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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Althea Medical Journal Medica Hospitalia Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Darma Agung Devotion: Journal of Research and Community Service Indonesian Journal of Health Science
Nina Tristina
Department Of Clinical Pathology Faculty Of Medicine Universitas Padjadjaran / Dr. Hasan Sadikin General Hospital, Bandung
Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Urinary Epithelial Sodium Channel (EnaC) Level as A Diabetic Marker of Nephropathy in Type 2 Diabetes Mellitus with Hypertension Heti Kus Erni; Nina Tristina; Agnes Rengga Indrati; Dewi Kartika Turbawaty
Majalah Kedokteran Bandung Vol 54, No 1 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n1.2533

Abstract

Increased prevalence of diabetes mellitus (DM) leads to the increased of various complications including diabetic nephropathy, which can lead to the end stage renal disease (ESRD). The Epithelial sodium channel (ENaC), which is located in distal convoluted tubules, plays an important role in transepithelial sodium reabsorption for electrolyte homeostasis. Diabetes mellitus can cause changes in ENaC function which will interfere with kidney blood pressure control, worsening hypertension, and kidney injury that eventually may trigger diabetic nephropathy. The aim of this study was to determine the validity of urinary ENaC for screening diabetic nephropathy in type 2 diabetes mellitus (T2DM) with uACR as the gold standard. This was a cross-sectional analytical observational study conducted in Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from December 2020 to July 2021. The subjects were 87 patients T2DM with hypertension with the majority of subjects (n=62) had a mean age of 56 years old and were experiencing albuminuria and hyperglycemia with DM for a duration of < 10 years. The poor glycemic control in these patients accelerated the occurrence of kidney damage. Result showed that urine ENaC level had a sensitivity and specificity of 82.3% and 48%, respectively, with 72.4% accuracy. The cut-off point of urine ENaC in this study was 0.98 ng/mL. Hence, urine ENaC level can be used as a test to screen for diabetic nephropathy with 82.3% sensitivity.
Validity of Serum Uromodulin as Early Diagnosis Marker of Diabetic Nephropathy in T2DM Rizki Dumpatna; Nina Tristina; Dewi Kartika Turbawaty; Anna Tjandrawati
Majalah Kedokteran Bandung Vol 53, No 2 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n2.2268

Abstract

Increased prevalence of DM is accompanied by increased in its various complications include diabetic nephropathy, which can lead to end stage renal disease (ESRD). Urinary albumin-creatinine ratio (uACR) is the gold standard for diabetic nephropathy; however, it has several limitations, including the inability to early diagnose due to the absence of increased level in uACR. Uromodulin is produced by thick ascending limb (TAL) at Henle’s loop and early distal tubule of nephron. Uromodulin will decrease when tubular atrophy occurs in early stage of renal impairment with normoalbuminuria. The aim of this study was to determine the validity of serum uromodulin in type 2 diabetes mellitus (T2DM) in identifying diabetic nephropathy by comparing it with uACR as gold standard. This study was a cross-sectional analytical observational study at Dr. Hasan Sadikin (RSHS) Bandung from June to August 2020. Subjects consisted of 62 patiens with T2DM. Results showed that the serum uromodulin level had a sensitivity of 93.3%, a specificity of 88.2%, a positive predictive value of 95.5%, a negative predictive value of 83.3%, and an accuracy of 91,9% and an AUC value of 0.975. The cut-off point of serum uromodulin in this study was 47.195 ng/mL. In conclusion, serum uromodulin, when compared to the uACR as the gold standard, has good sensitivity and specificity for identifying diabetic nephropathy.
Correlation Between Serum Ferritin and Testosterone Level in Adolescent Male with Transfusion Dependent Thalassemia Raja Iqbal Mulya Harahap; Nina Tristina; Delita Prihatni; Dewi Kartika Turbawaty
Majalah Kedokteran Bandung Vol 53, No 3 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n3.2389

