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All Journal Jurnal Ilmiah Farmasi Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Majalah Farmaseutik Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Borneo Akcaya : Jurnal Penelitian dan Pengembangan Pelayanan Publik Medical Sains : Jurnal Ilmiah Kefarmasian Media Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura

Wintari Taurina

Departement Of Pharmacy, Faculty Of Medicine, Tanjungpura University, Pontianak, Indonesia

Author-ID : 402195

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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UJI AKTIVITAS JAMU GENDONG KUNYIT ASAM (Curcuma domestica Val.; Tamarindus indica L.) SEBAGAI ANTIDIABETES PADA TIKUS YANG DIINDUKSI STREPTOZOTOCIN Mohamad Andrie; Wintari Taurina; Rizqa Ayunda
Majalah Obat Tradisional Vol 19, No 2 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. “Jamu gendong kunyit asam” (Curcuma domestica Val.; Tamarindus indica L.) is a traditional medicine that has antioxidant activity which can contribute to diabetic because of the phenolic content. This aim of this study is to determine the effect of “jamu gendong kunyit asam” on lowering blood glucose levels and repairing damage of the islet cells. 25 male wistar rats (Rattus norvegicus) were divided into five groups. Group I as a normal group without any treatment, group II, III, IV and V were induced with streptozotocin (7mg/ 200gBB) then treated with CMC 1%, glibenclamide (0.27mg / 200gBB), “jamu gendong kunyit asam” 1.90mL/ 200gBB and 3.80mL/ 200gBB. The treatment was done for 28 days. Glucometer was used to measure the gloucose blood level on day 4, 8, 12, 16, 20, 24 and 28. The damages on the islet cells were examined under the microscope on the histology sample of pancreas prepared with Hematoxyllin eosin stain. Datas were analyzed statistically with One Way Anova test, T-Test, and the Kruskal-Wallis test using SPSS 17.0 for Windows. Results showed there is a significant difference (p> 0.05) in blood glucose levels and damage to the islets of Langerhans of the pancreas between the glibenclamide group and treatment of “jamu gendong kunyit asam”. From the research it can be concluded that the “jamu gendong kunyit asam” have antidiabetic activity which is showed by a decrease in blood glucose levels and an improvement of pancreatic islets of Langerhans in streptozotocin-induced diabetic rats with an effective dose of 1.90mL/ 200gBB.

FORMULASI GEL EKSTRAK LENGKUAS (Alpinia galanga L.) SEBAGAI ANTIJAMUR DENGAN BASIS HIDROKSI PROPIL METIL SELULOSA (HPMC) DAN CARBOPOL Wintari Taurina; Mohamad Andrie
Majalah Obat Tradisional Vol 18, No 3 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Infection of Malassezia furfur on skin can be caused by bad factor. One of the materials that can be used as an antifungal is Lengkuas rhizome extract (Alpinia galanga L.). This study had purpose to determine the antifungal activity and the effectiveness of gels Lengkuas rhizome extract on pathogenic fungi using maseration method with etanol 96%. Gel making is used HPMC and carbopol base. Testing activity of extract and testing the effectiveness of the gel by disc diffusion method (Kirby-Bauer test). Screening result showed that the extract contains triterpenoids, flavonoids and essential oil. Based on the test results against Malassezia furfur, antifungal activity of the extract in the gel increased compared to extracts without formulated into a gel. But the activity increasing was not significant based on statistical analysis with one-way ANOVA test obtained a significance of 0.234 (p> 0.05).

