Article Per Year (5 Year)
p-Index From 2020 - 2025
2.429
P-Index
This Author published in this journals
All Journal Indonesian Journal of Human Nutrition Window of Health : Jurnal Kesehatan Jurnal Keperawatan Muhammadiyah Amerta Nutrition Jurnal Riset Kesehatan Poltekkes Depkes Bandung Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang
Aminuddin Aminuddin
1.Department Of Nutrition, Faculty Of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.2.Hasanuddin University Hospital, Makassar, South Sulawesi, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Amerta Nutrition

 1 
The Effect of Trehalose Sugar on Insulin Resistance in Old Rats by Assessing HOMA-IR (Homeostasis Model Assessment-Insulin Resistance) Desya Faradila Ismi; Aminuddin Aminuddin; Arif Santoso; Suryani As'ad; Ika Yustisia; Irfan Idris
Amerta Nutrition Vol. 6 No. 2 (2022): AMERTA NUTRITION
Publisher : Universitas Airlangga, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v6i2.2022.198-205

Abstract

Background: Insulin resistance is a condition in which insulin cannot take up glucose, increasing blood glucose. Elderly people are more exposed to insulin resistance, requiring dietary interventions that extend longevity. Trehalose, a naturally occurring sugar, showed potentially reduce insulin resistance which can be measured using the HOMA-IR index. Objectives: This study aimed to assess HOMA-IR levels as a parameter of insulin resistance in old rats after giving trehalose sugar. Methods:  Experimental research with 28 male Wistar rats (Rattus novergicus) was separated into 4 groups, the control group of young rats (Group A), the control group of old rats (Group B), a group of old rats that were given 2% Trehalose solution (Group C), and a group of old rats that given 2% sucrose solution (Group D) that observed for 8 weeks. Results: The results showed differences in HOMA-IR levels (p<0.001) between old and young subjects. The intervention in Group C was optimal in reducing levels of HOMA-IR (p<0.001) by 18.2% compared with the old control, while Group D increased levels of HOMA-IR by 14.3% (p<0.001) compared with the old control. The age of the subjects with HOMA-IR level is positively correlated (p<0.001; r=0.721) and the weight of subjects with the HOMA-IR level is also positively correlated (p<0.001; r=0.698), indicating that the older and the greater weight of subject resulting in the bigger of HOMA-IR value. Conclusion: Trehalose is effective in reducing HOMA-IR levels as a parameter of insulin resistance in old rats.
The Effect of Trehalose Supplementation on Macrovascular Inflammation Biomarker in Old Rats by Assessing NFκB-p65 Expression Inggrid -; Aminuddin -; Arif Santoso; Nurpudji A Taslim; Ika Yustisia; Irfan Idris
Amerta Nutrition Vol. 6 No. 2 (2022): AMERTA NUTRITION
Publisher : Universitas Airlangga, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v6i2.2022.183-190

Abstract

Background: Vascular inflammation is one of contributing factors to the pathogenesis of arterial aging. Age-related activation of the inflammatory process can lead to various macro-and microvascular pathologies. The pro-inflammatory microenvironment generated in the vascular wall can lead to the pathogenesis of vascular diseases due to an increase in vascular dysfunction. Trehalose is a disaccharide that has several functions, protecting against stressors (one of them is reactive oxygen species/ROS) and preventing the inflammatory responses induced by endotoxic shock. Objectives: To analyze the effect of trehalose supplementation on macrovascular inflammatory processes related to the aging process. Methods: The experimental study used 28 male Wistar rats (Rattus novergicus) which were divided into 4 groups, young control group (Group A), old control group (Group B), 2% sucrose group (Group C), and 2% trehalose group (Group D); were then observed for 8 weeks. Results: The results showed that there were no significant differences in aortic tissue NFκB-p65 expression between old and young subjects (p=0.247). The 2% trehalose group had 40% lower aortic tissue NFkB-p65 expression compared to the old control group (p=0.012); while the group given 2% sucrose solution had a 30% higher aortic tissue NFkB-p65 expression compared to the trehalose group (p=0.018). Conclusion: Trehalose has a good effect on aging-associated vascular inflammatory processes that can be seen from the low aortic tissue NFκB-p65 expression in old rats.
Co-Authors Agussalim Bukhari AM, Nasrudin Andi millaty Halifah Dirgahayu Andi Nilawati Usman Andina Setyawati Arif Santoso Arif Santoso Arif Santoso Arif Santoso Asni, Sitti Nur Bukhari, Agussalim Burhanuddin Bahar Burhanuddin Bahar Daranga, Erniwati Desya Faradila Ismi Firdaus Hamid Ika Yustisia Ika Yustisia Ika Yustisia Ika Yustisia Ika Yustisia Inez Marsha Gabriella Singgih Inggrid - Inna Mutmainnah Musa Irfan Idris Irfan Idris Irfan Idris Irfan Idris Kasim, Hasyim Liong Boy Kurniawan Mappaware Nasrudin A Mappaware, Nasrudin Andi Marhaen Hardjo Mayang Citra Hariati Meyta Rezki Putri Nasruddin Nasruddin AM Natalia Rorrong Pamilangan Nining Frianti Nurhikmah Asyari Nurpudji A. Taslim Nurpudji Astuti Nuurhidayat Jafar P Prihantono Rasud, Rismawati Rosdiana Natzir Saldy Yusuf Sello, Lenni Sharvianty Arifuddin Sharvianty Arifuddin Shofiyah Latief Sinrang A Wardihan Siswati Rahmadyana Sundun, Ririn Rezky Ananda Suryani As'ad Suryani As’ad Syafruddin Syarif Syamsuddin, Saidah Veni Hadju Veni Hadju Wahyuni Alinengsih Werna Nontji Zahir Zainuddin