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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Althea Medical Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Medica Hospitalia Jurnal Pengabdian Masyarakat Formosa (JPMF) Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Indonesian Health Journal
Ira Nurrasyidah
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Lambung Mangkurat University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Socialization of Black Cumin (Nigella Sativa) supplementation in Reducing Oxidative Damage Due to Covid-19 and Black Cumin Processing Training Ika Kustiyah Oktaviyanti; Ira Nurrasyidah; Eko Suhartono; Holly Diani
Jurnal Pengabdian Masyarakat Formosa Vol. 2 No. 6 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/jpmf.v2i6.7283

Abstract

Sungai Miai is a sub district located ini Banjarmasin Utara District, Banjarmasin, Kalimantan Selatan, Indonesia. The high activity of residents in services and trade and also many boarding houses for outsiders, may be one of the reasons why Sungai Miai in 2021 and 2022 received the title of 3rd sub-district with the highest number of Covid cases in Banjarmasin. The public does not yet know that Jintan Hitam can be used in the treatment of Covid 19. Jintan Hitam has been proven to repair oxidative damage from COVID 19. The solution we are trying to offer is increasing understanding of the benefits of Jintan Hitam and processing Jintan Hitam as a supplement that can repair oxidative damage from Covid 19. It is hoped that this training will encourage community members to be able to cultivate Jintan Hitam at home. There were 17 participants who attended with pretest results of 40 - 80 with an average of 65.29, while posttest results were 50 - 100 with an average of 81.17. The results show that there has been an increase in the knowledge of the Dasa Wasma of the Sungai Miai, Banjarmasin.
GAMBARAN PENGGUNAAN ANTIVIRUS PADA PASIEN COVID-19 DI RUANG ICU RSUD ULIN BANJARMASIN Nirmala, Anisa Feby Insan; Rahmiati, Rahmiati; Nur’Amin, Hendra Wana; Nurrasyidah, Ira; Yasmina, Alfi
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11445

Abstract

Antivirus is one of the main therapies for COVID-19. Patients with COVID-19 who need to be transferred to the ICU are those who are seriously ill to critically ill. The purpose of this study was to describe the use of antivirals in COVID-19 patients in the ICU room at Ulin Hospital, Banjarmasin. This study was necessary because no antiviral has been proven effective and specific yet for COVID-19 therapy, the high rate of spread of COVID-19 over the last two years, the large number of cases requiring ICU care, the risk of using antivirals in COVID-19 patients who have certain comorbidities, and this study had never been done before. This study used a descriptive observational study design with ICU patients aged >18 years who were given COVID-19 antiviral therapy with complete electronic data records and/or medical records in the 2020-2021 period. This study found 59 subjects with antivirals used included remdesevir (52.54%), lopinavir+ritonavir (22.03%), favipiravir (15.25%), and oseltamivir (10.16%). Most of the patients were 46-65 years and used remdesevir (50%). Based on gender, both male and female patients used remdesevir (52.54%) as the antiviral. The most common comorbidities were hypertension with remdesevir (42.30%). Based on the duration of hospitalization, the longest duration of hospitalization was remdesevir with an average of 8.74 days.
The Influence of inflammatory factors (IL-6, CRP, NLPR, D-Dimer, LDH) on the PaO2/FiO2 ratio, in patients with severe and critical degrees of COVID-19 Harnoto, Yulia Octaviany; Assagaf, Ali; Pratiwi, Dewi Indah Noviana; Isa, Mohamad; Nurrasyidah, Ira; Kusumawardhani, Erna
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.1014

