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All Journal Majalah Kesehatan FKUB Oceana Biomedicina Journal Jurnal Klinik dan Riset Kesehatan
Aina Angelina
Universitas Brawijaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Plasma cell myeloma: Pendekatan diagnosis dari aspek kliniko-morfologik dan imunofenotipe Angelina, Aina; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.5

Abstract

Plasma cell myeloma (PCM)/Mutiple myeloma (MM) is hematologic malignancy characterized by the proliferation of neoplastic plasma cells of bone marrow. The manifestation of disease include multifocal lytic bone lesions, increased serum or urine M protein, target organ damage, and can present as an extramedullary mass. Extramedullary tumor mass biopsy can show morphology that overlaps with other plasma cell neoplasms or malignant lymphoma, this become a diagnostic challenge especially if the clinical and radiological information is incomplete. End-organ damage attributable to abnormal plasma cell proliferation is known as CRAB consist of hypercalcemia, renal insufficiency, anemia and bone lesions. The clinical spectrum often varies so the diagnosis of PCM requires the integration of clinical, laboratory, imaging, morphology, and immunophenotype data. Histopathological examination of bone marrow biopsy and tumor mass biopsy needs to be confirmed by immunohistochemical examination and clonality tests to establish an accurate diagnosis. This review intends to explain the clinical, morphological and immunophenotypic aspects as well as construct an approach to the diagnosis of PCM.
Co-Authors Agustin Iskandar Anggie Sasmita Kharisma Putri Dewi, Rose Khasana Diah Prabawati Ervina, Rita Ery Olivianto Eviana Norahmawati Eviana Norahmawati Fadli, Muhammad Luqman Harun Al Rasyid Ihda Dian Kusuma Immanuel Natanael Tarigan Karyono Mintaroem Kenty Wantri Anita, Kenty Wantri Kurnia Penta Seputra Nurjati Chairani Siregar Putri, Anggie Putri, Anggie Sasmita Kharisma Rambe, Annisa Fadhila Aurelia Retnani, Diah Retnani, Diah Prabawati Soehartono Sudarmanto, Yohanes Ulfaningtyas, Kiki Yudhanto, Hendy