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All Journal Jurnal Pembelajaran Fisika JOURNAL ONLINE OF PHYSICS Jurnal Elektronika dan Telekomunikasi Journal Sport Science Indonesia (JASSI) Jurnal Penelitian Fisika dan Terapannya (JUPITER) Language and Education Journal Journal of Energy, Material, and Instrumentation Technology Jurnal Seni dan Pembelajaran Jurnal Kegiatan Pengabdian Mahasiswa (JKPM)
Rosita Wati
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Religion Arts Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Physics Public Health Social Sciences Other

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Fabrication of Bioceramic Carbonated Hydroxyapatite–Chitosan Composite Scaffold Derived from River Snail Shells via Freeze-Drying for Bone Grafting Applications Wati, Rosita; Alnovera, Vayza Deva; Herbanu, Aldi; Endah; Tresnaningtyas, Sekar Asri; Gifari, Muhammad Wildan; Siburian, Marsudi
Journal of Energy, Material, and Instrumentation Technology Vol 6 No 4 (2025): Journal of Energy, Material, and Instrumentation Technology (In Press)
Publisher : Departement of Physics, Faculty of Mathematics and Natural Sciences, University of Lampung

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Fabrication of Quartz Crystal Microbalance Coated with GO/PVC Nanofiber for Benzene Detection as Tuberculosis Biomarker Nugroho, Doni Bowo; Kamal, Nada Nadzira Ayasha; Wati, Rosita; Resfita, Nova
Jurnal Elektronika dan Telekomunikasi Vol 25, No 2 (2025)
Publisher : National Research and Innovation Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jet.765

Abstract

Tuberculosis (TB) is a highly contagious illness and a major contributor to global mortality, with over 1.5 million deaths reported annually. TB is caused by Mycobacterium tuberculosis (Mtb), which is often difficult to diagnose in the early stages of infection. Existing diagnostic methods are limited by long processing times, high costs, and suboptimal sensitivity. Therefore, this study aimed to develop a Quartz Crystal Microbalance (QCM)-based biosensor employing polyvinyl chloride (PVC) nanofibers coated with graphene oxide (GO) for rapid detection of volatile TB biomarkers, particularly benzene. The sensing platform utilized a 10 MHz AT-cut silver electrode QCM coated with electrospun PVC nanofibers, followed by GO deposition via immersion. Scanning Electron Microscopy (SEM) showed uniform nanofibers with diameters increasing from 183 ± 54 nm to 348 ± 50 nm after GO coating, while FTIR confirmed the presence of GO functional groups. Sensor evaluation revealed a clear and concentration-dependent frequency shift, with a sensitivity of 1.88 Hz·L/mg, a strong linear correlation (R² = 0.99) across 1.18–23.68 mg/L, and a fast response time of 71 seconds. The limits of detection and quantification were determined to be 0.88 mg/L and 2.66 mg/L, respectively. Adsorption followed the Langmuir isotherm model, indicating monolayer uptake. These results demonstrate that the GO/PVC nanofiber-coated QCM offers a promising, low-cost, and sensitive approach for TB biomarker detection in breath analysis.
Co-Authors Agung Kurniawan Agus Suyatna Alnovera, Vayza Deva Ananda, Putri Doni Bowo Nugroho Doni Bowo Nugroho, Doni Bowo Endah Endarwati, Intan Fatma, Yulia Fitri Novia Fitri Novia, Fitri Gifari, Muhammad Wildan Herbanu, Aldi Ismu Wahyudi Jamilah, Zahratul Joni Iswan Jumarni, Asiah Kamal, Nada Nadzira Ayasha Kiki Rizki Amelia Lilinantri Nainggolan, Mutiarasari Mita, Febria Muhammad Wildan Gifari Nurlela Nurlela Nurwijayanti Patimah, Azizah Rahman, Dui Yanto Resfita, Nova Siburian, Marsudi Sidabalok, Jenni Bunga Enjelita SLAMET MUJIONO, SLAMET Sulistyowati, Rita Susi Wendhaningsih Tresnaningtyas, Sekar Asri Widia Lestari Yuniernanda Sitanggang, Fidelina