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Formulasi Cangkang Kapsul dengan Kombinasi Kappa Karagenan dan Iota Karagenan Nurfita Amalina; Yuni Anggraeni; Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 2, No 1 (2020)
Publisher : UIN Syarif Hidayatullah Jakarta

Karagenan dapat dikombinasikan antara jenis kappa karagenan dengan kekuatan gel yang kuat dan iota karagenan yang bersifat elastis sebagai pengganti gelatin untuk pembuatan cangkang kapsul. Kombinasi keduanya dapat memperbaiki sifat mekanik dengan cara meningkatkan nilai elastisitas film. Tujuan penelitian ini untuk mengetahui karakteristik cangkang kapsul yang dihasilkan dari kombinasi kappa karagenan dan iota karagenan serta pengaruhnya terhadap kekuatan mekanik film. Konsentrasi karagenan yang digunakan adalah 6% terdiri dari empat perbandingan antara kappa karagenan dan iota karagenan yaitu 2:3 (Formula A), 1:1 (Formula B), 3:2 (Formula C), dan 2:1 (Formula D). Selanjutnya empat perbandingan tersebut dievaluasi cangkang kapsul dan evaluasi film karagenan. Hasil penelitian menunjukkan formula C (3:2) memenuhi persyaratan bobot, ketebalan, panjang, diameter, waktu hancur, dan kadar air cangkang kapsul, sedangkan pada formula lainnya terdapat beberapa parameter yang tidak terpenuhi. Peningkatan konsentrasi kappa sebanding dengan peningkatan nilai viskositas larutan, ketebalan dan bobot cangkang kapsul, dan kuat tarik film namun berbanding terbalik dengan persentase pemanjangan dan nilai permeabilitas film serta tidak berpengaruh terhadap waktu hancur, higroskopisitas, dan kadar abu cangkang kapsul. Formulasi terbaik berdasarkan parameter spesifikasi cangkang kapsul, kadar air, kadar abu, dan waktu hancur cangkang kapsul adalah formula C (3:2).

Deskripsi Komponen Major Metabolit Sekunder Tanaman dengan Khasiatnya Terhadap Organ Ginjal dalam Buku Al-qanun fi’l Tibb II Tri Yuliana Agustiani; Ofa Suzanti Betha; Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 2, No 2 (2020)
Publisher : UIN Syarif Hidayatullah Jakarta

Al-Qanun Fi’l Tibb II merupakan buku karya ilmuwan Islam yaitu Ibnu Sina yang digunakan sebagai pedoman pengobatan pada zaman keemasan islam. Penelitian ini bertujuan untuk memberikan informasi data komponen major tanaman yang berkhasiat terhadap organ ginjal dan mendeskripsikan hubungan antara komponen major metabolit sekunder tanaman dengan khasiatnya terhadap organ ginjal sesuai buku Al-Qanun Fi’l Tibb II. Penelitian dilakukan secara kualitatif dengan metode literature review melalui studi kepustakaan dan diperoleh 250 jurnal ilmiah. Hasilnya dari 44 tanaman yang berkhasiat terhadap organ ginjal terdapat senyawa metabolit sekunder terpen, flavonoid, asam fenolik, alkaloid dan tanin. Senyawa terpen merupakan metabolit sekunder terbanyak pada tanaman. Komponen major metabolit sekunder memiliki bioaktivitas terhadap organ ginjal seperti antioksidan, diuretik, anti-inflamasi, nefroprotektif, antilitiatik dan analgesik

Pengaruh Penambahan Enhancer Isopropil Miristat dan dan Propilen Glikol terhadap Penetrasi Krim Asiklovir Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.25859

Acyclovir, a BCS class III drug, has a high ability to fight the herpes virus but has low permeability and is poorly soluble in water. In order to obtain the expected effect of viral infection on the skin, the penetration of the active ingredients becomes a critical factor for a topical treatment to achieve the desired concentration. This study was to see the effect of adding isopropyl myristate and propylene glycol as enhancers that help diffuse the drug through the stratum corneum. The formulation is made by adding enhancer propylene glycol 8% (F1), isopropyl myristate 8% (F2), and without enhancers (F3). Physical stability of acyclovir cream, including homogeneity, organoleptic, pH, viscosity, type of emulsion and power spread, and in vitro cream penetration test with Franz diffusion cells will be observed. The result of acyclovir cream preparations F1, F2, and F3 had a homogeneous preparation of white semisolid and odorless with pH between 7,30-7,60, emulsion type o/w, and a viscosity between 35000-47000 cPS. The cumulative amount of acyclovir penetrated at F3 was 226,008± 8,462 μg/cm2, while the cream containing the enhancers F1 258,059±1,730 μg/cm2 and F2 268,336±0,740 μg/cm2, respectively. The presence of enhancers will increase the penetration ability of acyclovir cream, with more penetration using isopropyl myristate than propylene glycol.

