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All Journal Paediatrica Indonesiana AcTion: Aceh Nutrition Journal Jurnal Ilmiah Mahasiswa Kedokteran Medisia AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Budapest International Research in Exact Sciences (BirEx Journal) Narra J The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Peradaban Journal of Religion and Society Narra X
Sulaiman Yusuf
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation

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Association between tumor necrosis factor-α gene polymorphism and interleukin-6 level with mortality of neonatal sepsis Darnifayanti, Darnifayanti; Akmal, Muslim; Nur, Syahrun; Yusuf, Sulaiman
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1234

Abstract

Sepsis is a systemic infection that significantly causes morbidity and mortality among neonates, which is associated with immature immune response. Variations in the tumor necrosis factor-alpha gene (TNF-α) -308G/A may be linked to neonatal sepsis mortality by modulating interleukins (ILs) involved in the immune response cascade, such as IL-6. The aim of this study was to investigate the association between TNF-α -308G/A gene variation and IL-6 level with mortality of neonatal sepsis. A cohort of 30 neonates diagnosed with clinical sepsis was recruited. Blood culture was performed for all patients and serum IL-6 levels were examined 24 hours after suspected sepsis. Genetic analysis of TNF-α single nucleotide polymorphisms (SNP) -308G/A was conducted using polymerase chain reaction and DNA sequencing. The association was assessed based on bivariate logistic regression. We found that 12 (40%) of 30 patients had blood culture-proven sepsis. Genotype of TNF-α -308G/A stratified of the patients was 56.7% for GA and 43.3% for GG. There were no AA variations found in this study. There was no significant association between the TNF-α -308 G/A genotype and mortality in neonatal sepsis (p=0.211). Similarly, the allelic model of TNF-α -308 gene had no association with mortality (p=0.325). Additionally, there was no association between serum IL-6 level and mortality in neonatal sepsis (p=0.253). In conclusion, SNP of TNF-α -308 gene and IL-6 level are not associated with mortality in neonatal sepsis.
HUBUNGAN TINGGI BADAN IBU, SOSIAL EKONOMI DAN ASUPAN SUMBER ZINC DENGAN KEJADIAN STUNTING PADA ANAK USIA 3-5 TAHUN DI PUSKESMAS KOPELMA DARUSSALAM Ramadhan, Muhammad Haris; Salawati, Liza; Yusuf, Sulaiman
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol.6 : No.1 (Mei, 2020)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v6i1.2661

Abstract

Stunting merupakan status gizi masa lalu yang kurang baik akibat asupan gizi kurang, baik kualitas maupun kuantitas sehingga tinggi badan tidak sesuai dengan umur. Banyak faktor yang dapat menyebabkan stunting antara lain: defisiensi gizi makro dan mikro, genetik, sosial ekonomi, penyakit infeksi, pemberian air susu ibu ekslusif dan berat badan lahir rendah. Tujuan dari penelitian ini adalah mengetahui hubungan tinggi badan ibu, sosial ekonomi dan asupan sumber zinc dengan stunting pada anak usia 3-5 tahun di Puskesmas Kopelma Darussalam Banda Aceh. Jenis penelitian analitik observasional dengan design cross sectional. Pengambilan sampel tanggal 14 September sampai 14 November 2017 di 5 posyandu Puskesmas Kopelma Darussalam secara non probability sampling dengan metode accidental sampling. Penilaian tinggi badan ibu dan stunting dengan mengukur tinggi badan menggunakan mikrotoa, sosial ekonomi dan asupan sumber zinc diukur menggunakan kuesioner. Jumlah sampel sebanyak 46 ibu dan anak yang memenuhi kriteria inklusi. Anak usia 3-5 tahun stunting (pendek atau sangat pendek) sebesar 41,3%, tinggi badan ibu pendek 50%, sosial ekonomi rendah 52,2% dan asupan sumber zinc kurang 50%. Uji analisis Spearman terdapat hubungan antara tinggi badan ibu dengan stunting nilai p = 0,000 (p<0,05) dan r = 0,529 kekuatan hubungan kuat. Tidak terdapat hubungan sosial ekonomi dengan stunting nilai p = 0,930 (p>0,05) dan terdapat hubungan asupan sumber zinc dengan stunting nilai p = 0,016 (p<0,05) dan r = 0,352 kekuatan hubungan sedang. Kesimpulannya, tinggi badan ibu dan asupan sumber zinc berhubungan dengan stunting dan tidak terdapat hubungan antara sosial ekonomi dengan stunting.
Role of vitamin C in reducing cardiovascular oxidative stress: An in vivo study using sepsis rat models Raihani, Rifa; Sovira, Nora; Andid, Rusdi; Yusuf, Sulaiman; Safri, Mulya; Dimiati, Herlina; Fajri, Fauzan; Sentosa, Sukmawan F.; Hasan, Denny I.
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.179

