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Uji Aktivitas Antioksidan Sediaan Salep Ikan Gabus (Channa Striata) Kombinasi Vitamin C dan Madu Kelulut (Heterotrigona Itama) Risma Dwi Anugerah; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15271

Based on the results of research, snakehead fish extract and kelulut honey have properties to make wounds heal faster. Ointment with an active formulation of snakehead fish extract and extract of kelulut honey showed an oxidation process that could make the preparation rancid. The addition of BHA and Vitamin C is expected to prevent the oxidation process so that the preparation does not become rancid. This study aims to determine the effect of adding Antioxidant BHA and Vitamin C in preventing the oxidation process of the ointment in the aqueous phase of extracts of snakehead fish (Channa Striata)and of kelulut honey (Heterotrigona Itama) at 28 days storage. Stability was accelerated at a temperature of 40 ± 20ºC and a RH of 75 ± 5%. Variations in the concentration ofiBHA and Vitamin C used were BHA.0.02. : Vitamin C 0.1, BHA 0.02 : Vitamin C 0.01, BHA 0.005 : Vitamin C 0.01, and BHA 0.005 : Vitamin C 0.1 then tested the physical properties of the ointment, namely through organoleptic test, homogeneity test, spreadability test, adhesion test, protection test and acid number test which were then analyzed by SPSS. Based on the analysis of the scattering power showed a significant difference between F0, F1, and F3. The results of the adhesion analysis showed that there were significant differences in each formula. Furthermore, the results of the stability test showed that all formulas had good physical stability. Conclusion: F1 is a very good formula to prevent oxidation in the preparation as evidenced by a decreased acid number, which is 9.62 mg KOH/g.

Formulasi Salep Ekstrak Ikan Gabus (Channa striata) dan Madu Kelulut (Heterotrigona itama) sebagai Antioksidan Ely lisnawati; Wintari Taurina; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15270

Kelulut honey and snakehead fish extract have been demonstrated to improve wound healing, hence the two active components are combined in ointment formulations. Adeps lanae is a base that is included in the oil phase that undergo an oxidation process that causes rancidity in the ointment preparation, so in this study BHA and BHT antioxidants were added to suppress the oxidation process. The ointment was made with 5 concentrations consisting of 1 control group and 4 treatment groups which were given variations of BHA and BHT antioxidants. Organoleptic testing, homogeneity, adhesion, dispersion, protection, and acid numbers were all evaluated. SPSS 24 is used to test data related to adhesion, and dispersion. Results: The addition of antioxidants BHA and BHT based on acid number tests revealed that the higher the combination of antioxidants employed, the less the increase in acid numbers on day 28. The organoleptic test, homogeneity, protection, and adhesion on the preparation fulfilled the test criteria, whereas the adhesion test revealed significant differences in F1, F2, and F4 when compared to the control group. The optimum formula is F4, which fits the test parameters and has the minimum rise in acid number (9.22 mg KOH/g).

FORMULASI DAN EVALUASI STABILITAS FISIK SUSPENSI IBUPROFEN DENGAN MENGGUNAKAN NATROSOL HBr SEBAGAI BAHAN PENSUSPENSI Emilia -; Wintari TAURINA; Andhi FAHRURROJI
Media Farmasi Indonesia Vol. 8 No. 2 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.5 KB)

Ibuprofen it a non-steroidal anti-inflammatory drug which is practically insoluble in water it can be made in the form of suspension. Suspension requires suspending agent such as natrosol HBR for increasing the viscosity and reducing the rate of sedimentation that can produce stable suspension. The aimed of this research is to find the influence of natrosol HBR as the suspending agent toward physical stability of suspension. The method used in the manufacture of ibuprofen suspension is dispersion method. Ibuprofen suspensions were made with variation concentrations of 1%; 1.5%; 2% natrosol HBR respectively. In order to know the physical stability of suspension, it should be carried out organoleptic, density test, particle size distribution, viscosity test, sedimentation volume, redispersibility and pH test. The test result for three formulation suspensions for 30 days storage showed that the physical stablility changed in various showed concentration of natrosol. This research shown that the formulation with concentration of Natrosol Hbr 1% showed the best physical stability of the three formulas which indicated by the required results of the density test, sedimentation volume and redispersibility as well as the best particle size distribution and viscosity of the three formulas ibuprofen suspensions.

