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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Pharmaceutical Journal of Indonesia Jurnal Pengabdian Kesehatan Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal of Fundamental and Applied Pharmaceutical Science Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Sehati Jurnal Medika: Medika Journal of Tropical Pharmacy and Chemistry

Sri Hartati Yuliani

Sanata Dharma University

Author-ID : 424641

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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COMPOUNDING STERILE PREPARATIONS FOR INTENSIVE CARE UNIT PATIENTS (ICU) IN ONE PRIVATE HOSPITAL IN SEMARANG Sara Septi Widayani; Sri Hartati Yuliani; Dina Christin Ayuning Putri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 2 (2018)
Publisher : Sanata Dharma University

Sterile preparations for intravenous injection probably cause greater risk of errors than other preparation treatment routes due to their complex preparation steps. Errors in preparation and compounding stage will affect the quality and stability of the pharmaceutical product obtained. The aim of this study was to evaluate the process of compounding and assess both quality and stability of the parenteral preparations products that resulted from the compounding process for ICUs patients in one private hospital in Semarang, Central Java, Indonesia. This observational analytic study was conducted using accidental sampling technique. The descriptive study results showed that sterile preparation in hospital X was not performed according to the Guidelines for Drug Injection and Handling of Cytostatic Preparations. In order to evaluate the quality of the sterile preparations, three different drugs with the highest prevalence of use: namely ceftriaxone, meropenem and omeprazole were evaluated. It was found that the pH value of omeprazole was not acceptable due to the use of an appropriateness solvent. The sterility tests showed that the preparation products prepared by the nurses were free from microorganisms.

Analytical method validation and determination of dexamethasone in divided powder using reverse phase HPLC Florentinus Dika Octa Riswanto; Dita Maria Virginia; Dina Christin Ayuning Putri; Sri Hartati Yuliani
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Dexamethasone as glucocorticoids has been widely used to reduce inflammation and tissue damage in a variety of conditions. It was commonly prescribed in combination with the other compounds such as chlorpheniramine maleate for the relief of asthma. It was important to observe the quality and safety of the combination dosage form, called pulveres or puyer in order to serve the patient oriented medication. This research aimed to develop analytical method validation and determine the content uniformity of the divided powder containing dexamethasone compounded by pharmacy in Yogyakarta and hospital in Central Java, Indonesia. A validated high performance liquid chromatography (HPLC) method was chosen to determine dexamethasone in the samples. The column of ACE 5 C18 (250 x 4.6 mm) was used in this research and the methanol:water (65:35) was used as the mobile phase at the flow rate of 1 mL/min. The UV detection was performed at 239 nm. Analytical method validation was performed on the parameters of system suitability, limit of detection, limit of quantification, accuracy, precision, and linearity. The results showed that dexamethasone contains in divided powder compounded by pharmacy in Yogyakarta and hospital in Central Java were met the acceptance requirement.Â Â

Formulation of repellant gel of vetiver oil : Composition of carbopol 3% w/v – propilenglicol optimization Sri Hartati Yuliani
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

3% w/v solution and propilenglikol,and to observe the dominant effect among Carbopol 3% w/v, propilenglikol and their interaction in determining the physical properties of vetiver oil repellant gel. Moreover the repellant potency against female Aedes albopictus and iritation skin test on rabbit were also confirmed.Firstly, vetiver oil was collected from dried root of Vetivera zizoioides (L) Nogh by water steam destilation. The obtained oil then was gelled by the aid of Carbopol 3% w/v solution – propilenglikol at various compositions. Factorial design method was employed to create the optimum composition of Carbopol 3% w/v solution – propilenglikol and was used to determined the effect of Carbopol 3% w/v solution – propilenglikol and their interaction on the gel characteristics.The result showed that the effect of Carbopol 3% w/v solution was the dominant factor in the viscosity and repellant potency. While the effect of propilenglikol was the dominant factor in alteration of gel viscosity. The interaction between Carbopol 3% w/v solution and propilenglikol was dominant factor in spreadability. The optimum composition was created in superimposed countour plot. Irritation skin test on rabbit confirmed that all evaluated formulas were non irritatingKey words: formulation, repellant gel, vetiver oil

