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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Cermin Dunia Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Cermin Dunia Kedokteran
Edy Rizal Wahyudi
Division Of Geriatric Medicine, Department Of Internal Medicine, Faculty Of Medicine, Universitas Indonesia/Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Sarcopenia is Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma Koncoro, Hendra; Hasan, Irsan; Lesmana, C Rinaldi; Aditama, Humala Prika; Salamah, Thariqah; Rizka, Aulia; Wahyudi, Edy Rizal; Shatri, Hamzah; Teng, Wei
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (614.006 KB) | DOI: 10.24871/231202217-23

Abstract

Background: Sarcopenia has a notable impact on the prognosis of hepatocellular carcinoma (HCC). The prevalence of sarcopenia in patients with HCC is relatively high, with studies reporting rates between 39% and 41.7%. A substantial proportion of individuals diagnosed with HCC also exhibit muscle wasting and reduced muscle function. This study aims to determine the prevalence of sarcopenia in Indonesian patients with HCC (based on the Japanese Socuety of Hepatology (JSH) JSH criteria) and to examine its correlation with poor performance status.Methods: We performed a cross-sectional study of 85 HCC patients between January and October 2021). The skeletal muscle index at L3 (L3 SMI) was measured on CT scans (applying JSH cut-offs for sarcopenia). Clinical data, including Eastern Cooperative Oncology Group (ECOG) performance status, were collected. Bivariate analyses and logistic regression were performed to identify factors associated with sarcopenia.Results: A total of 85 HCC patients (median age: 52 years) were included in the analysis. Sarcopenia was observed in 49.4% of the cohort. Bivariate analysis revealed a statistically significant association between sarcopenia and an ECOG performance status of 2+ (p = 0.003), as well as a MELD-Na score of ≥15 (p = 0.023). In multivariate analysis, poor ECOG-PS remained independently associated with sarcopenia (adjusted OR 4.17; 95% CI 1.50–11.56, p = 0.006).Conclusion: Sarcopenia is highly prevalent among Indonesian HCC patients, and it is strongly associated with poor ECOG performance status. 
VALIDITY, RELIABILITY, AND DIAGNOSTIC PERFORMANCE OF GERIATRIC-8 AS A SCREENING TOOL FOR ABNORMAL COMPREHENSIVE GERIATRIC ASSESSMENT Ridzqie Dibyantari; Nina Kemala Sari; Edy Rizal Wahyudi; Muhadi; Aulia Rizka; Arif Mansjoer; Noorwati Sutandyo
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 13 No. 2 (2026): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v13i2.728

Abstract

The Geriatric Patient Plenary Assessment (P3G) is useful in the management of the elderly, but it is time-consuming, so screening instruments such as the Geriatric 8 (G8) have been developed. Initially designed for cancer patients, the G8 has also been shown to be valid in non-cancer elderly patients, but there have been no studies in Indonesia. This cross-sectional study (August 2023–March 2024) at the Geriatrics Clinic of Cipto Mangunkusumo National Hospital involved 80 subjects who underwent P3G and G8. An abnormal P3G was defined as impaired in ≥1 domain (ADL <20, IADL <8, MNA <24, MoCA-INA <26, or GDS >4). The results showed strong reliability (inter-rater kappa 1; intra-rater 0.904; ICC 0.77–1; Cronbach's α 0.697). The G8 had a sensitivity of 70.27% and a specificity of 83.33%, with an AUC of 0.846 (p<0.005). These findings demonstrate good diagnostic performance in identifying elderly individuals requiring a complete P3G. It is concluded that the G8 is valid and reliable as a screening tool for elderly individuals in the general Indonesian population, with good specificity.
Hubungan Kadar Vitamin D dengan Derajat Keparahan Pasien COVID-19 Dewasa dan Lanjut Usia Putri, Stella Andriana; Wahyudi, Edy Rizal
Cermin Dunia Kedokteran Vol 49 No 7 (2022): Nutrisi - Vitamin D
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i7.265