OPTIMASI KECEPATAN DAN LAMA PENGADUKAN TERHADAP UKURAN NANOPARTIKEL KITOSAN-EKSTRAK ETANOL 70% KULIT JERUK SIAM (Citrus nobilis L.var Microcarpa) Wintari Taurina; Rafika Sari; Uray Cindy Hafinur; Sri Wahdaningsih; Isnindar Isnindar
Majalah Obat Tradisional Vol 22, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Siam citrus peel (Citrus nobilis L. var. Microcarpa) is a plant derived from Sambas Regency, West Kalimantan Province. Bioavailability of herbal active compounds can be enhanced by formulating extract into nanoparticle. The polymer used was chitosan with crosslinker Na-TPP. Stirring speed and stirring time play an important role to produce small particle size in forming nanoparticle using ionic gelation method. Enhancement of stirring speed and stirring time could reduce particle size. Nanoparticles were prepared using ionic gelation method by mixing Na-TPP, extract and chitosan (1:1:6) with varying the stirring speed 500 rpm, 1000 rpm, 1500 rpm and stirring time 1 hrs, 2 hrs, 3 hrs. The particle size of nanoparticle was found to be 85.3 nm at 1000 rpm of stirring speed and 3 hrs of stirring times, with polidispersity index 0.287, zeta potential +32.37 mV and entrapment efficiency 87.12 %.

The Effectiveness Test of Oil Phase Ointment Containing Snakehead Fish (Channa striata) Extract on Open Stage II Acute Wounded Wistar Strain Male Rats Fransisca Daisa; Mohamad Andrie; Wintari Taurina
Majalah Obat Tradisional Vol 22, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The snakehead (Channa striata) contained fatty acids omega-3 and omega-6 are useful as nutrients in accelerating the wound healing process. This study aims to determine the effectiveness of the oil phase extract ointment snakehead in the healing of acute wounds open stage II. Testing the effectiveness of wound healing using 6 groups: normal, gel bioplacenton (positive control), ointment base (negative control), ointments snakehead extract oil phase concentration of 10; 20 and 40% of the 4 rats with acute wounds open stage II and observation until day 16 injury. The area of the wound was measured with the image J program Macbiophotonic, calculated% healing power, and AUC values. A statistical test to the total AUC values per rat with SPSS for Windows 22.0 program using One Way ANOVA and Post-hoc LSD test. The results showed a significant difference in the negative group with ointment concentration of 20% (p <0.05). The treatment group phase ointment fish oil extract is effective for wound healing is best to have a concentration of 20% for percentage of wound healing power of 97.157% and the average AUC value of 865.683% of the day.

Accelerated Stability Test of Snakehead Fish Extract (Channa striata) and Kelulut Honey (heterotrigona itama) Ointment Combination with Tween 80 and Span 80 as an Emulsifying Agent Wintari Taurina; Mohamad Andrie; Taufik Nanda Pratama
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.66608

The combination of Snakehead Fish and Kelulut Honey has activity in accelerating the wound healing process. The ointment with active ingredients of Snakehead Fish extract and Kelulut Honey showed separation from the active ingredient and its base. The addition of tween 80 and span 80 is expected to increase the stability of the ointment preparation by keeping the water-phase droplets distributed uniformly on the ointment base. This study aimed to determine the effect of adding Tween 80 and Span 80 on the stability of the ointment preparation. The ointment was made by varying Tween 80 and span 80 by 2,5%: 5%: 7,5% and control (active ingredients without the addition of tween 80 and Span 80) as a comparison. The preparation was subjected to an accelerated stability test using a temperature of 40 ° ± 2 ° C / Relative humidity 75% ± 5% for 28 days by observing the organoleptic test, adhesion, spreadability, homogeneity test, pH test, and protection power. The data obtained were analyzed statistically using One Way Anova. The analysis showed that the addition of tween 80 and span 80 with a total concentration of 5% and 7,5% had a significant effect in increasing the spreadability, decreasing adhesion, and reducing the pH of the preparation. Formulas that meet the requirements in this study are F2 and F3, which have an average spreadability of 5,11 cm and 5,25 cm, adhesion of 96 seconds and 51 seconds, and pH of 6,02 and 5,02.