Abstract

BACKGROUND: Several types of inflammatory biomarkers that are important in severe and critical Covid-19 infections include: levels of IL-6, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-Dimer and neutrophil-lymphocyte platelet ratio (NLRP), which are independent variables. Meanwhile, the severity of Covid-19 infection can be determined by measuring the PaO2 /FiO2 ratio. However, the relationship between the PaO2/FiO2 ratio as the dependent variable is not yet known. AIMS: To analyze the relationship between PaO2/FiO2 ratio and inflammatory biomarkers in COVID-19 patients METHOD: An analytic observational study with a retrospective, cross-sectional approach. The research sample consisted of PCR-confirmed severe and critical COVID-19 patients who were treated in the isolation room of the Ulin Hospital in Banjarmasin from August–December 2021, who met the inclusion and exclusion criteria. Data analysis used the Spearman test to see the relationship between the PaO2/FiO2 ratio and various inflammatory markers. RESULT: 52 severe and critical patients were observed according to the research flow. The number of male and female subjects (32/20) was found. The mean age was 55.38 years. The correlation test found that: there was no significant relationship between the PaO2/FiO2 ratio and IL-6 (p = 0.964), but there was a negative correlation between the PaO2/FiO2 ratio and: a).CRP (p = 0.038), b).LDH ( p<0.001), c).NLPR (p = 0.013), and d). D-dimer (p<0.001). The inflammatory biomarkers NLPR, LDH, and D-dimer are important independent variables for the severity of COVID-19, namely the PaO2/FiO2 ratio. CONCLUSION: There are a significant correlation between the PaO2/FiO2 ratio to measure the severity of Covid-19 and several inflammatory biomarkers CRP, LDH, NLPR and D-dimer  
The Association between Coagulation Parameters, C-Reactive Protein, D-Dimer and In-Hospital Mortality of Covid-19 Patients with Suspected Pulmonary Embolism Delmi, Anwari; Adiputro, Dwi Laksono; Nurrasyidah, Ira; Yasmina, Alfi
Berkala Kedokteran Vol 20, No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i1.18896

Abstract

COVID-19 is a respiratory disease with severe cardiovascular complications, one of them is pulmonary embolism (PE). Studies have shown many contributing factors related to mortality of hospitalized COVID-19 patients that developed pulmonary embolism. This study aimed to find the association between coagulation parameters (PT and APTT), C-reactive protein (CRP), and D-dimer with in-hospital mortality of COVID-19 patients with suspected PE. COVID-19 patients in Ulin General Hospital Banjarmasin who met the clinical criteria of suspected PE, assessed with clinical scorings (Well’s score for PE and Padua prediction score for venous thromboembolism), and receiving anticoagulant therapy recorded in medical records were included in this study. A total of 91 patients were included, with most patients were female (59.3%), average age of 53.36 years, average BMI of 25.82 kg/m2, having normal electrocardiogram (79.1%), with history of hypertension (56%), and no histories of smoking (94.5%), diabetes mellitus (70.3%), heart failure (93.4%), coronary artery disease (96.7%), and chronic lung disease (95.6%).  As much as 39.57% patients with suspected PE was deceased during the course of hospitalization. Unadjusted analysis showed significant increased levels of PT, APTT, and CRP, in deceased patients compared to those discharged alive (mean 14.62 vs 11.91 seconds, 42.94 vs 28.57 seconds, and 98.19 vs 47.01 mg/dL, respectively; p value < 0.01), and a non-significant increased level of D-dimer (mean 10.89 mg/L; p = 0.09). Multivariate logistic regression showed non-significant associations between PT, APTT, D-dimer, and CRP with in-hospital mortality (p values of 0.06, 0.14, 0.52, and 0.23, respectively). In conclusion, there is no association between coagulation parameters, CRP, and D-dimer levels with in-hospital mortality in COVID-19 patients with suspected PE.  A further study with a larger sample size is needed to see the role of laboratory findings in predicting in-hospital mortality in COVID-19 patients with suspected PE. 
The Effect Of Nigella Sativa Administration In Reducing Oxidative Damage In Covid-19 Patients: A Clinical And In Silico Study Diany, Holly; Nurrasyidah, Ira; Haryati, Haryati; Isa, Mohamad; Kusumawardhani, Erna
Indonesian Health Journal Vol. 3 No. 3 (2024): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v3i3.552