Abstract

The aim of this study was to evaluate the effect of vitamin C on reducing cardiovascular oxidative stress in sepsis rat models. An experimental animal study with a post-test control group design was conducted at the Laboratory of Animal Research, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, from September to December 2023, using 18 male Wistar strain rats (Rattus norvegicus). Rats were divided into three groups: control (Group K), lipopolysaccharide 5 mg/kg body weight (BW) (Group L), and lipopolysaccharide 5 mg/kg BW with oral vitamin C (18 mg/day) (Group LC). Rats were euthanized after two weeks with ketamine (15–20 mg/kg intraperitoneally) and cervical dislocation. Blood samples (3 mL) and heart organs were collected. Nitric oxide (NO) levels were measured through enzyme-linked immunosorbent assay (ELISA), and cardiac muscle cells were observed using an Olympus CX21 microscope.  The LC group exhibited a significantly lower mean endothelial dysfunction score than the L group (p<0.001), although no significant difference in NO levels was observed between L and LC groups (p=0.262), indicating that vitamin C did not significantly affect NO levels. This suggests that the improvement in endothelial function observed in the LC group may be mediated through mechanisms other than NO modulation. The MANOVA test revealed that vitamin C administration accounted for 84.8% of changes in endothelial function in the sepsis rat model (p<0.001). In conclusion, vitamin C confers a protective effect against severe cardiac and endothelial damage, as evidenced by the amelioration of necrosis, inflammatory cell infiltration, congestion, and vacuolization caused by lipopolysaccharide.
Risk factors for poor initial response to valproic acid therapy in children with epilepsy Sari, Eva Devita; Anidar, Anidar; Amna, Eka Yunita; Andid, Rusdi; Yusuf, Sulaiman; Sovira, Nora
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.286-90

Abstract

Background The initial response in the first three months of valproic acid therapy is a prognostic factor for predicting treatment success, and it is considered to be poor if seizures persist during the three months of valproic acid treatment. Several factors might influence the initial response to valproic acid therapy, including gender, age, family history of epilepsy, electroencephalogram (EEG), head circumference, type of seizure, cerebral palsy, and pre-therapy seizure frequency. Objective To determine the risk factors for poor early response to valproic acid therapy in children with epilepsy. Methods This retrospective cohort study was conducted in children newly diagnosed with epilepsy. Data were collected from medical records of patients who had been treated at the Pediatric Polyclinic of dr. Zainoel Abidin Hospital for one year. Results Of 90 subjects, most were male (58; 64.4%) and aged three years or older (79; 87.8%). Forty-five (50%) patients had a family history of epilepsy. More than a quarter of the subjects (35; 38.9%) showed initial poor responses to valproic acid therapy. Bivariate analysis revealed risk factors for poor initial response to valproic acid therapy were age ≥ 3 years, family history of epilepsy, normal EEG, normal head circumference, generalized seizure type, cerebral palsy, and pre-therapy seizure frequency. However, multivariate analysis revealed that risk factors for poor initial response to valproic acid therapy in children with epilepsy that retained significance were family history of epilepsy (RR 6.58; 95%CI 1.67 to 25.95; P=0,001), abnormal EEG (RR 5.27; 95%CI 1.16 to 23.87; P=0,000), focal seizures (RR 7.10; 95%CI 1.15 to 43.80; P=0,000), and cerebral palsy (RR 62.62; 95%CI 3.93 to 996.45; P=0,001). Conclusion The risk factors for poor initial response to valproic acid therapy in children with epilepsy are family history of epilepsy, abnormal EEG, focal seizures, and cerebral palsy.
Risk factors for progression of chronic kidney disease in children with nephrotic syndrome Adrian, Riki; Sovira, Nora; Haris, Syafruddin; Andid, Rusdi; Darnifayanti, Darnifayanti; Yusuf, Sulaiman
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.291-6

