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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Bandung Jurnal Kesehatan Andalas Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Human Care Journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Ophthalmologica Indonesiana
Kemala Sayuti
Universitas Andalas
Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Differential Diagnosis of Leukocoria : A Case Report: Poster Presentation - Case Report - Resident Rahman, Harrie Kurnia; Sayuti, Kemala
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/tap89h21

Abstract

Introduction : Leukocoria is an abnormal pupillary reflex more clearly seen after mydriasis or photography. It is often the first sign of a range of serious intraocular disorders, including congenital cataracts, Coats disease, retinoblastoma, Familial Exudative Vitreoretinopathy (FEVR). Case Illustration : Baby F, 10 months with chief complaint the vision in both eyes appears defocused since birth. A history of trauma to the head is denied, severe pain (-), a history of similar complaints in the family is denied. Pregnancy history: Mother had hypertension. The patient born spontaneusly at 39-40 weeks of gestation, crying immediately, birth weight 2700 grams. Ophtalmology Status ODS: VA Blink reflex(+), Following light (+), Following object (-), Konjungtiva : hiperemis (-), cornea : clear (+), Pupil : leukocoria (+). Funduscopy examination ODS: Vitreus : cloudy (+), papillae: cannot be assessed, blood vessels: visible images of raised blood vessels, retina: detached (+) retinal layers seen, macula: cannot be assessed. USG ODS: cloudy vitreus with hyperreflectivity moderate to high. Patient was diagnosed with Leucocoria ec Retinal Detachment ec Suspect FEVR differential diagnosis Retinoblastoma Bilateral. CT Scan : A mass with a calcified component in the right and left posterior bulbs, consistent with bilateral retinoblastoma Discussion : The clinical history of leukocoria, meaning loss of the normal red retinal reflex, is nonspecific. Key findings here are the normal size of the globes and the presence of calcifications, which are more compatible with retinoblastoma, Coats' disease, or FEVR. Conclusion Leucocoria in aterm baby has several differential diagnosis such as retinoblastoma that needs further examination.
Changes in Retinal Ganglion Cell (RGC) and Retinal Nerve Fiber Layer (RNFL) Thickness in Children with Type 1 Diabetes Mellitus at Dr. M. Djamil General Hospital, Padang, Indonesia lonanda, Gama Agusto; Kemala Sayuti; Havriza Vitresia; Hendriati; Andrini Ariesti; Weni Helvinda
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1047

Abstract

Background: Type 1 diabetes mellitus (DM) is a chronic metabolic disorder that causes hyperglycemia and increases the risk of morbidity and mortality. Diabetic retinopathy, a microvascular complication that often occurs in DM patients, can cause visual impairment and even blindness. Regular eye examinations are important for early detection of diabetic retinopathy. Optical coherence tomography (OCT) is a non-invasive method that can be used to measure the thickness of retinal layers, including RGC and RNFL. It is thought that thinning of the retinal layer can be a sensitive biomarker in detecting diabetic retinopathy in type 1 DM patients. This study aims to determine changes in RGC and RNFL thickness in children with type 1 DM. Methods: This cross-sectional design analytical observational study was conducted at the eye polyclinic of Dr. M. Djamil General Hospital Padang in November 2023-March 2024. A total of 46 eyes from 46 people, divided into two groups: the type 1 DM group and the control group, were recruited in this study. RGC thickness was measured using AS-OCT GC-IPL thickness analysis and RNFL with optic disc RNFL thickness analysis. Data analysis was carried out using the unpaired T-test. Results: The results showed RGC depletion in the type 1 DM group (RGC 83.48 ± 3.75) compared to the control group (RGC 86.70 ± 4.87) with a value of p = 0.016 (p < 0.05). There was no statistical difference in RNFL thickness between the type 1 DM group (RNFL 102 ± 11.80) and the control group (RNFL 100.96 ± 10.97) with a value of p = 0.581 (p> 0.05). Conclusion: This study found RGC thinning in type 1 DM patients, but did not find differences in RNFL thickness between the two groups. This RGC depletion is thought to be caused by apoptosis of retinal neuronal cells due to chronic hyperglycemia. Examination of RGC thickness with OCT can be developed as an early detection of diabetic retinopathy in children with type 1 DM.
Myopia Progression in Children: A Comparative Analysis of Pre-Pandemic and Pandemic Periods Harsya Luthfi Anshari; Kemala Sayuti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1175

Abstract

Background: The COVID-19 pandemic brought about significant changes in children's lifestyles, including increased screen time and reduced outdoor activities due to school closures and lockdowns. These changes raised concerns about potential myopia progression in children. Methods: This study compared the spherical equivalent (SE) measurements of children aged 8-17 years from two time visits: one before the pandemic (September 2019 - February 2020) and one during the pandemic (March 2020 - February 2022). Data on family history of myopia, screen time, and outdoor activities were also collected. Paired t-tests were used to analyze the differences in SE between the two visits. Results: A total of 11 children participated in the study. The mean change in SE was -1.55 D, indicating a significant increase in myopia during the pandemic (p = 0.046). The average daily screen time was 201 minutes, while outdoor activity time was 42 minutes. Conclusion: The findings suggest a potential corelation between increased screen time, reduced outdoor activities, and myopia progression in children during the pandemic. It is crucial to encourage healthy visual habits, including limiting screen time and promoting outdoor activities, to mitigate the impact of the pandemic on children's vision.
Co-Authors Adila Hanna Afdal Afdal Agustin Vira Agustin Vira Andrini Ariesti Andrini Ariesti Anum, Qaira Astria Rima Rara Yuswir Astria Rima Rara Yuswir Azharudina, Adiba Azwin Aziz Deddy Saputra Desmawati Desmawati Devilen, Yuki San Elmatris Sy Ennesta Asri Ennesta Asri Erlina Rustam Febiyola Ratu Khairani Fortuna, Fory Gardenia Akhyar Harmen Harmen Harsya Luthfi Anshari Hendriati Hendriati, Hendriati Hondrizal Hondrizal Husnil Kadri Ilahi, Fitratul Indah ARBR Tobing Indah Indria Sari Indah Indria Sari Izzati Mujahidah Julita Julita Julita Julita lonanda, Gama Agusto Martga Bella Rahimi Maya Nasrul Moestafa Nur Muhammad Syauqie Nabila Alifina Novian Novian Novian Novian Rahmadiansyah, Muhammad Fadhil Rahman, Harrie Kurnia Rendra Darma Satria Rendra Darma Satria Rika Desviorita Rika Desviorita Rina Gustia Rina Gustia Rinda Wati Rizki Dwayana Rizki Dwayana Rozy Oneta Rustam, Raihana Sandiyanto Satya Wydya Yenny Suci Permata Sari Tofrizal Tofrizal Tutty Ariani Tutty Ariani Ulya Uti Fasrini Vitresia, Havriza Weni Helvinda Weni Helvinda Yanwirasti Yanwirasti