Article Per Year (5 Year)
p-Index From 2021 - 2026
1.116
P-Index
This Author published in this journals
All Journal Jurnal Veteriner Biotika: Jurnal Ilmiah Biologi Bionatura Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Biodjati Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Sciences of Pharmacy
Yasmi Purnamasari Kuntana
Jurusan Biologi Fakultas MIPA Uiversitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Treatment of PLGA Nanoparticles Ointment-Ethanol Extract of Archidendron pauciflorum in the Wound Healing in Diabetic Mice Malini, Desak Made; Kuntana, Yasmi Purnamasari; Madihah, Madihah; Furqon, Wildanul; Hermawan, Wawan
Jurnal Biodjati Vol 5 No 2 (2020): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v5i2.9256

Abstract

Diabetic wounds lead to severe tissue damage and are diffi-cult to cure. Jengkol (Archidendron pauciflorum) is a plant commonly used by local Indonesian communities to treat diabetic wounds. The efficiency of herbal medicine still has a deficiency of its ability to reach the target organs, therefore nanotechnology is applied in the hope that all drug concentrations can reach the target organs successfully. This study aimed to evaluate the effectiveness of PLGA nanoparticle ointment-ethanol extract jengkol fruit peel (EEJFP) to accelerate the wound healing process in the skin of streptozotocin-induced diabetic mice. The research method used was experimental with a completely randomized design using six treatments and four replications. Diabe-tes was induced by intraperitoneal injection of streptozotocin 180 mg/ kg BW. Mice with a blood glucose level of ≥150 mg/dL were used for diabetic mice models. The incision wound created at the dorsolateral region of shaven skin at ±1 cm2 using sterile scissors. The treatments given were vaseline for Control Negative (CN) and Control Positive (CP), Betadine ointment (PB), 10% EEJFP ointment (P1), 5% PLGA nanoparticle ointment-EEJFP (P2), and 2.5% PLGA nanoparticle ointment-EEJFP (P3). The results showed that the administration of PLGA nanoparticles ointment-EEJFP with a concentration of 5% PLGA nanoparticle ointment-EEJFP (P2) resulted in the shortest wound length on day 3, 7 and 14; narrower granulation tissue; a larger number of blood capillaries; and denser collagen fibers (α <0.05) compared to CP and PB treatments. The administration of PLGA nanoparticle ointment-EEJFP with a concentration of 5% was the most effective concentration in accelerating wound healing in the skin of diabetic mice. 
Effect of Deferiprone on Hepatic Expression of Hamp, Ftl, and Tfr1 Genes in an Iron-Overloaded Rat (Rattus norvegicus) Model Salsabila, Nadhila Hasna; Kuntana, Yasmi Purnamasari; Arrizqiyani, Tanendri; Safitri, Ratu
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404387

Abstract

Iron overload is linked to progressive impairment of organ function, with the liver being the primary site of deposition due to the lack of a physiological route for iron elimination. The maintenance of systemic iron balance depends on key regulatory proteins, including hepcidin (Hamp gene), ferritin light chain (Ftl gene), and transferrin receptor 1 (Tfr1 gene). This study tested the hypothesis that Deferiprone (DFP), an oral iron chelator, modulates the hepatic expression of Hamp, Ftl, and Tfr1 genes in an iron-overloaded rat model. Eighteen male Wistar rats (150-200 g) were randomly assigned into three groups: Normal (N), Negative Control (NC; induced with Iron Dextran), and Treatment (T; Iron Dextran + DFP). Iron overload was induced via intravenous injection of Iron Dextran (120 mg/kg BW) over 15 days at 3-day intervals, while DFP was administered orally (100 mg/kg BW) in three divided doses for 28 consecutive days. Gene expression was assessed using RT-PCR, and relative quantification was performed using the Livak method. The iron-overloaded rats showed marked upregulation of Hamp and Ftl and downregulation of Tfr1. Administration of DFP significantly reversed these alterations, decreasing Hamp and Ftl levels while restoring Tfr1 expression to levels comparable to normal controls. These results highlight the potential role of DFP in modulating hepatic iron-regulatory genes under iron overload conditions. 
Co-Authors Andi Hiroyuki Arrizqiani, Tanendri Desak Made Malini Fadilah, Ardi Mufarriz Furqon, Wildanul Hikmat Kasmara Joko Kusmoro Kartiawati Alipin Madihah Madihah Permana, Andre Dian Ratu Safitri Ruly Budiono Salsabila, Nadhila Hasna Satria Ardi Tama Tanendri Arrizqiyani, Tanendri Virita Rossa Pratiwi Walida Tanzania Wawan Hermawan Wawan Hermawan Wibowo, Annisa Maharani Wildanul Furqon Yetty Yusri Gani -