Article Per Year (5 Year)
p-Index From 2021 - 2026
1.116
P-Index
This Author published in this journals
All Journal Biotika: Jurnal Ilmiah Biologi Bionatura Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Biodjati Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Sciences of Pharmacy
Yasmi Purnamasari Kuntana
Jurusan Biologi Fakultas MIPA Uiversitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Effect of Deferiprone on Hepatic Expression of Hamp, Ftl, and Tfr1 Genes in an Iron-Overloaded Rat (Rattus norvegicus) Model Salsabila, Nadhila Hasna; Kuntana, Yasmi Purnamasari; Arrizqiyani, Tanendri; Safitri, Ratu
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404387

Abstract

Iron overload is linked to progressive impairment of organ function, with the liver being the primary site of deposition due to the lack of a physiological route for iron elimination. The maintenance of systemic iron balance depends on key regulatory proteins, including hepcidin (Hamp gene), ferritin light chain (Ftl gene), and transferrin receptor 1 (Tfr1 gene). This study tested the hypothesis that Deferiprone (DFP), an oral iron chelator, modulates the hepatic expression of Hamp, Ftl, and Tfr1 genes in an iron-overloaded rat model. Eighteen male Wistar rats (150-200 g) were randomly assigned into three groups: Normal (N), Negative Control (NC; induced with Iron Dextran), and Treatment (T; Iron Dextran + DFP). Iron overload was induced via intravenous injection of Iron Dextran (120 mg/kg BW) over 15 days at 3-day intervals, while DFP was administered orally (100 mg/kg BW) in three divided doses for 28 consecutive days. Gene expression was assessed using RT-PCR, and relative quantification was performed using the Livak method. The iron-overloaded rats showed marked upregulation of Hamp and Ftl and downregulation of Tfr1. Administration of DFP significantly reversed these alterations, decreasing Hamp and Ftl levels while restoring Tfr1 expression to levels comparable to normal controls. These results highlight the potential role of DFP in modulating hepatic iron-regulatory genes under iron overload conditions. 
Co-Authors Andi Hiroyuki Arrizqiani, Tanendri Desak Made Malini Fadilah, Ardi Mufarriz Furqon, Wildanul Hikmat Kasmara Joko Kusmoro Kartiawati Alipin Madihah Madihah Permana, Andre Dian Ratu Safitri Ruly Budiono Salsabila, Nadhila Hasna Satria Ardi Tama Tanendri Arrizqiyani, Tanendri Virita Rossa Pratiwi Walida Tanzania Wawan Hermawan Wawan Hermawan Wibowo, Annisa Maharani Wildanul Furqon Yetty Yusri Gani -