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Preparation and evaluation of herbal cream Dubey, Aditi; Roy, Amit; Prasad, Pushpa
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
Publisher : Creative Pharma Assent

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A herbal fairness cream was formulated using herbal extracts which have potential antioxidant activity. Creams were basically formulated using the hydro alcoholic extracts of Glycyrrhiza glabra (root and Stolons),Camellia sinensis (leaf), Pleurotus osttreatus (mushroom plant). The prepared formulation were subjected to different evaluation like spreadability, pH, appearance, viscosity, drug content, irritability and antioxidant properties. The prepared formulation was found stable and effective. Among the several combination Liquorice & Green Tea based preparation shows better results. From the results it was concluded that it is possible to develop creams containing herbal extracts having potent antioxidant and fairness property and can be used as the provision of a barrier to protect skin. Â Â

A review of wound healing activity on different wound models Verma, Renuka; Gupta, Pushpa Prasad; Satapathy, Trilochan; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 7 No 1 (2019)
Publisher : Creative Pharma Assent

Wound is an injury of living tissue or break in the epithelial integrity of the upper layer of skin.which may lead to disturbance of skin anatomical structure and their function. The normal wounds are starts to healing immediately after an injury. Healing process are involved a series of coordinated events (inflammatory response, proliferation, maturation phase).  Wound healing remains a challenging clinical problem therefore correct and efficient wound management is essential. The screening models are important biological tools to understand basic process of tissue repair and treatment of wounds. Wide varieties of in-vitro, ex-vivo and in-vivo models have been developed for evaluation of wound healing activity. The in-vitro models includes Chick chorioallantoic membrane assay, Fibroblast assay, Collagen assay, Scratch assay, Endothelial cell in vitro tube formation assay, Keratinocytes assay. ex-vivo models includes organotypic culture, human ex vivo skin culture, porcine model, Human organotypic skin explanted culture And the  in-vivo models includes Excision wound model, Incision wound Model, Burn wound model, Dead space wound model, Skin wound induction.the aim of this review is detailed study on different types of in-vitro, ex-vivo and in-vivo models for evaluation of wound healing activity.

FORMULATION, OPTIMIZATION AND EVALUATION OF QUICK DISPERSIBLE TABLETS OF SUMATRIPTAN Baghel, Pragya; Roy, Amit; Chandrakar, Shashikant; Bahadur, Sanjib; Bhairam, Monika
Journal of Applied Pharmaceutical Research Vol 7 No 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.004

The main objective of this study was to prepare Quick Dispersible Tablets of drug Sumatriptan Succinate, which can rapidly disintegrate in the saliva using three different Superdisintegrants that is, Sodium Starch Glycolate, Crospovidone, and Croscarmallose Sodium with Taste Masking Polymer Beta-Cyclodextrin and Aspartame as a Sweetener. The taste masking of the drug was done by mixing it with the polymer beta-cyclodextrin using Solvent Evaporation method and then mixing optimized quantity of aspartame to it. The Quick Dispersible tablets were prepared by Direct Compression Technique using taste masked drug and other formulation excipients. The effect of various Superdisintegrants in three different concentrations has been studied. The prepared tablets were evaluated for wetting time, In-vitro Disintegration time, strength, and in-vitro Dissolution time. As per the results obtained, it was found that the formulation batch no. 4 was found to be the best formulation, as the data?s obtained by it was found to be in the required range of mouth dissolving tablets.

Standardization of herbal medicines – an overview Bhairam, Monika; Roy, Amit; Bahadur, Sanjib; Banafar, Alisha; Turkane, Dhanushram
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

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In the few decades, there has been exponentional growth in the field of herbal medicines. Most of the traditional systems of medicine are effective due to lack of standardization. So there is a need to develop a standardization technique. Standardization of herbal formulation is essential in order to assess the quality, purity, safety and efficacy of the drug. There is increasing awareness and general acceptability of the use herbal drugs in today’s medical practice. The world population depends on herbal medicines and product for healthy living. This rise in the use of herbal product has also given rise to various forms of adulteration of the products, which leading to consumers’ and manufacturers’ disappointment and in some instances fatal consequences. The challenge is innumerable and enormous, to fulfill the need of global herbal market. The standardization of this formulations like the organoleptic characters, physical properties, the various physic-chemical properties such as moisture content, ash values, extractive values need to be carried out along with Thin layer chromatography and heavy metal content study should also carried out to ascertain the quality, purity and safety of this herbal formulation.

