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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina E-Jurnal Medika Udayana E-Journal Obstetric & Gynecology Udayana Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Perinatology Journal of Global Pharma Technology

Tjokorda Gde Agung Suwardewa

Departemen Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Udayana, RSUP Prof. Dr. I.G.N.G. Ngoerah, Bali, Indonesia

Author-ID : 4222755

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

Published : 22 Documents Claim Missing Document

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Elevated Serum Ferritin and Interleukin-6 Level as the Risk Factor in Preterm Labor Kawilarang, Stella; Suwiyoga, I Ketut; Suwardewa, Tjokorda GA
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 2 April 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

  Objective : To investigate the association ofserum ferritin and Interleukin-6 (IL-6) elevation as the risk factors for preterm labor. Method : This study was a case-control study conducted at the Obstetrics and Gynecology Outpatient and Emergency Department at Sanglah General Hospital Denpasar, Bali in November 2014 until June 2015. The sample selection was done by consecutive sampling with total sample as many as 20 case samples (women with preterm labor) and 20 control samples (women with normal preterm pregnancy). Results : Based on the analysis, there was no significant difference of patient demografic such as age, gestational age, and parity among the two groups. Chi-square analysis showed that the increased serum ferritin level had 5 fold increased risk of developing preterm labor (OR = 4.89, 95% CI = 1.20-19.94; p = 0.022), and increased serum IL-6 level had 9 fold increased risk of developing preterm labor (OR = 9.33, 95% CI = 2.18-39.96; p = 0.001) compared to normal preterm pregnancy. Conclusion : It can be concluded that level of IL-6 and serum ferritin was the risk factor for preterm labor. Keywords: Interleukin-6, preterm labor, serum ferritin   Abstrak Tujuan :Untuk membuktikan hubungan kadar ferritin dan Interleukin-6 (IL-6) serum yang tinggi sebagai faktor risiko terjadinya persalinan preterm. Metode :Penelitian ini bersifat observasional dengan studi case-control yang dilakukan di Poliklinik dan IRD Kebidanan dan Penyakit Kandungan RSUP Sanglah Denpasar, yang dilakukan mulai bulan November 2014 hingga Juni 2015. Pemilihan sampel dilakukan dengan cara berurutan dengan sampel penelitian sebanyak 20 sampel kasus (ibu dengan persalinan preterm) dan 20 sampel kontrol (ibu hamil preterm normal). Hasil :Tidak didapatkan perbedaan bermakna dari demografik pasien yaitu usia, umur kehamilan, dan paritas pada kedua kelompok. Analisa chi-square menunjukkan peningkatan kadar ferritin serum memiliki peningkatan risiko 5 kali terjadinya persalinan preterm (OR = 4,90, IK 95% = 1,20-19,94; p = 0,022), dan peningkatan kadar IL-6 serum memiliki peningkatan risiko 9 kali terjadinya persalinan preterm (OR = 9,33, IK 95% = 2,18-39,96; p = 0,001) dibandingkan dengan kelompok ibu hamil preterm normal. Kesimpulan : Kadar feritin dan IL-6 serum adalah faktor risiko terjadinya persalinan preterm. Kata kunci: Interleukin-6, persalinan preterm, ferritin serum

Serum F2-Isoprostane Levels in Preterm Deliveries Compared to Normal Preterm Pregnancies Johannes Hartono; Tjokorda GA Suwardewa
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 4, October 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the difference between serum F2-isoprostane levels in women with preterm deliveries compared to women in normal preterm pregnancies. Method: Our study is a cross sectional study. During the period of January to August 2012, we collected 72 samples in the Emergency Department and Obstetrics and Gynecology outpatient clinic of Sanglah hospital, Denpasar. Our sample was divided into two groups, 36 cases of preterm deliveries at 28-37 weeks gestational age and 36 preterm normal pregnancies at 28-37 weeks gestational age. We collected 3 ml of blood sample from the cubital vein and quantified the F2-isoprostane levels at the Biology Molecular Laboratory, Faculty of Medicine University of Udayana, Denpasar. Data was analyzed using the Shapiro Wilk test and independent t-test with significance of =0.05. Result: The mean F2-isoprostane level for preterm deliveries and preterm normal pregnancies were 0.315 0.292 pg/ml and 0.017 0.018 pg/ml. Conclusion: We can conclude from this study that there is a difference in F2-isoprostane serum level in preterm labor and normal preterm pregnancies. [Indones J Obstet Gynecol 2014; 4: 182-184] Keywords: F2-Isoprostane, normal preterm pregnancy, preterm delivery

