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GAMBARAN PENGGUNAAN ANTIVIRUS PADA PASIEN COVID-19 DI RUANG ICU RSUD ULIN BANJARMASIN Nirmala, Anisa Feby Insan; Rahmiati, Rahmiati; Nur’Amin, Hendra Wana; Nurrasyidah, Ira; Yasmina, Alfi
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11445

Antivirus is one of the main therapies for COVID-19. Patients with COVID-19 who need to be transferred to the ICU are those who are seriously ill to critically ill. The purpose of this study was to describe the use of antivirals in COVID-19 patients in the ICU room at Ulin Hospital, Banjarmasin. This study was necessary because no antiviral has been proven effective and specific yet for COVID-19 therapy, the high rate of spread of COVID-19 over the last two years, the large number of cases requiring ICU care, the risk of using antivirals in COVID-19 patients who have certain comorbidities, and this study had never been done before. This study used a descriptive observational study design with ICU patients aged >18 years who were given COVID-19 antiviral therapy with complete electronic data records and/or medical records in the 2020-2021 period. This study found 59 subjects with antivirals used included remdesevir (52.54%), lopinavir+ritonavir (22.03%), favipiravir (15.25%), and oseltamivir (10.16%). Most of the patients were 46-65 years and used remdesevir (50%). Based on gender, both male and female patients used remdesevir (52.54%) as the antiviral. The most common comorbidities were hypertension with remdesevir (42.30%). Based on the duration of hospitalization, the longest duration of hospitalization was remdesevir with an average of 8.74 days.

The Influence of inflammatory factors (IL-6, CRP, NLPR, D-Dimer, LDH) on the PaO2/FiO2 ratio, in patients with severe and critical degrees of COVID-19 Harnoto, Yulia Octaviany; Assagaf, Ali; Pratiwi, Dewi Indah Noviana; Isa, Mohamad; Nurrasyidah, Ira; Kusumawardhani, Erna
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.1014

BACKGROUND: Several types of inflammatory biomarkers that are important in severe and critical Covid-19 infections include: levels of IL-6, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-Dimer and neutrophil-lymphocyte platelet ratio (NLRP), which are independent variables. Meanwhile, the severity of Covid-19 infection can be determined by measuring the PaO2 /FiO2 ratio. However, the relationship between the PaO2/FiO2 ratio as the dependent variable is not yet known. AIMS: To analyze the relationship between PaO2/FiO2 ratio and inflammatory biomarkers in COVID-19 patients METHOD: An analytic observational study with a retrospective, cross-sectional approach. The research sample consisted of PCR-confirmed severe and critical COVID-19 patients who were treated in the isolation room of the Ulin Hospital in Banjarmasin from August–December 2021, who met the inclusion and exclusion criteria. Data analysis used the Spearman test to see the relationship between the PaO2/FiO2 ratio and various inflammatory markers. RESULT: 52 severe and critical patients were observed according to the research flow. The number of male and female subjects (32/20) was found. The mean age was 55.38 years. The correlation test found that: there was no significant relationship between the PaO2/FiO2 ratio and IL-6 (p = 0.964), but there was a negative correlation between the PaO2/FiO2 ratio and: a).CRP (p = 0.038), b).LDH ( p<0.001), c).NLPR (p = 0.013), and d). D-dimer (p<0.001). The inflammatory biomarkers NLPR, LDH, and D-dimer are important independent variables for the severity of COVID-19, namely the PaO2/FiO2 ratio. CONCLUSION: There are a significant correlation between the PaO2/FiO2 ratio to measure the severity of Covid-19 and several inflammatory biomarkers CRP, LDH, NLPR and D-dimer

The Association between Coagulation Parameters, C-Reactive Protein, D-Dimer and In-Hospital Mortality of Covid-19 Patients with Suspected Pulmonary Embolism Delmi, Anwari; Adiputro, Dwi Laksono; Nurrasyidah, Ira; Yasmina, Alfi
Berkala Kedokteran Vol 20, No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i1.18896

