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All Journal Cermin Dunia Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Cermin Dunia Kedokteran
Edy Rizal Wahyudi
Divisi Geriatri, Departemen Ilmu Penyakit Dalam, Rumah Sakit Pusat Nasional Cipto Mangunkusumo, Fakultas Kedokteran Universitas Indonesia, Jakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Sarcopenia is Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma Koncoro, Hendra; Hasan, Irsan; Lesmana, C Rinaldi; Aditama, Humala Prika; Salamah, Thariqah; Rizka, Aulia; Wahyudi, Edy Rizal; Shatri, Hamzah; Teng, Wei
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (614.006 KB) | DOI: 10.24871/231202217-23

Abstract

Background: Sarcopenia has a notable impact on the prognosis of hepatocellular carcinoma (HCC). The prevalence of sarcopenia in patients with HCC is relatively high, with studies reporting rates between 39% and 41.7%. A substantial proportion of individuals diagnosed with HCC also exhibit muscle wasting and reduced muscle function. This study aims to determine the prevalence of sarcopenia in Indonesian patients with HCC (based on the Japanese Socuety of Hepatology (JSH) JSH criteria) and to examine its correlation with poor performance status.Methods: We performed a cross-sectional study of 85 HCC patients between January and October 2021). The skeletal muscle index at L3 (L3 SMI) was measured on CT scans (applying JSH cut-offs for sarcopenia). Clinical data, including Eastern Cooperative Oncology Group (ECOG) performance status, were collected. Bivariate analyses and logistic regression were performed to identify factors associated with sarcopenia.Results: A total of 85 HCC patients (median age: 52 years) were included in the analysis. Sarcopenia was observed in 49.4% of the cohort. Bivariate analysis revealed a statistically significant association between sarcopenia and an ECOG performance status of 2+ (p = 0.003), as well as a MELD-Na score of ≥15 (p = 0.023). In multivariate analysis, poor ECOG-PS remained independently associated with sarcopenia (adjusted OR 4.17; 95% CI 1.50–11.56, p = 0.006).Conclusion: Sarcopenia is highly prevalent among Indonesian HCC patients, and it is strongly associated with poor ECOG performance status. 
Co-Authors Aditama, Humala Prika Adityo Susilo, Adityo Arif Mansjoer Aulia Rizka, Aulia C Rinaldi A Lesmana C. Martin Rumende, C. Martin Cosphiadi Irawan Czeresna Heriawan Soejono Czeresna Heriawan Soejono E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eric Daniel Tenda Esthika Dewiasty Esthika Dewiasty, Esthika Hendra Koncoro Idrus Alwi Idrus Alwi Ika Prasetya Wijaya Ikhwan Rinaldi Irsan Hasan Kaka Renaldi Kuntjoro Harimurti Kusumaningrum, Profitasari Leonard Nainggolan Murdani Abdullah Murdani Abdullah Murdani Abdullah Nata Pratama Hardjo Lugito Noto Dwimartutie Pratiwi, Amalia Nur Rachmat Hamonangan Rachmat Hamonangan, Rachmat Rino Alvani Gani Rooshoeroe, A. G. Saskia Aziza Nursyirwan Saskia Aziza Nursyirwan, Saskia Aziza Setiati, Slti Siti Setiati Siti Setiati Siti Setiati Soejono, C. H. Stella Andriana Putri Stella Andriana Putri Sukamto Koesnoe Sukamto Koesnoe Sukamto Koesnoe Teng, Wei THARIQAH SALAMAH, THARIQAH Ummu Habibah Ummu Habibah, Ummu Victor, Hildebrand Hanoch