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All Journal Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Global Medical and Health Communication MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran Bandung Conference Series : Medical Science
Maya Tejasari
Bagian Biologi Medik Dan Histologi, Fakultas Kedokteran, Universitas Islam Bandung, Bandung
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Peran Vitamin D dalam Penanganan Pasien Covid-19 Dwi Widi Mandasari; Maya Tejasari; Widayanti
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1982

Abstract

Abstract. Corona Virus Disease-2019 (Covid-19) is a serious global problem that still needs to be addressed at this time. Covid-19 is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). One of the Covid-19 prevention measures related to nutrition is the consumption of vitamin D. This study is a Scoping review, a systematic search was carried out through 3 databases (PubMed, Spinger Link, Science Direct,) that met the eligibility criteria. The search results from a total of 5,662 articles contained 494 according to the inclusion criteria, namely 2019 - 2021, observational, experimental, full text, in English and obtained 8 articles according to PICOS. The results of a review and analysis of 9 articles, all of which showed that there was a reduced risk of mortality in the group given vitamin D supplements than the control group that was not given vitamin D. Vitamin D inactivates viral pathogens or inhibits viral replication. So it has a positive effect on the immune system. And useful for handling Covid-19 patients. The conclusion of this study is that the administration of vitamin D can reduce the risk of mortality and increase improvement in the treatment of COVID-19 patients. Abstrak. Corona Virus Disease-2019 (Covid-19) menjadi masalah global serius yang masih perlu ditanggulangi saat ini. Covid-19 disebabkan oleh virus Severe Acute Respiratory Syndrom Coronavirus-2 (SARS-CoV-2). Salah satu langkah pencegahan Covid-19 yang terkait bidang gizi adalah konsumsi vitamin D. Penelitian ini merupakan Scoping review, pencarian sistematis dilakukan melalui 3 database (PubMed, Spinger Link, Science Direct,) yang memenuhi kriteria kelayakan. Hasil pencarian dari total 5.662 artikel terdapat 494 sesuai dengan kriteria inklusi yaitu 2019 - 2021, observasioal, eksperimental, full text, berbahasa Inggrisdan didapatkan 8 artikel sesuai PICOS. Hasil telaah dan analisis dari 9 artikel, semua artikel menunjukan bahwa terjadi penurunan resiko mortalitas pada kelompok yang diberi suplemen vitamin D daripada kelompok kontrol yang tidak diberikan vitamin D. Vitamin D menonaktifkan patogen virus atau menghambat replikasi virus. sehingga memiliki efek positif untuk system kekebalan tubuh. Dan bermanfaat untuk penanganan pasien covid-19. Simpulan dari penelitian ini adalah pemberian vitamin D dapat mengurangi resiko mortalitas serta meningkatkan perbaikan dalam penanganan pasien covid-19.
Scoping Review: Mekanisme Antimetastasis Senyawa Bawang Putih (Allium sativum) pada Sel Kanker Payudara Hasani Farhan; Maya Tejasari; Noormartany
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.5455