Review Kandungan Metabolit Sekunder Tanaman Berkhasiat terhadap Tulang dan Sendi menurut Al-Qanun Fi’l Tibb II Barita Juliano Siregar; Sarah Nahdah Zhaafirah Sangadji; Ofa Suzanti Betha; Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.25611

Al-Qanun Fi’l Tibb II merupakan buku materia medica karya Ibnu Sina yang terkenal di dunia. Buku tersebut menjelaskan secara rinci mengenai monografi tanaman berkhasiat terhadap organ tubuh, salah satunya terhadap tulang dan sendi. Akan tetapi dalam buku tersebut belum memuat komponen major metabolit sekunder yang diduga berperan penting dalam memberikan efek farmakologis. Penelitian ini ditujukan untuk menginventarisasi tumbuhan yang terdapat di dalam buku Al-Qanun Fi’l Tibb II dan melakukan literatur review terkait kandungan metabolit sekunder yang terdapat dalam tanaman tersebut. Metode penelitian dilakukan dengan literature review melalui studi kepustakaan. Hasil pengambilan data menunjukan terdapat 74 tanaman yang berkhasiat terhadap tulang dan sendi diantaranya memiliki komponen major metabolit sekunder seperti senyawa terpen, flavonoid, alkaloid, tanin, alil isotiosianat, saponin, glikosida, alkohol lemak, asam fenolat, benzofenon, kuinon, sekoiridoid, kumarin, stilbene, anthrone, naftalen, benzaldehida dan asam karboksilat. Terpen merupakan metabolit sekunder yang paling banyak ditemukan dalam tanaman yang berkhasiat terhadap tulang dan sendi. Bioaktivitas yang ditemukan pada tanaman diantaranya antigout, antioksidan, osteoprotektif, antiosteoporosis, antibakteri, antiinflamasi dan analgesik.

Review Kandungan Metabolit Sekunder Tanaman Berkhasiat terhadap Tulang dan Sendi menurut Al-Qanun Fi’l Tibb II Barita Juliano Siregar; Sarah Nahdah Zhaafirah Sangadji; Ofa Suzanti Betha; Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 2 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.25611

Al-Qanun Fi’l Tibb II merupakan buku materia medica karya Ibnu Sina yang terkenal di dunia. Buku tersebut menjelaskan secara rinci mengenai monografi tanaman berkhasiat terhadap organ tubuh, salah satunya terhadap tulang dan sendi. Akan tetapi dalam buku tersebut belum memuat komponen major metabolit sekunder yang diduga berperan penting dalam memberikan efek farmakologis. Penelitian ini ditujukan untuk menginventarisasi tumbuhan yang terdapat di dalam buku Al-Qanun Fi’l Tibb II dan melakukan literatur review terkait kandungan metabolit sekunder yang terdapat dalam tanaman tersebut. Metode penelitian dilakukan dengan literature review melalui studi kepustakaan. Hasil pengambilan data menunjukan terdapat 74 tanaman yang berkhasiat terhadap tulang dan sendi diantaranya memiliki komponen major metabolit sekunder seperti senyawa terpen, flavonoid, alkaloid, tanin, alil isotiosianat, saponin, glikosida, alkohol lemak, asam fenolat, benzofenon, kuinon, sekoiridoid, kumarin, stilbene, anthrone, naftalen, benzaldehida dan asam karboksilat. Terpen merupakan metabolit sekunder yang paling banyak ditemukan dalam tanaman yang berkhasiat terhadap tulang dan sendi. Bioaktivitas yang ditemukan pada tanaman diantaranya antigout, antioksidan, osteoprotektif, antiosteoporosis, antibakteri, antiinflamasi dan analgesik.