Abstract

Transfusion-dependent thalassemia (TDT) is a type of beta-thalassemia that needs regular and long-term blood transfusions. Complications can occur due to the deposition of iron in TDT patients, including endocrine complications causing deficiency of testosterone that plays a role in the secondary sexual development in males. The objective of this study was to understand the correlation between ferritin and testosterone level in male adolescences with transfusion-dependent thalassemia. This cross-sectional observational correlative study was conducted from April to August 2019 on 74 males aged 12-18 years old who were presented to the Thalassemia Outpatient clinic, Dr. Hasan Sadikin General Hospital, Bandung. Blood was collected using phlebotomy for ferritin and total testosterone serum examination. Data were then analyzed using SPSS version 17.0. Low testosterone level (<3.0 ng/mL) was found in 63.5% of subjects. Results of the Spearmen correlation test demonstrated a negative correlation with r: -0,699 and p-value <0.001, showing a negative, strong, and significant correlation among those variables. The higher ferritin level in TDT patients indicates a high level of the free iron level in the body that can destroy the endocrine organs and cause deprivation of testosterone secretion, leading to hypogonadism in transfusion dependent thalassemia patients.
RERATA VOLUME TROMBOSIT DI DIABETES MELITUS (Mean Platelet Volume in Diabetes Mellitus) Maria Enrica; Nina Tristina; Anna Tjandrawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1254

Abstract

Diabetes Mellitus (DM) is a state of chronically hyperglycemia, which is caused by impaired insulin secretion and function. Thealteration in coagulation system in DM patients served as the basic etiology of macro and micro vascular complication. Platelets are oneof the factors that have a role in the coagulation system and undergo pathological changes in DM patients. Mean Platelet Volume (MPV)is an indicator of platelet function and activation. Larger platelets have more dense and more reactive pro coagulant granules. The aimof this study was to know whether there were differences in MPV between DM patients compared to medical check-up participants atthe Dr. Hasan Sadikin Hospital, Bandung.. The research used analytical descriptive, retrospective data. The inclusion criteria of thisresearch was DM patients and medical check up participants whose serum fasting glucose and two (2) hours post prandial serum glucosewere within the normal range. The data were taken from medical records of DM patients and medical check up participants. The datawere further analyzed with SPSS ver. 15 program using unpaired T-test. In this study, no significant difference between DM patientsand medical check up participants (p>0.05) was found. It can be concluded that Mean Platelet Volume if used as single, can not predictvascular complication in DM patients.
HYBRIDIZATION-BASED NUCLEIC ACID AMPLIFICATION TEST TERHADAP CARTRIDGE-BASED NUCLEIC ACID AMPLIFICATION TEST TERKAIT MULTIDRUG-RESISTANT TUBERCULOSIS (Hybridization-Based Nucleic Acid Amplification Test towards Catridge-Based Nucleic Acid Amplification Test in Multidrug-Resistant Tuberculosis) Ivana Agnes Sulianto; Ida Parwati; Nina Tristina; Agnes Rengga I
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1274

Abstract

Indonesia has high burden of multidrug-resistant tuberculosis (MDR-TB). Cartridge-based nucleic acid amplification test (CB-NAAT),which is recommended as a diagnostic method of MDR-TB by World Health Organization, is faster in achieving the result. This methoddetermines MDR-TB only from the rifampisin resistance, by detecting mutations that occur on the 81 bp hot-spot region of the rpoBgene. The isoniazid resistance is not included in the determination of MDR-TB by this method. Hybridization-based NAAT (HB-NAAT)detects MDR-TB not only from the rifampisin resistance (codon 526 and 531 rpoB gene), but also from the isoniazid resistance (codon315 katG gene). The aim of this study was to know the validity of the HB-NAAT in detecting MDR-TB using sputum with CB-NAATas the gold standard in a diagnostic study. All of 51 sputums were collected during June 2013 from patients suspected pulmonaryMDR-TB at Dr. Hasan Sadikin General Hospital. The result of CB-NAAT were 16 MDR-TB, 12 TB non MDR, and 23 non TB. HB-NAATexamination results were 3 MDR-TB, 25 TB non MDR (3 RMR, 6 IMR, 16 susceptible) and 23 non TB. The sensitivity of HB-NAAT was18.75% and specificity 100%. Low sensitivity values may due to the high mutation variations in the samples. So it could not be detectedonly by codons 526 and 531 for rifampisin resistance. For the detection of isoniazid resistance, HB-NAAT have optimal primer at lowconcentrations and it also need more than katG genes to detect isoniazid resistance. Based on this study, it can be conclued, that HBNAAThas low sensitivity but high specificity in the detecting MDR-TB.
UJI KESAHIHAN (VALIDITAS) PEMERIKSAAN D-DIMER CARA MENYARING KEKEBALAN (METODE IMUNOFILTRASI) DAN CARA MENGUKUR IMUNOTURBIDIMETRI David Rustandi; Delita Prihatni; Tiene Rostini; Nina Tristina
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 1 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i1.1049