Abstract

Abstract. Metastasis is the cause of mortality for 90% of breast cancer patients. One of the causes of metastasis is the side effects of breast cancer therapy including radiotherapy, chemotherapy, and surgery. One of the efforts to overcome these problems is to develop natural materials such as medicinal plants. Garlic (Allium sativum) and its compounds have been analyzed and shown various anticancer activities such as inhibiting proliferation, inducing apoptosis, and inhibiting the metastatic process. The aim of this study was to analyze research on the effect of garlic (Allium sativum) and its compounds on breast cancer cell metastasis. This research is a scoping review with the databases used are PubMed, Scopus, Willey Online Library, ProQuest, and EMBASE with the number of articles obtained as many as 3.935 articles. Screening results on articles that fit the inclusion criteria were 2.264 articles and exclusion criteria were 6 articles. After critical review, 6 articles were reviewed. The results of the review and analysis of the 6 articles showed that garlic (Allium sativum) compounds, namely ajoene, inhibit vimentin protein expression. DADS suppresses SRC/Rasa/ERK signaling and induces cell apoptosis through the mitochondrial pathway which causes a decrease in Bcl-2 and Bcl-XL expression. DATS inhibited the expression of L1CAM, VEGF-1, EMT related proteins (slug, snail, MMP-2) and decreased the activity and expression of ERK/NF-κB/MMP-2/MMP-9. SAMC inhibited the expression of Bcl-2, Bcl-XL, and ROS. In conclusion, garlic (Allium sativum) compounds have antimetastatic effect on breast cancer cell metastasis.Abstrak. Metastasis merupakan penyebab kematian dari 90% pasien kanker payudara. Salah satu penyebab metastasis yaitu efek samping terapi kanker payudara termasuk radioterapi, kemoterapi, dan pembedahan. Salah satu upaya untuk mengatasi permasalahan tersebut adalah dengan mengembangkan bahan alam seperti tanaman obat. Bawang putih (Allium sativum) dan senyawanya telah diteliti dan menujukkan berbagai aktivitas antikanker seperti menghambat proliferasi, induksi apoptosis, dan menghambat proses metastasis. Tujuan penelitian ini adalah untuk menganalisis penelitian tentang mekanisme antimetastasis senyawa bawang putih (Allium sativum) pada sel kanker payudara. Penelitian ini merupakan scoping review dengan database yang digunakan adalah PubMed, Scopus, Willey Online Library, ProQuest, dan EMBASE dengan jumlah artikel yang didapat sebanyak 3.935 artikel dengan artikel yang dinyatakan lulus telaah kritis yaitu sebanyak 6 artikel. Hasil Skrining pada artikel yang sesuai dengan kriteria inklusi sebanyak 2.264 artikel dan kriteria eksklusi sebanyak 6 artikel. Setelah dilakukan telaah kritis, artikel yang di-review sebanyak 6 artikel. Hasil telaah dan analisis dari 6 artikel menunjukkan bahwa senyawa bawang putih (Allium sativum) yaitu ajoene menghambat ekspresi protein vimentin. DADS menekan pesinyalan SRC/Ras/ERK dan menginduksi apoptosis sel melalui jalur mitokondria yang menyebabkan penurunan ekspresi Bcl-2 dan Bcl-XL. DATS menghambat ekspresi L1CAM, VEGF-1, EMT related proteins(slug, snail, MMP-2) dan menurunakan aktivitas dan ekspresi ERK/NF-κB/MMP-2/MMP-9. SAMC menghambat ekspresi Bcl-2, Bcl-XL, dan ROS. Simpulan, senyawa bawang putih (Allium sativum) memiliki efek antimetastasis pada sel kanker payudara.
Peran Sediaan Daun Kelor (Moringa Oleifera) dalam Pengobatan Kanker Payudara: Tinjauan Pustaka Firman Cahayadipura; Maya Tejasari; Usep Abdullah Husin
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6180