PHYSICAL PROPERTIES OF WOUND HEALING GEL OF ETHANOLIC EXTRACT OF BINAHONG (Anredera cordifolia (Ten) Steenis) DURING STORAGE. Sri Hartati Yuliani; Achmad Fudholi; Suwijiyo Pramono; Marchaban .
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Binahong (Anredera cordifolia (Ten) Steenis) has been used as wound healing in traditional Indonesian medicine. The developing of the dosage forms using the formulation technology approach has been done. The aim of this study was to examine the physical properties of the wound healing gel of ethanolic extract of binahong during storage. The factorial design method 3 factors and 2 levels was employed to achieve this study. The three factors used in this study were Carbopol, CMC-Na and Caalginate with low and high level for each factor. The physical properties of the wound healing gel of ethanolic extract of binahong was evaluated on day 1, 30, 60 and 90 for viscosity and bioadhesion study. The result showed that CMC-Na and Caalginate increased the alteration of physical properties of wound healing gel of ethanolic extract of binahong during storage. The carbopol maintained the physical properties of the gel during storage.Key words: bioadhesion, binahong, viscosity, wound healing gel.

THE EFFECT OF TEMPEH EXTRACT GEL ON WOUND HEALING IN DIABETES RAT: OVERVIEW OF TISSUE COLLAGEN, WOUND CLOSURE, EPITHELIALIZATION AND CAPILLARIZATION Ignasius Adi Kurniawan; Rini Dwiastuti; Sri Hartati Yuliani
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

The development of wound healing preparations in diabetes conditions needs to be done because the wound healing process in the respective conditions requires longer time. The aim of this study is to measure the effect of tempeh extract gel containing genistein on wound healing in diabetes rats by observing the response parameters of collagen expression, wound closure speed, epithelialization, and capillarization of wound tissue. The results of testing wound closure using a base gel treatment, tempeh extract gel 2.5%, 5%, 7.5% and without treatment indicated that the treated groups of tempeh extract gel 5% and 7.5% have significant effect on diabetes wound healing in the tested animals. This indication is strengthened by the results of the non-treatment groups statistical test with the 5% and 7.5% tempeh extract gel treatment which showed significant difference in influencing the wound closure response, epithelialization and collagen formation in tissue. The results of the statistical in group without treatment with the base treatment group without extract gel and tempeh extract gel 2.5% showed no significant difference in influencing the wound closure response, epithelialization and collagen formation. Statistical test results on capillarization responses indicated that the results were not significantly different from all treatment groups.

PENDAMPINGAN KEPADA SISWA SEKOLAH MENENGAH DI YOGYAKARTA DALAM PENERAPAN 5M SEBAGAI PERSIAPAN PEMBELAJARAN LURING Dina Christin Ayuning Putri; Sri Hartati Yuliani; Rini Dwiastuti
ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat Vol 5, No 1 (2022): April 2022
Publisher : Universitas Sanata Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/aa.v5i1.3830

The COVID-19 pandemic that has hit the whole world has affected various aspects of life, including education. Education during the pandemic is carried out online which has the potential to cause learning loss for students. Face-to-face learning is needed for students by considering all the risks. Preparation for offline learning is done by equipping students in implementing health protocols. This activity aims to equip students to be ready to carry out face-to-face learning by applying the ‘5M’ programs. Activities are carried out in the form of mentoring and discussion. The effectiveness of the activity was observed by comparing the pretest and posttest scores. The results show that the students' posttest scores are greater than the pretest scores, so it can be concluded that this activity is useful in adding students' knowledge of the ‘5M’ program as an effort to prevent COVID-19 transmission during face-to-face learning.

