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Imran, Arlan K
Health Polytechnic Of The Ministry Of Health Gorontalo
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Journal : Jurnal Katalisator

 1 
UJI AKTIVITAS ANTIBAKTERI SEDIAAN PEEL OFF MASK EKSTRAK ETANOL DAUN KELOR Pratiwi Ishak; Fihrina Mohamad; Prisca Safriani Wicita; Nangsih Sulastri Slamet; Arlan K. Imran
JURNAL KATALISATOR Vol. 7 No. 1 (2022): Jurnal Katalisator Volume 7 Nomor 1, April 2022
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.509 KB) | DOI: 10.22216/katalisator.v7i1.917

Abstract

Propionibacterium acnes is one of the bacteria that trigger acne. A popular face mask preparation today for acne skin care is the peel off Mask. The purpose of this study was to formulate ethanol extract of moringa leaves (Moringa oleifera L.) become a Peel Off mask preparation and see the antibacterial activity of the preparation against Propionibacterium acnes. This research method is quasi experimental, formulated Peel Off Mask preparation with variation of ethanol extract of moringa leaves F1 (10%), F2 (15%) and F3 (20%), then physical test (organoleptic test with hedonic scale 1-5, pH test, irritation test, spreadability test, dry time test) and antibacterial activity test with diffusion method. Data analysis of antibacterial activity test results using one way ANOVA test. The results showed organoleptic test, pH test, irritation test and drying time test F1-F3 all meet the standard. Antibacterial activity test has the greatest power is F1 17.17 mm. The result of one way anova test between F3 treatment with positive control 2 (peel Off mask Brand x®) obtained significance value (0.01) <(0.05), which means F3 has a significant difference to KP2. Conclusion; preparation peel Off Mask ethanol extract of Moringa leaves F3 is the best formula physically and has the greatest antibacterial activity of 17.17 mm (strong) against Propionibacterium acnes.
PENINGKATAN KELARUTAN SIMVASTATIN MELALUI PENAMBAHAN BAHAN PENGOMPLEKS SULFANILAMID Arlan Imran; Prisca Safriani Wicita; Zulfiayu Sapiun
JURNAL KATALISATOR Vol. 8 No. 1 (2023): Jurnal Katalisator Volume 8 No. 1, April 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.034 KB) | DOI: 10.62769/katalisator.v8i1.2205

Abstract

Simvastatin is a drug used to lower cholesterol levels in the blood. The mechanism of action of simvastatin is by inhibiting the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which competitively inhibits the cholesterol biosynthesis process in the body. Simvastatin is included in the class II BCS (Biopharmaceutics Classification System) drug, which has low water solubility and high permeability. The low solubility of simvastatin in water will affect its bioavailability in the body, which result in a therapeutic effect that is not achieved. Drug complexation is a method used to determine the solubility of a compound by adding a complexing agent. Complexing materials that are often used in other research are materials that do not have therapeutic activity such as cyclodextrin, but ini this study used complexing material from anti-microbial drug class by utilizing the reaction of glucoronide formation in the glucoronic acid structure of sulfanilamide. This research is a quantitative research with a laboratory experimental trial method which aims to see the effect of adding sulfanilamide complexing agents at various concentrations (25 ppm, 50 ppm, 75 ppm, and 100 ppm) on the solubility level of simvastatin using the acid-base titration method. The dissolved simvastatin concentration values ​​for F1, F2, F3, F4, and F5 were 0.261 ± 0.087, respectively; 0.348 ± 0.151; 0.416 ± 0.195; 0.444 ± 0.163; 0.539 ± 0.118. The results obtained showed that the higher concentration of the sulfanilamide complexing agent added, the greater solubility of simvastatin.
Co-Authors Abubakar, Fadlun Ahmad, Fadilah Almunawarrah, Alya Ary Kristijono Bandhi Prasetya Nugroho Basri, Insyira F Basri, Insyira Fadliana Basri, Rakhmadhana Fitraeni Daud, Rizka Puji Astuti Fendy Prasetyawan Fihrina Mohamad Fitriah Ayu Magfirah Yunus Hartati Hartati Hida, Fadli R. Husain, Fadli Isma Oktadiana Jahja, Sitti Rhomlah Kadir, Nur Fadillah Oktaviani Kisman, Deyanti Maku, Zahra Ainun Ma’ruf, Melis Nangsih Sulastri Slamet Panigoro, Nur’ainun Pratiwi Ishak PRISCA SAFRIANI WICITA Putri, Nurwigya Mohamad Ratna Mildawati Salman Salman Sapiun, Zulfiayu Sulfiani, Elin Tilamuhu, Divya Shakira Tunggali, Mein Munriyati Vyani Kamba Wantaa, Nurunnisa Wicita, Prisca S. Yahya, Cindy Yuneka Saristiana Yunus, Fitriah Ayu Magfirah