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Analisis Pola Peresepan Obat Berdasarkan Perbedaan Status Penjamin (BPJS dan Non-BPJS) Rahayu, Retno Tri; Marvel, Marvel; Nurmeilis, Nurmeilis; Dhilasari, Estu Mahanani
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.39009

Evaluasi penggunaan obat merupakan aspek krusial dalam pelayanan farmasi klinik di fasilitas kesehatan. Tujuan penelitian ini adalah menganalisis hubungan antara status penjamin (BPJS dan non-BPJS) dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kementerian Kesehatan Republik Indonesia (Kemenkes RI) di sebuah klinik di daerah Kroya (Provinsi Jawa Tengah) pada tahun 2020. Indikator peresepan yang digunakan mencakup rerata jumlah obat per lembar resep, persentase peresepan antibiotik untuk ISPA non-pneumonia (batuk-pilek) dan diare non-spesifik, serta peresepan injeksi untuk myalgia. Penelitian ini menggunakan desain cross-sectional dengan data diperoleh secara retrospektif dari resep dan buku rawat jalan pasien. Sampel dipilih menggunakan teknik total sampling, menghasilkan 2.206 sampel resep yang dianalisis. Hasil penelitian menunjukkan perbedaan yang bermakna secara statistik (p<0,05) antara penjamin BPJS dan non-BPJS dalam semua indikator peresepan yang dievaluasi. Perbedaan ini terlihat pada rerata jumlah obat yang diresepkan (BPJS: 2,91; non-BPJS; 3,42), persentase peresepan antibiotik pada ISPA non-pneumonia (BPJS: 41,5%; non-BPJS: 63,1%), persentase peresepan antibiotik pada diare non-spesifik (BPJS: 39,8%; non-BPJS: 68,1%), dan persentase peresepan injeksi pada myalgia (BPJS: 0,0%; non-BPJS: 4,1%). Terdapat hubungan yang signifikan antara status penjamin dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kemenkes RI.

Review Kandungan Metabolit Sekunder Tanaman Berkhasiat terhadap Tulang dan Sendi menurut Al-Qanun Fi’l Tibb II Siregar, Barita Juliano; Sangadji, Sarah Nahdah Zhaafirah; Betha, Ofa Suzanti; Dhilasari, Estu Mahanani
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 4 No. 2 (2022)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i2.25611

Al-Qanun Fi’l Tibb II merupakan buku materia medica karya Ibnu Sina yang terkenal di dunia. Buku tersebut menjelaskan secara rinci mengenai monografi tanaman berkhasiat terhadap organ tubuh, salah satunya terhadap tulang dan sendi. Akan tetapi dalam buku tersebut belum memuat komponen major metabolit sekunder yang diduga berperan penting dalam memberikan efek farmakologis. Penelitian ini ditujukan untuk menginventarisasi tumbuhan yang terdapat di dalam buku Al-Qanun Fi’l Tibb II dan melakukan literatur review terkait kandungan metabolit sekunder yang terdapat dalam tanaman tersebut. Metode penelitian dilakukan dengan literature review melalui studi kepustakaan. Hasil pengambilan data menunjukan terdapat 74 tanaman yang berkhasiat terhadap tulang dan sendi diantaranya memiliki komponen major metabolit sekunder seperti senyawa terpen, flavonoid, alkaloid, tanin, alil isotiosianat, saponin, glikosida, alkohol lemak, asam fenolat, benzofenon, kuinon, sekoiridoid, kumarin, stilbene, anthrone, naftalen, benzaldehida dan asam karboksilat. Terpen merupakan metabolit sekunder yang paling banyak ditemukan dalam tanaman yang berkhasiat terhadap tulang dan sendi. Bioaktivitas yang ditemukan pada tanaman diantaranya antigout, antioksidan, osteoprotektif, antiosteoporosis, antibakteri, antiinflamasi dan analgesik.