Difference of Maternal Serum Interleukin-8 in Preterm Labor and Full Term Labor Komang W Budiartha; Tjokorda GA Suwardewa
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 4, October 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the difference of maternal interleukin-8 (IL-8) in preterm labor and full term labor. Method: This is a cross sectional study with 68 samples, 29 subjects with preterm labor and 39 subjects with full term labor. IL-8 concentration was obtained from blood samples of the subjects, which were examined at Prodia Laboratory Denpasar. Data was analyzed using t-test for independent samples with =0.05. Result: The mean IL-8 level for the preterm labor group was 23.56 10.69 pg/ml and 12.19 5.79 pg/ml for the full term labor group. Statistical analysis using independent samples t-test showed that the average IL-8 level of both groups were significantly different (p=0.001). Conclusion: We concluded from this study that serum IL-8 concentration in women who had preterm labor is significantly higher in comparison to women who had full term labor. [Indones J Obstet Gynecol 2014; 4: 185-187] Keywords: full term labor, interleukin-8, preterm labor

Elevated Serum Ferritin and Interleukin-6 Level as the Risk Factor in Preterm Labor: Kadar Feritin dan Interleukin-6 Serum yang Tinggi Merupakan Faktor Risiko Terjadinya Persalinan Preterm Stella Kawilarang; I Ketut Suwiyoga; Tjokorda GA Suwardewa
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 2 April 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective : To investigate the association ofserum ferritin and Interleukin-6 (IL-6) elevation as the risk factors for preterm labor. Method : This study was a case-control study conducted at the Obstetrics and Gynecology Outpatient and Emergency Department at Sanglah General Hospital Denpasar, Bali in November 2014 until June 2015. The sample selection was done by consecutive sampling with total sample as many as 20 case samples (women with preterm labor) and 20 control samples (women with normal preterm pregnancy). Results : Based on the analysis, there was no significant difference of patient demografic such as age, gestational age, and parity among the two groups. Chi-square analysis showed that the increased serum ferritin level had 5 fold increased risk of developing preterm labor (OR = 4.89, 95% CI = 1.20-19.94; p = 0.022), and increased serum IL-6 level had 9 fold increased risk of developing preterm labor (OR = 9.33, 95% CI = 2.18-39.96; p = 0.001) compared to normal preterm pregnancy. Conclusion : It can be concluded that level of IL-6 and serum ferritin was the risk factor for preterm labor. Keywords: Interleukin-6, preterm labor, serum ferritin Abstrak Tujuan :Untuk membuktikan hubungan kadar ferritin dan Interleukin-6 (IL-6) serum yang tinggi sebagai faktor risiko terjadinya persalinan preterm. Metode :Penelitian ini bersifat observasional dengan studi case-control yang dilakukan di Poliklinik dan IRD Kebidanan dan Penyakit Kandungan RSUP Sanglah Denpasar, yang dilakukan mulai bulan November 2014 hingga Juni 2015. Pemilihan sampel dilakukan dengan cara berurutan dengan sampel penelitian sebanyak 20 sampel kasus (ibu dengan persalinan preterm) dan 20 sampel kontrol (ibu hamil preterm normal). Hasil :Tidak didapatkan perbedaan bermakna dari demografik pasien yaitu usia, umur kehamilan, dan paritas pada kedua kelompok. Analisa chi-square menunjukkan peningkatan kadar ferritin serum memiliki peningkatan risiko 5 kali terjadinya persalinan preterm (OR = 4,90, IK 95% = 1,20-19,94; p = 0,022), dan peningkatan kadar IL-6 serum memiliki peningkatan risiko 9 kali terjadinya persalinan preterm (OR = 9,33, IK 95% = 2,18-39,96; p = 0,001) dibandingkan dengan kelompok ibu hamil preterm normal. Kesimpulan : Kadar feritin dan IL-6 serum adalah faktor risiko terjadinya persalinan preterm. Kata kunci: Interleukin-6, persalinan preterm, ferritin serum

Co-Authors Agrifa Eko Albert Sembiring Alfonso Anggriawan Anak Agung Gede Putra Wiradnyana Anak Agung Ngurah Anantasika Anom Suardika Daniel Hadinata Susanto Endang Sri Widiyanti Evert Solomon Pangkahila Heni Sunyoto I Gde Sastra Winata I Gede Putu Surya I Gusti Kamasan Arijana I Gusti Putu Mayun Mayura I Ketut Surya Negara I Ketut Suwiyoga I Nyoman Gede Budiana I Nyoman Hariyasa Sanjaya I NYOMAN MANTIK ASTAWA I Wayan Artana Putra I Wayan Megadhana I Wayan Putu Sutirta Yasa IB Gde Udyoga Manuaba, IB Gde Udyoga Ida Bagus Putra Adnyana Jaqueline Sudiman Johannes Hartono Kirana, Ni Wayan Prabasiwi Komang W Budiartha Made Bagus Dwi Aryana Made Suyasa Jaya Mahastya, I Wayan Cahya Ni Putu Yoni Prastini Kaesasih Nyoman Bayu Mahendra Piere Emanuel Yoltuwu Ryan Saktika Mulyana Stella Kawilarang Stella Kawilarang, Stella Sugianto Sugianto Wijaya Surya, I Gede Ngurah Harry William Alexander Setiawan

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Found 4 Documents Search Journal : Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)

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Journal : Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)