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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Pharmaceutical Journal of Indonesia Cendekia Journal of Pharmacy Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal of Fundamental and Applied Pharmaceutical Science Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Sehati Journal of Tropical Pharmacy and Chemistry Journal of Pharmascience
Sri Hartati Yuliani
Sanata Dharma University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Optimization of Glycerin and Sorbitol in Hand Sanitizer Cream with Centella asiatica (L.) Extract Novela, Yuven; Yuliani, Sri Hartati
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.25629

Abstract

The use of alcohol-based hand sanitizers can cause dry skin. Centella asiatica (L.) extract can be used as an alternative to alcohol because it contains triterpenoids, especially asiatic acid, potentially an antibacterial and inhibitor of the SARS-CoV-2 virus. Cream is a preparation that can moisturize and protect the skin. Glycerin and sorbitol are humectants often used in cream preparations and have a large percentage in the cream preparation's formula so that they can affect the physical properties of the cream. This study aims to obtain the optimum composition range of glycerin and sorbitol and determine the effect of glycerin and sorbitol as humectants on the physical properties and stability of the hand sanitizer cream with Centella asiatica (L.) extract. The composition optimization was done using a factorial design method on two factors and two levels using the Design Expert 13 (free trial) application. The data on the physical properties and stability of the cream were statistically analyzed using a two-way ANOVA test at a 95% confidence level. The results of qualitative phytochemistry screening showed that the extract contained triterpenoid. The average test of physical properties and stability of physical properties meet the desired criteria: cream type O/W, viscosity 120–170 dPa.s., spreadability of 5-7 cm, shift of spreadability, and shift of viscosity below 10%. The optimum area shows that the formulas F1, FB, and FAB meet the desired criteria.
Quality of Extemporaneous Preparation Containing Theophylline, Salbutamol Sulphate and Methylprednisolone Sri Hartati Yuliani; Bernadetta Karina Sekar Maheswari; Melynia Sintha Dewi; Michael Raharja Gani; Dina Christin Ayuning Putri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005316

Abstract

Capsule preparations containing theophylline, salbutamol sulfate, and methylprednisolone were frequently prescribed in a private hospital in Yogyakarta. Theophylline is a narrow therapeutic index drug. Extemporaneous preparation products that contain narrow therapeutic index drugs have to meet the quality requirement. This study aimed to evaluate the quality of the capsule preparations. The sample was taken from a private hospital in Yogyakarta. The samples were assessed for physical characteristics, content uniformity, and chemical stability during storage. The result found that the physical characteristics of the product were good. The coefficients of variance of the content uniformity percentage for theophylline, salbutamol sulfate, and methylprednisolone were 11.96%, 3.33%, and 45.74%, respectively. During 30 days of storage, the content of theophylline, salbutamol sulfate, and methylprednisolone decreased by 1.44%, 7.64%, and 15.7%, respectively. Capsule preparations containing theophylline, salbutamol sulfate, and methylprednisolone did not meet the quality requirement.
Na-CMC and glycerine optimization in Binahong leaf extract (Anredera cordifolia) liposome gel and its burn wound healing activity Immanuel, Handika; Branitasandini, Regina Epiphania Adhika; Branitasandini, Adhika; Arpan, Verdynant Augusto; Pebrianty, Sahara; Kerenhapukh, Miracle; Wardhani, Kresentia Ayu Kusuma; Yuliani, Sri Hartati
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.30112

