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All Journal Buletin Udayana Mengabdi ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Andrology and Biomedical Journal
I Gusti Ngurah Pramesemara
Departemen Andrologi Dan Seksologi, Fakultas Kedokteran, Universitas Udayana, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology

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Hubungan disfungsi ereksi pada pasien dislipidemia dengan lama pengobatan statin di Puskesmas Denpasar Barat I Anak Agung Gde Ryantha Indra Pranamartha; I Gusti Ngurah Pramesemara; Yukhi Kurniawan Kurniawan
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.21 KB) | DOI: 10.15562/ism.v12i3.1100

Abstract

Introduction: There has been change in people's lifestyles that affect disease patterns, and dyslipidemia is one of those disease. Statins are the main pharmacological therapy for dyslipidemia. Many studies have researched the relationship between statin therapy in dyslipidemia and erectile dysfunction. However, existing research has not specifically explained this relationship.Objective: This study aims to determine the relationship between erectile dysfunction in dyslipidemic patients and duration of statin treatment at Community Health Center I West Denpasar.Methods: This research is analytic observational with cross sectional design. The study was conducted on dyslipidemic patients who took statins and met inclusion and exclusion criteria at Community Health Center I West Denpasar in May-June 2021. The sample size was 35. Duration of statin consumption was obtained through medical records and reconfirmed through questionnaire. Erectile dysfunction was measured by IIEF-5 questionnaire. Data analysis using SPSS version 21 with chi square test and Cramer's V correlation test.Results: The prevalence of erectile dysfunction in dyslipidemic patients with statin treatment at Community Health Center I West Denpasar was 85.7% with majority of the patients experiencing mild erectile dysfunction (37.1%) and taking statins for less than 12 months (51.4%). Characteristics of the patients were mostly aged 45-60 years (74.2%), obesity I (42.8%), smoking (60%), and drinking alcohol (57%). Statistical tests showed significant relationship between erectile dysfunction in dyslipidemic patients and duration of statin treatment at Community Health Center I West Denpasar  (p=0.031) with moderate correlation (r=0.552). Statins with treatment duration >12 months had protective effect against erectile dysfunction (RR = 0.81).Conclusion: There is a relationship between erectile dysfunction in dyslipidemic patients and duration of statin treatment with moderate correlation. Statins with duration of treatment >12 months have protective effect toward erectile dysfunction. Pendahuluan: Terdapat perubahan gaya hidup masyarakat yang dapat memengaruhi pola penyakit pada manusia, dimana dislipidemia adalah salah satu penyakit tersebut. Statin merupakan salah satu terapi utama untuk dislipidemia. Terdapat banyak penelitian yang telah meneliti hubungan antara terapi statin pada dislipidemia dan disfungsi ereksi. Namun, penelitian yang ada belum secara spesifik menjelaskan hubungan ini. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan disfungsi ereksi pada pasien dislipidemia dengan lama pengobatan statin di Puskesmas Denpasar Barat I.Metode: Penelitian ini adalah penelitian analitik observasional dengan desain cross-sectional. Penelitian dilakukan pada pasien dislipidemia yang mengonsumsu statin dan memenuhi kriteria inklusi dan eksklusi di Puskesmas Denpasar Barat I pada bulan Mei sampai Juni 2021. Sampel pada penelitian ini adalah 35 orang. Durasi konsumsi statin diperoleh melalui rekam medis dan dikonfirmasi ulang melalui kuisioner. Disfungsi ereksi diukur dengan kuisioner IIEF-5. Analisis data menggunakan SPSS versi 21 dengan uji chi-square dan uji korelasi Cramer’s V.  Hasil: Prevalensi disfungsi ereksi pada pasien dislipidemia dengan pengobatan statin di Puskesmas Denpasar Barat I sebesar 85,7% dengan mayoritas pasien mengalami disfungsi ereksi ringan (37,1%) dan mengonsumsi statin kurang dari 12 bulan (51,4%). Karakteristik pasien sebagian besar berusia 45-60 tahun (74,2%), dengan obesitas I (42,8%), merokok (60%), dan minum alkohol (57%). Hasil uji statistic menunjukkan hubungan yang bermakna antara disfungsi ereksi pada pasien dislipidemia dengan lama pengobatan statin di Puskesmas Denpasar Barat I (p=0,031) dengan korelasi sedang (r=0,552). Statin dengan lama pengobatan lebih dari 12 bulan memiliki efek protektif terhadap disfungsi ereksi (RR = 0,81).Kesimpulan: Terdapat hubungan antara disfungsi ereksi pada pasien dislipidemia dan lama pengobatan statin dengan korelasi sedang. Pengobatan statin dengan lama pengobatan lebih dari 12 bulan memiliki efek protektif terhadap disfungsi ereksi. 
Potensi terapi kombinasi Liver Growth Factor (LGF) dan Adrenomedullin (ADM) sebagai harapan baru penatalaksanaan Azoospermia Non-Obstruktif (ANO): tinjauan pustaka Ni Made Dian Hartaningsih; I Putu Yuda Prabawa; Benediktus Bosman Ariesta Gusti Putu; Dwijo Anargha Sindhughosa; Ida Bagus Amertha Putra Manuaba; I Gusti Ngurah Pramesemara
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i1.1363

