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Tinjauan atas Kanker Rongga Mulut Permasutha, Made Bayu
Cermin Dunia Kedokteran Vol 48, No 3 (2021): Obstetri dan Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Kanker rongga mulut merupakan keganasan daerah mulut dan rongga mulut. Beberapa faktor risiko kanker rongga mulut yang sering ditemukan di Indonesia meliputi merokok, menyirih, penggunaan tembakau, dan minuman beralkohol. Tumor rongga mulut dibagi menjadi tumor jinak, lesi prakanker, dan kanker rongga mulut. Modalitas terapi kanker rongga mulut dan orofaring berupa pembedahan, terapi radiasi, kemoterapi, targeted therapy, dan paliatif.Oral cancer is a malignancy in the mouth and oral cavity. Some risk factors often found in Indonesia are smoking, betel chewing , tobacco use, and alcohol. Oral tumours are divided into benign tumors, precancerous lesions, and oral cancer. Therapeutic modalities for oral and oropharynx cancer consist of surgery, radiation therapy, chemotherapy, targeted therapy, and palliative.Â

Tinjauan atas Kanker Rongga Mulut Made Bayu Permasutha
Cermin Dunia Kedokteran Vol 48, No 3 (2021): Obstetri dan Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i3.1327

Kanker rongga mulut merupakan keganasan daerah mulut dan rongga mulut. Beberapa faktor risiko kanker rongga mulut yang sering ditemukan di Indonesia meliputi merokok, menyirih, penggunaan tembakau, dan minuman beralkohol. Tumor rongga mulut dibagi menjadi tumor jinak, lesi prakanker, dan kanker rongga mulut. Modalitas terapi kanker rongga mulut dan orofaring berupa pembedahan, terapi radiasi, kemoterapi, targeted therapy, dan paliatif.Oral cancer is a malignancy in the mouth and oral cavity. Some risk factors often found in Indonesia are smoking, betel chewing , tobacco use, and alcohol. Oral tumours are divided into benign tumors, precancerous lesions, and oral cancer. Therapeutic modalities for oral and oropharynx cancer consist of surgery, radiation therapy, chemotherapy, targeted therapy, and palliative.

Tinjauan atas Kanker Rongga Mulut Made Bayu Permasutha
Cermin Dunia Kedokteran Vol. 48 No. 3 (2021): Obstetri - Ginekologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i3.47

Kanker rongga mulut merupakan keganasan daerah mulut dan rongga mulut. Beberapa faktor risiko kanker rongga mulut yang sering ditemukan di Indonesia meliputi merokok, menyirih, penggunaan tembakau, dan minuman beralkohol. Tumor rongga mulut dibagi menjadi tumor jinak, lesi prakanker, dan kanker rongga mulut. Modalitas terapi kanker rongga mulut dan orofaring berupa pembedahan, terapi radiasi, kemoterapi, targeted therapy, dan paliatif. Oral cancer is a malignancy in the mouth and oral cavity. Some risk factors often found in Indonesia are smoking, betel chewing, tobacco use, and alcohol. Oral tumors are divided into benign tumors, precancerous lesions, and oral cancer. Therapeutic modalities for oral and oropharynx cancer consist of surgery, radiation therapy, chemotherapy, targeted therapy, and palliative.

BLASTOCYSTIS HOMINIS INFECTION IN CHILDREN WITH HIV/AIDS DURING COVID-19 RELATED DISRUPTION ERA: A CROSS-SECTIONAL STUDY Permasutha, Made Bayu; Diptyanusa, Ajib
The Indonesian Journal of Public Health Vol. 19 No. 3 (2024): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v19i3.2024.520-533

