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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Althea Medical Journal Medica Hospitalia Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Darma Agung Devotion: Journal of Research and Community Service Indonesian Journal of Health Science
Nina Tristina
Department Of Clinical Pathology Faculty Of Medicine Universitas Padjadjaran / Dr. Hasan Sadikin General Hospital, Bandung
Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Correlation Between Testosterone Level With HBA1C Level As Glycemic Control Marker Among Type 2 Diabetes Mellitus Patient Harahap, Raja Iqbal Mulya; Tristina, Nina; Nurhayati, Imas; Rachmayati, Sylvia
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.941

Abstract

BACKGROUND: Type 2 Diabetes Mellitus could cause various complications due to formation of advanced glycation end products (AGEs).  The AGEs could destroy many organs into cellular level, one of them is testis, then causing testosterone production deficiency, and hypogonadism. Meanwhile, the AGEs formation in vivo will depend on on mean glucose level in T2DM patient. HbA1C is one of the most common parameter used to asses glycemic control among T2DM patient. OBJECTIVE: This research was conducted to find out the correlation between serum total testosterone with HbA1C level among T2DM patient METHOD:Research subject was collected from Outpatient Polyclinic of Internal Medicine Departement Hasan Sadikin Hospital. HbA1C examination was conducted with turbidimetry method, meanwhile total testosterone level was performed with ELISA method. The examination of research parameter was done at Clinical Laboratory Installation of Hasan Sadikin Bandung   RESULT: During sample collection periode, 70 patients was collected and fulfilled the inclusion criteria, 18 of 70 subjects has low testosteron level with Mean (SD): 424, 48 (204,82) ng/mL. Correlationntesting between the variables showed r = -0,619 , and p-value <0.001, which means strong and significant correlation between total testosterone and HbA1C among T2DM patient.   CONCLUSION: There was strong and significant correlation between total testosterone with HbA1C level among T2DM patients, further research could be conducted with prospective cohort method or using free testosterone examination.
Perbedaan Parameter Eritrosit Dan Retikulosit Pada Pasien Talasemia Beta Minor Dan Anemia Defisiensi Besi Ringan Roes, Bellya Affan; Prihatni, Delita; Tristina, Nina
Indonesian Journal of Health Science Vol 4 No 1 (2024)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v4i1.749

Abstract

Beta thalassemia and iron deficiency anemia (IDA) are most common microcytic hypochromic anemia. It is difficult to distinguish minor β thalassemia from mild iron deficiency anemia only by clinical findings and routine hematology examinations, it requires confirmatory tests which are limited in availability and relatively expensive. The presence of additional erythrocyte and reticulocyte parameters (RDW-CV, RBC-He, %MicroR, %Hypo-He, Ret-He, IRF) in hematology analysers are expected to be screening parameters in differentiating minor β thalassemia from mild IDA. The purpose of this study was to determine the differences in the values ​​of RDW-CV, RBC-He, %MicroR, %Hypo-He, Ret-He, and IRF between minor β thalassemia patients and mild IDA.              This study was an observational, analytical, comparative, with a cross sectional design. Research was conducted at RSU Kota Tangerang Selatan from July to October 2020. Subjects were children who went to an outpatient clinic/medical check-up, or with laboratory data of minor β thalassemia or had β thalassemia families. Samples were analysed using Sysmex XN 1000. Statistical analysis was performed by the independent t test for normally distributed data and the Mann Whitney difference test for abnormally distributed data.     The RBC-He and Ret-He values ​​were lower in minor β thalassemia than mild IDA and significantly different with p value 0.005 and 0.004, respectively. The %MicroR and %Hypo-He values were higher in minor β thalassemia than mild IDA and significantly different with p values ​ 0.000 and 0.003, respectively. The RDW-CV and IRF values ​​were higher in minor β thalassemia than mild IDA but were not significantly different with the p value 0.076 and 0.528 respectively.     Conclusion: RBC-He and Ret-He values which reflect hemoglobin content in erythrocytes and reticulocytes ​​were lower in minor β thalassemia patients compared to mild IDA and were significantly different. The values ​​of %MicroR and %Hypo-He which reflect microcytic and hypochromic in erythrocyte population were higher in patients with minor β thalassemia than mild IDA and were significantly different. RDW-CV which reflects variation size of erythrocytes and IRF which reflects erythropoiesis activity and ineffective erythropoiesis were higher in patients with minor β thalassemia than mild IDA and were not significantly different.
Lymphocyte Scattergram Profile in the Elderly With Bone Pain and Anemia Hayati, Taureni; Prihatn, Delita; Tristina, Nina
Devotion : Journal of Research and Community Service Vol. 3 No. 8 (2022): Devotion: Journal of Research and Community Service
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/dev.v3i08.173

Abstract

Old age according to the World Health Organization in 2017, is someone who has entered the age of 60 years and over. Due to various aging processes that occur in the elderly, the elderly will experience many complaints, one of which is bone pain and anemia. Various conditions in the elderly can cause bone pain and anemia, including: osteoporosis, osteomalacia, renal osteodystrophy, osteonecrosis, malignancy or bone metastases. From these conditions, a lymphocyte profile can be seen using a white blood cell differential scattergram in areas A, B, C, D, and E, according to the purpose of the study, wanted to know the scattergram profile of lymphocytes in the elderly with bone pain and anemia. This research method uses descriptive observation with a cross-sectional design method. The study was conducted from February-June 2020. The research subjects were elderly patients who experienced bone pain and anemia. Bone pain was measured by the Numeric Rating Scale on a scale of 1-10. Anemia was measured by examining hemoglobin on a hematology analyzer, then scattergram analysis was carried out through WDF using Sysmex XN 1000. The results of this study showed that the scattergram profile of lymphocytes in most elderly subjects with bone pain and anemia was in the SSC (A2, A3), SFL area. (B2, C2, D3, E3), which means that there are many changes in the lymphocyte profile, more atypical lymphocyte cells and suspicion of abnormal plasma cells or lymphocyte cells.
Co-Authors Afiq Syazwan Fauzi Agnes Rengga I Agnes Rengga Indrati Anna Tjandrawati Basti Andriyoko David Rustandi Delita Prihatni Dewi Kartika Turbawaty Efriyani, Yuhpita Indah Fauzi, Afiq Syazwan Florencia Idajanti Tandhana Gunalan Govindarajan Gunalan Govindarajan, Gunalan Hayati, Taureni Heti Kus Erni Ida Parwati Irawati, Indri Ivana Agnes Sulianto Leni Lismayanti Maria Enrica Miftanurachman Miftanurachman Miftanurachman, Miftanurachman Nida Suraya Noormartany Nugraha, Rifan Nurhayati, Imas Prihatn, Delita Raja Iqbal Mulya Harahap Reni Farenia Reni Farenia Rifan Nugraha Rizki Dumpatna Roes, Bellya Affan Sara Puspita Suresh Shanmugam Suresh Shanmugam, Suresh Sylvia Rachmayati Taureni Hayati Tiene Rostini, Tiene Toni M. Aprami Uun Sumardi Uun Sumardi, Uun