Abstract

Non-Obstructive Azoospermia (NOA) is caused by the failure of spermatogenesis process. This case becomes the highest prevalence, 95% of the total azoospermia. Therapeutic modalities in use today such as invasive techniques, hormonal therapy, and gene therapy are less effective in the treatment of azoospermia. In addition, the overall therapeutic modalities also have serious side effects such as infection, testicular atrophy, nerve damage and other side effects. Referring to the problems above, non-obstructive azoospermia is an urgent health issue and requires effective and efficient management with minimal side effects, as the combination of Liver Growth Factor (LGF) and Adrenomedullin (ADM). LGF is able to regenerate spermatogenesis after spermatogonia testicular stem cell damage. LGF also works specifically by stimulating germinal cells without changes in somatic cells. The motility of reactivation could be improved by combining the ADM into therapy, which bind to specific receptors, and the result of increasing the cAMP / PKA and NO that are important in the regulation of cilia’s movement. Combination LGF and ADM are potential to create new therapeutic candidates in the management of non-obstructive azoospermia, which can be immediately implemented as effective and efficient therapy. Azoospermia Non-Obstruktif (ANO) adalah azoospermia yang disebabkan kegagalan proses spermatogenesis dan merupakan kasus dengan prevalensi tertinggi (95% dari total azoospermia). Modalitas terapi yang digunakan sampai saat ini seperti teknik invasif, terapi hormonal, dan terapi gen terbukti belum efektif dalam tatalaksana azoospermia. Selain itu, keseluruhan modalitas terapi ini juga memiliki efek samping serius yang perlu diwaspadai seperti infeksi, testis atropi, kerusakan saraf, serta efek samping lainnya. Merujuk pada permasalahan diatas, azoospermia non-obstruktif merupakan masalah kesehatan yang mendesak dan membutuhkan tatalaksana yang efektif dan efisien dengan efek samping yang minimal seperti dengan kombinasi terapi LGF dan ADM. LGF mampu meregenerasi testis dan mereaktivasi spermatogenesis setelah kerusakan sel punca spermatogonia. LGF juga bekerja secara spesifik dengan menstimulasi sel-sel germinal tanpa menyebabkan perubahan pada sel-sel somatis. Motilitas sperma hasil reaktivasi spermatogenesis kemudian ditingkatkan dengan mengkombinasikan ADM kedalam terapi dimana berikatan pada reseptor-reseptor spesifik sehingga berefek pada peningkatan cAMP/PKA dan NO yang penting dalam pengaturan kibasan flagella. Perpaduan antara terapi LGF dan ADM ini sangat berpotensi menciptakan kandidat terapi baru dalam penatalaksanaan NOA yang efektif dan efisien. 
PELATIHAN KONSELOR PENINGKATAN KETERAMPILAN KONSELING KESEHATAN REPRODUKSI REMAJA BERKEBUTUHAN KHUSUS PADA GURU SLB NEGERI 1 DENPASAR I.G.A. Pramitaresthi; I.G.N. Pramesemara; I.A. Sanjiwani; L.M. Puspita
Buletin Udayana Mengabdi Vol 21 No 3 (2022): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.037 KB) | DOI: 10.24843/BUM.2022.v21.i03.p05