Accelerated Stability Test of Snakehead Fish Extract (Channa striata) and Kelulut Honey (Heterotrigona itama) Ointment Combination with BHT as an Antioxidant Mohamad Andrie; Wintari Taurina; Dyah Ayuningtias
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.68861

The oil phase of adeps lanae was used as a basis in the ointment formulation with snakehead fish extract and kelulut honey, which influences wound healing. Adeps lanae has the potential to become rancid due to the high water content in it (25-30%). The use of oil-soluble antioxidants such as Butyl Hydroxy Toluene (BHT) can overcome the rancidity in oil. This study aimed to see how adding BHT as an antioxidant affects the ointment's stability. The ointment is prepared in three different BHT concentrations: F1 (0.0075%), F2 (0.05%), F3 (0.1%), and a control for comparison. Organoleptic tests, homogeneity, spreadability, adhesion, protection power, and acid number were used to evaluate the stability of the preparation over 28 days at 40 ± 2°C / RH 75 ± 5%. The data obtained were analyzed statistically using One Way ANOVA. The addition of BHT affected the preparation's spreadability, adhesion, and acid number but did not affect the organoleptic, homogeneity, or protective power. At F3, there is a significant difference in spreadability (5.57 ± 0.21 cm) and adhesion (89.00±2.00 seconds) based on statistical analysis. F3 is the best ointment based on the physical characteristics test results and the minimum increase in acid number (8.83 mg KOH/g).

Uji Stabilitas Protein Salep Kombinasi Ikan Gabus (Channa striata) dan Ekstrak Etanol Daun Sirih (Piper betle L.) Menggunakan Metode Kjeldahl Mohamad Andrie; Wintari Taurina; Maya Widya Astuti Wulandari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.799

The endemic snakehead fish (Channa striata) supposed to speed up wound healing. Antibacterial properties of green betel leaf (Piper betle L.) are well known. Wound healing necessitates moist circumstances and prolonged medication contact. Such the fact that ointment fat-based preparation that can moisturize skin or wound area due to extended contact with the skin, increasing absorbance and effectiveness. Fish protein concentrate high-protein concentrate obtained by eliminating fat and water from fish. One way that can used is freeze drying. Using Kjeldahl method, this study intends investigate protein stability of combination freeze dry ointment extract of snakehead fish (Channa striata) and ethanol extract green betel leaf (Piper betle L.). The data was analyzed using the SPSS version 25 app. On day 28, average protein content of freeze dry ointment and a combination of freeze dry ointment in aqueous phase and ethanol extract of green betel leaf was 6.321 % and 6.630 %, respectively, indicating substantial difference in protein content. As result, the freeze dry ointment including aqueous phase and ethanol extract of green betel leaf more stable and has larger protein content than the freeze dry ointment containing snakehead fish extract.

Efektivitas Analgetik Nanopartikel Kitosan-Ekstrak Etanol Daun Pepaya (Carica Papaya L.) Pada Mencit Putih Jantan (Mus Mucculus) Juliferd Gredi; Wintari Taurina; Mohamad Andrie
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Papaya leaves has been shown to have efficacy as an analgesic. Analgesic effect caused by the flavonoids in leaves of papaya. To enhance the analgesic effi cacy papaya into dosage formulatio of nanoparticles. The purpose of this research was to create and characterized nanoparticles from ethanol extract of papaya leaves then tested for effectiveness as an analgesic. This study used polymer chitosan and NaTPP to created nanoparticles through ionic gelation method and analgesic activity tested using writhing test method and statistical tested. Optimal formula of nanoparticles were produced at concentration of 0.2% chitosan, Na-TPP extract 0.1% and 4% with a ratio of 6: 1: 1. The nanoparticles was formed a size of 255.4 nm with polidispers index of 0.7, the zeta potential of + 11,1mV, the adsorption effi ciency by 87% and rounded morphology (spherical). Analgesic effectiveness tested by comparison between the groups ethanol extract of papaya and the groups nanoparticles of chitosan-ethanol extract papaya statistically using the T-test Independent. The results of this research indicate that there are statistically signifi cant differences (p <0.05). This results shows that the preparation nanoparticles of chitosan-ethanol extract papaya is more effective as an analgesic than the ethanol extract of papaya leaves.