Abstract

Abstract. Breast cancer is the main cause of cancer incidence in Indonesia according to the Ministry of Health of the Republic of Indonesia. Moringa leaves (Moringa oleifera) is a plant that has been studied and reported that its extract has anticancer effects. Cell proliferation and apoptosis are mechanisms that influence the occurrence of cancer. The anticancer effect of moringa leaf extract (Moringa oleifera) has been studied on various types of cancer cells, one of which is breast cancer. The purpose of this study was to analyze the effect of the role of Moringa oleifera preparation on breast cancer growth. The method used is a systematic review using the PubMed, SpringerLink, ScienceDirect, and ProQuest databases. Selected articles in 2012 – 2022 with pre-experimental research designs (in vitro and in vivo). The search found 1,972 articles and 277 articles on screening. Then a PICOS analysis was carried out and four articles were obtained which would be critically reviewed. The results showed that administration of moringa leaf preparations (Moringa oleifera) could reduce proliferation and increase apoptotic activity in breast cancer cells. Moringa leaves (Moringa oleifera) have anticancer effects by inducing apoptosis and inducing cell growth in the S and G2/M phases of the cell cycle. Abstrak. Kanker payudara menjadi penyebab utama insiden kanker di Indonesia menurut Kementerian Kesehatan Republik Indonesia. Daun kelor (Moringa oleifera) salah satu tumbuhan yang telah diteliti dan dilaporkan bahwa ekstraknya memiliki efek antikanker. Proliferasi dan apoptosis sel menjadi mekanisme yang mempengaruhi terjadinya kanker. Efek antikanker pada sediaan ekstrak daun kelor (Moringa oleifera) telah diteliti diberbagai jenis sel kanker, salah satunya kanker payudara. Tujuan penelitian ini adalah untuk menganalisis efek peran sediaan daun kelor (Moringa oleifera) terhadap pertumbuhan kanker payudara. Metode yang dilakukan adalah systematic review menggunakan database PubMed, SpringerLink, ScienceDirect, dan ProQuest. Artikel yang dipilih adalah tahun 2012 – 2022 dengan desain penelitian pre-experimental (in vitro dan in vivo). Pada pencarian didapatkan 1.972 artikel dan pada skrining 277 artikel. Kemudian dilakukan analisis PICOS dan didapatkan empat artikel yang akan ditelaah kritis. Hasil penelitian menunjukan pemberian sediaan daun kelor (Moringa oleifera) dapat menurunkan proliferasi dan meningkatkan aktivitas apoptosis pada sel kanker payudara. Daun kelor (Moringa oleifera) memiliki efek antikanker dengan menginduksi apoptosis dan menginduksi pemberhentian pertumbuhan sel pada siklus sel fase S dan G2/M.
Perbandingan Perbaikan Klinis pada Pasien Gagal Napas yang Menggunakan dan Tidak Menggunakan Ventilator di Rumah Sakit Umum Daerah Al – Ihsan Provinsi Jawa Barat Zahra Al Khansa; Maya Tejasari; Dadang Rukanta
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6195

