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THE EFFECT OF ORAL VITAMIN D ON TUMOR NECROSIS FACTOR-? EXPRESSION IN TRABECULAR MESHWORK OF WISTAR GLAUCOMA MODEL: Oral Presentation - Experimental Study - Resident ERINA, RIKHA; Ariesti, Andrini; Hendriati
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/vrszrr85

Introduction & ObjectivesElevated intraocular pressure (IOP) is a risk factor for the development and progression of glaucomathat can induces inflammation in the trabecular meshwork through the production of proinflammatorycytokines such as TNF-?. Inflammation induce mechanical stress and changes in theextracellular matrix in the trabecular meshwork, resulting in hypertonicity and resistance toaqueous humor outflow. Vitamin D can modulate cytokine production by suppressing TH1 cellexpression and inducing TH2 cell expression. The production of pro-inflammatory cytokines can besuppressed by the presence of vitamin D. MethodsAn experimental study of 30 wistar glaucoma model were divided into 3 groups, non treatmentgroup ( A and B) and the oral vitamin D (1200 IU/kg/day) group (C) for 14 days. TNF-? expressionsin trabecular meshwork were measured by immunohistochemical staining. Group A was measuredon day 3, while group B and C were measured on day 14. The differences between the three groupswere analyzed statistically using one way ANOVA test. Significantly different if the p<0.05. ResultsThe mean expression of TNF- ? in the trabecular meshwork of wistar glaucoma model in group A, B,and C was 22,2 ± 2,51%, 39,1 ± 3.98%, 34.2 ± 3,19 % respectively. There was significantlydifference in TNF-? expressions between the three groups (p<0.001). ConclusionVitamin D per oral can decrease TNF-? expression in the trabecular meshwork of wistar glaucomamodel on day 14 . Studies in wistar and humans are still needed to assess the effect of vitamin D onothers pro-inflammatory cytokines in glaucoma.

Modified Hughes Tarsoconjunctival Flap Procedure for Lower Eyelid Defect: Poster Presentation - Case Series - Resident aulia; hendriati; mardijas efendi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/fqfns990

Introduction : Hughes procedure of tarsoconjunctival flap is a method of choice in reconstructing full thickness inferior eyelid defect that involves >50% of eyelid margin to restore anatomical integrity, function, and cosmetic of the eyelid. The modified Hughes procedure includes sparing of the marginal upper lid tarsus and removal of the levator muscle aponeurosis from the tarsoconjunctival flap.This article reports 2 patients who underwent modified Hughes procedure after basal cell carsinoma excision. Case Illustration : Two patients underwent inferior eyelid reconstruction using modified Hughes procedure. After wide excision of the tumor, tarsoconjunctival flap was made to reconstruct posterior lamella of the eyelid. Subsequently, anterior lamella of the eyelid were reconstructed using full thickness skin graft and advancement flap, respectively. Both patient then underwent second surgery, tarsus flap release, 6-8 week after the first surgery. Discussion : A tarsoconjunctival flap from the upper eyelid replaces the posterior lamella, whereas a skin graft, a skin flap, or a skin-muscle flap restores the anterior lamella. After surgery, tarsal flap apposition, skin flap/graft, and stitches were intact. After tarsus flap release, wound healing was good. Tumor biopsy showed basal cell carcinoma. Conclusion : Modified Hughes procedure is a treatment of choice in reconstructing full thickness inferior eyelid defect involving >50% of eyelid margin. Full thickness skin graft and advancement flap to reconstruct anterior lamella of the eyelid is choosen after considering skin color and texture similarity and laxity of eyelid and cheek.

