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All Journal Jurnal Ilmiah Farmasi Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Majalah Farmaseutik Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Borneo Akcaya : Jurnal Penelitian dan Pengembangan Pelayanan Publik Medical Sains : Jurnal Ilmiah Kefarmasian Media Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura
Wintari Taurina
Departement Of Pharmacy, Faculty Of Medicine, Tanjungpura University, Pontianak, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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UJI SIFAT FISIK SEDIAAN SALEP KOMBINASI MADU KELULUT (Trigona sp.) DAN MINYAK CENGKEH (Syzygium aromaticum L.) Suprawijaya, Perianus; Andrie, Mohamad; Taurina, Wintari
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 4, No 1 (2019): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Madu kelulut dan cengkeh adalah satu dari sejumlah bahan alam asli Indonesia yang memiliki banyak khasiat untuk kesehatan. Madu memiliki osmolaritas yang tinggi karena kandungan gula yang tinggi, akibatnya udem dapat di hambat sehingga tahap inflamasi pada tahap penyembuhan luka akan dipersingkat. Cengkeh mengandung eugenol yang betfungsi sebagai antimikroba. Bentuk sediaan yang dibuat adalah salep supaya pengaplikasianya mudah. Penelitian ini bertujuan untuk mengetahui kualitas sediaan salep kombinasi madu kelulut (Trigona sp.) dan minyak cengkeh (Syzygium aromaticum L.). Penelitian ini dilakukan dengan uji eksperimental. Evaluasi sifat fisik yang dilakukan adalah uji organoleptik, uji daya sebar,uji daya lekat dan uji homogenitas. Sifat fisik sediaan salep kombinasi madu kelulut menunjukkan hasil uji organoleptik menujukan warna kecoklatan dengan bau khas madu dan cengkeh serta menujukan sediaan homogen. Hasil uji daya sebar rata-rata salep F1, F2, dan F3 berturut-turut sebasar (14,42 ± 2,41 ; 16,02 ± 0.88 ;). Hasil uji daya lekat rata-rata pada salep F1, F2, dan F3 berturut-turut yaitu (70,19 ± 6,16; 88,16 ± 5,00; 14,86 ± 4,17).
Formulasi Sediaan Salep Kombinasi Fase Air Ekstrak Ikan Gabus (Channa striata) Dan Madu Kelulut (Heterotrigona itama) dengan Penambahan Alfa Tokoferol Sebagai Antioksidan Arifani, Nata Hadiati; Andrie, Mohamad; Taurina, Wintari
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 5, No 1 (2021): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Ekstrak ikan gabus dan madu kelulut memiliki kemampuan untuk mempercepat proses penyembuhan luka sehingga diformulasikan menjadi salep dengan basis adeps lanae. Adeps lanae dapat terdegradasi akibat proses oksidasi sehingga dapat menyebabkan pembentukan senyawa volatil sehingga menyebabkan ketengikan. Penambahan alfa tokoferol sebagai antioksidan pada salep dapat mencegah ketengikan basis adeps lanae. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan alfa tokoferol sebagai antioksidan pada sediaan salep ekstrak ikan gabus (Channa striata) dan madu kelulut (Heterotrigona itama) terhadap uji sifat fisik dan bilangan asam. Variasi alfa tokoferol yang digunakan adalah 0,001%, 0,01% dan 0,05% kemudian diuji sifat fisik dan bilangan asam dari sediaan. Pengujian daya sebar menunjukkan bahwa sediaan tidak memenuhi syarat 5-7 cm. Hasil analisis pada daya sebar menunjukan perbedaan yang signifikan antara F0, F1, F2, dan F3 sehingga dapat disimpulkan bahwa sediaan mengalami ketidakstabilan. Hasil analisis daya lekat menunjukkan tidak terdapat perbedaan signifikan pada tiap formula. Hasil uji stabilitas menunjukkan semua formula memiliki stabilitas fisik yang baik, memberikan proteksi. Sediaan juga mengalami penurunan oksidasi pada F3 dibandingkan dengan F0 dan F2 yang ditunjukkan dengan penurunan bilangan asam.
UJI STABILITAS PROTEIN SEDIAAN SALEP KOMBINASI FASA AIR EKSTRAK IKAN GABUS (Channa striata) DAN EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) MENGGUNAKAN METODE BIURET Wulandari, Dwi; Andrie, Mohamad; Taurina, Wintari
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 4, No 1 (2019): Jurnal Farmasi Kalbar
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