Abstract

Abstract. Respiratory failure is a condition in which the respiratory system is unable to maintain adequate gas exchange to meet metabolic demands, namely oxygenation and/or CO2 elimination. The disturbance primarily affects oxygenation, manifested by hypoxemia, or affects ventilation, manifested by hypercapnia and respiratory acidosis. This disease can cause dysfunction in other organs or be life-threatening. In patients with respiratory failure, treatment of the underlying cause is needed as also supportive measures, one of which can use a ventilator. The purpose of this study was to compare the clinical improvement in patients with respiratory failure who used and did not use a ventilator at Al-Ihsan Hospital, West Java Province. This research was conducted using the analytic observational method with a retrospective cohort study design. Samples in this study were taken from patients with respiratory failure who used ventilators and did not use ventilators in the hospital. The data in this study were taken from the medical records of patients with respiratory failure who used a ventilator and did not use a ventilator in the hospital. Of the 22 patients who used ventilators, 50% (11 patients) experienced improvement, and 50% (11 patients) did not improve or were declared dead. Of the 22 patients who did not use a ventilator, 81.8% (18 patients) did not improve or were declared dead, and 18.2% (4 patients) experienced improvement. The difference between patients who experienced a clinical improvement in the group who received a ventilator and those who did not get a ventilator can be said to be significant because the p-value is 0.026, which is smaller than the α value (0.05). Abstrak. Gagal napas merupakan suatu kondisi di mana sistem pernapasan tidak mampu mempertahankan pertukaran gas yang memadai untuk memenuhi kebutuhan metabolik, yaitu oksigenasi dan/atau eliminasi CO2. Gangguan tersebut terutama mempengaruhi oksigenasi, dimanifestasikan oleh hipoksemia, atau mempengaruhi ventilasi, dimanifestasikan oleh hiperkapnia dan asidosis respiratorik. Penyakit ini dapat menyebabkan disfungsi pada organ lain atau mengancam kehidupan. Pada pasien gagal napas diperlukan pengobatan penyebab yang mendasarinya dan juga tindakan suportif, salah satunya bisa menggunakan ventilator. Tujuan penelitian ini adalah untuk mengetahui perbandingan perbaikan klinis pada pasien gagal napas yang menggunakan dan tidak menggunakan ventilator di rumah sakit Al – Ihsan provinsi jawa barat. Penelitian ini dilakukan dengan metode observasional analitik dengan desain penelitian cohort retrospective. Sampel pada penelitian ini diambil dari pasien gagal napas yang menggunakan ventilator dan tidak menggunakan ventilator di rumah sakit. Data pada penelitian ini diambil dari rekam medis pasien gagal napas yang menggunakan ventilator dan tidak menggunakan ventilator di rumah sakit. Dari 22 pasien yang menggunakan ventilator 50% (11 pasien) diantaranya mengalami perbaikan, dan 50% (11 pasien) yang lain tidak mengalami perbaikan atau dinyatakan meninggal. Dari 22 pasien yang tidak menggunakan ventilator 81,8% (18 pasien) diantaranya tidak mengalami perbaikan atau dinyatakan meninggal, dan 18,2% (4 pasien) yang lain mengalami perbaikan. Perbedaan pasien yang mengalami perbaikan klinis pada kelompok yang mendapatkan ventilator dengan yang tidak mendapatkan ventilator dapat dikatakan signifikan, dikarenakan nilai p sebesar 0,026, lebih kecil dari nilai α (0,05).
Systematic Review: Khasiat Antikanker Sediaan Daun Kelor (Moringa oleifera) terhadap Pertumbuhan Kanker Paru Zahrah Qanitah; Maya Tejasari; Umar Islami
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6321

Abstract

Abstract: Moringa leaves (Moringa oleifera) have various pharmacological effects, such as antioxidant, anti-inflammatory, antimicrobial and anticancer activities. The anticancer effects present in various Moringa oleifera leaf preparations affect the proliferation and apoptosis of lung cancer. The purpose of this study was to analyze the effect of giving Moringa oleifera leaf preparations on the growth of lung cancer. A systematic review method was carried out using the Pubmed, ProQuest, ScienceDirect, and SpringerLink databases, pre-clinical research designs (in vitro and in vivo) in 2012–2022 articles. Search obtained 684 articles, screened to 327 articles. Then a PICOS analysis was carried out and three articles were obtained which would be critically reviewed. The results showed that administration of Moringa oleifera leaf preparations reduced proliferation and increased apoptotic activity in lung cancer cells. A decrease in cell proliferation was seen in the presence of cell cycle arrest and the modulation of cell cycle-related proteins, namely decreased expression of cyclin D1 and cyclin E, but increased expression of p21. Cell death triggered by apoptosis can be seen from decreased expression of Bcl2 and increased expression of the Bax gene. Caspase activity can trigger apoptosis in cancer cells. The results of a significant increase in caspase-3/7 were seen after administration of Moringa leaf extract while the results of a very significant increase were seen in caspase-9. Induction of apoptosis after administration of moringa leaf preparations depends on the type of caspase. Abstrak. Daun kelor (Moringa oleifera) memiliki berbagai efek farmakologi, seperti aktivitas antioksidan, antiinflamasi, antimikroba, dan antikanker. Efek antikanker yang ada di dalam berbagai sediaan daun Moringa oleifera memengaruhi proliferasi dan apoptosis kanker paru. Tujuan penelitian ini adalah untuk menganalisis efek pemberian sediaan daun kelor (Moringa oleifera) terhadap pertumbuhan kanker paru. Dilakukan metode systematic review menggunakan database Pubmed, ProQuest , ScienceDirect, dan SpringerLink, desain penelitian pra-klinik (in vitro dan in vivo) pada artikel tahun 2012–2022. Pencarian didapat 684 artikel, diskrining menjadi 327 artikel. Kemudian dilakukan analisis PICOS dan didapatkan tiga artikel yang akan ditelaah kritis. Hasil penelitian menunjukkan bahwa pemberian sediaan daun kelor (Moringa oleifera) dapat menurunkan proliferasi dan meningkatkan aktivitas apoptosis pada sel kanker paru. Penurunan proliferasi sel terlihat dengan adanya penghentian siklus sel dan adanya modulasi protein terkait siklus sel, yaitu penurunan pada eskpresi siklin D1 dan siklin E, tetapi meningkatkan ekspresi p21. Kematian sel yang dipicu oleh apoptosis dapat dilihat dari penurunan ekspresi Bcl2 dan peningkatan eskpresi gen Bax. Aktivitas caspase dapat memicu apoptosis pada sel kanker. Hasil peningkatan signifikan pada caspase-3/7 terlihat setelah pemberiaan ekstrak daun kelor sedangkan hasil peningkatan yang sangat signifikan terlihat pada caspase-9. Induksi apoptosis setelah pemberian sediaan daun kelor bergantung pada jenis caspase.
Systematic Review: Faktor yang Berperan terhadap Efektivitas Penggunaan APD dalam Mencegah Transmisi Covid-19 pada Tenaga Kesehatan Neng Salma Arina Azmi; Maya Tejasari; Listya Hanum
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6478

