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Amit Roy, Amit
Rajshahi University of Engineering & Technology
Chemistry Energy Medicine & Pharmacology

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Recent status on carbohydrate metabolizing enzyme inhibitors in regulation of diabetes: a mechanism based review Sinha, Durgeshnandani; Satapathy, Trilochan; Kumar Dewangan, Mehendra; Kumar, Arvind; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (938.073 KB)

Abstract

The important therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels which could be done by decreasing the absorption of glucose through the inhibition of the carbohydrates-hydrolyzing enzymes such as α-amylase and α-glucosidase present in the small intestinal brush border that are responsible for the breakdown of oligosaccharides and disaccharides into monosaccharide’s and suitable for absorption. Inhibition of α-amylase generally considered as strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity. Among the marketed allopathic preparations carbohydrates-hydrolyzing enzymes Inhibitors like acarbose, voglibose etc delay carbohydrate digestion and prolong overall carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently blunting the postprandial plasma glucose rise. Some of the plants are also considered as an important source of chemical constituent with potential for inhibition of α-amylase and can be used as therapeutic purposes. In this review our efforts have been devoted to explore the mechanism based carbohydrates-hydrolyzing enzymes Inhibitors for the regulation of diabetes.
Liposome: method of preparation, advantages, evaluation and its application Pradhan, Bhupendra; Kumar, Narendra; Saha, Suman; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 3 No. 3 (2015)
Publisher : Creative Pharma Assent

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Notable research in drug delivery started in 1950’s with the advent of polyclonal antitumor antibodies developed for targeting. Bangham et. Al. discovered liposomes in early 1960’s. In this review article we are discussing about the liposome, methods of the liposome preparation advantages and their different application of the liposome. Liposomes are artificially prepared vesicles made of lipid bilayer. Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. Liposome is used for the targeted drug delivery system and increase the bioavailability and half life of the any drugs. Liposomes are surfactants, sphingolipids, glycol-lipids, long chain fatty acids and even membrane proteins and drug molecules or it is also called vesicular system. Liposomes have been extensively investigated for drug delivery, drug targeting, controlled release and increased solubility.
Review on natural gums and mucilage and their application as excipient Bahadur, Sanjib; Sahu, Uttam Kumar; Sahu, Dipesh; Sahu, Ghanshyam; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 5 No. 4 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (732.392 KB) | DOI: 10.18231/2348-0335.2017.0010

Abstract

Natural mucilage’s are included in novel drug delivered (NDDS) to multitask functions and in any cases directly or indirectly control the increase and rate of drug release. Substantial research efforts have been directed towards develop safe and efficient natural based mucilage particulate drug delivery systems., natural gums and mucilages and their isolation, purification, standardization and characterization characteristics along with their applications are covered. Recent trend towards the use of plant based and natural products demands the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural mucilages have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, and widely available.
A review of wound healing activity on different wound models Verma, Renuka; Gupta, Pushpa Prasad; Satapathy, Trilochan; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 7 No. 1 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.187 KB) | DOI: 10.18231/2348-0335.2018.0013

Abstract

Wound is an injury of living tissue or break in the epithelial integrity of the upper layer of skin. This may lead to disturbance of skin anatomical structure and their function. The normal wounds start to heal immediately after an injury. Normal healing process involved: inflammatory phase, proliferation phase and maturation phase. Now a day wound healing is a challenging clinical problem. So, necessity of effective wound management is required. The various screening models play important role to understand the basic process of tissue repair and treatment of wounds. Wide varieties of in-vitro, ex-vivo and in-vivo models have been developed for evaluation of wound healing activity. The in-vitro models includes Chick chorioallantoic membrane assay, Fibroblast assay, Collagen assay, Scratch assay, Endothelial cell in vitro tube formation assay, Keratinocytes assay. Ex-vivo models includes organotypic culture, human ex vivo skin culture, porcine model, Human organotypic skin explanted culture and the in-vivo models includes Excision wound model, Incision wound Model, Burn wound model, Dead space wound model.The aim of this review article is detailed study of different types of in-vitro, ex-vivo and in-vivo models for evaluation of wound healing activity.
Formulation, optimization and evaluation of quick dispersible tablets of sumatriptan Baghel, Pragya; Roy, Amit; Chandrakar, Shashikant; Bahadur, Sanjib; Bhairam, Monika
Journal of Applied Pharmaceutical Research Vol. 7 No. 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (516.132 KB) | DOI: 10.18231/j.joapr.2019.004

