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All Journal Agroland : Jurnal Ilmu-Ilmu Pertanian Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Anggaran: Jurnal Publikasi Ekonomi dan Akuntansi
Nurkhasanah Nurkhasanah
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Agriculture, Biological Sciences & Forestry Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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PENGARUH PEMBERIAN EKSTRAK ETANOL DAN KLOROFORM DAUN SIRSAK TERHADAP KOLESTEROL TOTAL DAN TRIGLISERIDA PADA TIKUS YANG DIINDUKSI ALOKSAN Deni Firmansyah; Moch Saiful Bachri; Nurkhasanah Nurkhasanah
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.668 KB) | DOI: 10.12928/pharmaciana.v6i1.3221

Abstract

Annona muricata plant is a medicinal plant using by research and drug for human healthy including diabetes mellitus. This research aimed to determine the effect of ethanol extract and chloroform extract of the sirsak leaf as antidiabetes mellitus. This research was conducted in 9 groups of male Wistar rats consisting of 5 rats per group, consisting of normal control, alloxan control, glibenclamide control dose of 10 mg/Kg BW, group of ethanol extract sirsak leaf dose of 50 mg/Kg BW; 100 mg/Kg BW; 200 mg/Kg BW, and group of chloroform extract sirsak leaf dose of 50 mg/kg BW; 100 mg/Kg BW; 250 mg/Kg BW. Tests carried out for 2 weeks. It also conducted assays of total flavonoids and histopathological tests of pancreatic β cells. Results of this research showed that the ethanol extract of  sirsak leaves dose of 200 mg/Kg BW has activity in decreasing blood glucose levels better than any other group. Results of the ethanol extract and chloroform extract all doses except the ethanol extract treatment group dose of 200 mg/kg BW and 100 mg/kg BW after a 14-day look is still high triglyceride levels and decrease in total cholesterol (TC) were seen in all group Ethanol extract dose of 200 mg / kgBW  has a good potential to reduce levels of triglycerides and total cholesterol. The conclusion of this research is the ethanol extract of sirsak leaf have activity antidiabetic mellitusand decreased total cholesterol. 
EFEK EKSTRAK ETANOL KELOPAK ROSELLA (Hibiscus sabdariffa L.) TERHADAP SEKRESI NITRIT OXIDA (NO) MAKROFAG PERITONEUM TIKUS YANGDIINDUKSI 7,12-dimethylbenz(α)antracene (DMBA) Nurkhasanah Nurkhasanah; Lovrina Rahmi Zulkarmen
Media Farmasi: Jurnal Ilmu Farmasi Vol 11, No 2: September 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4887.25 KB) | DOI: 10.12928/mf.v11i2.1875

Abstract

Sistem imun merupakan sistem perlindungan tubuh terhadap penyakit. Senyawa DMBA dilaporkan memiliki efek imunosupresif. Tujuan penelitian ini untuk mengetahui efek ekstrak etanol kelopak rosella terhadap sekresi Nitrit Oxide makrofag tikus SD yang diinduksi DMBA. Tikus jantan galur SD sebanyak 25 ekor dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 5 ekor tikus, kelompok I (normal) yang hanya diberi makan dan minum saja, kelompok II diberi DMBA 15 mg/tikus dan kelompok III, IV, V sebagai kelompok perlakuan yaitu diberi ekstrak etanol kelopak rosella dengan dosis 10 mg/kgBB, 50 mg/kgBB dan 100 mg/kgBB per oral. Setelah diberikan perlakuan, 5 ekor tikus pada masing-masing kelompok dibedah dan uji sekresi NO makrofag. Sekresi NO dilakukan dengan metode Griess assay. Data yang diperoleh dianalisis dengan uji Kolmogorof Smirnov, kemudian dilanjutkan dengan uji ANOVA dan uji post hoc LSD untuk melihat kelompok mana saja yang menunjukkan perbedaan yang bermakna. Dari penelitian yang dilakukan diperoleh hasil bahwa terjadi pada kelompok DMBA terjadi penurunan sekresi NO dibandingkan normal. Perlakuan ekstrak rosella meningkatkan sekresi NO setelah perlakuan DMBA. Dosis ekstrak etanol kelopak rosella yang paling efektif dalam meningkatkan sekresi NO makrofag yaitu pada dosis 50 mg/kgBB.   
AKTIVITAS ANTIKANKER EKSTRAK ETANOL TANAMAN TAPAK LIMAN (Elephantopus scaber L.) TERHADAP SEL T47D MELALUI INDUKSI APOPTOSIS Panji Ratih Suci; Nurkhasanah Nurkhasanah; Nanik Sulistyani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.223 KB) | DOI: 10.36387/jiis.v6i1.605