Introduction: The coronavirus disease 2019 (COVID-19) epidemic has resulted in significant disruption to health services in multiple nations. In Indonesia, the impact occurred on changes in services for HIV/AIDS patients. As a result, there is a high rate of parasitic co-infection disease, including Blastocystis hominis. Prior research indicates that the occurrence of this illness varies greatly among individuals with HIV/AIDS, with rates ranging from 3.86% to 72.40%. Aims: The objective of this study is to ascertain the prevalence and molecular epidemiology of infection, develop a predictive model, and examine the correlation between clinical symptoms and the severity of Blastocystis results. Methods: Thirty-eight children with HIV/AIDS in Yogyakarta-Indonesia, from May until August 2021 were examined by direct examination, culture, PCR, and sequencing. In addition, a structured questionnaire was used to obtain additional data regarding baseline information and other factors influencing Blastocystis infection. The results obtained were subjected to phylogenetic, univariate and multivariate data analysis. Results: Out of the 38 samples studied, 26 (68.4%) were positive for Blastocystis. The results of sequencing demonstrated the finding of subtype 3 (ST3) and subtype 4 (ST4). From univariate and multivariate analysis, a longer duration of therapy is a predictor of Blastocystis infection (AOR 6.54, P=0.04). The relationship between clinical manifestations and intensity of Blastocystis findings showed a non-significant association (P>0.99). Conclusion: Children with HIV/AIDS had a significantly high incidence of Blastocystis infection, potentially attributed to the interruption of services resulting from the COVID-19 pandemic.

Tinjauan atas Kanker Rongga Mulut Made Bayu Permasutha
Cermin Dunia Kedokteran Vol 48 No 3 (2021): Obstetri - Ginekologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i3.47

Kanker rongga mulut merupakan keganasan daerah mulut dan rongga mulut. Beberapa faktor risiko kanker rongga mulut yang sering ditemukan di Indonesia meliputi merokok, menyirih, penggunaan tembakau, dan minuman beralkohol. Tumor rongga mulut dibagi menjadi tumor jinak, lesi prakanker, dan kanker rongga mulut. Modalitas terapi kanker rongga mulut dan orofaring berupa pembedahan, terapi radiasi, kemoterapi, targeted therapy, dan paliatif. Oral cancer is a malignancy in the mouth and oral cavity. Some risk factors often found in Indonesia are smoking, betel chewing, tobacco use, and alcohol. Oral tumors are divided into benign tumors, precancerous lesions, and oral cancer. Therapeutic modalities for oral and oropharynx cancer consist of surgery, radiation therapy, chemotherapy, targeted therapy, and palliative.

Effect of Fetal Bovine Serum Concentration on Detection and Morphological Identification of Blastocystis hominis in vitro Janendra, Putu Sathiya Adi; Sukarma, Kadek Edy; Sarita, Kadek intan Arta; Maheswari, Kadek Indira; Giri, Made Kurnia Widiastuti; Permasutha, Made Bayu; Pasala, Metamalik
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 2 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i2.64829

Diarrhea significantly contributes to the high rates of illness and death among young children. Diarrhea can be caused by bacterial infections, viruses, or even parasites. Blastocystis hominis causes parasitic diarrhea, which can be identified by microscopy, culture, and molecular methods. Previous reports have modified the Jones’ culture medium using three different serums, such as human plasma, donkey serum, and horse serum (in Jones’ medium). This research replaces horse serum with fetal bovine serum for detection tests, morphological observation, and diagnosis of B. hominis. The research encompasses five experimental groups, each subjected to varying concentrations of fetal bovine serum: 2%, 10%, 20%, 30%, and 40%. Detection analysis is conducted using the Mc-Nemar test, while the Wilcoxon test is applied to evaluate ordinal data from morphological assessments. Diagnostic tests and metrics such as accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) are performed using MedCalc® software. The findings demonstrate that serum concentrations of 2%, 10%, 20%, and 30% produced effective results in detection tests, morphological identification, and diagnostic evaluations of B. hominis, exhibiting high sensitivity, specificity, PPV, NPV, and accuracy. Fetal bovine serum can be used at a concentration of 2% in a Jones’ medium that has been modified. This depends on the results of detection tests, morphology, and diagnosis.

