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All Journal E-Jurnal Medika Udayana Universa Medicina Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Jurnal Pustaka Mitra : Pusat Akses Kajian Mengabdi Terhadap Masyarakat
I Wayan Gede Sutadarma
Faculty of Medicine Udayana University, Denpasar
Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Universa Medicina

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Effect of astaxanthin supplementation on oxidative stress in adult women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials Pratiwi, Donna; Harimawan, Agustinus I Wayan; Weta, I Wayan; Sumartini, Ni Ketut; Awan, Syuma Adhy; Sutadarma, I Wayan Gede
Universa Medicina Vol. 45 No. 1 (2026)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2026.v45.125-134

Abstract

BackgroundPolycystic ovary syndrome (PCOS) can cause significant morbidity through fertility disorders and most often found in the productive age. Recent research suggests that oxidative stress plays an important role in the pathogenesis of PCOS. Astaxanthin (AST) has broad protective effects, particularly in the regulation of antioxidant and anti-inflammatory activity. The objective of this systematic review and meta-analysis was to evaluate the efficacy of AST supplementation on PCOS management. MethodsA systematic literature search was conducted in PubMed, Scopus, Science Direct, and Cochrane Library from January 2020 to March 2025. Randomized controlled trials (RCTs) assessing astaxanthin supplementation in adult women with PCOS were included. Outcomes of interest were malondialdehyde (MDA), superoxide dismutase (SOD), and total antioxidant capacity (TAC). Data were analyzed using Review Manager (RevMan) version 5.4.1. Pooled effects were calculated as mean differences (MDs) with 95% confidence intervals (CIs).  ResultsFour RCTs involving 194 participants were included. Astaxanthin supplementation significantly reduced MDA levels (MD −0.670; 95% CI −1.070 to −0.270; p = 0.001; I² = 93%) and significantly increased TAC levels (MD 0.030; 95% CI 0.000 to 0.060; p = 0.030; I² = 76%). No significant effect was observed on SOD levels (MD 0.025; 95% CI −0.850 to 1.350; p = 0.660; I² = 57%). The overall risk of bias across included studies was low. ConclusionThis systematic review shows that AST supplementation significantly reduced lipid peroxidation in women with PCOS. These findings suggest that AST may serve as potential adjuvant antioxidant therapy in PCOS management.
Co-Authors Alvina, Made Kurnia Aryaweda, Made Dhiyo Wiweka Awan, Syuma Adhy Dewi, Ni Putu Ratih Cahaya Ekaputra, Ariel Harimawan, Agustinus I Wayan I Wayan Weta Ida Ayu Dewi Wiryanthini Made Adinanta Purnawijaya, Made Adinanta Ni Nyoman Ayu Dewi Pratiwi, Donna Prawitha Pinatih, Putu Teja Putu Diani Wirayanti, Putu Diani Ratha, I Putu Prayoga Saskara , I Dewa Gde Wira Sharma, Ansehs Siallagan, Rini Martha Sukawati, Cokorda Istri Mas Dalem Sumartini, Ni Ketut Surudarma, I Wayan Tjoantara, Andien Nikita Utami Dewi, Ayu Dian Yuliani, Eni