Abstract

Latar Belakang: Populasi lanjut usia berisiko mengalami defisiensi vitamin D akibat beragam faktor, seperti kurangnya suplementasi dan gaya hidup, serta obesitas. COVID-19 merupakan penyakit infeksi dengan morbiditas dan mortalitas global. Beberapa studi terkait COVID-19, salah satunya meneliti potensi vitamin D sebagai proteksi terhadap COVID-19. Tujuan: Studi ini bertujuan untuk mengetahui hubungan kadar vitamin D dengan derajat keparahan pasien COVID-19 pada dewasa dan lanjut usia. Metode: Kami menelusuri database PubMed, Cochrane, EBSCOhost, dan Scopus untuk mencari dan menyaring studi dalam bentuk kohort. Selanjutnya beberapa artikel dengan isu serupa dianalisis menggunakan instrumen prognosis dari Oxford Centre for Evidence Based Medicine. Hasil: Didapatkan dua studi kohort prospektif yang lolos seleksi, yakni studi Baktash, dkk. (2020) dan Campi, dkk. (2021). Keduanya menunjukkan kadar vitamin D rendah berhubungan dengan prognosis klinis dan marka inflamasi yang lebih buruk pada kasus COVID-19 dewasa dan lanjut usia (p<0,05). Simpulan: Kadar vitamin D rendah berisiko marka inflamasi ataupun prognosis klinis lebih buruk pada pasien COVID-19 dewasa dan lanjut usia. Background: Elderlies as well as adults are high-risk populations for vitamin D deficiency, caused by lack of supplementation, lifestyle, or obesity. COVID-19 is an infectious disease with global morbidity and mortality. Some studies showed vitamin D’s potential for protection against COVID-19. Objective: This evidencebased case report was to investigate the association between vitamin D levels with COVID-19 severity in adult and elderly patients. Method: Database such as PubMed, Cochrane, EBSCOHost, and Scopus were explored to search and filter relevant cohort studies. Articles with similar issue were analyzed with prognosis instrument from Oxford Centre for Evidence Based Medicine. Result: Two prospective cohort studies from Baktash, et al, (2020) and from Campi, et al, (2021) fulfilled the requirements. Both studies showed that low vitamin D levels was related to worse clinical prognosis and inflammation markers in COVID-19 cases (p<0.05). Conclusion: Low vitamin D levels were related to poorer clinical prognosis or COVID-19 inflammation markers in adult and elderly COVID-19 patients.
Co-Authors Aditama, Humala Prika Adityo Susilo, Adityo Arif Mansjoer Aulia Rizka Aulia Rizka, Aulia C Rinaldi A Lesmana C. Martin Rumende, C. Martin Cosphiadi Irawan Czeresna Heriawan Soejono Czeresna Heriawan Soejono E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eric Daniel Tenda Esthika Dewiasty Esthika Dewiasty, Esthika Hendra Koncoro Idrus Alwi Idrus Alwi Ika Prasetya Wijaya Ikhwan Rinaldi Irsan Hasan Kaka Renaldi Kuntjoro Harimurti Leonard Nainggolan Muhadi Murdani Abdullah Nata Pratama Hardjo Lugito Noorwati Sutandyo Noto Dwimartutie Pratiwi, Amalia Nur Profitasari Kusumaningrum Putri, Stella Andriana Rachmat Hamonangan Rachmat Hamonangan, Rachmat Ridzqie Dibyantari Rino A Gani Rooshoeroe, A. G. Sari, Nina Kemala Saskia Aziza Nursyirwan Setiati, Slti Siti Setiati Soejono, C. H. Stella Andriana Putri Stella Andriana Putri Sukamto Koesnoe Teng, Wei THARIQAH SALAMAH, THARIQAH Ummu Habibah Ummu Habibah, Ummu Victor, Hildebrand Hanoch