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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Sains dan Komunitas Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Fundamental and Applied Pharmaceutical Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Clinical and Pharmaceutical Sciences Journal
Siti Fatmawati Fatimah, Siti Fatmawati
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Investigating the Impact of Surfactant and Cosolvent on the Polyphenolic Content in Arumanis Mango Leaf Extract (Mangifera indica L.) Fatimah, Siti Fatmawati; Farida, Verda; Nuari, Yudha Rizky; Viviandhari, Daniek; Pertiwi, Deasy Vanda
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.39-47.2024

Abstract

The leaf of Mangifera indica L. contains flavonoids and mangiferin which showed positive effects on wound healing of diabetic ulcer. The used of suitable surfactant and co-solvent is required to ensure the high solubility of the active pharmaceutical ingredient (API), thereby optimizing the efficacy. This study aims to determine the ideal surfactant and cosolvent for a thermosensitive hydrogel formula of Mangifera indica leaf ethanol extract. The leaf was fextracted by maceration using 70% ethanol then determined for moisture content.  The extract was prepared for solubility tests of flavonoid and mangiferin on surfactants (Kolliphor® EL, Tween® 20, Tween® 80, Miranol® C2M) and co-solvents (Glycerin, PEG 400, and transcutol). Methods for total flavonoids content were Spectrophotometry UV-Vis and mangiferin with RP-HPLC method. The moisture content in the extract is 8.590 ± 0.754%. The surfactant demonstrating the highest capability in flavonoid dissolution is Tween 20 (1863.750 ± 0.838 µgQE/g extract), followed by Tween 80, Kolliphor EL, and Miranol C2M. In the context of co-solvents, PEG 400 (1309.583 ± 0.292 µgQE/g extract) show superior flavonoid dissolution capability, with glycerin and Transcutol following in descending order. Tween 20 and Tween 80 exhibite comparable efficacy in mangiferin dissolution, followed by Miranol C2M and Kolliphor EL. Among co-solvents, Transcutol demonstrate the highest aptitude for mangiferin dissolution, succeeded by PEG 400 and glycerin. This study indicates Tween 20 is a preferable surfactant and PEG 400 was considered as co-solvent to be further used in a thermosensitive gel formula for diabetic ulcer. 
Formulation and Antioxidant Activity of Syzygium polyanthum (Salam) Ethanolic Extract with Het-Cam Irritation Assessment Lina Widiyastuti; Siti Fatmawati Fatimah; Athiyyah Najelita Harahap; Leoni Nanda Wulandari; Hajjatuna Hasna Salsabil; Syifa Aulia Nugraheni; Aulia Salsabila Merdeksari
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 2 (2026): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i2.26833

Abstract

Ethanol extract of salam leaves (Syzygium polyanthum) contains flavonoids, tannins, essential oils, citric acid, and eugenol, which are efficacious as antioxidants, anti-cholesterol, antimicrobials, and antidiabetics. Extracts need to be formulated in gel dosage forms to obtain uniform doses, enhance the effectiveness of pharmacological effects, ensure hygiene, and facilitate ease of use. The study aims to develop a gel formula using the physical characteristics ANOVA method with ethanol extract from salam leaves at a 95% confidence level. The results revealed that the salam leaves ethanol extract gel had moderate to strong antioxidant activity. The results of the irritation test indicate that the characteristics have met the requirements for efficacious antioxidant dosage forms that do not cause irritation. The stages of the research method began with the development of a gel dosage form using Design Expert software. The gel formed exhibited physical characteristics, including organoleptic properties, viscosity, homogeneity, pH, adhesion, and spreadability. The gel effectiveness test included an antioxidant test using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method and an in vitro irritation test using the Hen's Egg Test Chorioallantoic Membrane (HET-CAM) method, which assessed the presence of lysis, bleeding, or coagulation in the test media.
Co-Authors Aisyah, Vani Aisyah, Vani Akhmad Kharis Nugroho Akmal Maulana Athiyyah Najelita Harahap Aulia Salsabila Merdeksari Azis Ikhsanudin Citra Ariani Edityaningrum, Citra Dzulhaifa Dzulhaifa Dzulhaifa Dzulhaifa Edityaningrum, Citra Ariyani Endang Darmawan Endang Darmawan Endang Lukitaningsih Hajjatuna Hasna Salsabil Ibnu Gholib Gandjar Iin Narwanti Iin Narwanti Ira Aprilia Wulandari Ira Aprilia Wulandari Laela Hayu Nurani Leoni Nanda Wulandari Lina Widiyastuti Nuari, Yudha Rizky Pertiwi, Deasy Vanda Ranila, Suciati Ria Putri Salma Ria Putri Salma Ronny Martien Sri Mulyaningsih Syifa Aulia Nugraheni Vani Aisyah Verda Farida Viviandhari, Daniek Wahyu Widyaningsih Widyasari Putranti Wihasty Nur Istyqomah