Abstract

The main objective of this study was to prepare quick dispersible tablets of drug sumatriptan succinate, which can rapidly disintegrate in the saliva using three different superdisintegrants that is, sodium starch glycolate, crospovidone, and croscarmallose sodium with taste masking polymer beta-cyclodextrin and aspartame as a sweetener. The taste masking of the drug was done by mixing it with the polymer beta-cyclodextrin using solvent evaporation method and then mixing optimized quantity of aspartame to it. The quick dispersible tablets were prepared by direct compression technique using taste masked drug and other formulation excipients. The effect of various super disintegrants in three different concentrations has been studied. The prepared tablets were evaluated for wetting time, in-vitro disintegration time, strength, and in-vitro dissolution time. As per the results obtained, it was found that the formulation batch no. 4 was found to be the best formulation, as the data’s obtained by it was found to be in the required range of mouth dissolving tablets.
Techno-Economic Evaluation of Solar Irrigation Plants Installed in Bangladesh Hoque, Najmul; Roy, Amit; Beg, Mohd. Rafiqul Alam; Das, B. K.
International Journal of Renewable Energy Development Vol 5, No 1 (2016): February 2016
Publisher : Center of Biomass & Renewable Energy, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ijred.5.1.73-78

Abstract

In the summer season, irrigation sector in Bangladesh suffers a lot due to the country wide electricity crisis. Solar pump offers a clean and simple alternative to the conventional fuel fired engine or grid electricity driven pump in this regard to resolve the issue. In this paper, the techno-economic analyses of solar irrigation plants installed in Bangladesh are evaluated.  It was observed that systems were running around 70% to 80% of the rated power which was quite acceptable. A 10 hp pump was able to pump 600 liter of water per minute which was also satisfactory to irrigate the land. Average operating time was found to be 8 hour/day. It was found that the overall efficiency of the systems were in between 11.39% to 16.52% whereas the typical average value of lit/Wp/year was 9200. On the other hand, the cost of irrigation to cultivate paddy in 0.161 hectares’ land for one season was 1,750 BDT by solar irrigation which was found to be lower than that of other available modes. This charge for grid electricity based irrigation was about 3,000 to 3500 BDT per 0.161 hectares’ and 2,300 to 2,600 BDT per 0.161 hectares’ for diesel engine based irrigation. According to the current financial scheme (15% equity investment, 35% credit support and remaining 50% from government through IDCOL) the average value of payback period was 5.43 years, NPV in the range from 7 to 15% and IRR was 18%. By considering 100% equity investment, however, these projects were not economically attractive. The payback period for this case was about 18 years. Study also revealed that each solar irrigation plant reduces 42.8 kg of CO2 emission per day compare to diesel engine operated pump and 2566.24 kg/day compared to grid electricity operated pump. A comprehensive effort from the Government as well as from all the stakeholders is required for further expansion of solar irrigation plants in Bangladesh. Article History: Received Sept 05, 2015; Received in revised form Dec 15, 2015; Accepted February 2, 2016; Available onlineHow to Cite This Article: Hoque, N., Roy, A., Beg, M.R.A. and Das, B.K. (2016) Techno-Economic Evaluation of Solar Irrigation Plants Installed in Bangladesh. Int. Journal of Renewable Energy Development, 5(1), 73-78.http://dx.doi.org/10.14710/ijred.5.1.73-78 
Co-Authors Aditi Dubey, Aditi Alisha Banafar, Alisha Ananta Choudhury, Ananta Arvind Kumar, Arvind B. K. Das, B. K. Bhupendra Pradhan, Bhupendra Chandrakar, Shashikant Devnarayan Sinha, Devnarayan Dhanushram Turkane, Dhanushram Dipesh Sahu, Dipesh Durgeshnandani Sinha, Durgeshnandani Ghanshyam Sahu, Ghanshyam Gupta, Pushpa Prasad Kumar Dewangan, Mehendra Mehendra Kumar Dewangan, Mehendra Kumar Mohd. Rafiqul Alam Beg, Mohd. Rafiqul Alam Monika Bhairam, Monika Monika Chauhan, Monika Najmul Hoque, Najmul Narendra Kumar Nushrat Praveen, Nushrat Parveen, Nushrat Pragya Baghel, Pragya Pushpa Prasad, Pushpa Ranabir Chanda, Ranabir Reema Verma, Reema Sahu, Uttam Kumar Sanjib Bahadur, Sanjib Saurabh Sahu, Saurabh Suman Saha, Suman SWATI VERMA Swati Yadav, Swati Tilochan Satapathy, Tilochan Trilochan Satapathy, Trilochan Uttam Sahu, Uttam Verma, Renuka