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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Althea Medical Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Medica Hospitalia Jurnal Pengabdian Masyarakat Formosa (JPMF) Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Indonesian Health Journal
Ira Nurrasyidah
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Lambung Mangkurat University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Berkala Kedokteran

 1 
Effectiveness of Dexamethasone, Methylprednisolone and Hydrocortisone Administration on LDH, CRP, D-and PaO2/FiO2 Ratio Muhammad Zubaidi; Mohamad Isa; Ira Nurrasyidah
Berkala Kedokteran Vol 19, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i1.15708

Abstract

Abstract: Steroids are the standard recommended therapy for COVID-19, especially in critically ill patients. Previous studies have shown that steroids are beneficial for inflammatory markers such as C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH) and D-dimer as well as the value of the PaO2/FiO2 ratio. This study aims to determine the differences in the effects of the steroid’s dexamethasone, methylprednisolone and hydrocortisone on inflammatory markers. This research is a retrospective cohort study. The samples were all COVID-19 patients with critical degrees from January to June 2021. The independent variables were dexamethasone, methylprednisolone and hydrocortisone. The dependent variables are CRP, LDH, D-dimer and the ratio of PaO2/FiO2. The statistical test used was the Kolmogorov-Smirnov test and continued with the Kruskal-Wallis test and the Mann-Whitney U test. A total of 148 subjects with a total sample of dexamethasone 60, methylprednisolone 55 and hydrocortisone 33. The statistical test results showed a significant difference in the effect of the steroid dexamethasone, methylprednisolone and hydrocortisone on the value of the PaO2/FiO2 ratio (p=0.04). Administration of hydrocortisone and dexamethasone was statistically superior to methylprednisolone for increasing the PaO2/FiO2 ratio.
The Association between Coagulation Parameters, C-Reactive Protein, D-Dimer and In-Hospital Mortality of Covid-19 Patients with Suspected Pulmonary Embolism Delmi, Anwari; Adiputro, Dwi Laksono; Nurrasyidah, Ira; Yasmina, Alfi
Berkala Kedokteran Vol 20, No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i1.18896

Abstract

COVID-19 is a respiratory disease with severe cardiovascular complications, one of them is pulmonary embolism (PE). Studies have shown many contributing factors related to mortality of hospitalized COVID-19 patients that developed pulmonary embolism. This study aimed to find the association between coagulation parameters (PT and APTT), C-reactive protein (CRP), and D-dimer with in-hospital mortality of COVID-19 patients with suspected PE. COVID-19 patients in Ulin General Hospital Banjarmasin who met the clinical criteria of suspected PE, assessed with clinical scorings (Well’s score for PE and Padua prediction score for venous thromboembolism), and receiving anticoagulant therapy recorded in medical records were included in this study. A total of 91 patients were included, with most patients were female (59.3%), average age of 53.36 years, average BMI of 25.82 kg/m2, having normal electrocardiogram (79.1%), with history of hypertension (56%), and no histories of smoking (94.5%), diabetes mellitus (70.3%), heart failure (93.4%), coronary artery disease (96.7%), and chronic lung disease (95.6%).  As much as 39.57% patients with suspected PE was deceased during the course of hospitalization. Unadjusted analysis showed significant increased levels of PT, APTT, and CRP, in deceased patients compared to those discharged alive (mean 14.62 vs 11.91 seconds, 42.94 vs 28.57 seconds, and 98.19 vs 47.01 mg/dL, respectively; p value < 0.01), and a non-significant increased level of D-dimer (mean 10.89 mg/L; p = 0.09). Multivariate logistic regression showed non-significant associations between PT, APTT, D-dimer, and CRP with in-hospital mortality (p values of 0.06, 0.14, 0.52, and 0.23, respectively). In conclusion, there is no association between coagulation parameters, CRP, and D-dimer levels with in-hospital mortality in COVID-19 patients with suspected PE.  A further study with a larger sample size is needed to see the role of laboratory findings in predicting in-hospital mortality in COVID-19 patients with suspected PE. 
Co-Authors Alfi Yasmina Alfi Yasmina Ali Assagaf Arganita, Fidya Rahmadhany Ciendy Shintya Alhadi Delmi, Anwari Desi Rahmawaty Desi Rahmawaty Desi Rahmawaty Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Diani, Holly Diany, Holly Dwi Laksono Adiputro, Dwi Laksono Eko Suhartono Eko Suhartono Elok Hikmatun Nikmah Erna Kusumawardhani Fajar Satria Rahman Farida Heriyani Fidya Rahmadhany Arganita Harnoto, Yulia Octaviany Haryati Haryati Haryati Haryati Hendra Wana Nur&#039;amin Ika Kustiyah Oktaviyanti Isa Ansori Isa, Mohamad Juhairina, Juhairina Kamila Rosyida Khairunisa Nurdin Khairunnisa Khairunnisa Kusumawardhani, Erna Madargerong, Vincentius Adrian Mashuri Mashuri Meitria Syahadatina Noor Meitria Syahdatina Noor Meitria Syahdatina Noor Mohamad Isa Mohamad Isa Muhammad Ajib Nuzula Muhammad Ilham Fadillah Muhammad Nor Muhammad Zubaidi Nanang Miftah Fajari Nirmala, Anisa Feby Insan Nurlatifah Nurlatifah Nur’amin, Hendra Wana Puspita Aisyiyah Rahmiati Rahmiati Rahmiati Rahmiati Riefani, Soraya Salma Hanina Siti Washilah Siti Washilah Siti Wasilah Soraya Riefani Syafa’ah, Irmi Syam, Shaogi Tenri Ashari Wanahari Vincentius Adrian Madargerong Winariani Koesoemoprodjo