COVID-19 is a respiratory disease with severe cardiovascular complications, one of them is pulmonary embolism (PE). Studies have shown many contributing factors related to mortality of hospitalized COVID-19 patients that developed pulmonary embolism. This study aimed to find the association between coagulation parameters (PT and APTT), C-reactive protein (CRP), and D-dimer with in-hospital mortality of COVID-19 patients with suspected PE. COVID-19 patients in Ulin General Hospital Banjarmasin who met the clinical criteria of suspected PE, assessed with clinical scorings (Well’s score for PE and Padua prediction score for venous thromboembolism), and receiving anticoagulant therapy recorded in medical records were included in this study. A total of 91 patients were included, with most patients were female (59.3%), average age of 53.36 years, average BMI of 25.82 kg/m2, having normal electrocardiogram (79.1%), with history of hypertension (56%), and no histories of smoking (94.5%), diabetes mellitus (70.3%), heart failure (93.4%), coronary artery disease (96.7%), and chronic lung disease (95.6%). As much as 39.57% patients with suspected PE was deceased during the course of hospitalization. Unadjusted analysis showed significant increased levels of PT, APTT, and CRP, in deceased patients compared to those discharged alive (mean 14.62 vs 11.91 seconds, 42.94 vs 28.57 seconds, and 98.19 vs 47.01 mg/dL, respectively; p value < 0.01), and a non-significant increased level of D-dimer (mean 10.89 mg/L; p = 0.09). Multivariate logistic regression showed non-significant associations between PT, APTT, D-dimer, and CRP with in-hospital mortality (p values of 0.06, 0.14, 0.52, and 0.23, respectively). In conclusion, there is no association between coagulation parameters, CRP, and D-dimer levels with in-hospital mortality in COVID-19 patients with suspected PE. A further study with a larger sample size is needed to see the role of laboratory findings in predicting in-hospital mortality in COVID-19 patients with suspected PE.

The Effect Of Nigella Sativa Administration In Reducing Oxidative Damage In Covid-19 Patients: A Clinical And In Silico Study Diany, Holly; Nurrasyidah, Ira; Haryati, Haryati; Isa, Mohamad; Kusumawardhani, Erna
Indonesian Health Journal Vol. 3 No. 3 (2024): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v3i3.552

The COVID-19 pandemic has posed significant challenges to public health, particularly about the oxidative damage caused by infection. Nigella sativa, known for its antioxidant properties, has been extensively studied as a potential therapeutic agent to reduce oxidative damage. This study aims to evaluate the effects of Nigella sativa administration in reducing oxidative damage in COVID-19 patients through a clinical and in silico approach. The research methods include a clinical trial on COVID-19 patients supplemented with Nigella sativa and in silico molecular analysis to identify the interaction mechanisms between the active components of Nigella sativa and SARS-CoV-2 proteins. The results showed that Nigella sativa significantly reduced oxidative stress biomarkers in patients, and in silico results revealed the potential of its active components to inhibit critical enzymes of the SARS-CoV-2 virus. Based on these findings, it is concluded that Nigella sativa has potential as an adjunct therapy in reducing oxidative damage in COVID-19 patients. Further research is required to confirm these results through broader, more in-depth clinical trials.

Differentiation of Malignant Pleural Effusions from Lung Squamous Cell Carcinoma and Adenocarcinoma through FTIR Spectroscopy: A Prognostic Approach Madargerong, Vincentius Adrian; Suhartono, Eko; Oktaviyanti, Ika Kustiyah; Haryati, Haryati; Isa, Mohamad; Assagaf, Ali; Kusumawardhani, Erna; Nurrasyidah, Ira; Syafa’ah, Irmi
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.114-122