KARAKTERISASI SIMPLISIA MADU KELULUT (Heterotrigona itama) SEBAGAI BAHAN BAKU SEDIAAN OBAT PENYEMBUHAN LUKA Nurlaila Afriliah; Wintari Taurina; Mohamad Andrie
Majalah Farmasi dan Farmakologi Vol. 26 No. 3 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i3.20969

Karakterisasi bahan alam merupakan langkah untuk mengetahui kejelasan identitas bahan alam. Identitas bahan alam merupakan aspek penting pada produksi suatu obat herbal. Madu kelulut (Heterotrigona itama) adalah salah satu bahan alam yang diperoleh dari lebah kelulut. Madu kelulut berkhasiat sebagai obat penyembuhan luka karena bersifat antiinflamasi, antibakteri, dan antioksidan. Penelitian ini bertujuan untuk mengetahui karakterisasi proses pembuatan simplisia dan simplisia madu kelulut yang berasal dari Desa Pangkalan 2, Kabupaten Bengkayang, sebagai bahan baku sediaan obat penyembuhan luka. Simplisia dikarakterisasi secara biologi meliputi habitat dan morfologi, secara fisika meliputi organoleptis, kadar air, kadar abu total, pH, dan bobot jenis, serta secara kimia meliputi skrining fitokimia. Proses pembuatan simplisia madu kelulut terdiri dari pengumpulan sampel, penyaringan, pengemasan, dan penyimpanan. Rendemen simplisia madu kelulut yang diperoleh sebesar 89,6%. Hasil karakterisasi yaitu lebah kelulut (Heterotrigona itama) hidup di daerah dataran rendah dengan iklim tropis, wilayah yang hangat dan lembap, serta memiliki sistem vegetasi yang didominasi 60% pohon kelapa (Cocos nucifera L.), 5% pohon kaliandra (Calliandra haematocephala), 5% tanaman air mata pengantin (Antigonon leptopus), serta 30% terdiri atas pisang (Musa paradisiaca L.), pinang (Areca catechu), rambutan (Nephelium lappaceum L), durian (Durio zibethinus), ceri (Prunus cerasus), buah naga (Selenicereus polyrhizus), dan beberapa tanaman liar. Morfologi lebah kelulut terbagi menjadi bagian kepala, dada, dan perut, berukuran panjang 6 mm, dan berwarna hitam. Simplisia madu kelulut memiliki rasa asam sedikit manis, berwarna hitam, beraroma khas madu kelulut, kadar air 27,11%, kadar abu total 0,28%, pH 3,07, bobot jenis 1,34 g/mL, serta mengandung senyawa alkaloid, flavonoid, dan triterpenoid. Berdasarkan hasil karakterisasi yang telah dilakukan, dapat disimpulkan simplisia madu kelulut yang diperoleh memiliki kualitas yang baik.

WATER PHASE CONCENTRATE SOLUBILITY TEST SNAKEHEAD FISH EXTRACT (Channa Striata) IN ORGANIC COSOLVENT Mohamad Andrie; Wintari Taurina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.658

Snakehead fish extract has been recognized for its potential in healing postoperative wounds and burns. The extract contains albumin, which aids in tissue formation and healing processes. To create a high-quality wound healing drug, the extract needs to be formulated into a concentrated form and combined with a solvent that can effectively dissolve its active substances. Understanding the solubility profile of the extract and the composition of the solvent is crucial for this purpose. This study aims to determine the solubility profile of the aqueous phase concentrate of snakehead fish extract in an organic co-solvent. Solubility is an important parameter as it can impact the release rate and therapeutic effectiveness of the drug. A solubility test was conducted to assess the solubility of the aqueous phase concentrate in various solvents. The results of the solubility test indicated that the aqueous phase concentrate of snakehead fish extract exhibited good solubility in aquadest (20%), slight solubility in propylene glycol (8.5%) and honey (2%), and was insoluble in ethanol, glycerin, mannitol, and sorbitol (0%). These findings provide valuable information for formulating the extract into a wound healing drug with an appropriate solvent composition, ensuring optimal solubility and therapeutic efficacy according to pharmacopeial standards. Keywords: Concentrate; Aqueous phase of snakehead fish extract; Solubility; Solvent; Polarity Properties