Abstract

Burns represent a critical global health issue, contributing to considerable morbidity and mortality rates, particularly within the Southeast Asian region. The administration of appropriate burn therapy is essential to prevent infections and promote effective wound healing. The binahong leaf (Anredera cordifolia) represents a highly promising natural substance for burn therapy, attributed to its ursolic acid content, which is acknowledged for its wound healing properties. However, the limitation caused by its limited solubility and bioavailibility requires the use of nanoparticle technology, such as liposomes, to enhance its efficacy. The aim of this research was to determine an optimal formulation of gel containing liposome-encapsulated binahong leaf extract, with the goal of promoting burn wound healing and examining its in vivo wound healing activity. Histological analysis was employed to provide additional insights into the activity of the gel. The formulation was assessed through a factorial design, exploring various amounts of Na-CMC utilized as a gelling agent alongside glycerine employed as a humectant. The results were subsequently analyzed utilizing Design Expert v13 software. The gel’s viscosity, spreadability, and uniformity were assessed. Na-CMC increased viscosity while reducing spreadability, whereas glycerine had the opposite effect. The optimal formulation contained 2.78–4 g Na-CMC and 5–10 g glycerine. Statistical validation confirmed the model's accuracy. In vivo studies demonstrated that liposomal binahong gel significantly accelerated burn wound healing compared to controls. The results suggest that 10% binahong liposomal gel is a promising alternative for burn treatment.
Preparation and Characterization of Binahong (Anredera cordifolia) Leaf Extract Transfersome Wound-Healing Gel Immanuel, Handika; Yuliani, Sri Hartati; Dwiastuti, Rini; Nugraha, Alvin Arya; Limianty, Angela; Annabel, Evangeline Keisha; Lu, Felisha; Lestari, Fajar Sri; Branitasandini, Regina Epiphania
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007311

Abstract

Burn injuries are a significant global health concern due to their profound impact on morbidity and mortality rates. Immediate medical care is essential given the potential for bacterial infections to complicated burn injuries. Binahong leaves (Anredera cordifolia (Ten.) Steenis) contain vitexin compounds that demonstrate wound healing and antibacterial potential. However, vitexin has low solubility, prompting the use of ethanol for extraction and the introduction of nanoparticle technology to enhance solubility, namely transfersomes. The present study explored the development of a gel using binahong extract transfersomes with the composition of carbopol 940 and Na-CMC to determine the effect of carbopol 940, Na-CMC, and the interaction of the two on the gel’s physical properties and stability as well as obtain the optimum composition of the two. This study demonstrates positive results in terms of gel physical properties, including pH, spreadability, and viscosity. A Factorial design method is used for optimization. The results showed that Na-CMC had the most effect on increasing viscosity, while carbopol 940 had the most effect on reducing spreadability. The optimal formula obtained in this research was to use 0.653 grams of Na-CMC and 4.391 grams of Carbopol as gelling agents. 
PENGARUH WAKTU DAN TEKNIK PENGGERUSAN TERHADAP SIFAT FISIKA SERBUK PUYER CAMPURAN AMBROXOL HCl, PSEUDOEFEDRIN HCl, DAN TRIPROLIDIN HCl Tahesa, Idola Zulfi; Yuliani, Sri Hartati
Cendekia Journal of Pharmacy Vol 9, No 2 (2025): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v9i2.368