Introduction: Malignant pleural effusion (MPE) is common in cancer patients and is often caused by neoplastic involvement of the pleural surface. This study aimed to determine the utility of Fourier transform infrared spectroscopy (FTIR) spectral analysis and anatomical pathological differentiation in MPE, squamous cell carcinoma (SCC), and lung adenocarcinoma as prognostic predictors. Methods: This study used a cross-sectional design at Ulin General Hospital, Banjarmasin, involving advanced lung cancer patients with MPE. A non-probability sampling technique was used to recruit 30 patients. Fourier transform infrared spectroscopy was analyzed to evaluate anatomical pathology differentiation. Results: Differences were observed in the FTIR spectral ratios A1080/A1243 and A1080/A1170 between SCC and adenocarcinoma, with p-values of 0.026 and 0.022, respectively. Significant differences were also found in the A2959/A1545 ratio between well-differentiated and poorly differentiated adenocarcinomas, with a p-value of 0.023. The receiver-operating characteristic curve (ROC) indicated good predictive value for poorly differentiated adenocarcinoma at a cut-off value of 0.944, with a sensitivity of 50% and specificity of 100%. However, no significant correlation was found between FTIR absorbance and anatomical pathology differentiation in MPE due to SCC and lung adenocarcinoma. Conclusion: The FTIR spectral ratios A1080/A1243 and A1080/A1170 differentiate SCC from adenocarcinoma. Fourier transform infrared spectroscopy may be an adjunct to cytology, offering a more rapid and cost-effective method for differentiating MPE.

The Effect Of Nigella Sativa Administration In Reducing Oxidative Damage In Covid-19 Patients: A Clinical And In Silico Study Diany, Holly; Nurrasyidah, Ira; Haryati, Haryati; Isa, Mohamad; Kusumawardhani, Erna
Indonesian Health Journal Vol. 3 No. 3 (2024): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v3i3.552

The COVID-19 pandemic has posed significant challenges to public health, particularly about the oxidative damage caused by infection. Nigella sativa, known for its antioxidant properties, has been extensively studied as a potential therapeutic agent to reduce oxidative damage. This study aims to evaluate the effects of Nigella sativa administration in reducing oxidative damage in COVID-19 patients through a clinical and in silico approach. The research methods include a clinical trial on COVID-19 patients supplemented with Nigella sativa and in silico molecular analysis to identify the interaction mechanisms between the active components of Nigella sativa and SARS-CoV-2 proteins. The results showed that Nigella sativa significantly reduced oxidative stress biomarkers in patients, and in silico results revealed the potential of its active components to inhibit critical enzymes of the SARS-CoV-2 virus. Based on these findings, it is concluded that Nigella sativa has potential as an adjunct therapy in reducing oxidative damage in COVID-19 patients. Further research is required to confirm these results through broader, more in-depth clinical trials.

Vitamin D, Body Mass Index, and Total Lymphocyte Count in Drug-Sensitive and Drug-Resistant Tuberculosis Patients in Banjarmasin Riefani, Soraya; Juhairina, Juhairina; Isa, Mohamad; Kusumawardhani, Erna; Haryati, Haryati; Syam, Shaogi; Nurrasyidah, Ira
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.14-22

Introduction: Tuberculosis (TB) remains a global health problem that causes high morbidity and mortality. Based on its classification, TB is divided into drug-sensitive (DS) and drug-resistant (DR). Several risk factors susceptible to TB are malnutrition with low body mass index (BMI), vitamin D deficiency (VDD), and low total lymphocyte count (TLC) related to low immune status. This study aimed to examine the relationship between vitamin D (VD), BMI, and TLC in the TB population in Banjarmasin. Methods: This was an analytic observational study with a cross-sectional design. The total study sample was 42 patients, confirmed by rapid molecular testing, who had not been treated for TB in Banjarmasin from January to May 2023 and met the inclusion and exclusion criteria. Chi-Square and Fisher's exact statistical tests were used to see the relationship between VD, BMI, and TLC in DS TB and DR TB. Results: The median age of DS TB was 38 (24-52) years old, and DR TB was 51 (37-58) years old. Most of the gender was male (24 patients/57.1%). There was a statistically significant difference between VD and BMI in DS TB and DR TB (p = 0.048; p = 0.019). There was a significant relationship between VD and TLC in DS TB and DR TB (p = 0.048). Conclusion: VD and BMI significantly differed in DS TB and DR TB. There was a significant correlation between VD and TLC in TB patients.

