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All Journal Medula Jurnal Ilmu Kesehatan JKM (Jurnal Kebidanan Malahayati) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati ARTERI : Jurnal Ilmu Kesehatan Jurnal Penelitian Fisika dan Terapannya (JUPITER) CEMERLANG :Jurnal Manajemen dan Ekonomi Bisnis Jurnal Riset Akuntansi Jurnal Kajian Dan Penalaran Ilmu Manajemen JOURNAL OF Mother and Child Health Concerns FINANCE : International Journal Of Management Finance Bersama: Jurnal Pengabdian Kepada Masyarakat
Dita Fitriani
Departemen Fisiologi Fakultas Kedokteran Universitas Malahayati
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Correlations of alanine and aspartate aminotransferase levels with high-sensitivity C-reactive protein in pediatric patients with beta-thalassemia major Wahyu Rahma Sari; Mulat Muliasih; Dita Fitriani; Muhammad Nur
THE JOURNAL OF Mother and Child Health  Concerns Vol. 5 No. 5 (2026): August 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/mchc.v5i5.3916

Abstract

Background: Beta-thalassemia major is a hereditary blood disorder characterized by severe anemia requiring lifelong regular blood transfusions. Repeated transfusions may lead to iron overload, which can cause oxidative stress, hepatocellular injury, and chronic inflammation. Serum glutamic-pyruvic transaminase (SGPT) and serum glutamic-oxaloacetic transaminase (SGOT) are commonly used to assess hepatocellular injury, whereas high-sensitivity C-reactive protein (hs-CRP) can detect low-grade systemic inflammation. Purpose: To determine the correlation between SGPT and SGOT levels and hs-CRP levels in pediatric patients with beta-thalassemia major. Method: This analytical observational study used a cross-sectional design and secondary data from medical records of pediatric patients with beta-thalassemia major treated at Pringsewu Regional General Hospital. Data were collected in February 2025 from records of patients treated between September and November 2024. A purposive sampling technique was used based on predetermined inclusion and exclusion criteria, resulting in 43 eligible patients. Data were analyzed using the Spearman correlation test with a significance level of p < 0.05. Results: The mean SGPT, SGOT, and hs-CRP levels were 58.86 ± 30.749 U/L, 55.67 ± 23.551 U/L, and 1.1216 ± 1.19167 mg/L, respectively. A significant positive correlation was found between SGPT and hs-CRP levels (p = 0.025; r = 0.341), indicating a weak positive correlation. A significant positive correlation was also found between SGOT and hs-CRP levels (p = 0.005; r = 0.421), indicating a moderate positive correlation. Conclusion: SGPT and SGOT levels were significantly and positively correlated with hs-CRP levels in pediatric patients with beta-thalassemia major. These findings suggest that hepatocellular injury and systemic inflammation may occur concurrently in patients with transfusion-dependent beta-thalassemia.
Co-Authors - Hwihanus Achmad Farich Ade Maria Ulfa Ahkmad Kheru Darmawan Annisa Putri Aswan Jhonet Austine Widya Kusuma Diah Adelia Emilda Elitha M. Uthari Endah Rachmawati Essy Nadya Putri Eza Bintang Ramadhan Fadel Al Barra Ferza Rusdiansyah Fonda Octarianingsih Shariff Hanifah Ulfa Azzahro Hasbie, Neno Fitriyani Hermawan, Dessy Hetti Rusmini Indri Widya Wulandari Kurniati, Mala Lulu' Rifatunnissa Maria Ulfa, Ade Maria Yovita R Pandin Miftahul Jannah Gafar Mohammad Hafizh Al Waali Muhammad Nur Mulat Muliasih Nanang Priambodo Neng Susi nurmalasari, yesi Prastowo, Sri Handono Budi Rahmah Rahmah Reza Mutiara Nur Fitriandinni Ricki Gustiawan Rina Kriswiastiny Risna Hidayanti Rita Agustina Rita Agustina Rusmini, Hetti Shinta Nuriyah Mahbubiyah Royani Syuhada Syuhada Talitha Nabilah Toni Prasetya Tri Ratnawati Vestnanda, Alfrida Diftia Wahyu Rahma Sari Widya Novita Sari Yuliana Wildani Marek Zahrotul Fuadiyah Zulfian Zulfian