Knowledge and Behavior of Household Medicine Storage: A Study from the Urban area of Jakarta, Indonesia Suci Ahda Novitri; Ofa Suzanti Betha; Annisa Triana Yusman; Mochamad Iqbal Nurmansyah; Estu Mahanani Dhilasari; Rurynta Ferly Shavira
Public Health of Indonesia Vol. 10 No. 2 (2024): April - June
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v10i2.781

Background: Medicine storage in households is significantly increasing due to the prevalence of self-medication behavior. Several people are still unfamiliar with proper medication storage procedures, which can affect the stability and effectiveness of the medicine. Objective: This study aimed to determine the knowledge and behavior of urban households regarding medicine storage in Jakarta. Methods: An analytical approach was used with the cross-sectional method and the data were collected through face-to-face interviews and observation. A total of 329 respondents and 1686 medicines were obtained through the purposive sampling method and the data collected were analyzed using univariate and bivariate analyses with SPSS 26. Results: The results showed that the majority of people have low knowledge (56.53%) and inappropriate behavior (57.45%), while most of the respondents got their medicines from a pharmacy or drugstore. The most commonly stored therapeutic classes were cough and cold medicines, including analgesic-antipyretics. A significant relationship was observed between age group and level of knowledge, as well as education, knowledge, and behavior related to the storage of medicine in households (p-value <0,05). Conclusion: In conclusion, the urban community in Jakarta has poor knowledge and inappropriate behavior regarding medicines storage in households, indicating the need for continuous education to promote proper practice. Keywords: Medicine storage; knowledge; behavior; households

Pemetaan Komponen Metabolit Sekunder Utama dari Tanaman Berkhasiat terhadap Paru paru menurut Al-Qanun fi at-Tibb 2 karya Ibnu Sina djamain, nelly suryani; Nurkholiza, Zahara Faiziah; Saibi, Yardi Yardi; Betha, Ofa Suzanti; Dahlizar, Sabrina Sabrina; Dillasari, Estu Mahanani
ALCHEMY:Journal of Chemistry Vol 12, No 1 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i1.21469

Al-Qanun fii at-Tibb 2 is a medical text book by Ibn Sina, which contains monographs of various natural materials, especially plants that have properties for organs including the lungs. In this book there is no data regarding the secondary metabolite content of these plants and this study aims to conduct a literature review of the main secondary metabolite components of these plants. and see the correlation between the major components and their efficacy on the lungs. This research was conducted using the literature review method through various databases by extracting from 124 scientific journals information about 58 plants that are efficacious for lung organs according to Al Qanun Fi'l Tibb and data has been produced in the form of the content of the main secondary metabolites of these plants, namely flavonoids, terpenes, tannins, lignans., saponins, anthraquinones, glucosinolates, phenolic acids, sekoiridoids, steroids, and alkaloids as the major components. Based on the results of this review, the main components of secondary metabolites are known to have reported beneficial bioactivities in the treatment of the respiratory system and lung organ.

Uji Aktivitas Ekstrak Daun Mengkudu (Morindra citrifolia Linn) dan Scopoletin secara In-Vitro terhadap Bakteri Tuberkulosis Dhilasari, Estu Mahanani; Kusumawati, Idha Kusumawati; Primaharinastiti, Riesta Primaharinastiti
Indonesian Journal of Pharmacy and Natural Product Vol. 2 No. 1 (2019)
Publisher : Universitas Ngudi Waluyo

