainan kongenital saluran cerna, dan 10,85% dari angka kematian bayi. Tujuan : Mengetahui karakteristik pasien atresia duodenum di RSD Gunung Jati Cirebon tahun 2019 – 2023. Metode : Penelitian deskriptif retrospektif menggunakan data rekam medis. Teknik pengambilan sampel adalah total sampling. Analisis univariat dilakukan untuk menilai variabel penelitian. Hasil : Prevalensi atresia duodenum di RSD Gunung Jati Cirebon 2019 – 2023 yaitu 42,39 per 10.000 kelahiran hidup. Dari 16 sampel, laki-laki lebih sering sebanyak 11 (68,8%). Lebih banyak pasien lahir cukup bulan (62,5%) dengan usia terbanyak 0 – 1 bulan (81,3%) dan berat badan lahir 2500 – 4000 gram (50 %). Jenis atresia duodenum yang sering dialami at duodenum pars 2 (62,5 %). Mayoritas 13 pasien (81,3%) disertai kelainan kongenital penyerta terutama annular pancreas. Tindakan gastrojejunostomy lebih sering dilakukan sebanyak 6 pasien (37,5%) dengan jumlah pasien meninggal yaitu 10 pasien (62,5%). Simpulan : Prevalensi atresia duodenum di RSD Gunung Jati Cirebon 2019 – 2023 cukup tinggi, dengan terbanyak laki – laki dan usia pasien tersering 0 – 1 bulan. Jenis atresia duodenum terbanyak yaitu at duodenum pars 2 disertai kelainan kongenital annular pancreas. Tindakan operasi yang paling sering gastrojejunostomy dan outcome operasi terbanyak meninggal (62,5%).
Angiotensin-Converting Enzyme Insertion/Deletion (ACE I/D) Gene Polymorphism as a Risk Factor for Essential Hypertension Kuswara, Hasna Nurazizah; Nauphar, Donny; Sari, Ariestya Indah Permata
GHMJ (Global Health Management Journal) Vol. 7 No. 3s (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-741044

Abstract

Background: Hypertension is the leading cause of death globally due to its complications, including coronary heart disease and stroke. In 2018, hypertension cases in West Java were the second highest among all populations in Indonesia. Genetics is one of the unmodifiable risk factors for hypertension. Angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism could affect ACE production in the renin-angiotensin-aldosterone system (RAAS), which is linked to the regulation of blood pressure. Aims: To analyze ACE I/D gene polymorphism as a risk factor for hypertension in Cirebon. Methods: An observational analysis with a case-control design was used in this study. Blood samples were collected from 30 hypertensive patients and 30 healthy individuals at Talun Health Center. DNA extraction was performed to evaluate polymorphisms using ARMS-PCR. Statistical analyses, including the Chi-square test, Fisher’s exact test, Mann-Whitney, and Kruskal-Wallis test, were conducted to compare the case and control groups. The odds ratio was calculated to see the risk of the assessed variables, including genotype, allele frequency, and the presence of ACE I/D gene polymorphism. Results: In the case group, the frequency of the II genotype was 2 (6.7%), the ID genotype was 25 (83.3%), and the DD genotype was 3 (10.0%). In the control group, the frequency of the II genotype was 2 (6.7%), the ID genotype was 26 (86.7%), and the DD genotype was 2 (6.7%). Statistically, there was no significant association between ACE I/D gene polymorphisms in essential hypertension patients and healthy people (p=0.500; OR=1.556; 95% CI=0.241-10.049). Conclusion: ACE I/D gene polymorphism was not significantly associated with essential hypertension in Cirebon, West Java, Indonesia.    Received: 25 September 2024  |  Reviewed: 21 October 2024  |  Revised: 23 November 2024  |  Accepted: 30 November 2024.
Genetic Polymorphism of Interferon-Gamma +874T/A as a Risk Factor for Pulmonary Tuberculosis in Cirebon, Indonesia Kiteswara, Allain Umadela Deuxawalu; Sari, Ariestya Indah Permata; Pratamawati, Tiar Masykuroh
GHMJ (Global Health Management Journal) Vol. 7 No. 3s (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-741107