WATER PHASE CONCENTRATE SOLUBILITY TEST SNAKEHEAD FISH EXTRACT (Channa Striata) IN ORGANIC COSOLVENT Mohamad Andrie; Wintari Taurina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.658

Snakehead fish extract has been recognized for its potential in healing postoperative wounds and burns. The extract contains albumin, which aids in tissue formation and healing processes. To create a high-quality wound healing drug, the extract needs to be formulated into a concentrated form and combined with a solvent that can effectively dissolve its active substances. Understanding the solubility profile of the extract and the composition of the solvent is crucial for this purpose. This study aims to determine the solubility profile of the aqueous phase concentrate of snakehead fish extract in an organic co-solvent. Solubility is an important parameter as it can impact the release rate and therapeutic effectiveness of the drug. A solubility test was conducted to assess the solubility of the aqueous phase concentrate in various solvents. The results of the solubility test indicated that the aqueous phase concentrate of snakehead fish extract exhibited good solubility in aquadest (20%), slight solubility in propylene glycol (8.5%) and honey (2%), and was insoluble in ethanol, glycerin, mannitol, and sorbitol (0%). These findings provide valuable information for formulating the extract into a wound healing drug with an appropriate solvent composition, ensuring optimal solubility and therapeutic efficacy according to pharmacopeial standards. Keywords: Concentrate; Aqueous phase of snakehead fish extract; Solubility; Solvent; Polarity Properties

Standardization of Golden Sea Cucumber (Stichopus hermanii) Extracts from Pelapis Island, Kayong Regency, West Kalimantan Rusmini, Rusmini; Taurina, Wintari; Andrie, Mohamad
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.539-545

Stichopus hermanii can be used as a medicinal material, a source of animal protein, and wound healing medicine products. Extracts as raw materials for products must go through a standardization process to ensure pharmaceutical reproducibility, a therapeutic quality, and to ensure a consistent and uniform final composition. The purpose of this research was to determine the test results of the standardization parameters of Stichopus hermanii extract from Pelapis Island, West Kalimantan as raw material for wound healing herbal medicinal preparations. Preparation of extracts using the maceration method with 96% ethanol. The extract was standardized with specific parameters, including organoleptic, water and ethanol soluble content, phytochemical screening, and protein content, and non-specific parameters, including drying shrinkage, water content, ash content, and acid insoluble ash content. The test results obtained were a water-soluble content of 61.89%, ethanol-soluble content of 41.81%, protein content of 7.62%, drying shrinkage of 38.81%, water content of 20.58%, ash content of 37.95%, and acid insoluble ash content of 2.07%.

The Effect of BHA as an Antioxidant to the Accelerated Stability Test of Snakehead Fish and Kelulut Honey Ointment Taurina, Wintari; Andrie, Mohamad; Mukkaromah, Siti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.37776

The ointment of snakehead fish extract and kelulut honey has a synergistic potential to boost the wound recuperation process. This ointment is formulated for topical use to be easily applied to the wound area. The ointment base used in this preparation is adeps lanae. Adeps lanae is an easily oxidized substance that can cause the preparation to become unstable. The addition of antioxidants is one way to prevent the oxidation process in the preparation. This has a look at aims to decide the impact of the addition of BHA as an antioxidant in the ointments of snakehead fish extract (Channa striata) and kelulut honey (Heterotrigona itama) at 28 days of storage with an accelerated stability test method with a temperature 40 ± 20C and RH 75 ± 5%. The ointment was made with various concentrations of BHA 0.005% (F1), 0.01% (F2), and 0.02% (F3) then tested the physical properties of the ointment and analyzed by SPSS. Results of spreadability test analysis showed an increase of the spread and significant differences between F1, F2, and F3 to F0. The adhesion test analysis results showed a decrease in the stickiness of time bonding strength and a significant difference. The test results showed a decrease in acid number on the acid number F2 and F3. Results of the organoleptic test, homogeneity, and power protection showed that all formulas have good stability. F2 is the best formula to prevent oxidization of the dosage indicated by the smallest value of the acid number.