Curcumin: a review Chauhan, Monika; Saha, Suman; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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The main objective of this review article is to overcome or to improve the problems related with curcumin with the help of new technologies or modifications to make a promising therapeutic agent which gives a good therapeutic response. Curcumin, a known natural polyphenolic compound obtained from dietary spice turmeric, possesses pharmacologic effects including anti-inflammatory, antioxidant, and many other activities. Clinical trials on curcumin have shown its safety and efficacy even at high doses in humans. But inspite of that it shows poor bioavailability (oral bioavailability) which is one of the major problems regarding curcumin. There are other reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numbers of approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipids complex; and fifth, the use of structural analogues of curcumin.

Antihyperlipidemic potential of herbals Yadav, Swati; Satapathy, Trilochan; Roy, Amit; Prasad, Pushpa
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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One of the most widespread diseases in the world is Coronary Heart Disease (CHD). It is also one of the most preventable. This review explores the management of CHD through changes in dietary modifications, lifestyle, and the use of dietary supplements and botanicals

Phytosome: a novel dosage form for herbal drug delivery Choudhury, Ananta; Verma, Swati; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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Phytosome is a complex of a natural active ingredient and phospholipids. The term ‘Phyto’ means plant while ‘some’ means cell like structure. It is claimed that phytosome increases absorption of "conventional herbal extracts" or isolated active principles both orally as well as topically. In this era phytosome gain popularity as a potential drug delivery device due to excessive demand and utility of herbs or herb based medicines. This advance technology offers amenities like improved absorption, enhanced delivery & increased bioavailability of herbal extracts. These drug-phospholipid complexes can be fabricated in the form of solution, suspension, emulsion, syrup, lotion, gel, cream, aqueous micro dispersions. Standardized plant extracts, mainly polar phytoconstituents like flavonoids, terpenoids, tannins, xanthones shall be introduced in form of phytosome.

Preparation and evaluation of herbal cream Dubey, Aditi; Prasad, Pushpa; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.655 KB)

A herbal fairness cream was formulated using herbal extracts which have potential antioxidant activity. Creams were basically formulated using the hydro alcoholic extracts of Glycyrrhiza glabra (root and Stolons),Camellia sinensis (leaf), Pleurotus osttreatus (mushroom plant). The prepared formulation were subjected to different evaluation like spreadability, pH, appearance, viscosity, drug content, irritability and antioxidant properties. The prepared formulation was found stable and effective. Among the several combination Liquorice & Green Tea based preparation shows better results. From the results it was concluded that it is possible to develop creams containing herbal extracts having potent antioxidant and fairness property and can be used as the provision of a barrier to protect skin.

Formulation and evaluation of enteric coated microcapsules of diclofenac sodium for modified release by combination of wet granulation and thermal change method Bahadur, Sanjib; Baghel, Pragya; Chanda, Ranabir; Roy, Amit; Saha, Suman; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol. 2 No. 4 (2014)
Publisher : Creative Pharma Assent

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The purpose of the present work was to develop optimized novel enteric microcapsules containing diclofenac sodium, a non steroidal anti inflammatory drug (NSAID) used for rheumatoid arthritis, for improved delivery and to diminish its adverse effect after oral administration. The microcapsule was prepared by using different polymers and the enteric coating was provided by using an innovative technique combining wet granulation method and thermal change method. This work also investigated different levels of enteric polymers like cellulose acetate phthalate (CAP) (X1) and ethyl cellulose (EC) (X2) and the stirring speed during coating ethyl cellulose (X3), by using 23 full factorial design. The dependent variables assessed were % yield (Y1), Q8 (% drug released after 8 hour) (Y2), n (Diffusion coefficient) (Y3), DEE (Drug entrapment efficiency) (Y4). The main effect and interaction terms were quantitatively evaluated using a mathematical model. The prepared microcapsules were evaluated for percentage drug dissolved, scanning electron microscopy, drug excipient interaction, angle of repose, particle size. Mean dissolution time (MDT) was used to compare dissolution patterns obtained. The results showed that X1 and X2 significantly affected the release properties.

Clock gene variation in type 2 diabetes: a review Parveen, Nushrat; Satapathy, Trilochan; Prasad, Pushpa; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Diabetes mellitus type 2 is a long-standing metabolic disorder that is exemplify by high blood sugar, insulin resistance, and comparative lack of insulin. General symptoms include increased thirst, frequent urination, and unsolved weight loss. Type 2 diabetes is mainly due to obesity and not sufficient work out in public who are heritably prone. Circadian clocks are significant to keep the moment in the sequence of physiological practice, series of behaviour and metabolism. The plasma level of glucose and numerous hormones implicated in glucose homeostasis for example insulin and glucagon exhibit circadian variation. Circadian desynchrony, a feature of alter occupation elevated-fat diet feed and sleep distraction in individual have been linked with metabolic disorders for instance obesity and type 2 diabetes. Circadian rhythm distraction can cause different fitness disarray. Current reading has discovered a seal connection among the pathophysiology of metabolic condition, which is characterized by obesity and hyperglycemia, and the operation of interior molecular clocks

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