Abstract

Abstract. The Coronavirus Disease (COVID-19) pandemic started first in Wuhan, China and listed as a pandemic by the World Health Organization (WHO). Health workers(HCW) treat COVID-19 patients directly, so the risk of infection with SARS-CoV-2 is higher than the general population. During the COVID-19 pandemic, personal protective equipment (PPE) has become a necessity. In particular, HCW need PPE to protect against the spread of infection. 1 The use of PPE can reduce the risk of infection associated with treating COVID-19 patients, to prevent the transmission of the SARS-Cov-2 virus must use PPE. PPE includes masks, gloves, eye protection, and gowns needed to protect individuals from exposure to the virus SARS-CoV-2. So this study aims to determine the Effectiveness of Using PPE in Prevention of COVID-19 Transmission in HCW. The type of research used is a systematic review using 3 databases ScienceDirect, SpringerLink, and Pubmed. then selected articles for 2020–2022 with an Observational research design and a special design. on data searching, 17,337 articles were found, and 818 articles were obtained. Then a PICOS analysis was carried out and 15 articles were obtained that would be critically reviewed and the results were 7 articles. From 7 articles, a relationship was obtained between the use of PPE in preventing the transmission of COVID-19 and influencing factors such as availability, quantity, training, compliance and type of use of PPE. Using respirator masks and N95 surgical masks is superior to disposable masks or cloth masks in reducing the spread of the virus because they have the highest filtration efficiency and reduce aerosol penetration >96.67% at a distance of 0–1.5 m. Abstrak. Pandemi Coronavirus disease (COVID-19) dimulai pertama kali di Wuhan, Cina dan terdaftar sebagai pandemi oleh World Health Organization (WHO). Tenaga kesehatan menangani pasien COVID-19 secara langsung sehingga berisiko lebih tinggi terinfeksi SARS-CoV-2 daripada populasi umum. Selama masa pandemic COVID-19, alat pelindung diri (APD) telah menjadi kebutuhan. Secara khusus, tenaga kesehatan membutuhkan APD untuk perlindungan terhadap penyebaran infeksi. Penggunaan APD dapat mengurangi risiko infeksi terkait dengan perawatan pasien COVID-19, untuk mencegah transmisi virus SARS-Cov-2 harus menggunakan APD. APD meliputi mask, hand gloves, eye protector, dan gown diperlukan untuk melindungi dari paparan virus SARS-CoV-2. Jenis penelitian yang digunakan adalah systematic review menggunakan 3 database ScienceDirect, SpringerLink, dan Pubmed. kemudian dipilih artikel tahun 2020–2022 dengan desain penelitian Observational dan design khusus. Pada pencarian data didapatkan 17,337 artikel dan pada skrining didapatkan 818 artikel. Kemudian dilakukan analisis PICOS dan didapatkan 15 artikel yang akan ditelaah kritis dan hasilnya 7 artikel. Dari 7 artikel diperoleh hubungan antara penggunaan APD dalam mencegah transmisi COVID-19 dengan faktor yang mempengaruhi seperti ketersediaan, kuantitas, peltihan, kepatuhan dan jenis penggunaan APD. Menggunakan masker respirator dan masker bedah N95 lebih unggul dibandingkan masker sekali pakai atau masker kain dalam mengurangi penyebaran virus karena memiliki efisiensi filtrasi tertinggi dan mengurangi penetrasi aerosol >96,67% pada jarak 0–1,5 m.
“Output Research Supporting Class” Manuscript Writing Training to Avoid Misconduct in an Islamic Perspective Yuniarti, Lelly; Batara, Triando; Garna, Herry; Tejasari, Maya
Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Vol 23, No 2 (2023)
Publisher : LP2M of Institute for Research and Community Services - UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/dms.2023.232.13495

