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Journal : INDONESIAN JOURNAL OF PHARMACY

Optimization of sorbitol, glycerol, and propyleneglycol mixture in sunscreen gel of ethanolic extract of Curcuma mangga Yuliani, Sri Hartati Hartati
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 2, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.168 KB) | DOI: 10.14499/indonesianjpharm0iss0pp83-89

Abstract

The research about optimization of sorbytol, glycerol, and propyleneglycol mixture  in  sunscreen  gel  of  ethanolic  extract  of  Curcuma  mangga has  been done.  The  aims  of  this  research  was  to  discover  the optimum  mixture  of sorbytol,  glycerol  and  propyleneglycol  that  gave  good  physycal  characteristic  of the  gel.  First, made the ethanolic extract of Curcuma mangga as active ingredient.  The SPF value of the ethanolic extract of Curcuma mangga was measured.  Simplex  lattice  design  was  employed  to  create  the  optimum composition  of  sorbitol,  glycerol  and  propyleneglycol  in  the  sunscreen  gel. Physical characteristic of the gel including spreadability, viscosity and the alteration of the gel viscosity was measured. The result showed that there were optimum composition between sorbytol, glycerol and propyleneglycol which gave good  physical  characteristics  based  on  the  shading  area  at  the  counterplot superimposed.Keywords: sorbitol, glycerol, propyleneglycol, Curcuma mangga, sunscreen gel
Computer-aided Design of Chalcone Derivatives as Lead Compounds Targeting Acetylcholinesterase Riswanto, Florentinus D. Octa; Hariono, Maywan; Yuliani, Sri Hartati; Istyastono, Enade Perdana
INDONESIAN JOURNAL OF PHARMACY Vol 28 No 2, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (897.108 KB) | DOI: 10.14499/indonesianjpharm28iss2pp100

Abstract

One of well-established biological activities for chalcone derivatives is as acetylcholinesterase inhibitors, which can be developed for the therapy of Alzheimer’s disease. Assisted byretrospectively validated structure-based virtual screening (SBVS) protocol to identify potent acetylcholinesterase inhibitors, 80chalcone derivatives were designed and virtually screened. The F-measure value as the parameter of the predictive ability of the SBVS protocol developed in the research presented in this article was 0.413, which was considerably better than the original SBVS protocol (F-measure = 0.226). Among the screened chalcone derivatives two were selected as potential lead compounds to designpotent inhibitors for acetylcholinesterase: 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one(3k) and 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one (4k).
Formulation of repellant gel of vetiver oil : Composition of carbopol 3% w/v – propilenglicol optimization Sri Hartati Yuliani
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.458 KB) | DOI: 10.14499/indonesianjpharm0iss0pp197-203

Abstract

3% w/v solution and propilenglikol,and to observe the dominant effect among Carbopol 3% w/v, propilenglikol and their interaction in determining the physical properties of vetiver oil repellant gel. Moreover the repellant potency against female Aedes albopictus and iritation skin test on rabbit were also confirmed.Firstly, vetiver oil was collected from dried root of Vetivera zizoioides (L) Nogh by water steam destilation. The obtained oil then was gelled by the aid of Carbopol 3% w/v solution – propilenglikol at various compositions. Factorial design method was employed to create the optimum composition of Carbopol 3% w/v solution – propilenglikol and was used to determined the effect of Carbopol 3% w/v solution – propilenglikol and their interaction on the gel characteristics.The result showed that the effect of Carbopol 3% w/v solution was the dominant factor in the viscosity and repellant potency. While the effect of propilenglikol was the dominant factor in alteration of gel viscosity. The interaction between Carbopol 3% w/v solution and propilenglikol was dominant factor in spreadability. The optimum composition was created in superimposed countour plot. Irritation skin test on rabbit confirmed that all evaluated formulas were non irritatingKey words: formulation, repellant gel, vetiver oil
PHYSICAL PROPERTIES OF WOUND HEALING GEL OF ETHANOLIC EXTRACT OF BINAHONG (Anredera cordifolia (Ten) Steenis) DURING STORAGE. Sri Hartati Yuliani; Achmad Fudholi; Suwijiyo Pramono; Marchaban .
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.975 KB) | DOI: 10.14499/indonesianjpharm23iss4pp203-208

Abstract

Binahong  (Anredera  cordifolia (Ten)  Steenis)  has  been used  as  wound  healing  in  traditional  Indonesian  medicine.  The developing of the dosage forms using the formulation technology approach  has  been  done.  The  aim  of  this  study  was  to  examine the  physical  properties  of  the  wound  healing  gel  of  ethanolic extract of binahong during storage. The factorial design method 3 factors  and  2  levels  was  employed  to  achieve  this  study.  The three  factors  used  in this  study  were Carbopol, CMC-Na  and Caalginate  with  low  and  high  level  for  each  factor.  The  physical properties  of  the  wound  healing  gel  of  ethanolic  extract  of binahong was evaluated on day 1, 30, 60 and 90 for viscosity and bioadhesion  study.   The  result  showed  that  CMC-Na  and  Caalginate  increased  the  alteration  of  physical  properties  of  wound healing  gel  of  ethanolic  extract  of  binahong  during  storage.  The carbopol  maintained  the  physical  properties  of  the  gel  during storage.Key words: bioadhesion, binahong, viscosity, wound healing gel.
Co-Authors Achmad Fudholi Adi, Antonius Iswara Agnes Mutiara Kurniawan Agustina Setiawati Ani, Ni Wayan Annabel, Evangeline Keisha Arini Safti Sandrapitaloka Arpan, Verdynant Augusto Ayaga Divadi Bernadetta Karina Sekar Maheswari Bertha Nathania Branitasandini, Adhika Branitasandini, Regina Epiphania Branitasandini, Regina Epiphania Adhika Christofori Maria Ratna Rini Nastiti Chusien, Adhita Wicaksaneng Naya Brena David Chandra Putra Desi Amroni Kasanah Dina Christin Ayuning Putri Dita Maria Virginia Elaina Elaina Elliora, Greata Elsa Irnandari Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Evy Fenny Veronica Felicia Satya Christania Florentinus Dika Octa Riswanto Fransiska Revana Restiana Gani, Michael Raharja Handika Immanuel Hede, Marry Grace Florensia Ignasius Adi Kurniawan Kerenhapukh, Miracle Kinanthi, Eleonora Galuh Windu Lestari, Fajar Sri Lewier, Bryan Melianus Agustinus Limianty, Angela Lu, Felisha Marchaban . Maria Faustina Sari Maria Ludya Pulung Maywan Hariono Melviya Sudianto Melynia Sintha Dewi Michael Raharja Gani Michael Raharja Gani Michael Raharja Gani Michael Raharja Gani Novela, Yuven Nugraha, Alvin Arya Nunung Yuniarti Paulus Unggul Wikan Prabandono Pebrianty, Sahara Petrus Damiani Tosan Aji Prita Patricia Radite Yogaswara reza eka putra Rini Dwiastuti Rini Dwiastuti Salainti, Madeleine Trisha Sara Septi Widayani Shirley Candra Kurniawan Sihombing, Meisyah Marito Sudianto, Melviya Suwijiyo Pramono Tasik, Sulistiana Tulung, Cindy Stevani Wandansari, Eustachia Diajeng Wardhani, Kresentia Ayu Kusuma Waskitha, Stephanus Satria Wira Wibowo, Safri Sekti Yulia Yulia YUMI RAHMADANI