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All Journal Jurnal Keperawatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Women´s Studies Medica Hospitalia Jurnal Kesehatan Kusuma Husada Journal of Nursing Science Update Jurnal Kebidanan dan Keperawatan Aisyiyah Medika Respati : Jurnal Ilmiah Kesehatan Medica Majapahit
Retty Ratnawati
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Agriculture, Biological Sciences & Forestry Arts Humanities Dentistry Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Evaluation Anxiolytic Effect of Methanol Extract of Ceplukan Leaves (Physalis minima L.) in the Elevated Plus Maze Test through IL-6 Level Changes in Ovariectomized Rats Siti Nurfitria; Nur Permatasari; Retty Ratnawati
Journal of Tropical Life Science Vol. 5 No. 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

Abstract

Ceplukan (Physalis minima L.) has long been used to treat various conditions in traditional medicine. This study aims to demonstrate the anxiolytic effects of Methanol Extract of Ceplukan Leaves (MECL) in the Elevated Plus Maze (EPM) test and correlate to IL-6 level of ovariectomized rat brain. Total of 24 Wistar rats were divided into six groups: one normal group, one group of 1 month ovariectomized (ovx), one group of 2 months ovx, three groups of 2 months ovx (each given with MECL 500; 1500 and 2500 mg/kg doses for 1 month). The anxiety-like behavior level was measured by EPM test. After EPM test, the brain was removed to measure level of IL-6 by ELISA. The data were processed and analyzed by one-way ANOVA and Pearson correlation. We found that the MECL-treated rats enter the opened-arm higher than the control rats. It indicates that the MECL-treated rats are less anxious than the control rats. The results also show the decreased of IL-6 level in MECL-treated rats.
Co-Authors Agus Khoirul Fuadi Asti Melani Astari Bintari Ratih Kusumaningrum Dina Dewi SLI Dini Widya Ayuningtyas Edi Yuswantoro Endah Setyowati Eviana Norahmawati Farida Maemunah Martiningsih Fransiska Erna Damayanti Fransiska Imavike Fevriasanty Ika Setyo Rini Ika Setyo Rini Ika Subekti Wulandari Indah Mukarromah Indah Winarni Intan Berlian K Kumboyono Kumboyono Kumboyono Lia Sawitri Lilik Supriyati Maria Wisnu Kanita Merry Januar Firstiana Mufidah Cholil Nur Permatasari Ose, Maria Imaculata Retno Lestari Rinik Eko Kapti Ririn Handayani Rita Rinjani Mekka Septi Dewi Rachmawati Setyo Martono Setyoadi Setyoadi Siti Nurfitria Sri Haryuni Sri Winarsih Sutono Sutono Tia Asmetiasih Tony Suharsono Tulus Sabrina Yati Nur Azizah Yonna Euinike Tanahitumesseng Yuldensia Avelina