Direct Closure Technique for Superior Palpebra Defect in Sebaceous Gland Carcinoma Palpebra Mandela, Kelvin; Mardijas Efendi; Hendriati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 11 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i11.886

Background: Sebaceous Gland Carcinoma (SGC) palpebra is a malignancy tumor on the palpebra that originates from the sebaceous gland. These tumors can spread peripherally through intraepithelial or pagetoid growths. The main management is surgery, and the defect reconstruction is performed according to the size and area of the defect. Case presentation: A 53-year-old female patient came with a mass on the upper eyelid of the right eye for 1 year, which progressively grew in size and stuck to the eyelid, with no bleeding and no pain. The history of treatment has not provided an adequate response for the last 1 year. Visual acuity was 6/12 in both eyes, and a mass was found approximately 8x8 mm in size, nodular, fixed, and accompanied by madarosis. The histopathological examination showed a palpebral sebaceous gland carcinoma. There was no enlargement of submandibular or parotid lymph nodes. The patient underwent a wide excision of the upper eyelid lesion. Then, the defect was reconstructed by direct closure technique. The patient has been controlled 4 weeks of follow‑up. The functional and cosmetic outcomes were satisfied. Conclusion: After a month of follow-up, no recurrence occurred. Reconstruction with direct closure technique has good results in terms of anatomy, function, and cosmetics.

Impact of Open-Angle Glaucoma Severity on Vision-Related Quality of Life: A Cross-Sectional Study in a Single Center in Indonesia Rino Agustian Praja; Andrini Ariesti; Hendriati; Muhammad Hidayat; Irayanti; Julita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1171

Background: Glaucoma is a progressive optic neuropathy characterized by the gradual loss of retinal ganglion cells (RGCs) and their axons, leading to irreversible visual field loss. This study aimed to investigate the relationship between the severity of primary open-angle glaucoma (POAG) and vision-related quality of life (VRQoL) in a single center in Indonesia. Methods: A cross-sectional study was conducted at the eye polyclinic of Dr. M. Djamil General Hospital, Padang, Indonesia, from June to August 2024. A total of 54 patients with POAG were included and categorized into mild, moderate, and severe groups based on their cup-to-disc ratio and visual field index (VFI). VRQoL was assessed using the Indonesian version of the National Eye Institute Visual Function Questionnaire (NEI-VFQ 25). Results: The mean VRQoL score was significantly lower in the severe group (60.63 ± 13.04) compared to the moderate (81.79 ± 10.42) and mild (85.04 ± 10.52) groups (p = 0.000). A strong negative correlation was observed between glaucoma severity and VRQoL (r = -0.667, p = 0.000). The social functioning subscale showed the strongest correlation with severity (r = -0.573, p = 0.000). Conclusion: The severity of POAG significantly impacts VRQoL, with more severe disease associated with lower QoL scores. The social functioning domain appears to be particularly affected. These findings underscore the importance of comprehensive glaucoma management that addresses not only clinical parameters but also the patient's overall quality of life.

Ethnic Differences in Myopia: Axial Length and Central Corneal Thickness in the Minang Population Pratama Yogi; Wati Rinda; Hendriati; Hidayat Muhammad; Ariesti Andrini; Helvinda Weni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1206

Background: Myopia is a prevalent vision disorder characterized by blurred distance vision. It is often associated with increased axial length (AL) and alterations in central corneal thickness (CCT). This study investigated the relationship between AL and CCT in individuals from the Minang ethnic group in Indonesia with varying degrees of myopia. Methods: A cross-sectional study was conducted at the Ophthalmology Clinic of Dr. M. Djamil General Hospital Padang from June to July 2024. The study involved 33 eyes from Minangkabau patients with myopia, categorized into three groups: mild, moderate, and high myopia. Axial length was measured using A-scan Biometry (immersion technique), and central corneal thickness (CCT) was assessed using Anterior Segment Optical Coherence Tomography (AS-OCT). Results: Significant differences were observed in the average values of AL and CCT among mild myopia (AL 23.93 ± 0.650 mm, CCT 530.45 ± 38.534 µm), moderate myopia (AL 25.03 ± 0.516 mm, CCT 518.64 ± 26.223 µm), and high myopia (AL 27.12 ± 1.524 mm, CCT 509.45 ± 30.422 µm) groups, with a p-value of 0.037 (p<0.05) and r = -0.729. A strong correlation between AL and CCT was found in individuals with myopia among the Minangkabau ethnic group (r = -0.729, p = 0.037). Conclusion: Higher degrees of myopia are associated with increased axial length and reduced central corneal thickness in the Minang ethnic group. These findings highlight the importance of considering ethnic differences in the assessment and management of myopia.