Abstract

D-Dimer parameter is the most usefull laboratory assay to detect the present of activated coagulation. The D-Dimer fragment directlyindicate the fibrinolitic proccess whereas the increasing mark of D-Dimer is the most hemostatic parameter that was used to detectthe early stage of Disseminated Intravascular Coagulation (DIC) and has a correlation with the patient prognosis. D-Dimer assay byimmunoturbidimetric method was used to detect antigen-antibody reaction automatically and it can detect D-Dimer concentration lessthan 0.5 μg/mL. The immunoturbidimetric method has a good correlation with the ELISA method, but the proccess is complicated, ishigh costed, and need the competence of practical human resource. D-Dimer assay with immunofiltration method has the same principleas immunoturbidimetric method, but it's work more simpler, low cost and does not need the competence of practical human resource.The aim of this study is to compare the D-Dimer assay concentration between immunofltration and immunoturbidimetric method. Therewere 30 plasma samples assayed with these two methods (immunoturbidimetric and immunofiltration), and then compared betweenthem. The samples were collected between November until December 2008 at Rumah Sakit dr. Hasan Sadikin Bandung. The validity ofD-Dimer using immunofiltration method showed sensitivity 74%, specificity 95%, predictive value of negative test (PV-) 22%, predictivevalue of positive test (PV+) 95% with likelihood ratio 5.2. The conclusion of this study so far that the immunofiltration method has agood validity for diagnosing. D-Dimer work rapidly with low cost laboratory assay than the immunoturbidimetric method.
PROFIL SCATTERGRAM LIMFOSIT PADA LANSIA DENGAN NYERI TULANG DAN ANEMIA Taureni Hayati; Delita Prihatni; Nina Tristina
Jurnal Darma Agung Vol 30 No 2 (2022): AGUSTUS
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Darma Agung (LPPM_UDA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46930/ojsuda.v30i2.1593

