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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Althea Medical Journal Acta Pharmaceutica Indonesia The Indonesian Biomedical Journal Medica Hospitalia Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Action Research Literate (ARL)
Tiene Rostini, Tiene
Departemen Patologi Klinik, Fakultas Kedokteran Universitas Padjadjaran/ Rumah Sakit Umum Pusat Dokter Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Althea Medical Journal

 1 
Incidence of Neonatal Hyperbilirubinemia based on Their Characteristics at Dr. Hasan Sadikin General Hospital Bandung Indonesia Nurani, Namira Bening; Kadi, Fiva Aprillia; Rostini, Tiene
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Althea Medical Journal

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Abstract

Background: Hyperbilirubinemia is the most frequent clinical condition that occurs in neonates identified by yellow discoloration of the skin and other tissues. It is caused by elevations of bilirubin level as the effect of increased breakdown of red blood cells, impaired conjugation of indirect bilirubin, and incomplete bilirubin excretion. This study was conducted to discribe the characteristics of neonates with hyperbilirubinemia.Methods: This study used descriptive quantitative method which took retrospective data from medical record of neonates with hiperbilirubinemia in 2014. The population of this study was neonates which were born in the perinatology division at Dr. Hasan Sadikin General Hospital, Bandung. The variables collected were gender, gestational age, weight birth, general condition ad treatment options. The collected data were tabulated and presented by percentage and in the form of a table.Results: One hundred and seventy four of 230 medical records of neonates with hyperbilirubinemia were collected based on the inclusion criteria. The results showed that 8.04% of 2,531 neonates born at Dr. Hasan Sadikin General Hospital in 2014 suffered from hyperbilirubinemia. Males (56.9%) were higher than females to have hyperbilirubinemia. Neonates born at term gestational age (55.2%) were more likely to have hyperbilirubinemia with low birth weight category (51.7%), healthy general condition (60.4%). The most treatment option was  phototherapy (54.6%).Conclusions: Most neonates with hyperbilirubinemia are males, who were born at aterm gestational age, with low birth weight. Most of the neonates are in healthy general condition and the most common treatment given to neonates is phototherapy.
Hyperuricemia and Proteinuria in Type 2 Diabetic Patients Haryandini, Fatya Annisa; Rostini, Tiene
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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   Background: Type 2 diabetes mellitus is a metabolic disorder that has diabetic nephropathy as a complication characterized by proteinuria. When type 2 diabetic patient’s kidney is damaged, hyperuricemia occurs. This study evaluated the correlation of serum uric acid and proteinuria levels in type 2 diabetic patients from outpatient Endocrine clinic at Dr. Hasan Sadikin General Hospital from January to December 2011.Methods: In a cross-sectional study of 125 patients (55 male and 70 female) with type 2 diabetes mellitus, the data of serum uric acid, fasting plasma glucose, 2-h post oral glucose load plasma glucose, serum high-density lipoprotein cholesterol, serum trygliceride, and proteinuria levels were accessed from the medical record. Spearman test was used to calculate the correlation of serum uric acid and proteinuria levels. The research used secondary data taken from medical records  of patients diagnosed with T2DM  from outpatient Endocrine clinic of Internal Medicine Department at Dr. Hasan Sadikin General Hospital Bandung who had alaboratory examination at Department of Clinical Pathology of Dr. Hasan Sadikin General Hospital Bandung from January to December 2011.Results: The mean age of the type 2 diabetic patients was 61.5±9.2 years old, with mean serum uric acid level of 6.2±1,8 mg/dl, of whom 52.8% had microalbuminuric and 4.8% had proteinuria. In type 2 diabetic patients, serum uric acid level correlated positively (r=0.273) with proteinuria (p=0.002).Conclusions: Higher serum uric acid levels associated significantly positive with a greater probability of proteinuria in type 2 diabetic patients, indicating a potential marker for disease severity.Keywords: Proteinuria, type 2 diabetes mellitus, uric acidDOI: 10.15850/amj.v2n1.430 
Incidence of Neonatal Hyperbilirubinemia based on Their Characteristics at Dr. Hasan Sadikin General Hospital Bandung Indonesia Namira Bening Nurani; Fiva Aprillia Kadi; Tiene Rostini
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.874 KB)