Uji Iritasi Sediaan Gel Penyembuh Luka Ekstrak Etanol Daun Binahong Menggunakan Slug Irritation Test SRI HARTATI YULIANI; YUMI RAHMADANI; ENADE PERDANA ISTYASTONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2884.528 KB)

Penyembuhan luka adalah proses dinamik yang rumit dan belum sepenuhnya dimengerti. Proses penyembuhan luka terdiri dari 3 fase yaitu fase inflamasi, fase pembentukan jaringan dan fase remodeling. Lama fase inflamasi memegang peranan penting pada proses penyembuhan luka. Fase inflamasi yang panjang akan menyebabkan penundaan proses penyembuhan luka. Iritan dapat memperpanjang waktu pelepasan interleukin-1 and TNF-α. Hal tersebut akan menyebabkan matriks ekstraseluler yaitu suatu material penting dalam pembentukan jaringan baru terdegradasi. Sediaan penyembuh luka tidak boleh mengandung iritan, sehingga semua sediaan penyembuh luka harus diuji potensi iritasinya. Potensi iritasi gel penyembuh luka ekstrak etanol daun binahong telah diuji menggunakan slug irritation test. Validasi terhadap metode ini telah dilakukan dengan hasil sensitivitas dan spesifisitas masing-masing 100% pada nilai batas produksi mukus 8,79%. Metode ini valid untuk menentukan potensi iritasi terhadap suatu produk. Produksi mukus sediaan gel penyembuh luka ekstrak etanol daun binahong adalah 4,55% sehingga dapat disimpulkan sediaan tersebut tidak menimbulkan iritasi pada kulit.

Uji Penyembuhan Luka dan Potensi Iritasi Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten) Steenis) SRI HARTATI YULIANI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1674.947 KB)

Binahong (Anredera cordi olia (Ten) Steenis) has been used as wound healing in traditional Indonesian medicine. The aim of this study was to examine the wound healing activity and irritation potency of ethanolic extract of Anredera cordifolia (Ten) Steenis. Dry Binahong leaves were ground and screened with mesh no 40. Dry Binahong leaves were macerated with 10 times of volume of 96% ethanol for 90 minutes with constant agitation (200 rpm). It was screened and concentrated until the liquid would be a quarter. Then the extract was incorporated to gel base as 2,5%; 5%; 10% and 20%. Incision wound method was employed to activity test of wound healing. Male mice (strain Swiss), weight between 25 ~ 30 g, was used to this test. The male mice were classified into 7 groups i.e. negative control, control vehicle, positive control and 4 groups of sample. The extract then was assessed to irritation potency using HET-CAM method. Lactic acid was used as the positive control for irritation assessment. The result of this study stated that the highest activity of wound healing was shown by the sample containing 5% of ethanolic extract. The percentage activity of wound healing was 63,3%. Irritation appeared on the 10% and 20% ethanolic extract of binahong leaves.

Evaluation of Compounding Sterile Preparations for Hospitalized Pediatric Patients in "X" Hospital Semarang City, Indonesia Melviya Sudianto; Dina Christin Ayuningputri; Sri Hartati Yuliani
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 8, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Compounding sterile preparation, especially for hospitalized pediatric patients, needs more concern due to dose adjustment. Things to be concerned about are compounding personnel, utilization of aseptic technique, and facilitation that affects the quality of sterile preparations. The aims of this study were to observe compounding process and to quality the sterile preparations for hospitalized pediatric patients in “X” Hospital, Semarang City, Indonesia. This research is an observational analitic with incidentally sampling research. Subject in this research was personnel who performed sterile preparations for hospitalized pediatric patients. Results from 114 sterile preparations which were observed in pediatric ward showed that compounding personnel (100%), facilities & infrastuctures, and sterile preparations procedure were not suitable with the Mixing Guideline for injectable drug and cytostatic (2009), hence it could impact the quality of sterile preparations. In addition, even after implementing appropriate solvent, compounding procedures, and aseptic technique had been utilized (100%), the physical incompatibility occurred was 8.77%. The pH of Ceftriaxone and Cefotaxime was similar with those in the literature, but for Omeprazole’s pH and based on sterility test, there were no bacterial growth.