Modification of the Kato-Katz Diagnosis Technique Using “Canang” Flower Waste Extract as a Staining for Ascaris lumbricoides Eggs Maheswari, Kadek Indira; Janendra, Putu Sathiya Adi; Widnyana, I Komang Tri Yasa; Mahayana, Dewa Gede Putra; Pramesti, Komang Kirana Ardhia; Dwisaputra, Indra; Permasutha, Made Bayu; Wiguna, Nyoman Intan Permatahati; Giri, Made Kurnia Widiastuti
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.71-78

Helminthiasis, particularly that caused by Ascaris lumbricoides, is a major global health issue, especially in areas with poor sanitation. One method for preventing and controlling Ascaris lumbricoides infection is through identification via the Kato-Katz diagnostic technique. The use of synthetic dyes, such as methylene blue, in the Kato-Katz method raises concerns for both human health and the environment. In humans, methylene blue causes skin irritation, gastrointestinal issues upon ingestion, and systemic effects. Furthermore, its environmental impact includes reducing light penetration and acting as a toxic component in food chains. An alternative approach involves utilizing post-use offerings from Hindu rituals in Bali, known as canang, which consist of flower components such as Impatiens balsamina L. and Tagetes erecta. The natural dyes found in these flowers serve as an alternative to traditional staining methods. This study examined the efficacy of flower extracts as stainings using the cellophane absorption test, helminth egg detection and morphology identification, pH test, and measurement of heavy metal concentration. The dye made from canang flower waste at 3% did not differ much from manufactured stainings. Thus, canang flower waste is a safe alternative.

UJI FITOKIMIA DAN GUGUS FUNGSI EKSTRAK ETANOL DAUN Spondias pinnata (L.f.) Kurz Sari, Desak Made Vina Puspita; Permasutha, Made Bayu; Wiguna, Nyoman Intan Permatahati; Kurniawathi, Ni Luh Ranthi; Krisnadevi, I Gusti Agung Ayu Ari; Maheswari, Ni Putu Devi
Jurnal Farmasi Higea Vol 17, No 2 (2025)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v17i2.759

Masyarakat Indonesia sampai saat ini masih sering menggunakan obat herbal karena manfaatnya dan harganya yang murah. Bali adalah daerah yang memanfaatkan tanaman sebagi obat-obatan, salah satunya adalah loloh daun cemcem. Loloh daun cemcem diyakini dapat menambah nafsu makan, mengurangi gejala batuk kering, memperlancar buang air kecil, mengontrol tekanan darah, meredakan panas dalam, mengembalikan cairan tubuh, dan obat pencahar. Penelitian ini bertujuan sebagai deteksi awal fitokimia dan validasi gugus fungsi yang dimiliki oleh ekstrak etanol daun cemcem. Proses ekstraksi pada penelitian ini menggunakan metode maserasi dengan pelarut etanol pronalisis. Uji fitokimia menganalisis alkaloid, flavonoid, fenolik, tanin, dan saponin. Analisis gugus fungsi dilakukan dengan metode Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR). Berdasarkan, pengujian fitokimia didapatkan bahwa senyawa metabolit sekunder alkaloid, flavonoid, fenolik, tanin, dan saponin terkandung dalam ekstrak etanol daun cemcem. Metode ATR-FTIR menunjukkan senyawa fenolik, flavonoid, tanin, dan glikosida karena teridentifikasinya gugus –OH, C–H, C=O, C=C, dan C–O.