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Abstract

Ikan gabus mengandung kadar albumin yang sangat tinggi. Albumin sendiri merupakan salah satu jenis protein yang sangat penting untuk proses penyembuhan luka di tubuh. Penelitian sebelumya telah dilakukan uji aktivitas salep fase air maupun fase minyak pada luka akut stadium II terbuka dan hasilnya menunjukkan daya penyembuhan yang signifikan terhadap kontrol negatif. Pada penelitian ini diujikan ke hewan penelitian dan luka mengalami infeksi, sehingga diperlukan antibakteri alami. Salah satu antibakteri alami adalah daun sirih. Daun sirih (Piper betle L.) hijau merupakan bahan alam yang memiliki kandungan aktif seperti tannin, minyak atsiri, flavonoid, dan fenol yang mempunyai kemampuan untuk membantu proses penyembuhan luka. Senyawa fenol cenderung bereaksi dengan kelompok sulfhidril protein. Reaksi tersebut dapat mengakibatkan protein terdenaturasi dan menyebabkan turunnya nilai protein. Penelitian dilakukan untuk mengetahui stabilitas protein fasa air ekstrak ikan gabus dalam sediaan salep yang dikombinasi dengan ekstrak etanol daun sirih hijau (Piper betle L.) Stabilitas obat penting untuk diperhatikan karena akan berdampak pada efektifitas, keamanan dan mutu obat. Pengukuran kadar protein ditentukan dengan menggunakan metode Biuret. Uji stabilitas protein fasa air ekstrak ikan gabus dalam sediaan salep kombinasi maupun tunggal dilakukan selama 28 hari. Sediaan salep disimpan di dalam lemari yang telah dimodifikasi dengan suhu dan kelembaban yang terjaga (30?C, 75%). Hasil dari penelitian terdapat selisih penurunan kadar antara salep tunggal tanpa ekstrak etanol daun sirih (F1) dan sediaan salep kombinasi dengan ekstrak etanol daun sirih (F2) sebesar 16,345 ppm. Berdasarkan hasil spss pada uji statistic one way anova penurunan kadar protein sediaan salep tunggal maupun salep kombinasi terjadi secara signifikan pada hari ke 28. Pada uji Independent sample t-test terdapat perbedaan signifikan kadar protein salep tunggal dan salep kombinasi ditandai dengan nilai signifikansi 0,008 < 0,05. Hal ini mengindikasikan bahwa adanya pengaruh dari ekstrak etanol daun sirih dalam menjaga stabilitas protein. Kata kunci : Protein, Ikan gabus, Ekstrak daun sirih hijau, Salep, Metode Biuret.
PERBANDINGAN EFEKTIVITAS TRAGAKAN DAN PVP SEBAGAI PENGIKAT TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK JAHE (Zingiber officinale Roxb.) Wintari Taurina; Melinda Dewi M; Yandi Syukri; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTGinger (Zingiber Officinale Roxb) is a traditional plants usually used to relieve pain, rheumatism,and neutralize poison. The aim of this study was to get the optimum concentration of tragacanthand PVP as a binding agent in ginger lozenges formulation. The components from ginger wereextracted using percolation with ethanol 70% and then evaporated using rotary evaporator.Lozenges were made in three formulas ; formula 1 (5%), 2 (7,5%), 3 (10%) of tragacanth and PVPusing wet granulation method. Granules and tablets were tested for its physical properties, andanalyzed using Pearson correlation. The result showed that, all of three formulas were good,comply with a regulation of physical properties and disolution time in the mouth. Variation oftragacanth and PVP concentration affected physical properties of tablets. It showed that the greaterconcentration of tragacanth and PVP, the larger the hardness and the longer the disolution time oftablets. The third formula (tragacanth 10% b/v) gave an optimum physical properties and solubletime of tablets, with weight variety deviation 0,98%, hardness 10,18 kg, friability 0.11% anddisolution time 11.50 minutes. The three formulas were received by respondens withprerequirement of improving sweetness, repairing form and the color of tablets.Key words :Ginger lozenges, tragacanth, PVP, wet granulation method.
PREPARASI NANOPARTIKEL GAMAVUTON-0 MENGGUNAKAN KITOSAN RANTAI PENDEK DAN TRIPOLIFOSFAT SEBAGAI CROSS LINKER Wintari Taurina; Ronny Martien; Hilda Ismail
Jurnal Ilmiah Farmasi Vol. 10 No. 2 (2013): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol10.iss2.art4