Abstract

The tridharma point that is most challenging for a lecturer to achieve is research, and currently, the benchmark for the research field is scientific publications. However, in reality, there are still many lecturers who are hampered in fulfilling research outputs in the form of scientific publications, this is because lecturers experience difficulties in compiling manuscripts of research results for publication. There are currently 144 lecturers at the Tasikmalaya Health Engineering Polytechnic and around 50% of the lecturers still have the functional position of expert assistant and do not have a functional position or teaching staff. This PKM aims to improve the ability of Tasikmalaya Health Polytechnic lecturers to compile manuscripts, avoid misconduct, and publish the manuscript in the intended journal. PKM methodThis is done using an Asset Based Community-Driven Development (ABCD) approach, namely focusing on the assets, potential and strengths of the Health Polytechnic lecturers. Workshop and coaching clinic preparing manuscripts, using reference management, and submitting manuscripts to journals. The research results showed that of the 50 participants who took part in the workshop, 15 lecturers succeeded in compiling manuscripts of research results, avoiding misconduct, and improving the manuscripts according to reviewer input. This shows the need for ongoing training and stimulation activities for lecturers in compiling research output.
Spray Preparation Nanoemulsion Containing Butterfly Pea Flower (Clitoria ternatea L) Ethanol Extract as an Antiaging Nanocosmetic Yuniarti, Lelly; Bhatara, Tryando; Tejasari, Maya; Dewi, Miranti Kania; Ahmad, Sadiah; Kharisma, Yuktian
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.189-197

Abstract

Background:  Nanotechnology has the potential to produce innovations in drug formulation and drug delivery systems. Nanocosmetics and nanocosmeceuticals containing natural ingredients have been proven to overcome the weaknesses of traditional cosmetics and also add value to their formulations.Objective: This study aims to analyze the application of nanocosmeceutical technology based on ethanol extract of butterfly pea flower (Clitoria Ternatea L) in the preparation of nanoemulsion spray as a skin antiaging agent for the growth of collagen, elastin and extracellular matrix.Methods Method used true experimental design with posttest control group with random allocation to model mice given UVB radiation. The levels of collagen, elastin, and cellular matrix extract were assessed using Verhoef staining and observed by two experts,Results: The results of this research show that a nanoemulsion spray preparation of ethanol extract of butterfly pea flower (Clitoria Ternatea L) improves skin damage in aging model mice by increasing the production of extra cellular matrix, collagen and elastin. Conclusion: The preparation of butterfly pea flower flower extract nanoemulsion sprey (Clitoria Ternate L) has antiaging, collagen and elastin formation activities  
Gambaran Karakteristik Pasien Dan Jenis Dermatitis Kontak Di Poliklinik Kulit Dan Kelamin Rsud Majalengka Aghata Shaumafitri Azzahra; Maya Tejasari; Deis Hikmawati
Jurnal Riset Kedokteran Volume 4, No.1, Juli 2024, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.v4i1.3687