Abstract

Breast cancer is the most dominant type of cancer in Indonesia. Traditional medicine using tapak liman (Elephantopus scaber L.) as an anticancer becomes an option because it contains compounds such as sesquiterpenes. The purpose of this study was to know the cytotoxic activity of ethanolic extract of tapak liman on T47D cells through induction of apoptosis. The extraction method uses maceration with 96%. Total flavonoids were tested using quercetin as a spectrophotometric standard. ethanol solvent, cytotoxic test using microtetrazoliom (MTT assay), and apoptosis test using double staining test (ethidium bromide-acrydine orange) under a fluorescence microscope. The results showed the linear regression equation y = 0.0934x-0.0292 with the resulting flavonoid levels of 0.979% w / w calculated against quercetin (QE) The concentration of the compound used was 1000 µg/ml; 500 µg/ml; 250µg/ml; 125 ?g/ml, 62.5 ?g/ml; 31.25 µg/ml. The MTT assay results are the values of IC50 which are analyzed using probit analysis and apoptosis tests which are analyzed descriptively. The results of the research show that the ethanol extract of tapak liman using MTT method has IC50 value of 59 µg/ml, while the testing of double staining method shows the color of bright green which indicates early apoptosis and the color orange in the cells which undergoing final apoptosis. DNA fragmentation results shows that Tapak Liman extract induces DNA fragments. The conclusion of this study is that tapak liman textract has the potential for cytotoxic activity against T47D breast cancer cells through the induction of apoptosis
Farmasi EFEK RAMUAN OBAT TRADISIONAL (BATRA) KALIPUTIH JAWA TENGAH, TERHADAP KOLESTEROL, TRIGLISERIDA DAN HDL TIKUS SPRAGUE DAWLEY YANG DIINDUKSI STREPTOZOTOSIN Urmatul Waznah; Nurkhasanah Nurkhasanah; Kintoko Kintoko; Djati Wulan Kusumo
JCPS (Journal of Current Pharmaceutical Sciences) Vol 3 No 1 (2019): September 2019
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.224 KB)

Abstract

ABSTRAK Ramuan Batra asli Kaliputih adalah ramuan tradisional yang secara empiris berkhasiat untuk mengobati penyakit diabetes dengan komplikasi gagal ginjal yang terdiri dari tumbuhan obat yaitu, daun keji beling, daun kumis kucing, biji kopi arabika mentah, tunas bambu kuning, cokol tebu ireng, ganyong merah, rimpang temulawak, rimpang kunir putih, rimpang kunyit, buah belimbing wuluh dan srintil hutan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian Ramuan Batra terhadap kadar kolesterol, trigliserid dan HDL. Penelitian ini menggunakan 30 ekor tikus jantan galur Sprague Dawley yang diinduksi dengan Streptozotosin (dosis 40 mg/dl) secara intra peritonial dengan dosis tunggal. Pemberian ramuan dilakukan selama 15 hari sesuai dengan terapi yang dilakukan oleh Batra kepada pasien. Parameter yang diamati meliputi kadar kolesterol, trigiserid dan HDL menggunakan metode enzimatik–kalorimetri secara CHOD–PAP. Hasil Pengukuran kadar kolesterol dan trigliserida menunjukan penurunan dibandingkan kontrol negatif pada dosis 36 mL/kg BB dan dosis 54 mL/kg BB untuk kolesterol dan dosis 18 mL/kg BB, 36 mL/kg BB 54 mL/kg BB untuk trigliserida.Sedangkan pemeriksaan terhadap kadar HDL menunjukkan kenaikan dibandingkan kontrol negatif pada dosis 18 mL/kg BB, 36 mL/kg BB , 54 mL/kg BB. Sehingga ramuan Batra pada ketiga dosis,mampu menurunkan kadar kolesterol, trigliserida dan meningkatkan HDL. Kata kunci : Ramuan Batra Kaliputih, kolesterol, trigliserida, HDL
PENGENDALIAN HAMA PENGGEREK TONGKOL JAGUNG Helicoverpa armigera HUBNER. (LEPIDOPTERA : NOCTUIDAE) DENGAN Beauveria bassiana strain lokal PADA PERTANAMAN JAGUNG MANIS DI KABUPATEN DONGGALA Nurkhasanah Nurkhasanah
Agroland: Jurnal Ilmu-ilmu Pertanian Vol 15, No 2 (2008)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.612 KB)