Analisis Pola Peresepan Obat Berdasarkan Perbedaan Status Penjamin (BPJS dan Non-BPJS) Retno Tri Rahayu; Marvel Marvel; Nurmeilis Nurmeilis; Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.39009

Evaluasi penggunaan obat merupakan aspek krusial dalam pelayanan farmasi klinik di fasilitas kesehatan. Tujuan penelitian ini adalah menganalisis hubungan antara status penjamin (BPJS dan non-BPJS) dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kementerian Kesehatan Republik Indonesia (Kemenkes RI) di sebuah klinik di daerah Kroya (Provinsi Jawa Tengah) pada tahun 2020. Indikator peresepan yang digunakan mencakup rerata jumlah obat per lembar resep, persentase peresepan antibiotik untuk ISPA non-pneumonia (batuk-pilek) dan diare non-spesifik, serta peresepan injeksi untuk myalgia. Penelitian ini menggunakan desain cross-sectional dengan data diperoleh secara retrospektif dari resep dan buku rawat jalan pasien. Sampel dipilih menggunakan teknik total sampling, menghasilkan 2.206 sampel resep yang dianalisis. Hasil penelitian menunjukkan perbedaan yang bermakna secara statistik (p<0,05) antara penjamin BPJS dan non-BPJS dalam semua indikator peresepan yang dievaluasi. Perbedaan ini terlihat pada rerata jumlah obat yang diresepkan (BPJS: 2,91; non-BPJS; 3,42), persentase peresepan antibiotik pada ISPA non-pneumonia (BPJS: 41,5%; non-BPJS: 63,1%), persentase peresepan antibiotik pada diare non-spesifik (BPJS: 39,8%; non-BPJS: 68,1%), dan persentase peresepan injeksi pada myalgia (BPJS: 0,0%; non-BPJS: 4,1%). Terdapat hubungan yang signifikan antara status penjamin dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kemenkes RI.

A retrospective descriptive cross-sectional study of Oral Dosage Form Administered in The Form of Suspension to ICU Patients at Hospital X Nelly Suryani; Vidia Arliani Anwar; Yardi Saibi; Estu Mahanani Dhilasari; Sabrina Dahlizar; Ofa Suzanti Betha; Ismiarni Komala; Afifah Nurnishrina Azzahra
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.41341

Patients in the intensive care unit were often very sick and had lost consciousness. Because they had trouble swallowing, individuals with reduced awareness frequently depended on enteral tubes (NGT) for their daily medical and nutritional requirements. Since not all medications were accessible in parenteral forms, patients who relied on enteral tubes often had issues, including drug stability. Many problems arose in clinical usage when the medication was crushed or suspended and put into the NGT, including drug obstruction in the enteral tube and a reduction in drug stability as a result of the dose form being altered, making the drug unstable. Thus, this study aimed to ascertain the stability of oral suspension medications given to intensive care unit patients. The medical records of intensive care unit patients who had received oral medication therapy at X Hospital in Jakarta were examined retrospectively using a cross-sectional, descriptive approach. According to the statistics, coated tablets accounted for 68% of the most frequently used oral medication preparations. It was highly likely that crushing the coated tablets and administering them via NGT had resulted in tube obstruction. Additionally, 59.26% of the medications used had exhibited hygroscopic qualities, and several had been readily hydrolyzed. Based on these findings, it was concluded that oral medications, particularly crushed-coated tablets, could negatively affect drug stability. Active substances with hygroscopic properties and those prone to hydrolysis were also identified as potential contributors to instability.