Abstract

Abstract. Contact dermatitis is a skin disease caused by exposure to substances that are both irritants and allergens, divided into Irritant Contact Dermatitis (ICD) and Allergic Contact Dermatitis (ACD). Contact dermatitis is influenced by endogenous factors such as age, gender, lesion location, history of atopy, genetics and exogenous factors such as work. This study aims to determine the characteristics of patients and types of contact dermatitis at the Skin and Venereology Polyclinic at Majalengka Regional Hospital. This research is a descriptive study with a cross sectional design. The sampling technique was carried out by total sampling with a total of 399 patients. Data was obtained from medical records in the form of patient characteristics, namely age, gender, occupation, lesion location and diagnosis of ACD or ICD. The research results showed that contact dermatitis was mostly found in the early adolescent age group (17-25) (10.8%). The majority were female (63.4%). The job most often found in Housewives (IRT) (27.6%). The most common lesion locations occurred in the hand area (35.1%). There were 284 (71.2%) cases of patients diagnosed with ACD and 115 (28.8%) cases of ICD. Abstrak. Dermatitis kontak adalah penyakit pada kulit yang disebabkan oleh paparan zat baik yang bersifat iritan dan alergen, terbagi menjadi Dermatitis Kontak Iritan (DKI) dan Dermatitis Kontak Alergi (DKA). Dermatitis kontak dipengaruhi oleh faktor endogen seperti usia, jenis kelamin, lokasi lesi, riwayat atopi, genetik dan faktor eksogen seperti pekerjaan. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik pasien dan jenis dermatitis kontak di Poliklinik Kulit dan Kelamin RSUD Majalengka. Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional. Teknik pengambilan sampel dilakukan secara total sampling dengan jumlah 399 pasien. Data diperoleh dari rekam medis berupa karakteristik pasien yaitu usia, jenis kelamin, pekerjaan, lokasi lesi dan didiagnosis DKA atau DKI. Hasil Penelitian menunjukan dermatitis kontak terbanyak ditemukan pada kelompok usia Remaja awal (17-25) (10,8%). Mayoritas jenis kelamin perempuan (63,4%). Pekerjaan yang paling sering ditemukan pada Ibu Rumah Tangga (IRT) (27,6%). Lokasi lesi paling banyak terjadi di daerah tangan (35,1%). Ditemukan kasus pasien yang diagnosis DKA sebanyak 284 (71,2%) dan kasus DKI sebanyak 115 (28,8%).
Kejadian Transmisi Vertikal Covid-19 Berdasarkan Jenis Persalinan Shinta Mourinda Rachmani; Maya Tejasari; Winni Maharani Mauliani
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.10526