Abstract

The  attack  of  pod borer  Helicoperva  armigera  Huebner  (Lepidoptera:Noctuidae)  on  corn  ear  stems  represent  the main constraint of sweet corn planting development in Donggala Regency Central Sulawesi.  The biological control using a pathogen  insect  (entomopathogen)  as  one  of  the  integrated  pest  control  components  can  be  developed  to  overcome  this problem.  One type of the pathogenic insect is a Beuverria bassiana fungi.The research aims were to identify the effectiveness of various concentrations and application time interval of B. bassiana as bioinsecticide to control of H. armigera pod borer. The experiment used a Randomized Block design with two factors consisting of B. bassiana concentrations (K): k 1 = 0,4, k 2 = 0,6 and k 3  = 0,8, and time interval of B. bassiana applications (W) : w 1  = 5 d, w 2 = 7 d, and w 3 = 9 d.  Each treatment was replicated 3 times; therefore, there were 27 experimental units in total. The parameters observed were: (i) density of larva population (ii) mortality of larva, and (iii) percent of ear corn stem damage.  Data were analysed using the analysis of variance, and differences between means was tested using honest significant difference (HSD) test at 5%. The research results showed that the concentration and the application time interval of B. bassiana each had significant effect on all parameters observed but their interaction effect was insignificant. The treatment k 2 w 3  (0.6 mg B. bassiana/L water applied every 9 d) was more effective in suppressing the population density, the larva mortality and the ear corn stem damage percent than other treatments. Considering the negative impacts of using chemical insecticide, B. bassiana bioinsecticide can be used as an alternative control of sweet corn pod borer H. armigera.
KARAKTERISASI SIMPLISIA DAN EKSTRAK ETANOL DAUN BERTONI (Stevia rebaudiana) DARI TIGA TEMPAT TUMBUH Dian Kartikasari; Nurkhasanah Nurkhasanah; Suwijiyo Pramono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.356 KB) | DOI: 10.31942/jiffk.v0i0.1216

Abstract

ABSTRAK Khasiat obat tradisional didasarkan pada senyawa kimia yang terkandung dalam suatu bahan obat. Bahan baku obat dari hasil pertanian atau kumpulan tumbuhan liar tidak dapat dijamin kandungan kimianya selalu konstan, karena adanya variasi bibit, tempat tubuh, iklim, maupun kondisi bahan bakunya (umur dan cara panen). Kandungan senyawa kimia yang bertanggung jawab terhadap respon biologis harus mempunyai spesifikasi kimia, yaitu informasi tentang komposisinya baik jenis maupun kadarnya. Oleh karena itu penetapan karakterisasi suatu simplisia dan ekstrak perlu dilakukan guna menjamin mutu suatu produk obat tradisional. Karakterisasi dilakukan terhadap simplisia dan ekstrak etanol 50% daun Stevia rebaudiana (Bertoni). Karakterisasi simplisia meliputi organoleptis, susut pengeringan, kadar sari larut air, serta kadar sari larut etanol. Cara penetapannya dilakukan sesuai prosedur yang telah ditetapkan Farmakope Herbal Indonesia (2008). Karakterisasi ekstrak etanol meliputi karakteristik non spesifik yakni kadar air, kadar abu total, dan kadar abu tidak larut asam. Hasil karakterisasi diperoleh nilai rentang dari tiap jenis parameter simplisia maupun ekstrak etanol daun Stevia rebaudiana yang diperoleh dari daerah Bogor, Malang, dan Tawangmangu. Kata kunci: Daun Stevia Rebaudiana (Bertoni), Karakterisasi simplisia, Karakterisasi ekstrak etanol 50%
PENETAPAN KADAR STEVIOSIDA PADA SIMPLISIA DAN EKSTRAK DAUN Stevia rebaudiana DARI TIGA DAERAH BERBEDA Dian Kartikasari; Nurkhasanah Nurkhasanah; Suwijiyo Pramono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.792 KB) | DOI: 10.31942/jiffk.v15i2.2574