Abstract

Penggunaan obat racikan dalam bentuk puyer semakin meluas di kalangan praktisi kesehatan, terutama dalam penanganan pasien pediatrik yang mengalami kesulitan dalam mengonsumsi sediaan padat. Fenomena ini muncul sebagai solusi atas kendala keterbatasan dosis pediatrik yang beredar di pasaran. Kombinasi bahan aktif Ambroxol HCl dan Trifed (Pseudoefedrin HCl dan Triprolidin HCl) merupakan salah satu resep yang umum diresepkan untuk mengatasi gangguan saluran pernapasan pada anak-anak. Penelitian ini mengkaji perbandingan metode penggerusan menggunakan dua alat yang berbeda, yaitu mortir-stamper konvensional dan blender, dengan variasi waktu penggerusan 1 menit, 3 menit, dan 5 menit. Evaluasi dilakukan melalui serangkaian pengujian komprehensif meliputi uji organoleptis, uji kelembaban, dan analisis karakteristik partikel menggunakan Scanning Electron Microscope (SEM) untuk menilai kualitas sediaan yang dihasilkan. Hasil analisis menunjukkan bahwa kedua metode penggerusan menghasilkan serbuk dengan karakteristik organoleptis yang serupa, yakni berwarna putih, tidak berbau tengik, dan memiliki tekstur yang halus. Namun, terdapat perbedaan signifikan dalam ukuran partikel yang dihasilkan. Penggerusan menggunakan blender menghasilkan ukuran partikel yang lebih kecil, pada durasi 1 menit, 3 menit dan 5 menit secara berurutan mendapati ukuran partikel terkecil 48,7 µm, 45,8 µm, dan 35,6 µm. Sedangkan, penggerusan dengan mortir-stamper selama 1 menit, 3 menit, dan 5 menit adalah 67 µm, 56,8 µm, dan 38 µm. Penelitian ini mengungkapkan bahwa durasi penggerusan berbanding terbalik dengan ukuran partikel yang dihasilkan. Semakin lama waktu penggerusan, semakin kecil ukuran partikel yang terbentuk. Namun, perlu diperhatikan bahwa pengurangan ukuran partikel mengakibatkan peningkatan luas permukaan spesifik, yang berkorelasi dengan peningkatan nilai kelembaban sediaan. Temuan ini memiliki implikasi penting dalam formulasi dan penyimpanan sediaan puyer, mengingat kelembaban dapat mempengaruhi stabilitas dan masa simpan produk.
Optimasi Tween 80 dan Setil Alkohol pada Sediaan Hand Sanitizer Cream Ekstrak Pegagan (Centella asiatica (L.)) Sisna Sisna; Sri Hartati Yuliani
Journal of Pharmascience Vol. 10 No. 2 (2023): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i2.14755

Abstract

Pegagan (Centella asiatica (L.)) merupakan salah satu tanaman yang memiliki potensi antivirus dan aktivitas sebagai antibakteri. Ekstrak kering pegagan akan diformulasikan dalam sediaan hand sanitizer cream sebagai alternatif dari hand sanitizer berbasis alkohol. Penelitian ini bertujuan untuk mengetahui pengaruh tween 80 dan setil alkohol terhadap sifat fisik dan stabilitas hand sanitizer cream serta mendapatkan komposisi optimum dari tween 80 dan setil alkohol dengan sifat fisik dan stabilitas yang baik. Optimasi komposisi tween 80 dan setil alkohol dilakukan dengan metode desain faktorial pada dua faktor dan dua level menggunakan aplikasi Design Expert Version 13 (free trial). Data sifat fisik dan stabilitas berupa viskositas, daya sebar, pergeseran viskositas, dan pergeseran daya sebar akan dianalisis secara statistik dengan uji two-way ANOVA pada tingkat kepercayaan 95%. Overlay plot digunakan untuk menentukan area optimum dari tween 80 dan setil alkohol. Hasil uji kualitatif menunjukkan bahwa ekstrak pegagan mengandung senyawa triterpenoid. Tween 80 dan setil alkohol dapat memengaruhi viskositas secara signifikan, sedangkan interaksi antara tween 80 dan setil alkohol secara signifikan dapat memengaruhi pergeseran daya sebar. Area berwarna kuning yang didapatkan pada overlay plot merupakan area optimum untuk menghasilkan sediaan hand sanitizer cream dengan sifat fisik dan stabilitas yang memenuhi kriteria. Kata Kunci: Krim, Desain Faktorial, Hand Sanitizer, Optimasi, Pegagan Centella asiatica (L.) is one of the plants with antiviral potential and antibacterial activity. Centella asiatica (L.) dry extract would be formulated in hand sanitizer cream as an alternative to alcohol-based hand sanitizer. This research aimed to determine the effect of tween 80 and cetyl alcohol on hand sanitizer cream's physical properties and stability and obtained the optimum composition of tween 80 and cetyl alcohol with good physical properties and stability. The composition of tween 80 and cetyl alcohol was optimized using a factorial design method on two factors and two levels using the Design Expert Version 13 application (free trial). Viscosity and spreadability physical properties, viscosity and spreadability shift stability data will be analyzed statistically by a two-way ANOVA test at a 95% confidence level. The overlay plot determined the optimum tween 80 and cetyl alcohol composition. The qualitative test results showed that Centella asiatica (L.) extract contained triterpenoid compounds. Tween 80 and cetyl alcohol can significantly affect the viscosity, while the interaction between tween 80 and cetyl alcohol can significantly affect the spreadability shift. The yellow area obtained on the overlay plot is the optimum area to produce hand sanitizer cream preparations with physical properties and stability that meet the criteria.
Spray Gel Formulation of Goroho Banana (Musa acuminata L.) Peel Extract: Optimization and Wound Healing Activity Analysis Madeleine Trisha Salainti; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0011512