Abstract

Background: Tuberculosis (TB) is one of the leading causes of death globally, caused by Mycobacterium tuberculosis. With 10% of all cases worldwide in 2022, Indonesia is the second-largest contributor of tuberculosis cases. IFN-γ gene polymorphism is one of the factors that have been studied extensively for its association with TB. Aims:  To analyze IFN-γ +874T/A gene polymorphism as a risk factor for pulmonary tuberculosis in Cirebon. Methods: Observational analysis with case control design was used in this study. Thirty-two tuberculosis patients as cases and 32 healthy controls at RSUD Waled were collected and performed DNA extraction to evaluate the polymorphism by using Amplification-refractory mutation system–polymerase chain reaction (ARMS–PCR). Statistical comparison was performed by using Pearson Chi-square and Kruskal Wallis test. Mann-Whitney U test was done for post hoc test. Odds ratio was calculated to see the risk of the assessed variables, including genotype, allele frequency, and the presence of polymorphism. Results:  In the case group, the frequency of TT genotype was 3 (9.4%), TA genotype was 26 (81.3%), AA genotype was 3 (9.4%). In the control group, the frequency of TT genotype was 12 (37.5%), TA genotype was 17 (53.1%), AA genotype was 3 (9.4%). A significant difference (p=0.034) was found among 3 genotype groups. Post hoc test revealed that TT and TA was the pair with significant difference (p=0.007). In addition, TA polymorphism was significantly associated (p=0.004) with tuberculosis (OR=6.614; CI95% = 1.660-26.349). Conclusion: IFN-γ +874 TA gene polymorphism is associated with pulmonary tuberculosis in the population of Cirebon, West Java, Indonesia.   Received: 25 September 2024  |  Reviewed: 23 October 2024  |  Revised: 10 November 2024  |  Accepted: 30 November 2024
Co-Authors Agastya, I Gusti Ngurah amanah amanah Amanah Amanah Amanah Amanah Anak Agung Istri Sri Wiadnyani Andang Adi Fitria Hananto Andi Pancanugraha Andrew John Macnab Ary Norsaputra Canggih Puspo Wibowo Catur Setiya Sulistiyana Destiwi, Monita Diary, Dwina Gustia Dimas Sondang Dimas Sondang Irawan Doni Marisi Sinaga Doni Marisi Sinaga, Doni Marisi Donny Nauphar Dwina Gustia Diary Dyah Anantalia Widyastari Dyah Anantalia Widyastari Eni Suhaeni Fattah, Rifqi Abdul Febrian Hendra Kurniawan Galih Albarra Shidiq Galih Albarra Shidiq Gunawan Gunawan Hafizh Muhammad Noor Hananto, Andang Adi Fitria I Gusti Ngurah Agastya I Gusti Ngurah Edi Putra Ivana Aprilia Pratiwi Jamhari Jamhari Kiteswara, Allain Umadela Deuxawalu Kurniawan, Febrian Hendra Kuswara, Hasna Nurazizah Lestari, Mega Ayu Macnab, Andrew John Made Dian Shanti Kusuma Mahendrawan Nugraha Aji Pratama Maretalinia Maretalinia Maretalinia Maretalinia, Maretalinia Marina Ayu Viniriani Maulidiany, Rachma Ayu Mega Ayu Lestari Mega Ayu Lestari Moehas, Puput Kusumawardani Monita Destiwi Ni Wayan Kesari Dharmapatni Noor, Hafizh Muhammad Norsaputra, Ary Pamuko Aditya Rahman Pancanugraha, Andi Pichpisith Pierre Vejvisithsakul Pratama, Mahendrawan Nugraha Aji Pratamawati, Tiar Masykuroh Pratiwi, Ivana Aprilia Puput Kusumawardani Moehas Putra, I Gusti Ngurah Edi Putra, Wahyu Manggala Rachma Ayu Maulidiany Rachma Ayu Maulidiany Rahman, Pamuko Aditya Ricky Alexander Samosir Rifqi Abdul Fattah Samosir, Ricky Alexander Tiara Fatmarizka Tilova, Izaura Navra Vejvisithsakul, Pichpisith Pierre Viniriani, Marina Ayu Wahyu Manggala Putra Wibowo, Canggih Puspo