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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) Agromet BALI MEDICAL JOURNAL (BMJ) Jurnal Kimia (Journal of Chemistry) INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Jurnal Ilmu Komputer dan Agri-Informatika Scientific Journal of Informatics JOIN (Jurnal Online Informatika) JOIV : International Journal on Informatics Visualization Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) Journal Of Vocational Health Studies Journal of Robotics and Control (JRC) Jurnal Ilmu dan Teknologi Peternakan Terpadu (JITPU) Dharma Jnana Journal of Global Pharma Technology Eduvest - Journal of Universal Studies Jurnal Sistem Informasi
Sri Wahjuni
Chemistry Department, Faculty Of Math And Science, Udayana University, Bali-Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Neuroscience Social Sciences

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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

 1 
ANTI-HIPERCHOLESTEROLEMIA OF ANREDERA CORDIFOLIA IN HYPERCHOLESTEROLEMIA RAT WISTAR THROUGH DECREASE OF MALONDIALDEHYDE AND 8-HYDROXY-DIGUANOSINE Wahjuni, S.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 8 No 1 (2014): IJBS Vol8 No1
Publisher : Udayana University

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Abstract

High cholesterol diet leads to increase of plasma cholesterol and subsequently will end up with hypercholesterolemia. Ignorance of healthy food and lacks of activity are the trend of modern life style. These conditions exacerbated the incidence of hypercholesterolemia in either developed or developing countries. This research aims to determine potential of anredera cordifolia leafs extracts as an anti-hypercholesterolemia by lowering of malondialdehyde (MDA) and 8-hydroxy-diguanosine (8-OHdG) blood levels in hypercholesterolemia Wistar Rat. This is an experimental study applied post only control group design. A number of 15 male wistar rats were used in this study. Rats were randomly divided into 3 groups, i.e. negative control group (C1), positive control group (C2) and anredera cordifolia leaf extract at dose of 100 mg/kg BW group (T). MDA was determined based on malondialdehyde assay (NWLSSTM).  8-OHdG was determined based on oxidative DNA Damage (Cell Biolabs, Inc). The mean difference between control and treatment was assessed by applying ANOVA and consider significant at p < 0.05. In this study, we observed that there were a significant of MDA and 8-OHdG levels between group C1 and T; C2 and T within p < 0.05. This result indicates anredera cordifolia leafs extract has an ability to inhibit hypercholesterolemia in wistar rat fed with high cholesterol diet.
ORAL INTAKE OF SARDINELLA LONGICEPS OIL THE DECREASE OF TNF-? AND IL-6 LEVELS IN ATHEROSCLEROTIC WISTAR RAT Wahjuni, S.; Sudewa, A.A.G.; Wita, I Wayan; Astawa, I.N. Mantik
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 2 Mei 2011
Publisher : Udayana University

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Lifestyle changes to consumption of variegated instant food may be associated several heath hazards, such as obesity, dyslipidemia, and atheroschlerosis. This study was conducted to investigate the effects of orally administered Sardinella longiceps oil as an anti inflammatory agent on the serum levels of TNF-? and IL-6 considered as biomarkers for atherosclerosis.The study design is an true experimental with randomized pretest and posttest control group design, using 50 Wistar rat equaly divided into 5 groups, i.e. placebo control group 0% and 4 treatment groups each treated daily with 10%, 15 %, 20 % and 25 % fish oil respectively for 6 weeks. Before the treatment was started, all rats were orally fed daily with a high cholesterol diet for 13 weeks to induce atherosclerosis. Our study showed that the intake of 20% fish oil had resulted in the significantly greatest decrease of 45,63 % in the TNF-? serum levels,from 28.62 ± 1.25 to 15.56 ± 7.20 ?g/mL and similar significant decrease 15,42% in of IL-6 serum levels from 134.64 ± 1.98 to 113.87 ± 4.30 ?g/mL. The overall results of our study seemed to imply than in the Wistar rats, oral intake of Sardfinella longiceps oils signifacantly decreased serum levels of TNF-? and IL-6 probably through their anti-inflamatory effects. Futher research to determin the magnitude of effects sardinella longiceps oils on the serum levels TNF-? and IL-6 human.
Co-Authors A.A.G. Sudewa Agus Buono Alfiansyah Halomoan Siregar Anisa Nur Halimah Ariyani Tanti Auriza Rahmad Akbar Barlianto, Agus Betty Kostradiyanti Budi Indra Setiawan dan Luh Putu Arisanti Djaksana, Yan Mitha Edi Santosa Eknanda, Rafael Tektano Grandiawan Elly Rusdiana, Elly Eny Inayati, Eny Faisyah, Shilvy Arofatul Haris, Abdul Haula Robbi, M. Kautsar Hendra Rahmawan Hendra Rahmawan Hermadi , Irman Hidayat Hidayat I M, Sukadana I NYOMAN MANTIK ASTAWA I W. Wita, I W. I Wayan Suirta I Wayan Wita I. A Raka Astiti Asih Ida Bagus Putra Manuaba Iman Rahayu Hidayati Soesanto Irman Hermadi Ishak, Sahrial Ihsani Karlisa Priandana Komara N, Fatthurohman Kusdarjanti, Endang Laksmi Lita Rosa, Mia Lusiana Tabuni Marimin , Maxiwinata, Maxdha Michel Williams, Michel Ni Luh Rustini Ni Made Puspawati Ni Made Puspawati Ni Nyoman Astuti Wulandari Ni Putu Rahayu Artini Nirmala Ratna Harda, Sasadhara Nur Halimah, Anisa Oka Ratnayani Putu Yuliantari Rahmadani, Annisa Ratwita, Rr. Dwiyanti Feriana Sanjiwo, Suryo Hamukti Sefy Ayu Mandanie, Sefy Ayu Setyowati, Okti Sianiwati Goenharto Sri Rahayu Santi Sri Redjeki Sri Redjeki Indiani, Sri Redjeki Sufiatul Maryana Sujati Sujati Sujati, Sujati Wafi, Azmi Sabilakisbatul Wahyu Dwijani Sulihingtyas Wasudewa, K. M. Willy Bayuardi Suwarno Wulandari Wulandari Zakiah, Rizqi Alifahasni