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All Journal CERATA Jurnal Ilmu Farmasi Prosiding University Research Colloquium CERATA IJF (Indonesia Jurnal Farmasi) Jurnal Ilmu Keperawatan dan Kebidanan Jurnal Abdimas Indonesia International Journal of Health Science
Endang Setyowati
Universitas Muhammadiyah Kudus
Religion Humanities Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Chemometric Analysis of Phytochemical Content and Antioxidant Activity of Ethanol Extract 70% and Ethyl Acetate of Kersen Leaf (Muntingia calabura L.) Afif Putri Habibah; Endang Setyowati; Emma Jayanti Besan
International Journal Of Health Science Vol. 5 No. 2 (2025): International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i2.5583

Abstract

This study analyzed the phytochemical content and antioxidant activity of kersen leaf extract (Muntingia calabura L.) obtained with 70 % ethanol and ethyl acetate through a chemometric approach. Extraction is carried out by maceration, total flavonoids are determined by UV-Vis spectrophotometry with quercetin, while total phenolics with gallic acid. Antioxidant activity was tested using the DPPH method and the IC₅₀ value was calculated. The results showed that the total flavonoid content in 70% ethanol extract was 3.374 ± 0.082 mg EK/mL, while in ethyl acetate extract it was 2.726 ± 0.014 mg EK/mL. The total phenolic content in 70% ethanol extract was 152.34 ± 5.71 mg EAG/mL, while in ethyl acetate extract it was 262.78 ± 6.27 mg EAG/mL. The highest antioxidant activity was obtained from ethyl acetate extract with an IC₅₀ value of 34.45 ± 1.23 μg/mL, while ethanol extract 70% showed an IC₅₀ value of 42.35 ± 7.22 μg/mL. Chemometric analysis using Principal Component Analysis (PCA) showed a relationship between the 70% ethanol flavonoid content and ethyl acetate on the antioxidant activity of the DPPH method.  
Chemometric Analysis of Phytochemical Content and Antioxidant Activity of 70% Ethanol and Ethyl Acetate Extracts of Butterfly Pea Flowers Nabila Naila Amelia; Endang Setyowati; Muhamad Khudzaifi
International Journal Of Health Science Vol. 5 No. 2 (2025): International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i2.5594

Abstract

Antioxidants are essential for the body to inhibit or ward off free radicals. Naturally, the body can produce antioxidants, but they can also be obtained from external sources. Interestingly, antioxidants can also be found in plants, one of which is the butterfly pea flower (Clitoria ternatea L.). Compounds contained in butterfly pea flowers, such as flavonoids and phenolics, were macerated with 70% ethanol and ethyl acetate solvents. This study aims to analyze the phytochemical content (flavonoids and phenolics) and evaluate the antioxidant activity of butterfly pea flower extract and their relationship with the PCA (Principal Component Analysis) chemometric method. The total flavonoid content test was carried out with quercetin as a comparator, while the total phenolic content test was carried out with gallic acid as a comparator. Meanwhile, antioxidant activity was carried out using the DPPH method. In this study, the total flavonoid content in the 70% ethanol extract was 4.109 ± 0.027 mg QE/mL, while in the ethyl acetate extract it was 6.616 ± 0.22 mg QE/mL. The total phenolic content produced was 28.276 ± 1.36 mg GAE/mL for the 70% ethanol extract and 31.579 ± 1.59 mg GAE/mL for the ethyl acetate extract, respectively. Meanwhile, the IC50 value for antioxidant activity showed that the ethanol extract had a value of 54.23 ± 2.37 µg/mL, while the ethyl acetate extract had a value of 39.38 ± 3.14 µg/mL. The ethyl acetate extract had higher flavonoid, phenolic, and antioxidant activity than the 70% ethanol extract. Chemometric analysis showed a positive correlation between flavonoids and phenolics in the ethanol solvent. Chemometric analysis showed a relationship between flavonoid and phenolic content in both the ethanol and ethyl acetate solvents and the antioxidant activity of the DPPH method.
Co-Authors Adinda Triatna Maullidiyah Afif putri Habibah Amalia Khoirunnisa Andhika Setyawan Ari Simbara Ari Simbara Arina Zulfah P Dewi Septiyaningrum Diah Putri Nugraheni Diana Tri Lestari Dwi Asmawati Eko Retnowati Emma Jayanti Besan Eni Istiqamah Ezara Mila Fawwazah Prayitno Fatika Oktasari Fina Sari Arstianti Hardiyani Presticasari Irma Ravika Mila Umdatunnisa Muhamad Khudzaifi Muhammad Nurul Fadel Nabila Naila Amelia Nisa Oktadayana Nur Farida Ulfa Nura Ali Dahbul Ratna Dewi Isnaeni Ria Etikasari Rika Muharyanti Riska Ardiana Sabaan, Wahid Yayuk Mundriyastutik Yulis Trinovitawati Yunita Rusidah