Socialization of Black Cumin (Nigella Sativa) supplementation in Reducing Oxidative Damage Due to Covid-19 and Black Cumin Processing Training Oktaviyanti, Ika Kustiyah; Nurrasyidah, Ira; Suhartono, Eko; Diani, Holly
Jurnal Pengabdian Masyarakat Formosa Vol. 2 No. 6 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/jpmf.v2i6.7283

Sungai Miai is a sub district located ini Banjarmasin Utara District, Banjarmasin, Kalimantan Selatan, Indonesia. The high activity of residents in services and trade and also many boarding houses for outsiders, may be one of the reasons why Sungai Miai in 2021 and 2022 received the title of 3rd sub-district with the highest number of Covid cases in Banjarmasin. The public does not yet know that Jintan Hitam can be used in the treatment of Covid 19. Jintan Hitam has been proven to repair oxidative damage from COVID 19. The solution we are trying to offer is increasing understanding of the benefits of Jintan Hitam and processing Jintan Hitam as a supplement that can repair oxidative damage from Covid 19. It is hoped that this training will encourage community members to be able to cultivate Jintan Hitam at home. There were 17 participants who attended with pretest results of 40 - 80 with an average of 65.29, while posttest results were 50 - 100 with an average of 81.17. The results show that there has been an increase in the knowledge of the Dasa Wasma of the Sungai Miai, Banjarmasin.

Pregnancy With Multidrug-Resistant Pulmonary Tuberculosis and Autoimmune Hemolytic Anemia Complicated by Intrauterine Growth Restriction - A Case Report Permata, Putri Indah; Aditya, Renny; Putri, Ruth Widhiati Raharjo; Isa, Mohamad; Kurniawan, Sigit Prasetia; Nurrasyidah, Ira
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.878

AbstractIntroductionIntrauterine growth restriction (IUGR) is a major obstetric complication often caused by maternal infections and anemia. We present a case of IUGR in a pregnant woman caused by multidrug-resistant tuberculosis (MDR-TB) and autoimmune hemolytic anemia (AIHA).Case presentationA 37-year-old G5P2A2 woman with confirmed MDR-TB and AIHA was treated with levofloxacin, clofazimine, cycloserine, ethambutol, bedaquiline, and methylprednisolone. Fetal biometry showed estimated fetal weight below the 10th percentile, with a significantly declining growth curve thereafter. After administration of fetal lung maturation at 33 – 34 weeks, she underwent an elective cesarean section at 35 – 36 weeks. A female infant weighing 1,840g was delivered. The treatment for MDR-TB and AIHA in the mother was continued afterward.ConclusionPregnancies complicated by MDR-TB and AIHA require strict monitoring and individualized multidisciplinary treatment. Further research is needed to establish treatment strategies that improve maternal and fetal outcomes in similar cases.Keywords : Autoimmune hemolytic anemia; intrauterine growth restriction; multidrug resistance; pregnancy; tuberculosis. Kehamilan dengan Tuberkulosis Paru Resisten Obat Ganda dan Anemia Hemolitik Autoimun yang Diperberat oleh Pertumbuhan Janin Terhambat – Laporan Kasus AbstrakPendahuluanIUGR adalah komplikasi obstetrik yang dapat disebabkan infeksi dan anemia pada maternal. Pada kasus ini dipresentasikan kasus wanita hamil dengan IUGR yang disebabkan multidrug resistant TB (MDR-TB) dan autoimmune hemolytic anemia (AIHA).Ilustrasi kasusIbu hamil 37 tahun G5P2A2 datang dengan TB-MDR dan AIHA. Pasien menjalani terapi TB-MDR dengan levofloksasin, klofazimin, sikloserin, etambutol, dan bedaquiline, serta metilprednisolon untuk AIHA. Pada fetal biometri ditemukan estimated fetal weight (EFW) di bawah 10 persentil dengan kurva pertumbuhan janin menurun signifikan setelahnya. Setelah dilakukan induksi pematangan paru janin pada usia kehamilan 33 - 34 minggu, operasi sesar elektif dilakukan pada usia kehamilan 35 – 36 minggu melahirkan bayi perempuan dengan berat janin 1840gram. Pengobatan TB-MDR dan AIHA pada ibu dilanjutkan setelahnya.KesimpulanKehamilan dengan TB dan AIHA memerlukan pemantauan ketat dan terapi multidisiplin yang terindividualisasi. Penelitian lebih lanjut diperlukan.Kata kunci : Hemolitik anemia autoimun; kehamilan; pertumbuhan janin terhambat; resisten obat; tuberkulosis.

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