Modified Hughes Tarsoconjunctival Flap Procedure for Lower Eyelid Defect: A Case Series Aulia; Hendriati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1226

Background: The Hughes procedure, or tarsoconjunctival flap, is a technique used in reconstructing full-thickness lower eyelid defects involving >50% of the eyelid margin to restore anatomical integrity, function, and cosmesis of the eyelid. The modified Hughes procedure spares the marginal upper lid tarsus and removes the levator muscle aponeurosis from the tarsoconjunctival flap. This study reports a case series of patients who underwent a modified Hughes procedure after basal cell carcinoma excision. Case presentation: Two patients underwent lower eyelid reconstruction using the modified Hughes procedure. After a wide excision of the tumor, a tarsoconjunctival flap was created to reconstruct the posterior lamella of the eyelid. Subsequently, the anterior lamella of the eyelid was reconstructed using a full-thickness skin graft and an advancement flap, respectively. Both patients underwent a second surgery, tarsus flap release, 6-8 weeks after the first surgery. Postoperatively, tarsal flap apposition, skin flap/graft, and stitches were intact. After the tarsus flap release, wound healing was good. A tumor biopsy showed basal cell carcinoma. Conclusion: The modified Hughes procedure is a treatment of choice in reconstructing full-thickness lower eyelid defects involving >50% of the eyelid margin. Full-thickness skin graft and advancement flap to reconstruct the anterior lamella of the eyelid are chosen after considering skin color, texture similarity, and the laxity of the eyelid and cheek.

Clinical Characteristics and Management of Steroid-Induced Glaucoma Pattih Primasakti; Lucyana; Fitratul Ilahi; Hendriati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1285

Background: Steroid-induced glaucoma (SIG) is a secondary glaucoma characterized by elevated intraocular pressure (IOP) due to steroid use. This study aimed to analyze the clinical characteristics and management of SIG patients at Dr. M. Djamil General Hospital Padang, Indonesia, from January 2019 to August 2023. Methods: A retrospective descriptive study was conducted using medical records of patients diagnosed with SIG. Data collected included age, gender, steroid type, route of administration, duration of use, IOP at diagnosis, underlying diseases, glaucoma stage, and treatment. Results: Seventeen patients were diagnosed with SIG. The majority were female (70.58%) and aged 4-39 years (58.83%). The most common underlying diseases were systemic lupus erythematosus (SLE) and allergic conjunctivitis (47%). Oral steroid administration was most frequent (76.4%), with a usage duration of 2-12 months in most cases (70.6%). IOP at diagnosis ranged from 22 to 31 mmHg in most patients (82.3% right eye, 64.7% left eye). Most patients presented with mild glaucoma (70.5%). Topical anti-glaucoma medications were the primary treatment (76.4%), with trabeculectomy performed in some cases (23.6%). Conclusion: SIG is a preventable condition. Early detection and appropriate management are crucial to prevent vision loss. The clinical characteristics identified in this study contribute to a better understanding of SIG in our population. Further research on the interplay of risk factors, genetics, and histopathology is needed to enhance our comprehension of SIG.