Abstract

Abstract. The incidence of COVID-19 has been increasing since its emergence at the end of 2019 in the city of Wuhan, China, eventually developing into a pandemic. Pregnant women are a susceptible group to COVID-19. Pregnant women diagnosed with COVID-19 can transmit the virus to their unborn babies through vertical transmission, which can occur through three mechanisms: antepartum, intrapartum, and postpartum. This study aims to investigate the comparison of vertical transmission of COVID-19 between groups of mothers delivering spontaneously and through cesarean section at Al Ihsan Regional General Hospital in West Java Province. The observational study employs a population-based study design with medical record with a total of 122 pregnant women diagnosed with COVID-19 who gave birth at Al Ihsan Regional General Hospital in West Java Province. Data analysis is conducted using the Chi-Square test. The results indicate that there is no significant difference in vertical transmission of COVID-19 between the group of mothers delivering spontaneously and through cesarean section (p-value> 0.05). The low incidence of vertical transmission in six babies born spontaneously and seven babies born through cesarean section suggests that the placenta acts as a barrier effectively, and the low number of ACE receptors in reproductive organs causes vertical transmission not to occur always. Abstrak. Angka kejadian COVID-19 semakin meningkat sejak kemunculannya pada akhir 2019 di kota Wuhan, China, dan akhirnya berkembang menjadi pandemik. Ibu hamil merupakan kelompok yang rentan terhadap COVID-19. Ibu hamil yang didiagnosis COVID-19 dapat menularkan virus tersebut kepada bayi yang dikandungnya melalui transmisi vertikal, yang dapat terjadi melalui tiga mekanisme: antepartum, intrapartum, dan postpartum. Penelitian ini bertujuan untuk menyelidiki perbandingan transmisi vertikal COVID-19 antara kelompok ibu yang melahirkan secara spontan dan melalui operasi caesarea di RSUD Al Ihsan Provinsi Jawa Barat tahun 2020-2021. Penelitian observasional ini menggunakan desain studi berbasis populasi data diambil dari rekam medis dengan total 122 ibu hamil yang didiagnosis COVID-19 yang melahirkan di RSUD Al Ihsan Provinsi Jawa Barat. Analisis data dilakukan dengan uji Chi-Square. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan yang signifikan dalam transmisi vertikal COVID-19 antara kelompok ibu yang melahirkan secara spontan dan melalui operasi caesarea (p-value > 0,05). Rendahnya kejadian transmisi vertikal pada enam bayi yang lahir secara spontan dan tujuh bayi yang lahir melalui operasi caesarea menunjukkan bahwa plasenta berfungsi sebagai penghalang dengan efektif, dan jumlah reseptor ACE yang rendah pada organ reproduksi menyebabkan transmisi vertikal tidak selalu terjadi.
Co-Authors Aghata Shaumafitri Azzahra Agista Rohani Agly Adithya Agly Adithya, Agly Ahmad, Sadiah Anissa Febie Melati Annisa Rahmah Furqaani Arief Budi Yulianti Azmi Azkiatul Fikri Batara, Triando Bhatara, Tryando Dadang Rukanta Deis Hikmawati Dilla Latul Anjaniah Djanuarsih Iwan Djanuarsih Iwan, Djanuarsih Dwi Prasetyo Dwi Widi Mandasari Eka Nurhayati Eneng Mira Enggar Hestu Enggar Hestu, Enggar Evana Sandhiya Riksabaya Faisal, Sandy Fenda Khafidhotenty Firman Cahayadipura Hasani Farhan Herri S. Sastramihardja Herry Garna Hoirunisa Fathia Hoirunisa Fatiha, Hoirunisa Ismet Muchtar Nur Karina Dinda Azzahra Kharisma, Yuktian Lelly Yuniarti Listya Hanum Siswanti M. Nurhalim Shahib Meta Maulida Damayanti Miranti Kania Dewi Nabila Tarlita Luthfiyah Namira Putri Hermawan Naufal Fadhillah Alam Neng Salma Arina Azmi Noormartany Noormartany Nur Azmiati Mundiri Nurhalim Shahib Raden Anita Indriyanti Retno Ekowati Sadeli Masria Santun Bhekti Rahimah Sara Shafira Shinta Mourinda Rachmani Siti Aminah Abdurachman Siti Annisa Devi Trusda, Siti Annisa Devi Sitti Indah Sari Pratiwi Maradjabessy Titik Respati Umar Islami Usep Abdullah Husin Waya Nurruhyuliawati Wida Purbaningsih Widayanti Widayanti Winni Maharani Winni Maharani Mauliani Yani Triyani Yuktiana Kharisma Zahra Al Khansa Zahrah Qanitah