Kajian Potensi Inkompatibilitas dan Instabilitas: Studi Kasus Sediaan Racikan Mengandung Amitriptilin, Trifluoperazine Dihidroklorida dan Alprazolam Desi Amroni Kasanah; Dina Christin Ayuning Putri; Sri Hartati Yuliani; Rini Dwiastuti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 4, No 2 (2019)
Publisher : Universitas Sebelas Maret

Meracik obat merupakan salah satu tugas tenaga kefarmasian. Peracikan obat merupakan salah satu risiko penyebab medication error. Resep racikan yang mengandung amitriptilin, trifluoperazin dihidroklorida dan alprazolam adalah jenis peresepan dengan tingkat risiko tinggi, sedangkan informasi tentang sediaan racikan kombinasi obat tersebut masih sangat terbatas. Studi ini bertujuan untuk memberikan informasi mengenai risiko peracikan, potensi instabilitas, dan potensi inkompatibilitas pada resep racikan sediaan kapsul yang mengandung amitriptilin, trifluoperazin dihidroklorida dan alprazolam di sebuah rumah sakit di Semarang. Analisis risiko resep dilakukan dengan memperhatikan aspek risiko teknis dan risiko klinis, sedangkan pengkajian terhadap potensi instabilitas dan inkompatibilitas dilakukan secara sistematis menggunakan beberapa literatur sengan kriteria yang telah ditetapkan. Hasil analisis risiko menunjukkan bahwa resep racikan mengandung amitriptilin, trifluoperazin dihidroklorida dan alprazolam memiliki risiko peracikan yang sangat tinggi. Berdasarkan penelusuran literatur sistematis, ditemukan adanya potensi ketidakstabilan dan inkompatibilitas yang mungkin terjadi yaitu penarikan lembab dan reaksi hidrolisis. Berbagai upaya teknis dapat dilakukan oleh tenaga kefarmasian untuk meningkatkan kualitas obat dan menjamin keamanannya yaitu menggunakan cangkang kapsul HPMC, menyimpan sediaan dalam wadah tertutup kedap, terhindar dari cahaya langsung pada suhu ruang dan menambahkan silika gel. Meskipun demikian, potensi instabilitas dan inkompatibilitas yang ditemukan dalam studi ini masih berdasar pada kajian pustaka, sehingga perlu dilakukan penelitian eksperimental untuk mengetahui profil stabilitas dan kompatibilitas sediaan racikan tersebut.

Co-Authors Achmad Fudholi Adi, Antonius Iswara Agnes Mutiara Kurniawan Agustina Setiawati Ani, Ni Wayan Annabel, Evangeline Keisha Arini Safti Sandrapitaloka Arpan, Verdynant Augusto Ayaga Divadi Bernadetta Karina Sekar Maheswari Bertha Nathania Branitasandini, Adhika Branitasandini, Regina Epiphania Branitasandini, Regina Epiphania Adhika Christofori Maria Ratna Rini Nastiti Chusien, Adhita Wicaksaneng Naya Brena David Chandra Putra Desi Amroni Kasanah Dina Christin Ayuning Putri Dita Maria Virginia Elaina Elaina Elliora, Greata Elsa Irnandari Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Evy Fenny Veronica Felicia Satya Christania Florentinus Dika Octa Riswanto Fransiska Revana Restiana Gani, Michael Raharja Handika Immanuel Hede, Marry Grace Florensia Ignasius Adi Kurniawan Kerenhapukh, Miracle Kinanthi, Eleonora Galuh Windu Lestari, Fajar Sri Lewier, Bryan Melianus Agustinus Limianty, Angela Lu, Felisha Marchaban . Maria Faustina Sari Maria Ludya Pulung Maywan Hariono Melviya Sudianto Melynia Sintha Dewi Michael Raharja Gani Michael Raharja Gani Michael Raharja Gani Michael Raharja Gani Novela, Yuven Nugraha, Alvin Arya Nunung Yuniarti Paulus Unggul Wikan Prabandono Pebrianty, Sahara Petrus Damiani Tosan Aji Prita Patricia Radite Yogaswara reza eka putra Rini Dwiastuti Rini Dwiastuti Salainti, Madeleine Trisha Sara Septi Widayani Shirley Candra Kurniawan Sihombing, Meisyah Marito Sudianto, Melviya Suwijiyo Pramono Tasik, Sulistiana Tulung, Cindy Stevani Wandansari, Eustachia Diajeng Wardhani, Kresentia Ayu Kusuma Waskitha, Stephanus Satria Wira Wibowo, Safri Sekti Yulia Yulia YUMI RAHMADANI

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