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All Journal Century: Journal of Chinese Language, Literature and Culture Jurnal e-Komunikasi Indonesian Journal of Obstetrics & Gynecology Science Jurnal Ilmu Manajemen dan Akuntansi Terapan Review of Management and Entrepreneurship Jurnal Bakti Masyarakat Indonesia Jurnal Pengabdian Masyarakat (ABDIRA) International Journal of Tourism and Hospitality in Asia Pasific Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi LINGUISTS : JOURNAL OF LINGUISTICS AND LANGUAGE TEACHING Folia Medica Indonesiana International Journal of Chinese Interdisciplinary Studies
Nathania Nathania, Nathania
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Centella asiatica Nanoparticles as Potential Acetylcholinesterase Inhibitor for Cognitive Decline Therapy using Ellman's Method: An in Vitro Study Nathania, Nathania; Kusumaningrum, Selvina Cindy; I'tishom, Reny; Kumalasari, Feranita; Margiana, Ria
Folia Medica Indonesiana Vol. 60, No. 4
Publisher : Folia Medica Indonesiana

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Highlights: 1. This research contributes novel data to current studies by combining the potential of Centella asiatica extract with PEG-400 to develop a therapeutic agent aimed at improving cognitive function through an effective drug delivery system capable of penetrating the blood-brain barrier. 2. The findings of this study revealed that the combination of Centella asiatica extract and PEG-400 at an adequate ratio exhibits great potential as an acetylcholinesterase inhibitor. Abstract Cognitive impairment, caused by neurocognitive changes and neuroinflammation, affects 65.6 million elderly people worldwide and can interfere with their quality of life. Centella asiatica is recognized for its neuroprotective potential due to its active compounds. This study aimed to investigate the acetylcholinesterase inhibitory properties of Centella asiatica as potential therapeutic agents for cognitive decline. Polyethylene glycol 400 (PEG-400) was used to achieve an effective drug delivery system of Centella asiatica extract, facilitating the inhibition of the apoptosis signaling pathway and allowing neuroprotective agents to cross the blood-brain barrier (BBB). This research involved several testing stages, including gas chromatography-mass spectrometry (GC-MS) to identify active compounds (e.g., tryptamine, γ-sitosterol, and β-sitosterol) that contribute to cognitive function improvement. Particle size analysis (PSA) tests were conducted on three formulations of the extract and PEG-400, with ratios of 1:100, 100:1, and 1:1, to determine the optimal formulation for subsequent testing. Scanning electron microscopy (SEM) was utilized to observe the morphology and surface structure of the samples, while Ellman's method was employed to test the ability of acetylcholine (ACh) in improving cognitive abilities. The results subsequently underwent descriptive analysis, particle distribution analysis, analysis of variance (ANOVA), nonparametric tests, image analysis, regression tests, multivariate analysis, and correlation tests. The synthesis demonstrated that the 1:100 formulation produced ideal-sized nanoparticles (5–7 nm), optimal for penetrating the BBB. The PSA and SEM analyses supported this finding by demonstrating homogeneous particle morphology and consistent chemical composition. The in vitro Ellman's assay revealed a high inhibitory rate of 97.63% for the 100:1 formulation. The 1:1 and 1:100 formulations demonstrated a very high effectiveness as acetylcholinesterase inhibitors. The combination of PEG-400 and Centella asiatica extract has great potential as an innovative pharmacological therapy for cognitive decline. However, further research is required to ensure the right dosage and development of the research findings.
DELAYED MANAGEMENT OF BILATERAL MASSIVE EPIDURAL HEMATOMA INVOLVING PARASAGITTAL SINUS: A COMPREHENSIVE SCOPING REVIEW FROM INDONESIAN PERSPECTIVES Suryaningtyas, Wihasto; Armando, Alivery Raihanada; Ramadhan, Candra Dwantara; Kamaruddin, Muhammad Fadhil; Zamzam, Ramadhani Rizki; Nathania, Nathania
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Introduction: Vertex epidural hematomas (VEDH) involving the superior sagittal sinus (SSS) are rare, critical injuries often complicated by massive venous hemorrhage. This study evaluates the clinical outcomes of VEDH and identifies systemic barriers contributing to treatment delays in Low- and Middle-Income Countries (LMICs). Methods: We present a case series of three patients managed at an Indonesian tertiary center alongside a scoping review of 33 studies. Delayed management was defined as prolonged injury-to-surgery intervals resulting from referral inefficiencies and transport logistics. Results: The series highlights a unique case of a 66-year-old male with bilateral VEDH and SSS laceration who underwent surgery 32 hours post-injury. Despite massive intraoperative blood loss (6000cc) requiring aggressive transfusion and sinus repair, the patient achieved a good functional recovery. The scoping review identified primary barriers to timely care, including geographical constraints, lack of organized emergency transport, and a scarcity of neurosurgical specialists and CT scanners in rural regions. Conclusion: While delayed presentation exacerbates surgical risks, aggressive management via bicoronal craniotomy remains effective. Improving prehospital infrastructure and referral networks is essential to reducing preventable delays in neurotrauma management.
“Ma’nene” 与 “赶尸” 仪式死亡传统比较研究 Nathania, Nathania
International Journal of Chinese Interdisciplinary Studies Vol. 1 No. 2 (2024): IJCIS
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ijcis.v1i2.30080

