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All Journal Journal of Dentistry Indonesia Jurnal Riset Kesehatan Damianus Journal of Medicine Jurnal SOLMA Padjadjaran Journal of Dental Researchers and Students Jurnal Pelayanan dan Pengabdian Masyarakat (Pamas) Narra J Jurnal Pengabdian Pada Masyarakat
Mora Octavia
Periodontics Residency Program, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430
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Development and evaluation of a synthetic Cu-Zn-reinforced biphasic calcium phosphate scaffold for periodontal bone repair Novelia, Devina; Cahyadi, Theophani O.; Sidharta, Natasya MP.; Octavia, Mora; Situmorang, Evi UM.; Edbert , Daniel
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3001

Abstract

Periodontal bone defects require bone grafting materials that provide structural stability, biocompatibility, and reliable biological performance. Synthetic alloplastic scaffolds composed of biphasic calcium phosphate, integrating hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP), offer a promising alternative to other graft materials. Polycaprolactone provides flexibility and support for pore formation, while copper (Cu) and zinc (Zn) ions contribute to their antimicrobial and osteogenic benefits. This study aimed to investigate the physicochemical, morphological, mechanical, and biological properties of a synthetic HAp40/β-TCP60 alloplastic scaffold reinforced with polycaprolactone and to compare them with those of a commercial xenograft. The scaffold was fabricated using a freeze-drying method with dimethylformamide, and characterization included Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) for chemical and crystalline confirmation, Archimedes principle for porosity, light microscopy, and scanning electron microscopy (SEM) for morphological assessment, compressive testing, blood adhesion, as well as water and blood absorption analysis. FTIR and XRD verified the successful incorporation of polycaprolactone and the formation of a well-ordered biphasic calcium phosphate structure. Light microscopy showed that the synthetic scaffold had smaller macropore dimensions (324±49 µm) than the control (1410±541 µm), while SEM demonstrated markedly higher microporosity (8.184±2.581 µm) compared to the control (0.287±0.091 µm). Water absorption was lower in the synthetic scaffold (174.7%) than in the control (1172.5%), whereas blood absorption was comparable (300% vs 316.6%). The synthesized scaffold also exhibited superior blood adhesion, as evidenced by the absence of turbidity after agitation. Mechanical testing revealed that the control had superior compressive and yield strengths (0.980 MPa and 0.537 MPa, respectively) compared to the synthesized scaffold (0.287 MPa and 0.126 MPa, respectively). In conclusion, the synthetic HAp40/β-TCP60 scaffold exhibited properties within optimal ranges, highlighting its potential as a promising synthetic alloplastic material for clinical bone regeneration.
Co-Authors Airina Airina Aristo, Emanuel Jovan Cahyadi, Theophani O. Daniel Edbert, Daniel Djiady, Audie Dwiyanti, Stephani Edbert , Daniel Evans, Gunterus Evi Ulina Margaretha Situmorang Felicia Anggraini, Felicia Gaverio, Nicholas Francisco Indayang, Willyanto Kurniawan Isadora Gracia, Isadora Kaisar, Maria Mardalena Martini Linawati Hananta, Linawati Maria Dara Novi Handayani, Maria Dara Novi Muhyidin, Muhammad Fadli Novelia, Devina Oktaria, Indriani Oktarina, Indriani Pakpahan, Hotmaria Agustina Santoso, Bryan Sidharta, Natasya MP. Situmorang, Evi UM. Sunjaya, Hendro Anthonius Surianggo, Jenita Susanto, Alvira Tantra, Cornelia Tyara Usman, Hadiyanto Yulianti Kemal Yuniarti Soeroso