Characterization of the manufacturing process simplicia Syzygium aromaticum as raw material for wound healing drug preparations Naziella Naziella; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14184

Characterization is the first step before standardization. Standardization of a drug substance is a requirement to achieve parameters that will ensure constant quality in a preparation. The main compounds contained in clove leaves have analgesic and antibacterial properties to accelerate wound healing. This study aims to characterize the process of making clove leaf simplicia and Simplicia (Syzygium aromaticum) originating from Lemukutan Island, Bengkayang Regency, West Kalimantan as raw material for wound healing drug preparations. Clove leaf Simplicia was characterized biologically including habitat and morphology, physically including organoleptic, microscopic, moisture content, ash content, and acid insoluble ash content, and chemically, namely phytochemical screening. Making clove leaf Simplicia consists of harvesting, wet sorting, washing, drying, dry sorting, packaging, and storage. The yield of clove leaf Simplicia was obtained as much as 70.90%. The results of the characterization of clove leaves showed that the clove tree grows in the highlands, with a tropical climate, with a temperature range of 25 C-32 C. Clove leaves are oval in shape, tapered tip, pinnate leaf bone, leaf length is approximately 9-12 cm and width 4 cm-4.5 cm. The moisture content, ash content, and insoluble ash content of the clove leaf Simplicia powder were 9.21%, 3.05%, and 0.69%, respectively. The outcomes of the phytochemical screening of clove leaf Simplicia powder have beensuperbfor holding flavonoids, saponins, triterpenoids, and tannins.

THE EFFECT OF SWEETENER TO THE FORMULATION OF LOZENGES TABLET FROM CITRUS FRUIT PEELS PONTIANAK’S ESSENTIAL OILS Ella Sriasih; Wintari Taurina; Rafika Sari
Majalah Farmaseutik Vol 12, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Pontianak orange (Citrus nobilis Lour. var. microcarpa) has good benefit for health. Adding value of peel waste, it can be the waste of Pontianak citrus it can be formulated into lozenges contains essential oils. The lozenges were made by direct compress method with variation of manitol-sukrose ratio as sweetening agent. Formula 1 uses sucrose as sweetener, formula 2 employs combination of manitol-sukrose (1:1). Meanwhile, formula 3 uses manitol as sweetening agent. Based on the research, it showed that variations of the sweetener affect the physical properties of lozenges. Friability test of the tablet performed significant difference between formula 1 and formula 2 which formula 1 is better than formula 2 in friability. Taste test and preference of the respondent showed formula 1 as the most preferred with score of 124 in flavor aspect and texture with score of 113.

Co-Authors Andhi FAHRURROJI Andhi FAHRURROJI Anjeli, Lea Argo, Septian Fernando Arifani, Nata Hadiati Asih Triastuti Dwi Wulandari Dyah Ayuningtias Ella Sriasih Ely lisnawati Emilia - Emilia - Fransisca Daisa Gusfarendi Hilda Ismail, Hilda Isnindar Isnindar Juliferd Gredi Lea Anjeli Mardiansyah, Furqaan Maya Widya Astuti Wulandari Melinda Dewi M Mohamad Andrie Mukkaromah, Siti Naziella Naziella Nur Firdiena Titian Ratu Nurlaila Afriliah Pratama, Taufik Nanda Rafika Sari Rafika Sari Rafika Sari Rafikasari Rafikasari Rahmawati . Rinaldy, Iqmal Arfan Risma Dwi Anugerah Rizqa Ayunda Rizqa Ayunda, Rizqa Ronny Martien Rusmini Rusmini Saragi, Restian Rony Sri Wahdaningsih Suprawijaya, Perianus Taufik Nanda Pratama Uray Cindy Hafinur Yandi Syukri

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