Article Per Year (5 Year)
p-Index From 2021 - 2026
1.785
P-Index
This Author published in this journals
All Journal AL KAUNIYAH Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Biota Elkawnie Phenomenon : Jurnal Pendidikan MIPA Jurnal Pendidikan Biologi Sinkron : Jurnal dan Penelitian Teknik Informatika Jurnal Biodjati Journal of Tropical Crop Science AL-HAYAT: Journal of Biology and Applied Biology Jambura Edu Biosfer Journal Gunung Djati Conference Series
Lianah Lianah, Lianah
Program Studi Biologi, Fakultas Sains Dan Teknologi, UIN Walisongo Semarang
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

Published : 31 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 31 Documents
Search

 1   2   3   4 
Black Cumin (Nigella sativa) Against Mycobacterium tuberculosis Strain H37RV And MDR-TB Mashuri Masri; Cut Muthiadin; Masita Masita; Tri Cahyanto; Lianah Lianah; Rusny Rusny; Siska Tridesianti
Elkawnie Vol. 7 No. 1 (2021)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v7i1.9335

Abstract

Abstract: Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. 10 million people suffer from TB Every year. Although TB is a preventable and treatable disease, 1.5 million people die every year due to TB. Alternative treatments continue to be pursued, and treatment with the latest TB drugs that are continuously being encouraged. Black cumin (Nigella sativa) seed contains essential oils with active compounds such as thymohydroquinone, Oleoresins, flavonoids, alkaloids, saponins, tannins, and terpenoids that act as antibacterial drugs. This study aims to determine the sensitivity of  N. sativa seed extract in inhibiting the growth of  M. tuberculosis strain H37RV and MDR-TB (Multidrug Resistance-TB). This research using Microscopic-Observation and Drug-Susceptibility Assay (MODS) method. Extraction of N. sativa was carried out by the maceration method using 70% methanol as a solvent. The results showed that the M. tuberculosis strain H37RV and MDR-TB were sensitive to N. sativa extract at concentrations of 5 and 10% but resistant to N. sativa extract at concentrations of 1 and 3%.Abstrak: Tuberkulosis (TB) adalah penyakit menular yang disebabkan oleh Bakteri Mycobacterium tuberculosis. Penyakit ini menimbulkan dampak kematian yang cukup mengkhawatirkan.  Penyakit tersebut dapat dicegah dan diobati. Salah satu sumber pengobatannya menggunakan biji jintan hitam (Nigella sativa) yang mengandung minyak atsiri dengan senyawa aktif seperti timohidrokuinon, oleoresin, flavonoid, alkaloid, saponin, tanin, dan terpenoid yang berfungsi sebagai obat antibakteri. Penelitian ini bertujuan untuk mengetahui sensitivitas ekstrak biji N. sativa dalam menghambat pertumbuhan M. tuberculosis strain H37RV and MDR-TB (Multidrug-Resistance-TB). Penelitian ini menggunakan metode Microscopic-Observation and Drug-Susceptibility Assay (MODS). Ekstraksi N. sativa dilakukan dengan metode maserasi menggunakan pelarut metanol 70%. Hasil yang diperoleh menunjukkan bahwa bakteri M. tuberculosis strain H37RV dan TB-MDR, kedua  strain tsb sensitif terhadap ekstrak N. sativa konsentrasi 5 dan 10%,  tetapi resisten terhadap  ekstrak N. sativa konsentrasi 1 dan 3%.
Co-Authors Ahmad Afdholi Ahmad Fauzan Hidayatullah Ahmad, Milya Ulfa Ainun Nadhifah Ainun Nadhifah, Ainun Ami Nurohmah Anila Umriana Atsni Lestari Baiq Farhatul Wahidah Cut Muthiadin Delima Engga Maretha Dian Ayuning Tyas Dian Triastari Armanda Fadla Orsida Fakhrudin Aziz Fakhrudin Aziz, Fakhrudin Fifi Dismayanti Indriani Nainu Fitriana Rochmah Hafsan Hidayat, Saifullah Hidayatullah, Ahmad Fauzan Irmayati, Irmayati Isvana Dalaila Kusrinah Kusrinah LAILATUL MAGHFIROH Lailatul Maghfiroh Lestari, Atsni Mashuri Masri Masita Masita Melisa Oktaviani Sukma Melisa Oktaviani Sukma Milya Ulfa Ahmad Muhammad A’tourrohman Muhammad Hasiibun Nuhaa Mukhlisi Mukhlisi Mukhlisi Mukhlisi Niken Kusumarini Niken Kusumarini, Niken Nuhaa, Muhammad Hasiibun Orsida, Fadla Rita Ariyana Nur Khasanah Rochmah, Fitriana Rusny Rusny Siska Tri Desianti Siti Mukhlishoh Setyawati Siti Mukhlisoh Setyawati Sukma, Melisa Oktaviani Syaiful Zuhri Harahap Tri Cahyanto Tridesianti, Siska Tyas, Dian Ayuning Tyas, Dian Ayuning Umu Zulfatu Rizki