Abstract

Lanjut usia menurut World Health Organization tahun 2017, adalah seseorang yang telah memasuki usia 60 tahun ke atas. Akibat berbagai proses aging yang terjadi pada lansia, maka lansia akan mengalami banyak keluhan, salah satunya nyeri tulang dan anemia. Berbagai keadaan pada lansia dapat menyebabkan nyeri tulang dan anemia antara lain: osteoporosis, osteomalasia, osteodistrofi renal, osteonekrosis, keganasan atau metastasis pada tulang, dari berbagai keadaan ini dapat dilihat profil limfosit dengan mengunakan scattergram white blood cell differential pada area A, B, C, D, dan E, sesuai dengan tujuan penelitian, ingin mengetahui profil scattergram limfosit pada lansia dengan nyeri tulang dan anemia. Metode penelitian: Penelitian ini merupakan observasional deskriptif dengan metode rancangan cross-sectional. Penelitian dilakukan dari bulan Februari-Juni 2020. Subjek penelitian adalah pasien lansia yang mengalami nyeri tulang dan anemia. Nyeri tulang diukur dengan Numeric Rating Scale skala 1-10. Anemia diukur dengan pemeriksaan hemoglobin pada alat hematology analyzer, kemudian dilakukan analisis scattergram melalui WDF menggunakan Sysmex XN 1000. Hasil Penelitian: Dari subjek yang memenuhi kriteria inklusi dan ekslusi didapatkan 30 subjek, berumur antara 60 - 72 tahun, laki laki 23 subjek (77%), perempuan 7 subjek (23%). Anemia rentang 8 - 10,9 g/dL, didapatkan profil scattergram pada area B SSC (A2, A3); SFL (B2, C2, D3, E3) sebanyak 21 subjek (70%) penelitian dibandingkan profil scattergram pada area A SSC (A2, A3); SFL (B2, C2, D3) ditemukan sebanyak 9 subjek (30%). Kesimpulan : Profil scattergram limfosit pada sebagian besar subjek lansia dengan nyeri tulang dan anemia berada pada area SSC (A2, A3), SFL (B2, C2, D3, E3), artinya adalah banyak yang mengalami perubahan profil limfosit, lebih banyak sel limfosit atipik dan dicurigai kearah sel plasma ataupun sel limfosit abnormal.
PREVALENSI HIPOKALEMIA DAN HIPONATREMIA PADA PASIEN TUBERKULOSIS MULTIDRUG RESISTANCE DI RS. HASAN SADIKIN BANDUNG Raja Iqbal Mulya Harahap; Nina Tristina; Tiene Rostini; Nida Suraya
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 5 No 1 (2022): Medika Kartika : Jurnal Kesehatan dan Kedokteran
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.396 KB)

Abstract

Tuberkulosis Multidrug Resistance (TB MDR) adalah infeksi M. tuberculosis yang resistenrifampisin, isoniazid, atau obat antituberkulosis lainnya. TB MDR dapat menyebabkanberbagai komplikasi baik lokal ataupun sistemik seperti electrolyte imbalance, termasukhiponatremia dan hipokalemia. Hiponatremia dan hipokalemia pada pasien TB MDRdisebabkan oleh berbagai faktor seperti invasi ke organ lain, Syndrome InappropriateAntidiuretic Hormone (SIADH), asupan rendah, serta efek samping pengobatan. Penelitian inibertujuan untuk mengetahui prevalensi hiponatremi dan hipokalemi pada penderita TB MDR.Penelitian adalah deskriptif retrospektif dengan data pasien baru TB MDR. Subjek adalah 115pasien yang berobat di Poliklinik TB MDR RSHS Bandung yang memeriksakan elektrolitnyadi laboratorium RSHS. Subjek penelitian laki-laki (54,8%) lebih banyak dibanding subjekpenelitian wanita (45,2%), dengan rerata usia pasien 38,06 ± 12,83 tahun. Rerata kadarnatrium adalah 136±4 mEq/L, 67% subjek memiliki kadar natrium normal, dan 33% subjekmemiliki kadar natrium di bawah normal. Rerata kadar kalium adalah 3,9±0,5 mEq/L, sebesar85,2% subjek memiliki kadar kalium normal, dan 14,8% subjek memiliki kadar kalium dibawah normal. Hiponatremia pada pasien MDR disebabkan asupan kurang, anoreksia danSIADH. Hipokalemia dapat disebabkan efek samping pengobatan TB sebelumnya, danpeningkatan katabolisme protein yang menyebabkan efluks kalium dari plasma. Hiponatremiapada pasien memiliki prevalensi sebesar 33%, dan Hipokalemia sebesar 14,8%. DOI : 10.35990/mk.v5n1.p12-20
Positive Lateral Flow Urine Lipoarabinomannan Assay (LF-LAM) Result in Detection of Active Tuberculosis Sara Puspita; Dewi Kartika Turbawaty; Nina Tristina; Leni Lismayanti
Majalah Kedokteran Bandung Vol 53, No 3 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n3.2265