Abstract

多元的民族文化催生了每个国家或地区独有的仪式传统。 本研究考察了在北托拉贾发现的“Ma’nene” 死亡仪式传统的意义在湘西地区 “赶尸” 从跨文化研究的角度来看，使用定性描述性研究方法，通过分析和综合来自书面资料和访谈的信息来仔细检查研究。 本研究旨在通过说明两种仪式传统的相似之处和不同之处来展示两种仪式传统之间双重联系的意义。这项研究表明，“Ma'nene” 与“赶尸”的仪式传统具有几乎相似的观点的文化意义。 相似之处是（1）尊重死者，（2）家庭和后代，（3）精神信仰，（4）涉及身体的护理和保养，（5）仅发生在某些领域，区别在于（1）实施时间，（2）仪式传统的过程，（3）文化和宗教背景，以及（4）仪式传统的发展。
Penyuluhan Kesehatan Reproduksi dan Senam Dismenore: Strategi Partisipatif Meningkatkan Pengetahuan dan Kesehatan Remaja Putri Tampubolon, Masrina Munawarah; Siregar, Nabilah; Lestari, Widia; Chesy, Chesy; Dafri, Dafri; Dini, Dini; Putri, Putri; Siti, Siti; Fandra, Fandra; Fitri, Fitri; Hasniati, Hasniati; Irza, Irza; Monika, Monika; Nathania, Nathania; Septia, Septia; Septiana, Septiana
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 6, No 2 (2026): Abdira
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v6i2.1797

Abstract

Adolescent girls are a vulnerable group to reproductive health issues, particularly a lack of knowledge about menstrual care and dysmenorrhea, which can disrupt daily activities. This community service activity aims to improve adolescent girls' knowledge and skills in maintaining reproductive health and implementing non-pharmacological methods to reduce menstrual pain. The program involved 30 participants through participatory health education and demonstrations of dysmenorrhea exercises at MTs Bustanul Ulum, Pekanbaru City. Evaluation was conducted using pre- and post-tests. Results showed a significant increase in knowledge scores from 83.33 to 98.33, as well as improved ability to perform the exercises correctly. Most participants also reported reduced pain and greater relaxation. This activity effectively increased reproductive health literacy and introduced safe alternatives for managing menstrual pain.
Co-Authors Agus Riadi Annaletchumi, Annaletchumi Ariaji, Priscilla Epifania Armando, Alivery Raihanada Chesy, Chesy Christine Winstinindah Sandroto Dafri, Dafri Dani Setiawan Dini, Dini Ervila, Ervila Fandra, Fandra Farzana, Anis Fitri Fitri Hasniati, Hasniati I'tishom, Reny Indrawati, Klara Puspa Irza, Irza Kamaruddin, Muhammad Fadhil Kee, Daisy Mui Hung Kumalasari, Feranita Kusumaningrum, Selvina Cindy Margiana, Ria Merry C. N. Rumagit Monika, Monika Nabilah Siregar Novia, Feby Putri Putri, Putri Ramadhan, Candra Dwantara Rosinta Ria Panggabean Sampeliling, Dave Grant Septia, Septia SEPTIANA SEPTIANA Siti, Siti Sofea, Anis Song, Ng Hee Tampubolon, Masrina Munawarah Utari , Grace Elysia Widia Lestari wihasto suryaningtyas Yosafat Barona Valentino, Yosafat Barona Zamzam, Ramadhani Rizki Zuraya, Anis