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The Triglyceride-Glucose Index: A Potential Simple Screening Tool for Insulin Resistance in Young Adults Kenny; Efrida; Elfira Yusri; Rismawati Yaswir; Husni; Syofiati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1281

Background: Insulin resistance is a key factor in the development of metabolic diseases, which are increasingly prevalent in young adults. Early detection is crucial for timely intervention. The triglyceride-glucose (TyG) index, calculated from fasting triglyceride and glucose levels, has emerged as a potential alternative to the more complex homeostasis model assessment of insulin resistance (HOMA-IR). This study aimed to evaluate the agreement between the TyG index and HOMA-IR in detecting insulin resistance in young adults. Methods: A cross-sectional study was conducted on 102 non-diabetic young adults (aged 18-22 years). Fasting blood samples were collected to measure triglyceride, glucose, and insulin levels. The agreement between the TyG index and HOMA-IR was assessed using the Kappa coefficient. Results: The median age of the participants was 20 years, with 65.7% being female. The prevalence of insulin resistance was 79.4% based on the TyG index (cut-off value of 4.25) and 43.1% based on HOMA-IR (cut-off value of 2.2). The agreement between the two indices was slight (Kappa = 0.155, p = 0.001). Conclusion: The TyG index showed a higher prevalence of insulin resistance compared to HOMA-IR in this population. However, the agreement between the two indices was low. Further research is needed to validate the TyG index as a screening tool for insulin resistance in young adults.

UPAYA PENCEGAHAN DAN PENGENDALIAN COVID-19 MELALUI PEMBUATAN DAN PENDISTRIBUSIAN ALAT PELINDUNG DIRI PADA BERBAGAI PUSKESMAS DI KOTA PADANG Efrida Efrida; Fachzi Fitri; Sukri Rahman; Ade Asyari; Al Hafiz; Dolly Irfandy; Yan Edward; Novialdi Novialdi; Bestari Jaka Budiman; Effy Huriyati; Jacky Munilson; Nirza Warto; Rossy Rosalinda
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 3 No. 3 (2020)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v3i3.241

The Covid-19 case that has spread in Indonesia requires efforts from various parties to resolve it. The Faculty of Medicine, Andalas University, is also making efforts to prevent and control Covid-19. The purpose of this activity is to minimize the possibility of the rapid spread of Covid-19 and preventive efforts to keep the people around Pauh, Kuranji, and Air Cold healthy and protected from Covid-19. This activity was carried out in three health centers: Pauh Puskesmas, Kuranji Health Center, and Padang City Puskesmas Air Cold. The method used is KIE (Educational Information Communication) about the COVID-19 disease in publishing articles in the mass media and giving masks. The target of the activity is the community around Pauh, Kuranji, and Air Cold Padang City. The results of the activities obtained include producing PPE (Personal Protective Equipment) as many as 80 face shields, 400 masks, and 60 hazmat suits involving MSMEs (Micro, Small, and Medium Enterprises) and convection. Furthermore, this PPE is distributed to health centers in need, namely Pauh Puskesmas, Kuranji Health Center, and Puskesmas Air Cold Padang City. Furthermore, it is distributed to parties in need, namely the public and medical personnel. The Covid-19 prevention and control program is carried out to suppress and reduce the positive number of Covid-19 and protect medical personnel from providing top service to patients. Furthermore, making PPE that involves MSMEs and convection can help the community's economy, which has declined due to this pandemic.

Profound Alpha-Fetoprotein Elevation in Hepatocellular Carcinoma with Concomitant Cirrhosis: A Case Report Fadhilaturrizqie Siregar; Efrida
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1259

Background: Hepatocellular carcinoma (HCC) is a primary liver cancer that often arises in the setting of chronic liver disease, most commonly cirrhosis. Alpha-fetoprotein (AFP) is a tumor marker frequently elevated in HCC, but its diagnostic performance varies. We present a case of HCC with concomitant cirrhosis and a significant elevation of AFP. Case presentation: A 30-year-old male presented with hematemesis, abdominal distension, and jaundice. He had a history of heavy alcohol consumption. Physical examination revealed anemia, icterus, hepatomegaly, and palmar erythema. Laboratory investigations showed elevated AFP (>400 IU/mL), reactive hepatitis B surface antigen (HBsAg), anemia, coagulopathy, and liver dysfunction. Imaging studies confirmed HCC and cirrhosis. This case highlights the diagnostic value of AFP in HCC, particularly when combined with clinical and imaging findings. The patient's history of alcohol abuse and HBsAg positivity are well-established risk factors for both cirrhosis and HCC. The marked elevation of AFP, along with the characteristic imaging features, strongly supported the diagnosis of HCC. Conclusion: AFP remains a valuable tool in the diagnosis and monitoring of HCC, especially in patients with cirrhosis. However, it is essential to interpret AFP levels in conjunction with other clinical and laboratory data to ensure accurate diagnosis and timely management.