Abstract

ABSTRACTPharmaceutical raw materials from agriculture or collection of wild plant chemical content can not be guaranteed always constant due to variable seed, the body, the climate, the conditions (age and how to harvest). The content of the chemical compounds responsible for the biological response must have chemical specifications, namely the composition information (type and concentration). The efficacy of traditional medicine based on the chemical compound. Therefore, the assay of the active substance a crude drugs and extracts needs to be done to ensure that a traditional medicinal products can be assured of quality and usefulness. The assay performed on botanicals and 50% ethanol extract of leaves of Stevia rebaudiana. The assay of the crude drugs and extracts from the stevia leaf area of Malang, Tawangmangu, and Bogor using High Performance Liquid Chromatograph method. Results of the assay stevioside on simplicia and stevia leaf extract obtained stevioside levels in simplicia stevia leaves from Malang, Bogor, Tawangmangu consecutive namely 5.65%; 3.89%; 1.59%. Stevioside levels in the stevia leaf extract of Malang, Bogor, Tawangmangu respectively, are 14.14%; 22.40%; 66.65%.Key word: Stevia rebaudiana leaf, stevioside content, High Performance Liquid Chromatograph
PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL BIJI KALANGKALA (LITSEA ANGULATA BLUME) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Daipadli Daipadli; Nurkhasanah Nurkhasanah; Sapto Yuliani
JCPS (Journal of Current Pharmaceutical Sciences) Vol 7 No 2 (2024): March 2024
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Buah kalangkala (Litsea angulata Blume) adalah tanaman yang sering digunakan dalam pengobatan tradisional Kalimantan dan telah dilaporkan mengandung senyawa fenolik dan flavonoid. Biji kalangkala telah dimamfaatkan masyarakat Kalimantan untuk mengobati bisul, antioksidan dan antidiabetes. Beberapa penelitian mengatakan bahwa senyawa yang berperan pada aktivitas tersebut adalah senyawa flavonoid. Penelitian inin bertujuan untuk mendapatkan data kadar flavonoid dalam biji kalangkala. Berdasarkan kadar kuersetin strandar. Ekstraksi menggunakan metode maserasi sebagai pelarutnya adalah etanol 96%. Penetapan kadar flavonoid total menggunakan metode spektrofotometri UV-Vis dengan larutan pembanding kuersetin. Kualitatif analisis menggunakan FeCl3 dengan membentuk kompleks hijau. Penentuan kandungan total flavonoid dilakukan berdasarkan Metode AlCl3 dengan total flavonoid dinyatakan dalam QE (Quercetin setara) pada panjang gelombang maksimum 435 nm. Hasil penelitian menunjukkan rata-rata kandungan total flavonoid sebesar 6,2728 mgQE/g ekstrak.
Pengaruh Pemahaman Pencatatan Akuntansi Dan Kesiapan Modal Terhadap Efesiensi Pendapatan Usaha Sembako: Studi Kasus Usaha Sembako Kecamatan Bayung Lencir Nurkhasanah Nurkhasanah; Eka Julianti Efris Saputri; Aditya Pradana; Kiki Helencia
Anggaran : Jurnal Publikasi Ekonomi dan Akuntansi Vol. 2 No. 2 (2024): Juni : Anggaran: Jurnal Publikasi Ekonomi dan Akuntansi
Publisher : Asosiasi Riset Ekonomi dan Akuntansi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/anggaran.v2i2.530

Abstract

To determine the influence of understanding accounting and capital readiness on the efficiency of basic food business income. Quantitative is a research method that uses data in the form of numbers and the collected data is analyzed using statistical formulas. The population that will be used in this research is MSME actors, especially basic food businesses registered with the Bayung Lencir District Cooperatives, Small and Medium Enterprises Service, totaling 100 MSME business actors. The classical assumption test is a prerequisite for multiple regression analysis, this test must be influenced so that the estimates of parameters and regression coefficients are not biased. In testing this class of assumptions, namely the normality test, multicollinearity test, heteroscedasticity test, autocorrelation test. Partially, accounting records have a more dominant influence than capital readiness in increasing income efficiency. This shows that understanding accounting records is very influential in increasing revenue efficiency and business sustainability, because by understanding accounting records, business actors can manage business finances and make decisions about managing their business easily.
Co-Authors Aditya Pradana Daipadli Daipadli Deni Firmansyah Dian Kartikasari Eka Julianti Efris Saputri Fitrilya Mustikahati Yusuf Kiki Helencia Kintoko Kintoko Kusumo, Djati Wulan Lovrina Rahmi Zulkarmen Moch. Saiful Bachri Nanik Sulistyani Panji Ratih Suci Sapto Yuliani Suwijiyo Pramono Urmatul Waznah