Physical Stability Test and Total Phenolic Content Determination of Spray Gel Formulation with Ethanol 70% Melinjo Leaf (Gnetum gnemon L.) Extract with Combination of Carbopol 940 and HPMC as Gelling Agent Nelly Suryani; Vivi Anggia; Halimah Dewi; Rosa Adelina; Sabrina Dahlizar; Ofa Suzanti betha; Estu Mahanani Dhilasari; Ismiarni Komala; Yardi Saibi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.45975

The stability of a pharmaceutical preparation is very important in formulation to ensure product efficacy and safety. This research aims to test the physical stability and total phenolic content of a spray gel preparation made from 70% ethanol extract of melinjo leaves (Gnetum gnemon L.) with a combination of Carbopol 940 and HPMC as gelling agents. Antioxidant activity was tested using the DPPH method, while total phenolic content was measured using the Folin-Ciocalteu reagent and expressed in gallic acid equivalents (mgGAE/g). The results analysis of total phenolic content in the 70% ethanol extract of melinjo leaves showed a value of 46.237 mg GAE/g. Meanwhile, the total phenolic content in the spray gel formulation of the 70% ethanol extract of melinjo leaves was recorded at 0.88 mg GAE/g."Based on evaluation, the best formula is a combination of Carbopol and Hidroxypropyl methylCellulosa, HPMC (0.4%:0.4%), but the stability test results show physical instability. Further modifications are required to produce a physically stable formula.

Analisis Kandungan Hidrokuinon dan Niasinamid pada Krim Pemutih Racikan di Klinik Kecantikan Wilayah Bekasi Selatan Novia Ramadhani; Supandi; Estu Mahanani Dhilasari; Mabrurotul Mustafidah; Nelly Suryani; Marvel
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.48740

Hydroquinone and niacinamide are whitening agents used alone or combined with cream products. Currently, the level of hydroquinone still exceeds the recommended safety limit. This study aimed to identify and determine the levels of hydroquinone and niacinamide in whitening creams prescribed by a beauty clinic in South Bekasi. The UV-Vis spectrophotometry was performed simultaneously. This study begins with the validation of analytical methods using validation parameters. Hydroquinone and niacinamide were identified using five samples, determined by purposive sampling, and measured at the maximum wavelengths of hydroquinone (293.4 nm) and niacinamide (261.4 nm). The results of the method validation showed that the linearity values expressed in the correlation coefficient (r) at concentrations of hydroquinone 8-28 µg/mL and niacinamide 10-34 µg/mL were 0,9999 and 0.998, LOD values 0,3990 and 0,3525 µg/mL, LOQ values were 1,3299 and 1,1749 µg/mL, RSD values of 0,0909% and 0,2591%, and recovery values were in the range of 99,154±0,223% to 107,387±0,121%. Based on the research data, it can be concluded that the five samples contained hydroquinone and niacinamide compounds at levels of 17,246% and 1,211% (A), 18,002% and 2,034% (B), 5,033% and 0,823% (C), 0,952% and 0,575% (D), and 0,10% and 5,367% (E). Samples A, B, and C have hydroquinone content exceeding the permitted maximum, while sample E contains niacinamide in an amount exceeding the recommendation.

Formulation and Stability of Miana Leaf Extract Spray Gel with Antioxidant Nelly Suryani; Rachmadi Wibowo; Rosa Adelina; Vivi Anggia; Tania Sabarini; Sabrina Dahlizar; Ofa Suzanti Betha; Estu Mahanani Dhilasari
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.100561.179-190

The extract of Miana leaves (Coleus scutellarioides L.) is recognized for possessing potent antioxidant Action. This research aimed to develop a physically stable spray gel incorporating miana leaf extract and to evaluate its antioxidant potential through the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Three formulations with different proportions of Carbopol and hydroxypropyl methylcellulose (HPMC) were evaluated for stability under room-temperature storage and during cycling tests, with organoleptic characteristics and viscosity as assessment parameters. The extract alone exhibited very strong antioxidant Action (IC₅₀ = 47.71 ppm). In comparison, the spray gel formulations showed IC₅₀ values of 141.18 ppm (FE1, 1%), 113.72 ppm (FE2, 3%), and 80.90 ppm (FE3, 5%), corresponding to moderate, moderate, and strong Action, respectively. Among these, FE2 (3% extract) demonstrated the most favorable physical stability.

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