EVALUATION OF PAIN SCALE ON CIRCUMCISION PATIENTS UNDER LIDOCAINE HYDROCHLORIDE LOCAL ANESTHESIA Aulia Achmad, Baraz; Manela, Citra; Zulfiqar, Yevri; Hendriati; Effendi, Rinal; Myh, Etriyel
Indonesian Journal of Urology Vol 32 No 2 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i2.924

Objective: Evaluating the pain scale of circumcision patients under lidocaine hydrochloride local anesthesia. Material & Methods: An observational descriptive research was carried out on 30 children with a body weight of 20-29 kilograms from February 2023-April 2023. Circumcision was performed under 2 ampoules of 2% lidocaine as local anesthesia. Data consisted of pain onset measure using a stopwatch and the pain scale were obtained through the Wong-Baker Face Pain Rating Scale (WBFPRS), these variables were recorded when pain occurs post-local anesthesia effects ends. Results: The average onset of pain is 47.73 minutes with the fastest onset of pain was 20 minutes and the longest onset of pain was 72 minutes. The average pain scale as measured by the WBFPRS is 2.33. Conclusion: The average pain scale in this study was less than 3 which indicated that the pain felt did not interfere with activities. Keywords: Circumcision, pain, anesthesia, lidocaine.

Clinical Characteristics and Management of Steroid-Induced Glaucoma Pattih Primasakti; Lucyana; Fitratul Ilahi; Hendriati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1285

Background: Steroid-induced glaucoma (SIG) is a secondary glaucoma characterized by elevated intraocular pressure (IOP) due to steroid use. This study aimed to analyze the clinical characteristics and management of SIG patients at Dr. M. Djamil General Hospital Padang, Indonesia, from January 2019 to August 2023. Methods: A retrospective descriptive study was conducted using medical records of patients diagnosed with SIG. Data collected included age, gender, steroid type, route of administration, duration of use, IOP at diagnosis, underlying diseases, glaucoma stage, and treatment. Results: Seventeen patients were diagnosed with SIG. The majority were female (70.58%) and aged 4-39 years (58.83%). The most common underlying diseases were systemic lupus erythematosus (SLE) and allergic conjunctivitis (47%). Oral steroid administration was most frequent (76.4%), with a usage duration of 2-12 months in most cases (70.6%). IOP at diagnosis ranged from 22 to 31 mmHg in most patients (82.3% right eye, 64.7% left eye). Most patients presented with mild glaucoma (70.5%). Topical anti-glaucoma medications were the primary treatment (76.4%), with trabeculectomy performed in some cases (23.6%). Conclusion: SIG is a preventable condition. Early detection and appropriate management are crucial to prevent vision loss. The clinical characteristics identified in this study contribute to a better understanding of SIG in our population. Further research on the interplay of risk factors, genetics, and histopathology is needed to enhance our comprehension of SIG.

ANGKA KEBERHASILAN TERAPI EKSISI DAN RADIOTERAPI ADJUVAN PADA PASIEN KELOID YANG DIOPERASI DI RUMAH SAKIT UNAND Iffah Annadiyah; Fory Fortuna; Hendriati
JURNAL KESEHATAN INDRA HUSADA Vol 13 No 1 (2025): Juni 2025
Publisher : SEKOLAH TINGGI ILMU KESEHATAN INDRAMAYU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36973/jkih.v13i1.709

Keloid is a benign fibroproliferative tumor of the dermal that extends beyond the original wound and invades adjacent dermal tissue due to an abnormal healing response from the wound in the dermis. Keloids can have a disturbing impact on individuals such as cosmetic disorders, pruritus, pain, and in severe cases, limited joint movement so that it is very necessary to be managed. One of the keloid therapies with quite promising results is surgical excision and adjuvant radiotherapy. This aim of this research was to determine the success rate of excision therapy and adjuvant radiotherapy in keloid patients operated on at Unand Hospital. This research is an observational descriptive study and uses a cross- sectional design using a total sampling technique of 12 samples. Data analysis uses univariate analysis and research data is presented in the form of a table of success rates. The Results In this study, the highest success rate was found in the 12-16 year age group, female gender, lower extremity predilection. All patients received external radiation with the highest success rate in the group of patients who were given a total dose of 20 Gy in 5 fractions, a follow-up interval of 6 months, and a distance of excision and adjuvant radiotherapy for <3x24 hours, and adhered to the fixed therapy protocol. The success of therapy is largely influenced by predilection, age, gender, radiation dose, and patient compliance with therapy.

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