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All Journal MEDIA MEDIKA INDONESIANA Media Ekonomi dan Manajemen EQUILIBRIUM Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Universa Medicina Generics: Journal of Research in Pharmacy Perigel: Jurnal Penyuluhan Masyarakat Indonesia Serat Acitya Generics : Journal of Research in Pharmacy Strada Jurnal Ilmiah Kesehatan (SJIK)
Endang Sri Sunarsih
Department Of Pharmaceutical Medicine, Faculty Of Medicine, Universitas Diponegoro
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
The effect of variation of dose, time toward cauli flower (Brassica oleracea var BotrytisL.) On hepatic cytochrome P-450 level rats given theophylline Sunarsih, Endang Sri; hakim, Lukman; ., Sugiyanto; ., Sumantri
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.974 KB) | DOI: 10.14499/indonesianjpharm0iss0pp323-329

Abstract

Cytochrome  P-450  as  a  major  component  enzyme  system  in  drug metabolism. Activity  enzyme  of  cytochrome  P-450  was  influenced  by  internal and external factors. Vegetables of Brassicaceae such as cauli flower were often consumed  in  the  long  term,  its   has  inductor  activity  of  oxidation  enzyme systems and conjugation reactions. Theophylline as a bronchodilator drugs have the unknown effects on hepatic microsomal enzyme, such as cytochrome P-450 and   have  not  been  many  studies  that  tried  to  prove  it.  The  purpose  of  this study  was  to  prove  the  effects  of Cauliflower  and  indol  on  level  cytochrome  P-450  enzyme.  90  rats  were  divided  into  3  groups.  Group   I,  were  given Theophylline  20  mg/kg  BW.  In  group  II  30  rats  were  treated  with  indole  1,2; 2,4; 3,6 mg/kg BW, and group III 30 rats were treated with cauliflower extract respectively  doses  100,  200,  300  g/kg  BW.  Each  dose  was  given  on  10  rats, each group were divided 2 sub-groups were treated for 5, 10 days. On the last day  of  treatment  were  given  Theophylline  20  mg/kg  BW.   Cytochrome  P-450 enzyme  levels  were  determined  by  the  method  of  Omura  and  Sato(Snell,  and Mullock,1987). An induction cauliflower and indole did not increased levels of hepatic  cytochrome  P-450.  The  long  treatment  and  the   increased  of administered  dose  did  not  enhanced  the  levels  of  hepatic  cytochrome  P-450 enzyme. cauliflower and indole contained in vegetables when consumed together with theophylline drug, would not affect the metabolism of theophyllineKey words: Cauli flower, cytochrome P-450, theophylline, indole, spectrofotometric.
Influence of administration of gadung corm ((Dioscorea hispida Dennst) infusion to decrease of blood glucose level at aloksan inducted male diabetic rats. Endang Sri Sunarsih; Djatmika .; Retno Sri Utomo
Indonesian Journal of Pharmacy Vol 18 No 1, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.566 KB) | DOI: 10.14499/indonesianjpharm0iss0pp29-33

Abstract

Traditional herba medicine, Gadung (Dioscorea hispida Dennst) has already known can be used for oral anti diabetic drug. But it have not be proved experimentally. The purpose of experiment want to know the influence of Gadung (Dioscorea hispida Dennst) corm infuse, can decrease blood glucose consentration diabetic aloxan inducted rats.This experiment use 20 rats by randomized design at 2-3 months, 140-280 gram BW, Aloxan inducted diabetic male albino Wistar strain. The dose of aloxan 150 mg/BW given by intraperitonial. The rats divided in 4 groups, each group consist of 5 rats. First group : positif controle which is given insulin 12,6 UI/BW subcutanly; Second group : negative controle which is given aqua dest 5 mL/BW orally; Third group is given Gadung (Dioscorea hispida Dennst) corm infuse 630 mg/BW orally and Forth group is given Gadung (Dioscorea hispida Dennst ) corm infuse 1260 mg/BW dose orally. The experiment results of blood glucose level, was analyzed by 2 way ANOVA (p<0,05).The conclusion of the experiment is the rats has given Gadung (Dioscorea hispida Dennst) corm infuse 630 mg/BW and 1260 mg/BW can decrease blood glucose consentration proporsionally with insulin effect (p<0,05).Key words : Gadung (Dioscorea hispida Dennst), Aloksan, antidiabetic drug.
The effect of cauli flower (Brassica oleracea var. botrytis L.) to the change of : cholesterol, MDA level of rats hiperlipide Endang Sri Sunarsih; M. Caecilia Nanny S.; Nita Fajaryanti
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.885 KB) | DOI: 10.14499/indonesianjpharm0iss0pp35-41

Abstract

The unbalance of oxidant and antioxidant can effect of various diseases, for example atherosclerosis. High total cholesterol level was given the risk factor to atherosclerosis. This research aims to know the effect of cauliflower (Brassica oleracea var. botrytis L.) juice to change of total cholesterol level and peroxide of lipid (MDA level). A twenty white rats Wistar strain were treated as hiperkolesterolemia with consumed a high fat meal for 14 days, then devided in to 4 groups. Group I as positive control was given a green tea leaf infuse through a dosage 0,605 g/ kg BW, group II as negative control was given an aquadestilata. Then Group III and IV as were given cauliflower juice through a dosage 15 mL/ kg BW and 20 mL/ kg BW for 14 days. The result of this research were concluded that cauliflower juice through a dosage 15 mL/ kg BW and 20 mL/ kg BW was decreased of total cholesterol level and lipid peroxide (MDA level). Cauliflower juice through a dosage 20 mL/kg BW was found as an effective dosage to decreased of total cholesterol level and lipid peroxide (MDA level) of male white rats Wistar strain with high fat diet treatment.Key words : Juice, cauliflower, total cholesterol, peroxide of lipid, MDA.
Co-Authors Ali Djamhuri Anggraeny, Ebta Narasukma Arum Purwaningtyas Dini, Intan Rahmania Eka Djatmika . Dwi Hadi Setya Palupi Dwi Hadi Setya Palupi Ebta Narasukma Anggraeny Ebta Narasukma Anggraeny Elisa, Novi Indriati Hapsari Indriati Hapsari, Indriati Kumala, Charisha Mahda Lukman Hakim Lukman Hakim Lukman Hakim M. Caecilia Nanny S. Mufidah, Nabila Nita Fajaryanti Novi Elisa Patricia Sanggita Listyoputri Wibowo Retno Sri Utomo Sugiyanto . Sugiyanto Sugiyanto Sugiyanto Sugiyanto Sumantri . Sumantri Sumantri Sumantri Sumantri Suparjo Suparjo, Suparjo Wibowo, Patricia Sanggita Listyoputri Yoga Adhi Dana, Yoga Adhi