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All Journal Journal of Natural Sciences and Mathematics Research Jurnal Sains & Teknologi Lingkungan Journal Of Nursing Practice Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research Jurnal Katalisator Walisongo Journal of Chemistry Jambura Journal of Chemistry Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Sainstech Farma: Jurnal Ilmu Kefarmasian Pena Medika : Jurnal Kesehatan Natural Sciences Engineering and Technology Journal Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Sains dan Teknologi Jurnal Farmasi Sains dan Praktis Pharmacy Genius SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Jurnal Keperawatan dan Kesehatan (JKK) Journal Of Health Innovation And Community Services Jurnal Penelitian dan Pengkajian Ilmiah Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Adita Silvia Fitriana
Program Studi Farmasi Program Sarjana, Universitas Harapan Bangsa
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary

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Journal : Sainstech Farma: Jurnal Ilmu Kefarmasian

 1 
Sintesis Analog Kurkumin (2E,6E)-2-(4-Hidroksi-3-Metoksi-5-((Pirolidin)metil)benziliden) -6-(4-Metoksibenziliden)Sikloheksan-1-on Rahmawati, Nur; Fitriana, Adita Silvia; Sholikha, Munawarohthus
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1578

Abstract

Curcumin is a potential compound to be developed. However, the clinical use of these compounds is limited due to their low stability and bioavailability. Therefore, to increase the pharmacological activity of curcumin, it is necessary to modify the chemical structure of curcumin. Curcumin analog compound (2E,6E)-2-(4-hydroxy-3-methoxy-5-((pyrrolidine)methyl)benzylidene)-6-(4-methoxybenzyliden)cyclohexane-1-on can be synthesized in 3 steps. Phase I, the reaction between p-methoxybenzaldehyde and cyclohexanone took place aldol condensation reaction with NaOH catalyst. Phase II, the Clasein-Schmidt reaction between compound 1 (the result of the synthesis of stage I) and vanillin involved dilute HCl as the catalyst. Phase III, reacting the results of the synthesis of phase II with Mannich pyrrolidine base by adapting the method used by Geschickter and Maeadow. Compound 3 as a result of purification was observed using Thin Layer Chromatography using Ethyl Acetate:Methanol (1:1) as an eluent to obtain Rf 0.46 and a melting range of 130-131 oC. The yield obtained was 51.52% with the characteristics of a reddish brown powder. This compound needs further identification using the Mass Spectrum and NMR.
Co-Authors Afni Mirlandari Afresa Bias Putri Enarga Afresa Bias Putri Enarga Al Mu’izzah, Nurul Alfaeni Salmatuzzahro Ali Djamhuri Aminurita, Agus Arni Nur Rahmawati Aurellia, Rizky Natasya Awal Tunis Yantoro Bambang Purwono Dessy Nawangsari Desy Nawangsari Desy Nawangsari Desy Nawangsari Dewi Rahmawati Dina Febrina dina febrina Dwi Novitasari Erni Lovianasari Galih Samodra Galih Samodra Hanif Zufrialdi Bagaskara Haniyah, Siti Harno Dwi Pranowo Iga Melasasi Indarwati, Atika Khofifatul Muamanah Kurnia Panggih Rahayu Lestari, Afnida Dwi Munawarohthus Sholikha Murniati Murniati Nawangsari, Desy Nawangsari, Desy Nawangsari Nisa Nur Fadilah Noor Yunida Triana Nur Rahmawati Nur Rahmawati Rani Prabandari Riska Norma Sarita Royani, Sri Samodra, Galih Setyaji, Andy Anggoro Sri Royani Sri Royani Suryani, Roro Lintang Tanti Purwanti Tiwi Setianingrum Triana, Noor Yunida Triana, Noor Yunida Umayah, Dani Yatul