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All Journal Pharmaciana: Jurnal Kefarmasian IJISTECH (International Journal Of Information System & Technology) Jurnal Dunia Farmasi Jurnal Pendidikan dan Konseling Jurnal Farmamedika (Pharmamedica Journal) IJISTECH Jurnal Ilmiah Wahana Pendidikan Innovative: Journal Of Social Science Research PharmaCine: Journal of Pharmacy, Medical and Health Science
Devi Ratnasari
Universitas Singaperbangsa Karawang
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Uji Aktivitas Penghambatan Enzim Tirosinase Serta Uji Iritasi Sediaan Masker Peel-Off Ekstrak Etanol Daun Sukun (Artocarpus Altilis F) Devi Ratnasari; Fiona Rosa Sofyanita; Padmono Citroreksoko
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 1 No. 1 (2020): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v1i1.4419

Abstract

Abstrak : Daun sukun (Artocarpus altilis F) diketahui memiliki senyawa metabolit sekunder salah satunya adalah flavonoid. Pada penelitian ini ekstrak etanol 96% daun sukun (Artocarpus altilis F) dan sediaan masker peel-off ekstrak etanol 96% Artocarpus alitilis diuji aktivitas penghambatan enzim tirosinase menggunakan substrat L-tirosin dan L-dopa. Hasil uji aktivitas penghambatan enzim tirosinase menunjukkan bahwa ekstrak dan sediaan tidak memiliki kemampuan penghambatan terhadap melanin yang dilihat dari nilai . Ekstrak etanol 96% daun sukun memiliki nilai dengan substrat L-tirosin sebesar 4889,467 ppm dan substrat L-Dopa sebesar 6916,626 ppm. Sediaan masker peel-off memiliki nilai dengan substrat L-tirosin sebesar 12680,48 dan untuk substrat L-Dopa sebesar 33402,96 ppm. Dilakukan uji iritasi primer pada sediaan masker peel-off ekstrak etanol daun sukun. Hasil uji iritasi primer tidak menunjukkan adanya iritasi pada kulit seperti edema, maupun eritema. Kata Kunci: Ekstrak etanol 96%, Daun sukun, Masker peel-off, Enzim tirosinase.
Modification of black glutinous rice (Oryza Sativa var. glutinosa) starch: effect on pharmaceutical properties Devi Ratnasari; Jekmal Malau; Dhavina Maharani
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.30660

Abstract

Black glutinous rice is rich in starch, specifically amylopectin by 92-98%, making it a potential pharmaceutical excipient. However, black glutinous rice starch also has disadvantages, such as poor flowability and compressibility, which necessitate modification. This study investigates the impact of various modification methods on the pharmaceutical properties of black glutinous rice starch, including its Carr’s index, flowability, loss on drying, pH, and swelling power. The starches were modified using acetylation, butanol addition, autoclave-cooling, and pregelatinization. The results showed that modified butanol and pregelatinization exhibited increases in Carr’s index, 3.4 ± 0.13% and 31.10 ± 0.18%, respectively, indicating improved compressibility. Flow rate analysis revealed that pregelatinized starch exhibited the highest flowability, followed by autoclave-cooling, butanol, and acetylated starch. The swelling power was significantly enhanced in autoclave-cooled starch (100%), likely due to structural changes induced by high-temperature treatment, increasing water absorption. The pH values of all modified starches remained within pharmaceutically acceptable ranges (4–8). Overall, starch modification, particularly autoclaving and pregelatinization, significantly enhanced the functional properties relevant to pharmaceutical applications, highlighting their potential use as excipients in solid dosage forms.
Co-Authors Baiq Annisa Apriyanti A.R Dhavina Maharani Dia Septiani Dinda Shafira Rahmawati Fiona Rosa Sofyanita Harry Noviardi Indah Laily Hilmi Ineke Rossa Caroline Jekmal Malau Kirana Aulia Pasha Azis Lely Sulfiani Saula Mahiya Mahiya Marsah Rahmawati Utami Mira Irawati Agustin Padmono Citroreksoko Salman Salman Saniyyah Septiani Tita Maulidia Andiani Vesara Ardhe Gatera Vesara Ardhe Gatera Wildani Zakiyah