Abstract

Background: Hyperbilirubinemia is the most frequent clinical condition that occurs in neonates identified by yellow discoloration of the skin and other tissues. It is caused by elevations of bilirubin level as the effect of increased breakdown of red blood cells, impaired conjugation of indirect bilirubin, and incomplete bilirubin excretion. This study was conducted to discribe the characteristics of neonates with hyperbilirubinemia.Methods: This study used descriptive quantitative method which took retrospective data from medical record of neonates with hiperbilirubinemia in 2014. The population of this study was neonates which were born in the perinatology division at Dr. Hasan Sadikin General Hospital, Bandung. The variables collected were gender, gestational age, weight birth, general condition ad treatment options. The collected data were tabulated and presented by percentage and in the form of a table.Results: One hundred and seventy four of 230 medical records of neonates with hyperbilirubinemia were collected based on the inclusion criteria. The results showed that 8.04% of 2,531 neonates born at Dr. Hasan Sadikin General Hospital in 2014 suffered from hyperbilirubinemia. Males (56.9%) were higher than females to have hyperbilirubinemia. Neonates born at term gestational age (55.2%) were more likely to have hyperbilirubinemia with low birth weight category (51.7%), healthy general condition (60.4%). The most treatment option was  phototherapy (54.6%).Conclusions: Most neonates with hyperbilirubinemia are males, who were born at aterm gestational age, with low birth weight. Most of the neonates are in healthy general condition and the most common treatment given to neonates is phototherapy.
Hyperuricemia and Proteinuria in Type 2 Diabetic Patients Fatya Annisa Haryandini; Tiene Rostini
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (668.522 KB)

Abstract

   Background: Type 2 diabetes mellitus is a metabolic disorder that has diabetic nephropathy as a complication characterized by proteinuria. When type 2 diabetic patient’s kidney is damaged, hyperuricemia occurs. This study evaluated the correlation of serum uric acid and proteinuria levels in type 2 diabetic patients from outpatient Endocrine clinic at Dr. Hasan Sadikin General Hospital from January to December 2011.Methods: In a cross-sectional study of 125 patients (55 male and 70 female) with type 2 diabetes mellitus, the data of serum uric acid, fasting plasma glucose, 2-h post oral glucose load plasma glucose, serum high-density lipoprotein cholesterol, serum trygliceride, and proteinuria levels were accessed from the medical record. Spearman test was used to calculate the correlation of serum uric acid and proteinuria levels. The research used secondary data taken from medical records  of patients diagnosed with T2DM  from outpatient Endocrine clinic of Internal Medicine Department at Dr. Hasan Sadikin General Hospital Bandung who had alaboratory examination at Department of Clinical Pathology of Dr. Hasan Sadikin General Hospital Bandung from January to December 2011.Results: The mean age of the type 2 diabetic patients was 61.5±9.2 years old, with mean serum uric acid level of 6.2±1,8 mg/dl, of whom 52.8% had microalbuminuric and 4.8% had proteinuria. In type 2 diabetic patients, serum uric acid level correlated positively (r=0.273) with proteinuria (p=0.002).Conclusions: Higher serum uric acid levels associated significantly positive with a greater probability of proteinuria in type 2 diabetic patients, indicating a potential marker for disease severity.Keywords: Proteinuria, type 2 diabetes mellitus, uric acidDOI: 10.15850/amj.v2n1.430 
Solanum muricatum Aiton Juice as A Hepatoprotective Agent in Wistar Rats Induced With Carbon Tetrachloride Justine Sim Wei Yang; Istriati Istriati; Tiene Rostini
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Liver participates in various metabolic processes in human body. Exposures to toxins such as carbon tetrachloride (CCl4) results in hepatocyte destruction and release the cell contents. Enzymes such as serum glutamic pyruvic transaminase (SGPT) were used as a parameter to diagnose liver damage. Pepino (Solanum muricatum Aiton) contains antioxidants that protect liver from hepatoxicity. The aim of this experiment is to determine the effect of pepino in protecting the hepatocyte from hepatotoxic effect of CCl4.Methods: A total of 16 Wistar rats used as the subject were divided into Control and Therapeutic Group. The Control group was induced with CCl4 but was not given pepino juice. Meanwhile, the Therapeutic Group was given pepino juice for 10 days. For induction of hepatotoxicity, CCl4 10% was given at a dosage of 2.0 ml/kg intra-peritoneal. Each Wistar rat in Therapeutic Group was given 1.0 ml of 300 g/ml pepino juice via oral feeding. Spectrophotometer with adjusted wavelength of 340 nm was used to measure SGPT level of the Wistar rats and statistical T-test was used to analyze the data.Results: Wistar rats in Therapeutic group showed a larger decrease (6898.9 IU/L–79.1 IU/L) in SGPT level compared to the Control group (6469.8 IU/L–418.5 IU/L). The SGPT level of the Wistar rat in Therapeutic group reached normal baseline (50 IU/L–150 IU/L). The significance of the experiment was supported by the T-test, P-value <0.05Discussion: Pepino juice had antioxidants that protect the hepatocyte of Wistar rats from free radicals. The synergistic action of antioxidants and hepatocyte regeneration of Wistar rats in Therapeutic group caused a decrease in SGPT level. Therefore, the experiment concluded that pepino juice at the dosage of 300 g/ml has hepatoprotective effect.Key words: Carbon tetrachloride, hepatotoxicity, Pepino, Solanum muricatum Aiton, SGPT DOI: 10.15850/amj.v2n4.484
Aspartate Aminotransferase to Platelet Ratio Index Score in Correlation with Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio to Predict Hepatic Cirrhosis in Hepatitis C Patients Jane Haryanto; Agnes Rengga Indrati; Tiene Rostini
Althea Medical Journal Vol 9, No 2 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n2.2553