Abstract

Gamavuton-0 (GVT-0) adalah suatu senyawa hasil modifikasi molekul kurkumindengan potensi analgetika dan anti inflamas iyang terbukti cukup baik. Saat ini pemberian senyawa GVT-0 sangat terbatas melalui rute parenteral, karena rendahnya bioaviabilitas senyawa pada pemberian secara peroral. Hal ini disebabkan karena sifat-sifat fisikokimia GVT-0 yang tidak menguntungkan (hidrofilisitas, ukuran molekul, dan densitas muatan negatif) yang menyebabkan permeabilitasnya terhadap intestinal menjadi buruk. Keterbatasan tersebut dapat diatasi dengan sistem nanopartikel. Penelitian ini bertujuan untuk mengembangkan nanopartikel GVT-0 dengan pembawa kitosan rantai pendek sebagai sebuah sistem penghantaran obat per oral. Pada penelitian ini nanopartikel GVT-0 diformulasikan menggunakan metode ionik gelasi dengan penambahan tripolifosfat (TPP) yang bermuatan negatif. Nanopartikel akan dikarakterisasi menggunakan TEM dan PSA untuk melihat morfologi dan ukurannya, kemudian dilakukan uji Entrapment Efficiency. Selanjutnya dilakukan uji stabilitas di dalam HCl dan AIF. Nanopartikel GVT-0 yang dipreparasi mempunyai ukuran partikel ratarata antara 504,7 nm - 638,2 nm dan umumnya mempunyai bentuk sferik. Entrapment Efficiency yang diperoleh yaitu antara 30,27% - 71,63%. Nanopartikel GVT- 0 relatif stabil dalam HCl 0,1N pH 1 sampai jam ke-3 dengan stabilitas antara 53,03 - 83,56%, dan dalam AIF sampai jam ke-4 dengan stabilitas antara 63,08 - 97,08%. Berdasarkan hasil penelitian terlihat bahwa GVT-0 dan kitosan rantai pendek dapat dipreparasi menjadi nanopartikel GVT-0 yang stabil dalam AIF dan HCl 0,1N pH 1.
Ointment formulation of snakehead fish (Channa striata) Extract with variations of CMC-Na and carbopol Mohamad Andrie; Wintari Taurina
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.595 KB) | DOI: 10.12928/pharmaciana.v11i1.18385