Abstract

Goroho banana (Musa acuminata L.) peel extract has been traditionally used in Minahasa for wound healing. This study aimed to develop and optimize a spray gel formulation containing Goroho banana peel extract and evaluate its wound healing activity. A factorial design was employed with two factors (Carbopol 940 and HPMC) at two levels. Preliminary testing determined 3% as the optimal extract concentration through wound healing evaluation in rats. Four spray gel formulations were developed and characterized for physicochemical properties, including viscosity, pH, and drying time. Results showed Formula B (Carbopol 0.5% and HPMC 0.6%) exhibited optimal characteristics with viscosity 223.8 ± 7.6 cPs, pH 5.13 ± 0.05, and drying time 4.22 ± 0.05 minutes. The HET-CAM irritation test revealed mild irritation scores (2.5-3.8) for all formulations, with Formula B showing the lowest score (2.5). Design Expert optimization generated 100 solutions, with the optimal formula containing Carbopol 0.670% and HPMC 0.517%. The wound healing activity showed no significant differences between spray gel formulations and Bioplacenton (p0.05), indicating comparable efficacy. This study demonstrates the successful development of a safe and effective spray gel formulation of Goroho banana peel extract for wound healing applications.
Co-Authors Achmad Fudholi Adi, Antonius Iswara Agnes Mutiara Kurniawan Agustina Setiawati Ani, Ni Wayan Annabel, Evangeline Keisha Arini Safti Sandrapitaloka Arpan, Verdynant Augusto Ayaga Divadi Bernadetta Karina Sekar Maheswari Bertha Nathania Branitasandini, Adhika Branitasandini, Regina Epiphania Branitasandini, Regina Epiphania Adhika Christofori Maria Ratna Rini Nastiti Chusien, Adhita Wicaksaneng Naya Brena David Chandra Putra Desi Amroni Kasanah Dina Christin Ayuning Putri Dita Maria Virginia Elaina Elaina Elliora, Greata Elsa Irnandari Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Evy Fenny Veronica Felicia Satya Christania Florentinus Dika Octa Riswanto Fransiska Revana Restiana Gani, Michael Raharja Handika Immanuel Ignasius Adi Kurniawan Kerenhapukh, Miracle Lestari, Fajar Sri Lewier, Bryan Melianus Agustinus Limianty, Angela Lu, Felisha Madeleine Trisha Salainti Marchaban . Maria Faustina Sari Maria Ludya Pulung Maywan Hariono Melviya Sudianto Melynia Sintha Dewi Michael Raharja Gani Michael Raharja Gani Michael Raharja Gani Michael Raharja Gani Novela, Yuven Nugraha, Alvin Arya Nunung Yuniarti Paulus Unggul Wikan Prabandono Pebrianty, Sahara Petrus Damiani Tosan Aji Prita Patricia Radite Yogaswara reza eka putra Rini Dwiastuti Rini Dwiastuti Sara Septi Widayani Shirley Candra Kurniawan Sisna Sisna Sudianto, Melviya Suwijiyo Pramono Tahesa, Idola Zulfi Tasik, Sulistiana Wardhani, Kresentia Ayu Kusuma YUMI RAHMADANI