Abstract

Background Nephrotic Syndrome (NS) is a progressive kidney disease in children that can lead to chronic kidney disease (CKD). Understanding the interactions between various risk factors is critical in developing new strategies to prevent the progression of CKD in pediatric patients with NS. Objective To determine the risk factors for the progression of CKD in children with nephrotic syndrome at Dr. Zainoel Abidin Public Hospital, Banda Aceh. Methods This analytical observational study with a cross-sectional approach was conducted from September 2021 to September 2023. Data were obtained from medical records of 52 children aged 2 to 18 years in the inpatient and outpatient wards of Dr. Zainoel Abidin Public Hospital, Banda Aceh who met the inclusion criteria. Bivariate analysis using the Chi-square and Fisher's tests and multivariate analysis using logistic regression test were performed. Results Of 52 subjects, most were male and over ten years of age; 53.8% of subjects had Stage 1 CKD. The majority of stage 3-5 of CKD cases had immunosuppressive toxicity and anemia, while the majority of all subjects had hyperfiltration and proteinuria. Risk factors for CKD progression in children with NS are Hypertension (OR 2.54; 95%CI 0.32 to 20.1; P=0.003), immunosuppressant toxicity with (OR 33.67; 95%CI 2.59 to 437.5; P=0.007) and anemia (OR 33.92; 95%CI 2.77 to 414.5; P=0.006). Conclusion Hypertension, immunosuppressant toxicity and anemia for CKD progression in children with NS.
Nutritional status, age and gender factors associated on pneumonia in congenital heart disease: A hospital-based cross-sectional study in Banda Aceh, Indonesia Sovira, Nora; Dimiati, Herlina; Yusuf, Sulaiman; Bakhtiar, Bakhtiar; Ismy, Jufitriani
AcTion: Aceh Nutrition Journal Vol 10, No 3 (2025): September
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i3.2442

Abstract

Pneumonia is a leading cause of morbidity and mortality in children with congenital heart disease (CHD). Risk factors for pneumonia in these children include anemia, hypoxemia, nutritional status, congestive heart failure, and neuromuscular disorders. This study aimed to determine the risk factors for pneumonia in children with CHD at the Dr. Zainoel Abidin Public Hospital, Banda Aceh, Indonesia. This analytical, observational study employed a cross-sectional approach. This study included children aged 1 month to 18 years who were treated at the Dr. Zainoel Abidin Public Hospital from January 2022 to December 2023. Data were collected from medical records of 121 children who met the inclusion and exclusion criteria. Data were analyzed using bivariate analysis with the chi-square test and multivariate analysis with logistic regression. Pneumonia was observed in 66 (54,5%) patients. The majority of children with critical illnesses who developed pneumonia were between 1 month and 5 years of age (60%), female (61,7%), had poor nutritional status (53,2%), and had a birth weight ≥ 2500 g (54,5%). The type of CHD was found to be a significant risk factor for pneumonia (p = 0,024), with an odds ratio of 3,16 (95% CI: 1,162–8,617). In conclusion, the CHD type is a risk factor for pneumonia in children with CHD.
Co-Authors Adrian, Riki Al-shather, Zain Amna, Eka Yunita Anidar Anidar Anidar Anidar, Anidar Arqam, Abil Badriul Hegar Badriul Hegar Bakhtiar Bakhtiar Carolina, Infra Yunita Cut Zahara Phoenna Darnifayanti Darnifayanti Darnifayanti, Darnifayanti Dora Darussalam Dora Darussalam, Dora Fajri, Fauzan Feliatra Harrika, Fenny Hasan, Denny I. Herlina Dimiati, Herlina Heru Noviat Herdata Intan Chaharunia Mulya Ismy, Jufitriani Jufitriani Ismy Liza Salawati, Liza Mulya Safri, Mulya Muntadhar, Muntadhar Muslim Akmal Muzakkir, Yumna Nadia, Nurul Nora Sovira, Nora Nuriyanto, Alivia R. Nurul Maghfirah Octavina Susanti Raihani, Rifa Ramadhan, Muhammad Haris Rusdi Andid Rusdi Andid, Rusdi Sari, Eva Devita Sentosa, Sukmawan F. Siti Hajar Susanti, Nurhayani D. Syafruddin Haris Syafruddin Haris, Syafruddin Syahrun Nur T.M. Thaib