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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Sain Veteriner Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Media Farmasi JCPS (Journal of Current Pharmaceutical Sciences)
Sapto Yuliani
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary Other

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Journal : Pharmaciana: Jurnal Kefarmasian

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AKTIVITAS EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) PADA RADIAL ARM MAZE DAN PASIVE AVOIDANCE TEST TIKUS MODEL DEMENSIA Didik Yuni Prasetya; Sapto Yuliani
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.796 KB) | DOI: 10.12928/pharmaciana.v4i2.1573

Abstract

Curcuma xanthorrhiza Roxb. is a plant containing curcumin. Curcumin has been shown toreduce oxidative damage and memory deficits associated with aging. The aim of the researchwas to know the effect of Curcuma xanthorrhiza Roxb. rhizome ethanol extract to memoryfunction on Wistar rats induced by trimethyltin. The research design was post test onlycontrolled group with 42 rats divided into 6 groups, Each group consist of 7 rats. Group I(healthy controls) were given a solution of 0.5% CMC-Na orally. Group II (negative control)were given a solution of 0.5% CMC-Na orally. Group III, IV, and V were given Curcuma xanthorrhiza Roxb. extract each 120 mg/kgBW, 240 mg/kgBW, and 480 mg/kgBW orally.Group VI (positive control) were given piracetam 500 mg/kgBW intraperitoneally. All groupswere given trimethyltin intraperitoneally except group I. Data indicating memory function wereobtained from radial maze test and passive avoidance test. Radial maze test data were analyzedby ANOVA followed by LSD test, while the passive avoidance test data were analyzed with theKruskal Wallis test followed by Mann-Whitney test. In conclusion, ethanol extract oftemulawak rhizome (Curcuma xanthorrhiza Roxb.) at doses of 120 mg/kgBW, 240 mg/kgBWand 480 mg/kgBW can prevent memory function decline on Wistar rats induced bytrimethyltin.
Combination of Spirulina platensis powder and Stichopus variegatus powder against Bcl2 expression in the hippocampus of dementia Rats Lisa Agustina Botutihe; Rizka Safira; Sapto Yuliani; Kintoko Kintoko
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.26205

Abstract

Spirulina (Spirulina platensis) and golden sea cucumber (Stichopus variegatus) are known to have antioxidant activity that has the potential to prevent neurodegeneration disease. The aim of this study was to examine the effect of the combination of spirulina and golden sea cucumber on Bcl2 gene expression in pyramidal hippocampus cells of trimethyltin-induced dementia (TMT) rats. The study used Sprague Dawley rats  which were divided into 6 groups, namely the normal control group (CMC-Na and NaCl 0.9%), pain control (CMC-Na and TMT), positive control (citicoline dose 200 mg / kg and TMT) and test control injected with TMT and given a combination of spirulina and golden sea cucumber dose 200 mg/KgBB with three ratios namely 3: 1, 1: 1 and 1: 3. Extract and citicoline were given on day 1 to day 28, while TMT injection was given a single dose of 8 mg/KgBB on day 8. On the 36th day the rats were sacrificed, brains were removed and the right hemispherium cerebri was fed to 10% formalin in pbs. After 6 days the hippocampus was separated for immunohistochemical observation. The test result data was statistically analyzed with a one-way ANOVA test then followed by post hoc tukey to see the differences between groups. Results showed the combination of spirulina and golden sea cucumber can increase the expression of the Bcl2 gene in the hippocampus. The combination of spirulina and golden sea cucumber (ST1: 3) dose of 200 mg / kg body weight was able to increase hippocampus Bcl2 expression with the number of Bcl2 cell expression almost the same as citicoline in both CA1 and CA2-CA3 regions.
Co-Authors Adi Permadi Daipadli Daipadli Daru Estiningsih Desi Eko Wulansari Didik Yuni Prasetya Dwi Retno Nengtyas Hastari Wuryastuti Ibdal Satar Iis Wahyuningsih Kintoko Kintoko Laela Hayu Nurani Lalu Muhammad Irham Lisa Agustina Botutihe Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Ma'ruf Nining Sugihartini Nurkhasanah Nurkhasanah Putri Dwi Lestari Rizka Safira Uswatun Chasanah Vivi Sofia Vivi Sofia Wahyu Widyaningsih Wasito . Wiki Yuli Anita Wiki Yuli Anita