Abstract

The COVID-19 pandemic has posed significant challenges to public health, particularly about the oxidative damage caused by infection. Nigella sativa, known for its antioxidant properties, has been extensively studied as a potential therapeutic agent to reduce oxidative damage. This study aims to evaluate the effects of Nigella sativa administration in reducing oxidative damage in COVID-19 patients through a clinical and in silico approach. The research methods include a clinical trial on COVID-19 patients supplemented with Nigella sativa and in silico molecular analysis to identify the interaction mechanisms between the active components of Nigella sativa and SARS-CoV-2 proteins. The results showed that Nigella sativa significantly reduced oxidative stress biomarkers in patients, and in silico results revealed the potential of its active components to inhibit critical enzymes of the SARS-CoV-2 virus. Based on these findings, it is concluded that Nigella sativa has potential as an adjunct therapy in reducing oxidative damage in COVID-19 patients. Further research is required to confirm these results through broader, more in-depth clinical trials.
Differentiation of Malignant Pleural Effusions from Lung Squamous Cell Carcinoma and Adenocarcinoma through FTIR Spectroscopy: A Prognostic Approach Madargerong, Vincentius Adrian; Suhartono, Eko; Oktaviyanti, Ika Kustiyah; Haryati, Haryati; Isa, Mohamad; Assagaf, Ali; Kusumawardhani, Erna; Nurrasyidah, Ira; Syafa’ah, Irmi
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.114-122

Abstract

Introduction: Malignant pleural effusion (MPE) is common in cancer patients and is often caused by neoplastic involvement of the pleural surface. This study aimed to determine the utility of Fourier transform infrared spectroscopy (FTIR) spectral analysis and anatomical pathological differentiation in MPE, squamous cell carcinoma (SCC), and lung adenocarcinoma as prognostic predictors. Methods: This study used a cross-sectional design at Ulin General Hospital, Banjarmasin, involving advanced lung cancer patients with MPE. A non-probability sampling technique was used to recruit 30 patients. Fourier transform infrared spectroscopy was analyzed to evaluate anatomical pathology differentiation. Results: Differences were observed in the FTIR spectral ratios A1080/A1243 and A1080/A1170 between SCC and adenocarcinoma, with p-values of 0.026 and 0.022, respectively. Significant differences were also found in the A2959/A1545 ratio between well-differentiated and poorly differentiated adenocarcinomas, with a p-value of 0.023. The receiver-operating characteristic curve (ROC) indicated good predictive value for poorly differentiated adenocarcinoma at a cut-off value of 0.944, with a sensitivity of 50% and specificity of 100%. However, no significant correlation was found between FTIR absorbance and anatomical pathology differentiation in MPE due to SCC and lung adenocarcinoma. Conclusion: The FTIR spectral ratios A1080/A1243 and A1080/A1170 differentiate SCC from adenocarcinoma. Fourier transform infrared spectroscopy may be an adjunct to cytology, offering a more rapid and cost-effective method for differentiating MPE.
Co-Authors Alfi Yasmina Alfi Yasmina Ali Assagaf Arganita, Fidya Rahmadhany Ciendy Shintya Alhadi Delmi, Anwari Desi Rahmawaty Desi Rahmawaty Desi Rahmawaty Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Diany, Holly Dwi Laksono Adiputro, Dwi Laksono Eko Suhartono Eko Suhartono Elok Hikmatun Nikmah Erna Kusumawardhani Fajar Satria Rahman Farida Heriyani Fidya Rahmadhany Arganita Harnoto, Yulia Octaviany Haryati Haryati Haryati Haryati Hendra Wana Nur&#039;amin Holly Diani Ika Kustiyah Oktaviyanti Isa Ansori Isa, Mohamad Kamila Rosyida Khairunisa Nurdin Khairunnisa Khairunnisa Kusumawardhani, Erna Madargerong, Vincentius Adrian Mashuri Mashuri Meitria Syahadatina Noor Meitria Syahdatina Noor Meitria Syahdatina Noor Mohamad Isa Mohamad Isa Muhammad Ajib Nuzula Muhammad Ilham Fadillah Muhammad Nor Muhammad Zubaidi Nanang Miftah Fajari Nirmala, Anisa Feby Insan Nurlatifah Nurlatifah Nur’amin, Hendra Wana Puspita Aisyiyah Rahmiati Rahmiati Rahmiati Rahmiati Salma Hanina Siti Washilah Siti Washilah Siti Wasilah Soraya Riefani Syafa’ah, Irmi Tenri Ashari Wanahari Vincentius Adrian Madargerong Winariani Koesoemoprodjo