The Triglyceride-Glucose Index: A Potential Simple Screening Tool for Insulin Resistance in Young Adults Kenny; Efrida; Elfira Yusri; Rismawati Yaswir; Husni; Syofiati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1281

Background: Insulin resistance is a key factor in the development of metabolic diseases, which are increasingly prevalent in young adults. Early detection is crucial for timely intervention. The triglyceride-glucose (TyG) index, calculated from fasting triglyceride and glucose levels, has emerged as a potential alternative to the more complex homeostasis model assessment of insulin resistance (HOMA-IR). This study aimed to evaluate the agreement between the TyG index and HOMA-IR in detecting insulin resistance in young adults. Methods: A cross-sectional study was conducted on 102 non-diabetic young adults (aged 18-22 years). Fasting blood samples were collected to measure triglyceride, glucose, and insulin levels. The agreement between the TyG index and HOMA-IR was assessed using the Kappa coefficient. Results: The median age of the participants was 20 years, with 65.7% being female. The prevalence of insulin resistance was 79.4% based on the TyG index (cut-off value of 4.25) and 43.1% based on HOMA-IR (cut-off value of 2.2). The agreement between the two indices was slight (Kappa = 0.155, p = 0.001). Conclusion: The TyG index showed a higher prevalence of insulin resistance compared to HOMA-IR in this population. However, the agreement between the two indices was low. Further research is needed to validate the TyG index as a screening tool for insulin resistance in young adults.

Hubungan antara Jumlah Trombosit dan Manifestasi Perdarahan pada Pasien DBD di Rumah Sakit dr. Reksodiwiryo Padang pada Tahun 2022 Ihsan, Rafiq; Reza , Mohamad; Husni; Efrida; Wahid , Irza; Rahmah Burhan , Ida
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 3 (2025): September 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i3.1477

Latar Belakang: Demam Berdarah Dengue (DBD) merupakan masalah kesehatan yang disebabkan oleh virus dengue, yang ditularkan melalui gigitan nyamuk Aedes, khususnya Aedes aegypti. Trombositopenia adalah salah satu tanda yang diamati pada DBD. Trombositopenia terjadi ketika jumlah trombosit <100.000 sel/mm³ sehingga fungsi trombosit dalam hemostasis terganggu sehingga mengurangi integritas pembuluh darah, menyebabkan kerusakan pada pembuluh darah dan pada akhirnya mengarah pada manifestasi perdarahan. Penyebaran DBD yang cepat dan berpotensi fatal tetap menjadi masalah kesehatan masyarakat yang signifikan dengan dasar lingkungan. Data dari Dinas Kesehatan Kota Padang menunjukkan adanya peningkatan kasus DBD, dengan 441 kasus yang dilaporkan pada tahun 2022 dibandingkan dengan 366 kasus pada tahun 2021. Kelompok usia 15 hingga 44 tahun adalah yang paling terdampak oleh penyakit ini. Objektif: Penelitian ini bertujuan untuk mengetahui hubungan antara jumlah trombosit dan manifestasi perdarahan pada pasien DBD di Rumah Sakit dr. Reksodiwiryo Padang pada tahun 2022. Metode: Penelitian ini menggunakan desain analitik korelasional dengan pendekatan potong lintang (cross-sectional). Pengambilan sampel dilakukan dengan metode consecutive sampling. Data didapatkan dari rekam medis di Rumah Sakit dr. Reksodiwiryo Padang, dari Januari 2022 hingga Desember 2022, dengan jumlah sampel 100 pasien berusia di atas 18 tahun. Analisis statistik dilakukan menggunakan uji Chi-square. Hasil Hasil penelitian menunjukkan bahwa sebagian besar kasus DBD mengalami trombositopenia berat (49%). Proporsi pasien DBD yang juga mengalami manifestasi perdarahan lebih tinggi (51%). Analisis bivariat menggunakan uji Chi-square menghasilkan nilai p sebesar 0,001 (p < 0,05). Kesimpulan: Dapat disimpulkan bahwa terdapat hubungan yang signifikan secara statistik antara jumlah trombosit dan manifestasi perdarahan pada pasien DBD di Rumah Sakit dr. Reksodiwiryo Padang pada tahun 2022

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