Joni Wahyuhadi, Joni
Department Of Neuro-surgery, Faculty Of Medicine, Universitas Airlangga

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Monitoring Serum Creatinine, Blood Urea Nitrogen in Patients Brain Injury with Mannitol Therapy Sari, Erni A; Suharjono, Suharjono; Wahyuhadi, Joni
Folia Medica Indonesiana Vol. 56 No. 4 (2020): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (656 KB) | DOI: 10.20473/fmi.v56i4.24588

Abstract

Increased intracranial pressure is a further effect of brain injury due to structural damage and osmotic and water imbalances (Edema). Mannitol works in the proximal tubules and mannitol in the absorption of tubular cells by the mechanism of pinocytosis. The fluid transfer will draw fluid into the intracellular, so that the cell will be switched and broke. This phenomenon is referred to as the phenomenon of "Nephrosis Osmotic", in which mannitol administration may occur as a result of accumulation of drugs in the kidneys due to prolonged exposure to mannitol in the kidney and given dosage. The effects of osmotic diuresis occurring plus the dose and duration of mannitol administration are reported to cause renal function disorders (Scr and BUN). The aim of this study was to analyze changes in serum creatinine and BUN in patients with brain injury from before receiving mannitol therapy and during mannitol treatment. From the results of the study the number of patients who met the inclusion criteria, 32 patients. Serum creatinine, the initial average of 0.85 ± 0.17 mg / dl and the last day of the mean SCr 0.74 ± 0.30 mg / dl. While the mean BUN (Blood Urea Nitrogen) was 11.27 ± 2.75 mg / dl and the mean last day was 17.08 mg / dl ± 8.59 mg / dl. From Serum Creatinine and BUN data it can be concluded that there is no significant change.
EDUCATION REGARDING EARLY DETECTION AND EARLY TREATMENT OF BRAIN TUMORS IN BANYUWANGI REGENCY, INDONESIA Susilo, Rahadian Indarto; Haq , Irwan Barlian Immadoel; Apriawan, Tedy; Wahyuhadi, Joni; Puspikawati, Septa Indra; Ramadhaningtyas , Erica Medina
Journal of Public Health Research and Community Health Development Vol. 9 No. 1 (2025): October
Publisher : Fakultas Ilmu Kesehatan, Kedokteran dan Ilmu Alam (FIKKIA), Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jphrecode.v9i1.68478

Abstract

Brain tumors were estimated to occur at 6.4 per 100,000 people each year. The incidence rate of brain tumors in children is reported to be 5.7% out of every 100,000 children, while in adults, the reported rate is significantly higher at 29.9% out of every 100,000 people. Banyuwangi Regency has an area of 5,782.50 km2 with a population in 2018 of 1,609,677 people with a density of around 278 people/km2. With such a large population, early detection of brain tumors is important for the public to understand. Early detection activity programs from community health centre need to be held with the hope that health workers will be able to provide education and information regarding early symptoms and signs of brain tumors as well as risk factors for brain tumors for prevention. Increasing public knowledge about alerting the early symptoms of brain tumors is one strategy that can be used to reduce death and disability rates due to brain tumors. The aim of this community service program is to increase the knowledge of the lay public and health workers regarding early detection and early treatment of brain tumors in Banyuwangi Regency. Pre- and post-test questionnaires were given before and after the material to evaluate the increase in knowledge about brain tumors for lay people and health workers in Banyuwangi Regency. The results obtained a significant increase (p < 0.01) between the pre-test and post-test scores so that this community service increases the knowledge of the community in Banyuwangi Regency.
Risk of meningioma associated with exposure of hormonal contraception. A case control study Wahyuhadi, Joni; Heryani, Dini; Basuki, Hari
Majalah Obstetri & Ginekologi Vol. 26 No. 1 (2018): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.511 KB) | DOI: 10.20473/mog.V26I12018.36-41

Abstract

Objective: To determine the effect of hormonal contraceptive exposure on the development of meningioma. Materials and Methods: This case–control study, conducted in 2016, included all patients diagnosed histopathologically with meningioma between 2012 and 2013 and treated at Dr. Soetomo General Hospital, Surabaya, Indonesia. Medical record data from these patients were collected and compared with a control group consisting of non-meningioma patients who underwent contrast-enhanced head CT scans and direct interviews. A total of 101 cases and 101 controls were analyzed. Data were evaluated using univariate logistic regression analysis. Results: Patients with a history of hormonal contraceptive use had a 12.31-fold higher risk of developing meningioma (p = 0.000). In this study, women using monthly injectable contraceptives or oral contraceptive pills demonstrated a lower risk of meningioma compared to those using three-month injectable contraceptives. Participants who had used hormonal contraception for more than 10 years had an 18.216-fold increased risk of developing meningioma (p = 0.000). Histopathological analysis revealed no significant association between hormonal contraceptive history and meningioma subtype distribution; however, descriptive data indicated that the transitional type was the most frequent histopathological subtype among the case group. Conclusion: There is a significant association between hormonal contraceptive use and the occurrence of meningioma, particularly with the use of three-month injectable hormonal contraception and long-term use exceeding 10 years. No significant association was observed between meningioma histopathological grade and a history of hormonal contraceptive exposure.