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Journal : NurseLine Journal

PHYTOESTEROGEN COMPONENT OF ETHANOLIC ROOT EXTRACT OF FLAXSEED (Boehmeria nivea) DECREASES CHOLESTEROL SERUM LEVEL ON OVARIECTOMIZED RATS Ika Rahmawati Sutejo; Hazmi Dwinanda Nurqistan; Imama Rasyada; Ni Nyoman Yuniasih; Annafira Yuniar; Rakhmat Ramadhani
NurseLine Journal Vol 1 No 1 (2016): May 2016
Publisher : Faculty of Nursing, Universitas Jember

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Abstract

Dyslipidemia is a major cause of morbidity, mortality and high cost of treatment. Dyslipidemia associated with coronary heart disease (CHD), which causes 4 million deaths every year. Estrogen, a hormone produced by women during menarche protect women from coronary heart disease. The decrease of estrogen production during menopause periode, higher the risk of dyslipidemia and coronary heart disease. Phytoestrogen therapy used to prevent dyslipidemia and coronary heart disease during menopause. hytoestrogens are estrogen-like compounds found in plants. Phytoestrogenic effects of Boehmeria nivea, which was used in this study, mainly contributed by isoflavone and lignan compounds. The purpose of this study was to prove the ability of ethanolic extract of root of Boehmeria nivea (EBN) to increase uterine weight and improve dyslipidemia on ovariectomized mice using a quasi-experimental with post test only design of research. Ovariectomized female rats were given an atherogenic diet of 3.5 cc egg yolk each day with an intravenous injection of 0.006 mg/200 gBB adrenaline. There are 6 groups consisting of a negative control, ovariectomized group, variectomized and atherogenic diet group, group with treatment of Boehmeria nivea (EBN) dose 125 mg/kg, 250 mg/kg, and 500 mg/kg. The results shows that there is a decrease of uterine weight on ovariectomized group compare to control group. Treatment of EBN increase uterine weight, decrease the levels of blood cholesterol and increase the levels of blood triglyceride. It can be concluded that fitoestrogen content of EBN improve lipid profile in ovariectomized rats.
ETHANOLIC LEAVES EXTRACT OF AWAR-AWAR (FICUS SEPTICA) AS SELECTIVE CHEMOPREVENTIVE AGENT ON VARIOUS CANCER CELLS Ika Rahmawati Sutejo; Herwandhani Putri; Edy Meiyanto
NurseLine Journal Vol 1 No 2 (2016): November 2016
Publisher : Faculty of Nursing, Universitas Jember

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Abstract

Treatment of cancer such as surgery, radiotherapy and chemotherapy have many side effects such as cardiotoxicity, hepatotoxicity, and immunosuppressant, therefore selective cochemopreventive agent is needed. Awar-awar (Ficus septica) is a traditional medicinal plant that is known as a potential cancer chemopreventive agent. The purpose of this study was to determine the cytotoxic effect of ethanolic leaves extract of awar-awar (EFs) against 4T1 and MCF7/HER2 breast cancer cells; WIDR colon cells cancer, HeLa cervix cells cancer, and Vero normal cells. The cytotoxic test was performed by MTT assay. The parameter obtained from the cytotoxic test was IC50. Selectivity index was determined from IC50 ratio of cancer cells to normal cells Vero. The results showed that EFs has a cytotoxic activity on cancer cell line with IC50 61,2 µg/mL on 4T1; 48 µg/mL on MCF7/HER2; 122,4 µg/mL on Hela; 75,9 µg/mL on WiDR; and 394,8 µg/mL on Vero. It can be concluded that EFs has high selectivity on various cancer cells with selectivity index more than 3.
Co-Authors Adistha Eka Noveyani Adji, Novan Krisno Ain Yuanita Insani Al Munawir Alief Ilman Zaelany Alief Ilman Zaelany Anaditya Wahyu Kumudhaningsih Anang Dwi Atmoko Ancah Marchianti Angga Mardro Raharjo Annafira Yuniar Annafira Yuniar Arif, Dina Rizky Amalia Arifah Nur Hasanah Avita Lukmawati Baskoro Adi Prayitno Brilliant Givya Ariansari Cholis Abrori, Cholis Diana Chusna Mufida Dimas Zabirrurohman Putra Dini Agustina Dwita Aryadina Rachmawati EDY MEIYANTO Edy Meiyanto Edy Meiyanto Edy Meiyanto ENNY SUSWATI Erfan Efendi Erma Sulistyaningsih Fauqi Amalia Fuad Adi Prasetyo Hairrudin Hairrudin Handayani, Sri Hazmi Dwinanda Nurqistan Hazmi Dwinanda Nurqistan Heni Fatmawati Heri Puguh Widodo Herwandhani Putri Herwandhani Putri Herwandhani Putri Herwandhani Putri Hilyatul Fadliyah I Nyoman Insan Parisudha Ida Srisurani Wiji Astuti Imama Rasyada Imama Rasyada Jenie, Riris Istighfari Jenie, Riris Istighfari Kiky Martha Ariesaka Kiky Martha Arieska Kristianingrum Dian Sofiana Laila Auliya Noviyanti Lailatul Maghfiroh M. Ali Shodikin Meirizky Zulharini Mudzakkir Taufiqurrqhman Ni Nyoman Yuniasih Nunung Nurhasanah Nur Hasyimiyyah Nurfahimi, Yudriani Nurul Indah Saffanah Pratikno, Dela Putri Puput Sagita Mey Sandra Putra Uta, Diego Rafi Putri, Herwandhani Rakhmat Ramadhani Rayyan, Muhammad Isra Rafidin Rini Riyanti septa surya wahyudi, septa surya Septyawati, Ratna Siti Marissa Aisyah Sugiyanta Sugiyanta Tristira Urvina Viddi Agustian Rosyidi Viddi Rosyidi Viddy Agustian Rosyidi Wiwien Sugih Utami Yasmin Auralia Putri Zahrah Febianti