Abstract

Sexual education for adolescents with special needs is very important. Basically, teenagers with special needs do not have enough courage to tell stories and lack the ability to find information that can be obtained from articles or books. Based on philosophical and juridical, sex education is a preventive effort so that every teenager with special needs can recognize, understand and deal with biological developments and changes. In addition, sex education for teenagers with special needs also aims to guide them to respect the sexual behavior of others and not be trapped in deviant sexual behavior and not get sexual violence and harassment from others. Teachers are responsible for teaching their independence in schools. Therefore, there is a need for training for teachers so that later they can become counselors for adolescents with special needs who need reproductive health information. The purpose of this activity is to provide knowledge and train teachers' skills to provide sexuality information to adolescents with special needs. The method of this activity is in the form of lectures, question and answer discussions and the provision of pre-test and post-test questionnaires which will be held on October 7, 2021 online using the Zoom application which was attended by teachers and then continued with consultations through the Whatsapp group. The results of the questionnaire analysis showed an increase in participants' knowledge after being given training. The conclusions and implications are expected that after this, teachers can provide reproductive health and sexuality education to adolescents with special needs. Keywords: Teachers, Counselors, Reproductive Health, Youth with Special Needs
The Relationship Between Varicocele in Infertile Male and Intrauterine Insemination Success at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar Andhika Bhayangkara Putra Anak Agung Gde; I Gusti Ngurah Pramesemara; Yukhi Kurniawan; I Gusti Ayu Widianti
Indonesian Andrology and Biomedical Journal Vol. 3 No. 2 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v3i2.35877

Abstract

Background: Assisted Reproductive Technology (ART), such as intrauterine insemination (IUI), can be an option for infertile couples who are expecting a pregnancy. However, the success of IUI can be influenced by various factors, one of which is varicocele.   Objective: This study aims to determine the association between varicocele and IUI success. Methods: This study is an analytical cross-sectional study using patient medical records. The sample of this study was male patients aged 25-45 years with infertility and undergoing IUI in the period April to June 2021 at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar. The sampling technique used, purposive sampling, was selected based on inclusion and exclusion criteria. Based on the criteria, this study selected 32 samples. Result: From 32 participants, 5 had varicocele (15.6%), and 27  were without varicocele (84.4%). In this study, we found 12 success pregnancy after IUI (37.5%), with 3 participants having varicocele (9.4%) and 9 participants without varicocele (28.1%). The chi-square analysis carried out obtained the results (p>0.05), and the calculation of the relative risk got the result (RR=0.600). Conclusion: This study showed no significant association between varicocele in infertile men and the success of IUI. The RR calculation showed that varicocele was not a risk factor for IUI failure.
Leukospermia in Infertile Men and Successful Intrauterine Insemination at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar Anak Agung Ngurah Perdana Anantadiva; I Gusti Ngurah Pramesemara; Yukhi Kurniawan; I Gusti Ayu Widianti
Indonesian Andrology and Biomedical Journal Vol. 4 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v4i1.41761