Penyakit tuberkulosis disebabkan oleh bakteri Mycobacterium tuberculosis. Secara tradisional mengkudu digunakan untuk pengobatan tuberkulosis. Scopoletin merupakan komponen utama dalam mengkudu, oleh karena itu scopoletin sering dijadikan marker dalam studi farmakokinetik. Tujuan penelitian ini adalah untuk mengetahui aktivitas anti-Mycobacterium tuberculosis (H37RV) ekstrak daun mengkudu dan scopoletin melalui penentuan Konsentrasi Hambat Minimum (KHM). Uji aktivitas antibakteri dan penentuan KHM dari ekstrak etanol 50% daun mengkudu dilakukan dengan metode dilusi agar dengan konsentrasi 1,0Ã—10-4 Âµg/ml â€“ 5,1Ã—10-11 Âµg/ml. Uji aktivitas menunjukan bahwa ekstrak etanol 50% daun mengkudu dapat menghambat pertumbuhan Mycobacterium tuberculosis dengan KHM 4,0Ã—10-6 Âµg/ml. Sedangkan scopoletin dengan konsentrasi yang setara dengan kandungan pada ekstrak tidak menunjukan aktivitas anti-Mycobacterium tuberculosisnya.Kata kunci: Mengkudu, Scopoletin, tuberkulosisTuberculosis (TB) is a disease caused by a bacterium, Mycobacterium tuberculosis. Morinda citrifolia Linn has been found to kill Mycobacterium tuberculosis. Scopoletin is a major component in Morinda citrifolia Linn, therefore scopoletin often used as markers in studies of pharmacokinetic. This research purpose to determine anti-Mycobacterium tuberculosis (strain H37RV) activity based on the value of Minimum Inhibitory Concentration (MIC) used to ethanolic extracts from Morinda citrifolia Linn leaf and scopoletin. Experiment of anti-Mycobacterium tuberculosis activities tested by well dillution methods with a dose 1,0Ã—10-4 Âµg/ml â€“ 5,1Ã—10-11 Âµg/ml . The results showed that ethanolic extract Morinda citrifolia Linn leaf Â were found to be active to Mycobacterium tuberculosis activity with MIC 4Ã—10-6 Âµg/ml while scopoletin at the same concentration with extract had no antiÂ- Mycobacterium tuberculosis activity.Keywords:Â Noni, scopoletin, tuberculosis

Pengaruh Penambahan Enhancer Isopropil Miristat dan dan Propilen Glikol terhadap Penetrasi Krim Asiklovir Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.25859

Acyclovir, a BCS class III drug, has a high ability to fight the herpes virus but has low permeability and is poorly soluble in water. In order to obtain the expected effect of viral infection on the skin, the penetration of the active ingredients becomes a critical factor for a topical treatment to achieve the desired concentration. This study was to see the effect of adding isopropyl myristate and propylene glycol as enhancers that help diffuse the drug through the stratum corneum. The formulation is made by adding enhancer propylene glycol 8% (F1), isopropyl myristate 8% (F2), and without enhancers (F3). Physical stability of acyclovir cream, including homogeneity, organoleptic, pH, viscosity, type of emulsion and power spread, and in vitro cream penetration test with Franz diffusion cells will be observed. The result of acyclovir cream preparations F1, F2, and F3 had a homogeneous preparation of white semisolid and odorless with pH between 7,30-7,60, emulsion type o/w, and a viscosity between 35000-47000 cPS. The cumulative amount of acyclovir penetrated at F3 was 226,008± 8,462 μg/cm2, while the cream containing the enhancers F1 258,059±1,730 μg/cm2 and F2 268,336±0,740 μg/cm2, respectively. The presence of enhancers will increase the penetration ability of acyclovir cream, with more penetration using isopropyl myristate than propylene glycol.

A retrospective descriptive cross-sectional study of Oral Dosage Form Administered in The Form of Suspension to ICU Patients at Hospital X Suryani, Nelly; Anwar, Vidia Arliani; Saibi, Yardi; Dhilasari, Estu Mahanani; Dahlizar, Sabrina; Betha, Ofa Suzanti; Komala, Ismiarni; Azzahra, Afifah Nurnishrina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.41341

Patients in the intensive care unit were often very sick and had lost consciousness. Because they had trouble swallowing, individuals with reduced awareness frequently depended on enteral tubes (NGT) for their daily medical and nutritional requirements. Since not all medications were accessible in parenteral forms, patients who relied on enteral tubes often had issues, including drug stability. Many problems arose in clinical usage when the medication was crushed or suspended and put into the NGT, including drug obstruction in the enteral tube and a reduction in drug stability as a result of the dose form being altered, making the drug unstable. Thus, this study aimed to ascertain the stability of oral suspension medications given to intensive care unit patients. The medical records of intensive care unit patients who had received oral medication therapy at X Hospital in Jakarta were examined retrospectively using a cross-sectional, descriptive approach. According to the statistics, coated tablets accounted for 68% of the most frequently used oral medication preparations. It was highly likely that crushing the coated tablets and administering them via NGT had resulted in tube obstruction. Additionally, 59.26% of the medications used had exhibited hygroscopic qualities, and several had been readily hydrolyzed. Based on these findings, it was concluded that oral medications, particularly crushed-coated tablets, could negatively affect drug stability. Active substances with hygroscopic properties and those prone to hydrolysis were also identified as potential contributors to instability.

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