Abstract

Background: Tissue biopsy examination which is an invasive procedure has become the mainstay for hepatic cirrhosis identification in patients with hepatitis. Alternatively, noninvasive method using the aspartate aminotransferase (AST) to platelet ratio index (APRI) score has been developed to predict hepatic cirrhosis. Furthermore, the neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) have been used to predict the severity of hepatitis C. This study aimed to analyze the relationship between APRI scores and NLR and PLR in chronic hepatitis C patients.Methods: This correlative cross-sectional observational study used secondary data of complete blood counts such as neutrophil, lymphocyte, and platelet values, as well as AST values of patients with hepatitis C in the outpatient and inpatient installation of Dr. Hasan Sadikin General Hospital during 2019. The inclusion criteria were patients aged ≥18 years, male and female, who were diagnosed as hepatitis C patients, patients who had AST examination data, leukocytes, count type, and platelets. Data were analyzed using the Spearman rank correlation test.Results: The 123 subjects were dominantly male with an age range of 46–55 years. There was no correlation between the APRI and NLR scores (p=0.229). However, there was a moderate and significant negative correlation between APRI and PLR scores with a correlation coefficient of -0.468 (p=0.000).Conclusion: There is a significant negative correlation between APRI and PLR scores to predict the occurrence of hepatic cirrhosis in patients with Hepatitis C.
Co-Authors Agnes Rengga Indrati Anna Tjandrawati Arto Yuwono Astuti, Yunita Puji Coriejati Rita David Rustandi Delita Prihatni Dewi Kartika Turbawaty Dewi Nurhayati Fatya Annisa Haryandini Fatya Annisa Haryandini, Fatya Annisa Fiva Aprillia Kadi Hartanto Bayuaji Ida Parwati Istriati Istriati Jane Haryanto Justine Sim Wei Yang Kadi, Fiva Aprillia Khairunnissa, Khairunnissa Kurnia Pramono, Laila Leni Lismayanti Lisda Amalia Muhammad Alamsyah Mulya Harahap, Raja Iqbal Mustari, Asri Dini Namira Bening Nurani neli sumanti Nida Suraya Nida Suraya Nina Tristina Noormartany Novi Vicahyani Utami Nurani, Namira Bening Nurmin, Rahmawati Pujiyanti, Hapsari Raja Iqbal Mulya Harahap Rita Rachmayanti Rizki Andriyani Ryan Bayusantika Sylvia Rachmayati Towifah Fauziah Choerunisa Yunita Puji Astuti