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All Journal PHARMACON Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Kesehatan Suara Forikes JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Pharmasipha Jurnal Farmasi Komunitas Duta Pharma Journal JK Jurnal Kesehatan Pharmacon: Jurnal Farmasi Indonesia
Clara Ritawany Sinaga
Program Studi S1 Farmasi, Sekolah Tinggi Ilmu Kesehatan Dirgahayu Samarinda
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Antihypercholesterolemic Activity of Tahongai Leaf infusion (Kleinsovia hospita L.) In Mice (Mus musculus L.) Sianturi, Sister; Sinaga, Clara Ritawany; Leswana, Nurillahi Febria; Butar-Butar, Maria Elvina Tresia
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.233-238

Abstract

Tahongai (Kleinhovia hospita L.) is an indigenous plant of East Kalimantan known for its health benefits, including antibacterial, anti-inflammatory, antioxidant, anticancer, and antidiabetic properties. This study evaluates the antihypercholesterolemic activity of Tahongai leaf infusion in hypercholesterolemic mice (Mus musculus L.), induced by egg yolk. The test groups included a positive control (simvastatin), a negative control (distilled water), and three treatment groups with Tahongai leaf infusion at concentrations of 15%, 30%, and 60%. The results indicated that the highest reduction in cholesterol levels was observed in the P1 group (15% infusion) with an average decrease of 30.84%, followed by P2 (30% infusion) at 24.79%, and P3 (60% infusion) at 9.31%. The positive control group showed an average reduction of 8.64%. Statistical analysis using One-Way ANOVA revealed a significant difference (p<0.05) in cholesterol level reduction among the treatment groups.
Co-Authors Allunan, Febyola Sascia Andayani, Tri Murti Annafiatuzakiah Delvi, Teresia Dewanti, Christy Alma Esty Elvinda Esty Elvinda Gunawan Pamudji Widodo Liniati Geografi Lujuk, Herlina Maria Elvina Tresia Butar-Butar Mukhlis Agus Setiawan Putra Nurillahi Febria Leswana Oktaviya, Hana Simanullang, Raymon Sister Sianturi Teresia Delvi Tikes, Roivelisko Weking, Katharina Kening Wiwi Erwina