Abstract

 Snakehead fish (Channa striata) and kelulut honey (Trigona sp.) have the potential to accelerate the wound-healing process. These natural ingredients are formulated in the form of ointment because ointment is an external medicine that is easy to apply and has long contact with the skin. Previous research has shown that the snakehead fish extract ointment undergoes phase separation, so it needs a material that can bind the snakehead fish extract and kelulut honey as the active substances in the preparation. This study aimed to determine the effect of variations in the concentration of CMC-Na (3%, 4.5%, 6%) and Carbopol (0.5%, 1%, 2%) as a binder on the ointment physical properties and to determine the best snakehead fish (Channa striata) extract ointment formulation. The ointment of snakehead fish extract was tested for organoleptic, homogeneity, spreadability, and adhesion. The test results were analyzed by One Way ANOVA with a confidence level of 95%. The results showed that the higher the concentrations of CMC-Na and Carbopol used, the greater the adhesive power and the lower the spreadability. Ointment with Carbopol has a wider spreadability and a softer consistency than ointment with CMC-Na. The best formulation is shown by the Carbopol 0.5% (F4) formula, where the average spreadability with a load of 150 g is 5.09 cm and the average adhesion is 229 seconds.
Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder Wintari Taurina; Mohamad Andrie; Nur Firdiena Titian Ratu
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.873 KB) | DOI: 10.12928/pharmaciana.v11i3.20628

Abstract

The extract of snakehead fish (Channa striata) and kelulut honey (Heterotrigona itama) ointment was proven to have activity in wound healing. However, previous studies showed instability in the ointment as indicated by the occurrence of phase separation. This study used CMC-Na (Carboxymethyl Cellulose Sodium) with a concentration of 3% (F1), 4.5% (F2), and 6% (F3) as a binder. The stabilizer was added to increase the stability of the ointment preparation by binding to the aqueous phase and preventing it from leaving the ointment base. The test was carried out with the accelerated stability method at a temperature of 40° ± 2° C and a humidity of 75% ± 5% for 28 days. The evaluation includes organoleptic tests, homogeneity, spreadability, adhesion, and protection power. The results showed that CMC-Na increased the stability of the ointment. The data obtained show that the higher the CMC-Na concentration used, the higher the consistency and adhesion were, but the lower the spreadability of the preparation. The results of the average spreadability and adhesion power for formulation 1 were 5.09 cm and 1797.33 seconds, formulation 2 were 4.42 cm and 1798.33 seconds, and formulation 3 were 3.69 cm and 1799 seconds. The results of the One-Way ANOVA showed that all formulations experienced a significant decrease in adhesion and increase in spreadability during 28 days of storage. The best ointment that meets the physical stability criteria is shown by the CMC-Na 3% (F1) formulation, with a soft texture, homogeneous, a good spreadability (5-7 cm), a good adhesion (more than 4 seconds), and a good protective power for 28 days of testing.
The gel formulation of the aqueous phase of snakehead fish (Channa striata) extract with various combinations of HPMC K4M and Carbopol 934 Wintari Taurina; Mohamad Andrie; Lea Anjeli
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.809 KB) | DOI: 10.12928/pharmaciana.v8i1.8356

Abstract

Gel is a clear and semi-solid material, translucent and contains active material. The liquid phase of Ekstrak Ikan Gabus contains reactive Albumin benefits to advance the wound-healing process. HPMC and carbopol is the gelling agent uses to form gel material. This research aims to acknowledge the effect of basic combination variety (gelling agent) towards physical and chemical stability of gel material during liquid phase of Ekstrak Ikan Gabus in length of period 28 days.  Variety of HPMC: Carbopol used, 25:75%, 50:50%, and 75:25%. Physical and chemical test conducted they are, organoleptic test, dispersion test, bonding strength test and pH test. The result is analyzed through one-way ANOVA and continued by LSD test with validity 95%. The whole formula is resulted a stable physical and chemical during 28 days. The higher the consentration of HPMC the the better its physic and chemistry stability. The best and optimum formula was shown by F3 (75:25%), with a stable organoleptic result during 28 days, homogen, the result of the dispere power weight 50 g (±14,517 cm2) weight 100 g (±16,169 cm2) weight 150 g (±16,957 cm2 ) and the average weight is (±15,881 cm2), the sticky power (±2301,78 second) and pH (±6,42) in which can be considered safe for skin.
PENGARUH TRAGAKAN SEBAGAI PENGIKAT TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK JAHE (Zingiber officinalle Roxb.) Wintari Taurina; Yandi Syukri; Asih Triastuti
Majalah Obat Tradisional Vol 18, No 2 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.951 KB) | DOI: 10.22146/tradmedj.7982