Formulasi Sediaan Salep Ekstrak Ikan Gabus (Channa Striata) Dan Madu Kelulut (Heterotrigona Itama) Menggunakan Butil Hidroksil Toluen Dan Vitamin C Sebagai Antioksidan Mardiansyah, Furqaan; Andrie, Mohamad; Taurina, Wintari
Journal Pharmacy Of Tanjungpura Vol 2, No 1 (2024): Oktober
Publisher : Universitas Tanjungpura

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Sediaan salep kombinasi fase air ekstrak ikan gabus dan madu kelulut terbukti memiliki aktivitas dalam penyembuhan luka. Sediaan salep ekstrak ikan gabus dan madu kelulut pada orientasi menunjukkan bahwa adanya ketidakstabilan pada sediaan. Hal ini ditandai dengan adanya bau tengik, sehingga ditambahkan BHT dan Vitamin C untuk mencegah terjadinya proses oksidasi sehinga tidak terjadi bau tengik. Penelitian ini bertujuan untuk mengamati apakah penambahan BHT dan Vitamin C sebagai antioksidan dapat mencegah terjadinya proses oksidasi pada sediaan terhadap sifat fisik dan kestabilan salep pada suhu 40 ±2 °C dan RH 75 ±5% selama penyimpanan 28 hari. Evaluasi yang dilakukan berupa uji organoleptis, homogenitas, daya sebar, daya lekat, daya proteksi dan bilangan asam kemudian dianalisis dengan bantuan program SPSS. Hasil menunjukkan bahwa formula 3 (BHT 0,1% dan Vitamin C 0,1%) merupakan formula yang terbaik karena memenuhi syarat uji stabilitas fisik sediaan salep yaitu menghasilkan sediaan yang homogen, bertekstur kental, memiliki daya proteksi yang baik, bilangan asam 10,02 mg, rata-rata daya lekat 54 detik dan daya sebar 5,07 cm. Analisis SPSS menunjukkan bahwa Semua formula memiliki perbedaan yang signifikan antara daya sebar dan daya lekat terhadap waktu penyimpanan (P0,05).

PENGARUH ALFA TOKOFEROL DAN VITAMIN C TERHADAP STABILITAS FISIK SALEP EKSTRAK IKAN GABUS (Channa striata) DAN MADU KELULUT (Heterotrigona itama) Argo, Septian Fernando; Andrie, Mohamad; Taurina, Wintari
Journal Pharmacy Of Tanjungpura Vol 2, No 1 (2024): Oktober
Publisher : Universitas Tanjungpura

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Ekstrak ikan gabus dan madu kelulut memiliki kemampuan untuk mempercepat proses penyembuhan luka. Salep dengan bahan aktif ekstrak ikan gabus dan madu kelulut menunjukan adanya proses okidasi yang dapat membuat sediaan menjadi tengik. Penambahan Alfa Tokoferol dan Vitamin C diharapkan dapat mencegah proses oksidasi sehingga sediaan tidak menjadi tengik. penelitian menggunakan uji stabilitas dipercepat pada penyimpanan 28 hari suhu 40 ± 20 ºC dan RH 75 ± 5%. Variasi konsentrasi Alfa tokoferol dan Vitamin C yang digunakan adalah 0,005% : 0,01% ; 0,005% : 0,1% ; 0,05% : 0,1% ; 0,05% : 0,01% kemudian dilakukan pengujian sifat fisik salep pada hari ke 0, 3, 7, 14, 21 dan 28. Adapun uji yang dilakukan yaitu uji organoleptik, uji homogenitas, uji daya sebar, uji daya lekat, uji daya proteksi dan uji bilangan asam kemudian dianalisis dengan pendekatan kualitatif dan SPSS. Hasil uji stabilitas dipercepat memenuhi kriteria sediaan fisik yang baik pada semua uji kecuali pada daya sebar. formula yang memberikan hasil paling optimal adalah F4. Pada uji bilangan asam F4 memiliki bilangan asam yang paling kecil (9,62 mg KOH/g)

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