Abstract

Lipoarabinomannan (LAM) is the main component of M. tuberculosis (MTB) wall as result of MTB degradation by macrophages in the human body. In patients with active TB and HIV co-infection, a decrease in antibody responses may be apparent that some of LAM may not be bound with antibodies. In this condition, LAM can pass through the normal glomerular basement membrane and can be detected in the urine. One laboratory examination for detecting LAM is the Lateral Flow Urine Lipoarabinomannan (LF-LAM) assay that uses urine as the sample. The purpose of this cross-sectional observational descriptive comparative study was to compare the positivity rate of LF-LAM examination results in active TB patients with and without HIV infection. Random urine samples were collected from patients diagnosed with active TB with and without HIV infection who visited Dr. Hasan Sadikin General Hospital Bandung from August to October 2020. The proportion between the group with HIV and group without HIV was analyzed with the Chi-Square test. Subjects were 52 patients, consisting of 25 (48%) subjects with HIV infection and 27 (52%) subjects without HIV infection. The positive LF-LAM results were found in 11 (21%) subjects, consisting of 9 (36%) subjects with HIV infection and 2 (7%) subjects without HIV infection, with p=0.012. In conclusion, the positivity rate of LF-LAM results is higher in active TB patients with HIV infection compared to those without HIV infection. 
C-Reactive Protein (CRP) Value and Platelet Counts in Pediatric Dengue Patients at RSUP Dr. Hasan Sadikin Bandung Irawati, Indri; Tristina, Nina; Andriyoko, Basti
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.8

Abstract

Plasma leakage, thrombocytopenia, and cytokines play roles in pathogenesis of dengue infection. Thrombocytopenia correlates with severity of the disease. Dengue virus infection produces cytokines that stimulate C-Reactive Protein (CRP). This study aims to describe the results of CRP and platelet counts with severity of dengue infection in paediatric inpatient at Hasan Sadikin Hospital Bandung. This is a descriptive observational study with retrospective, cross-sectional data collection in January 1-December 31, 2021 at Hasan Sadikin Hospital. From 32 total subjects, there were 24(75%) non-severe dengue infections compared to severe dengue 8(25%). Non-severe dengue 19(79.2%), had the most platelet counts of 50,000-150,000/L, while platelets count 20,000-50,000/µL was mostly in severe dengue 4/8(50%). CRP value was mostly normal (<0.3mg/dl) as many as 18/24(75%) in mild dengue, whereas in severe dengue CRP was mostly high as many as 6/8(75%). CRP examination is mostly done in critical phase, both in severe and non-severe dengue. Severe dengue infection was found mostly in platelet counts of 50,000-150,000/µL and normal CRP level as many as 14(58.3%). In severe dengue infection, platelet counts was found mostly in 20,000-50,000/µL and high CRP (≥0.3mg/dl) as many as 3(37.5%). Most cases of dengue fever infections in children at Hasan Sadikin General Hospital in 2021 were of mild severity, with platelet counts ranging from 50,000 to 150,000/µL and normal CRP levels. Examinations were typically carried out during the critical phase.
Co-Authors Afiq Syazwan Fauzi Agnes Rengga I Agnes Rengga Indrati Anna Tjandrawati Basti Andriyoko David Rustandi Delita Prihatni Dewi Kartika Turbawaty Efriyani, Yuhpita Indah Fauzi, Afiq Syazwan Florencia Idajanti Tandhana Gunalan Govindarajan Gunalan Govindarajan, Gunalan Hayati, Taureni Heti Kus Erni Ida Parwati Irawati, Indri Ivana Agnes Sulianto Leni Lismayanti Maria Enrica Miftanurachman Miftanurachman Miftanurachman, Miftanurachman Nida Suraya Noormartany Nugraha, Rifan Nurhayati, Imas Prihatn, Delita Raja Iqbal Mulya Harahap Reni Farenia Reni Farenia Rifan Nugraha Rizki Dumpatna Roes, Bellya Affan Sara Puspita Suresh Shanmugam Suresh Shanmugam, Suresh Sylvia Rachmayati Taureni Hayati Tiene Rostini, Tiene Toni M. Aprami Uun Sumardi Uun Sumardi, Uun