Abstract

Ginger (Zingiber Officinale Roxb.) is a traditional plants usually used to relieve pain, rheumatism, and neutralize poison. The aim of this study was to get the optimum concentration of tragacanth as a binding agent in ginger lozenges formulation. The components from ginger were extracted using percolation with ethanol 70% and then evaporated using rotary evaporator. Lozenges were made in three formulas ; formula 1 (5%), 2 (7,5%), 3 (10%) of tragacanth using wet granulation method. Granules and tablets were tested for its physical properties, and analyzed using Pearson correlation. The result showed that, all of three formulas were good, comply with a regulation of physical properties and soluble time in the mouth. Variation of tragacanth concentration affected physical properties of tablets. It showed that the greater concentration of tragacanth, the larger the hardness and the longer the soluble time of tablets. The formula (tragacanth 10% b/v) gave an optimum physical properties and soluble time of tablets, with weight variety deviation 0,98%, hardness 10,18 kg, friability 0.11% and soluble time 11.50 minutes. The three formulas were received by respondens with prerequirement of improving sweetness, repairing form and the color of tablets.
UJI EFEKTIVITAS SEDIAAN GEL MINYAK ATSIRI KULIT BUAH JERUK PONTIANAK (Citrus nobilis Lour. Var. microcarpa) TERHADAP Escherichia coli DAN Staphylococcus aureus Wintari Taurina; Rafikasari Rafikasari
Majalah Obat Tradisional Vol 19, No 2 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (828.018 KB) | DOI: 10.22146/tradmedj.8143

Abstract

Essential oil is a natural substance that has been known as antibacterial. This research aimed to examine the effectiveness of antiseptic gel from essential oil which taken from rind Pontianak orange. Essential oil from rind Pontianak orange are formulated into a gel and it tested its effectiveness as an antibacterial to Escherichia coli and Staphylococcus aureus. Based on the result of the study, the effective concentration of essential oil to inhibit Escherichia coli is 0,5%, while Staphylococcus aureus is inhibited at concentration 0,1%, 0,3% and 0,5%. The results of the gel test stabilization showed that the homogenity of gel, pH value and stable adhesion are good. Coverage gel increased during 30 days of storage. One Way Anova test analysis showed that the dispersive power of each gel formula does not differ significantly.
Co-Authors Andhi FAHRURROJI Andhi FAHRURROJI Anjeli, Lea Argo, Septian Fernando Arifani, Nata Hadiati Asih Triastuti Dwi Wulandari Dyah Ayuningtias Ella Sriasih Ely lisnawati Emilia - Emilia - Fransisca Daisa Gusfarendi Hilda Ismail, Hilda Isnindar Isnindar Juliferd Gredi Lea Anjeli Mardiansyah, Furqaan Maya Widya Astuti Wulandari Melinda Dewi M Mohamad Andrie Mukkaromah, Siti Naziella Naziella Nur Firdiena Titian Ratu Nurlaila Afriliah Pratama, Taufik Nanda Rafika Sari Rafika Sari Rafika Sari Rafikasari Rafikasari Rahmawati . Rinaldy, Iqmal Arfan Risma Dwi Anugerah Rizqa Ayunda Rizqa Ayunda, Rizqa Ronny Martien Rusmini Rusmini Saragi, Restian Rony Sri Wahdaningsih Suprawijaya, Perianus Taufik Nanda Pratama Uray Cindy Hafinur Yandi Syukri