Stroke Hemorrhagic et Causa Ruptur Aneurysma Anterior Communicating Artery: Case Report Meilani, Ni Komang Putri; Kamelia, Luh Putu Lina; Permasutha, Made Bayu; Puspitayanti, Ni Putu Leony; Soeka, Luh Made Anindita Adristi
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10454

Bleeding in the brain is life-threatening. Two types of bleeding are subarachnoid hemorrhage (SAH) and intraventricular hemorrhage (IVH). SAH is defined as bleeding that occurs in the subarachnoid space, which is the space between the arachnoid membrane and the pia mater. Meanwhile, IVH is bleeding that occurs within the brain's ventricular system, which is a cavity containing cerebrospinal fluid (CSF). The incidence of SAH is quite high, reaching 8.09 million cases out of all stroke cases. Meanwhile, IVH only accounts for 0.31% of total stroke cases. The purpose of this study is to document medical cases as a form of the latest clinical knowledge. The method used is qualitative with a case study design to analyze the management of hemorrhagic stroke patients at the RSUD Buleleng. The patient underwent a neurological physical examination in the form of a meningeal sign examination, which showed positive neck stiffness, Kernig's sign (-), and Brudzinski's sign I-IV (-). Eye examination revealed that both pupils were 3 mm in size, with light reflexes +/+. The patient did not exhibit any weakness or paralysis on one side of the body. Based on clinical symptoms and findings from radiological examinations and DSA, the patient was diagnosed with Hemorrhagic Stroke + Intraventricular Hemorrhage due to rupture of the anterior communicating artery aneurysm segment A1 with daughter SAC. The patient was administered Loading Normal Saline 0.9% 18 tpm, Oxygen 3 lpm, loading Mannitol 200 mL followed by 100 mL 6 times tapering off, Citicoline 2x250 mg intravenously, Omeprazole 2x40 mg intravenously, Painless 2x400 mg, and Dexamethasone injection 2x1 ampoule. as initial treatment.

LITERATUR REVIEW : POTENSI PENGGUNAAN EKSTRAK DAUN KAYU MANIS (CINNAMOMUM BURMANNII) SEBAGAI ANTIBIOTIK ALTERNATIF BERBASIS HERBAL Jayachrisna, Komang Satrya Jati; Permasutha, Made Bayu; Rahmayani, Irma
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 3 (2025): DESEMBER 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i3.51656

Infeksi yang disebabkan oleh bakteri terus menjadi tantangan besar bagi kesehatan masyarakat, terutama di negara berkembang. Penggunaan antibiotik sintetis yang berlebihan dan tidak tepat telah berkontribusi besar terhadap munculnya bakteri resisten antibiotik, yang saat ini bertanggung jawab atas sekitar 1,27 juta kematian setiap tahunnya. Kondisi ini menegaskan adanya kebutuhan mendesak akan terapi alternatif yang lebih aman dan berkelanjutan, termasuk pemanfaatan antibiotik berbasis herbal. Salah satu opsi yang berpotensi adalah daun Cinnamomum burmannii, yang kaya akan berbagai senyawa bioaktif seperti flavonoid, alkaloid, saponin, tanin, dan fenol. Senyawa-senyawa ini memiliki berbagai mekanisme antibiotik, seperti merusak membran sel bakteri, menghambat sintesis asam nukleat dan protein, menonaktifkan enzim, serta mengganggu metabolisme energi. Sejumlah penelitian in vitro menunjukkan bahwa ekstrak daun Cinnamomum burmannii memiliki aktivitas antibiotik sedang hingga kuat terhadap patogen seperti Staphylococcus aureus, Escherichia coli, dan Salmonella Typhi. Selain efektivitasnya, penggunaan ekstrak daun Cinnamomum burmannii dianggap lebih aman, ekonomis, dan memiliki risiko lebih rendah dalam memicu resistensi. Namun, penerapan ekstrak ini di lingkungan klinis masih terbatas karena minimnya penelitian in vivo dan studi klinis yang membahas keamanan, toksisitas, farmakokinetik, dan farmakodinamiknya. Penelitian lebih lanjut sangat diperlukan untuk menggali secara menyeluruh potensi terapeutik ekstrak daun Cinnamomum burmannii sebagai agen antibiotik alternatif berbasis bukti.

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