Abstract

Infertility is a condition after a year of regular sexual intercourse, without the use of contraceptives, and ends with the absence of pregnancy. Intrauterine Insemination (IUI) is a procedure that is widely used in fertility clinics and is usually the first treatment option in patients who are experiencing infertility disorders, diagnosis of infertility due to cervical factors, diagnosis of factor infertility in men, and diagnosis of unexplained infertility. the cause. IUI is also a simple, inexpensive, and quite effective infertility treatment. One of the factors that can influence the success of IUI is leukospermia. This study is an analytical study using a cross-sectional design and using medical records of patients diagnosed with infertility, aged from 25 to 45 years, and undergoing IUI procedures from January to June 2022 at the RSIA Puri Bunda Denpasar. The sampling method in this study used a purposive sampling method which was selected based on inclusion and exclusion criteria. In this study, 53 samples were obtained. Of the 53 samples that have been collected, 13 people experienced leukospermia (24.5%), 40 people were non-leukospermic (75.5%). The success of IUI in this study was 17 people (32.1%) consisting of 3 leukospermic (23.1%) and 14 non-leukospermic (35.0%). The results of the Fisher's Exact test obtained, namely the p value = 0.511, it can be concluded that leukospermia with the success of IUI does not have a significant relationship. Calculation of odds ratio (OR) obtained a figure of 1.759 (CI95% 0,423-7,610).
Sperm Agglutination in Infertile Men and The Success Rate of Intrauterine Insemination in Rumah Sakit Ibu dan Anak Puri Bunda Denpasar Anak Agung Sintya Padma Dewi; I Gusti Ngurah Pramesemara; Yukhi Kurniawan; I Gusti Ayu Widianti
Indonesian Andrology and Biomedical Journal Vol. 4 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v4i1.42110

Abstract

Background: Every human being, especially a married couple, wants children. Obstacles to obtaining children are called infertility. One of the Assisted Reproductive Technology (ART) procedures used for treating infertility is intrauterine insemination (IUI), a non-invasive procedure with affordable costs. The success of IUI is influenced by many factors, one of which is sperm agglutination. Objective: This study determined the relationship between sperm agglutination and the success rate of the IUI procedure. Methods: The study is a descriptive-analytic study with a cross-sectional approach. The sample collection technique uses non-probability. The data used were medical records of male patients diagnosed with infertility, aged 25-45 years, and undergoing IUI procedures at the Rumah Sakit Ibu dan Anak Puri Bunda Denpasar from January to July 2022. Results: Of the 91 samples obtained, 9 people experienced sperm agglutination (9,9%), and 82 people did not experience sperm agglutination (90,1%). The success rate of the IUI procedure was 29 people (31,9%), 1 person (11.1%) experiencing sperm agglutination, and 28 people (34,1%) not experiencing sperm agglutination. Fisher's Exact test carried out has obtained a result (p=0.263). And the value of the odds ratio (OR) obtained=0.241) Conclusion: This study concluded that there is no significant relationship between sperm agglutination in infertile men and the success rate of the IUI procedure. The value of OR showed sperm agglutination is not included in the factors that affect the success rate of IUI. Keywords: Sperm Agglutination, Intrauterine Insemination, Male Infertility
Co-Authors Ahmad Ricardo Syukur Silalahi Albert Salim Alexander Petra Sihite Alexander Petra Sihite Alycia Madeleine Amelia Heryanto Anak Agung Ayu Dian Indah Lestari Anak Agung Gde Ryantha Indra Pranamartha Anak Agung Ngurah Perdana Anantadiva Anak Agung Sintya Padma Dewi Andhika Bhayangkara Putra Anak Agung Gde Assuncao Caviota Da Silva Pinto Benediktus Bosman Ariesta Gusti Putu Dwijo Anargha Sindhughosa Dyah Pradnyaparmita Duarsa G. Wirata I Gusti Ayu Pramitaresthi I Gusti Ayu Widianti I Putu Yuda Prabawa I Wayan Surudarma I Wayan Surudarma I. A. Sanjiwani I.A. Sanjiwani Ida Bagus Amertha Putra Manuaba Judie Hartono L.M. Puspita M. H. S. Nugraha N. A. J. Raya Ni Made Dian Hartaningsih Ni Made Dian Kurniasari Ninik Andrias Rezia Octarina Rossy Sintya Marthasari Tanojo, Tjahjo Djojo Yukhi Kurniawan Yukhi Kurniawan Yukhi Kurniawan Kurniawan